TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation

Prospects for modulating the CD40/CD40L pathway in the therapy of the hyper-IgM syndrome

(2017) Xiangxue Meng et al.   Innate Immunity

Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists

(2016) Gregory L. Beatty et al.   Expert Review of Anticancer Therapy

TRAF3 as a powerful and multitalented regulator of lymphocyte functions

(2016) Gail A. Bishop   JOURNAL OF LEUKOCYTE BIOLOGY

Constraints Contributed by Chromatin Looping Limit Recombination Targeting during Ig Class Switch Recombination

(2015) Scott Feldman et al.   JOURNAL OF IMMUNOLOGY

Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination

(2015) Z. Chen et al.   JOURNAL OF IMMUNOLOGY

AID-Initiated DNA Lesions Are Differentially Processed in Distinct B Cell Populations

(2014) Zhangguo Chen et al.   JOURNAL OF IMMUNOLOGY

IgH Chain Class Switch Recombination: Mechanism and Regulation

(2014) Janet Stavnezer et al.   JOURNAL OF IMMUNOLOGY

Roles of the Kinase TAK1 in CD40-Mediated Effects on Vascular Oxidative Stress and Neointima Formation after Vascular Injury

(2014) Zifang Song et al.   PLoS One

NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation

(2014) Di-Feng Fang et al.   Nature Communications

Generation and repair of AID-initiated DNA lesions in B lymphocytes

(2014) Zhangguo Chen et al.   Frontiers of Medicine

Nuclear Factor κB Mediates Suppression of Canonical Transient Receptor Potential 6 Expression by Reactive Oxygen Species and Protein Kinase C in Kidney Cells

(2013) Yanxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

(2013) Rami Rahal et al.   NATURE MEDICINE

Three-dimensional architecture of the IgH locus facilitates class switch recombination

(2012) Amy L. Kenter et al.   Annals of the New York Academy of Sciences

Regulation ofAicdaexpression and AID activity

(2012) Hong Zan et al.   AUTOIMMUNITY

The role of activation-induced deaminase in antibody diversification and genomic instability

(2012) Jing H. Wang   IMMUNOLOGIC RESEARCH

Roles of the Kinase TAK1 in TRAF6-Dependent Signaling by CD40 and Its Oncogenic Viral Mimic, LMP1

(2012) Kelly M. Arcipowski et al.   PLoS One

Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

(2012) Egest J. Pone et al.   Nature Communications

Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes

(2011) Ping Xie et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

(2010) Cristian Boboila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling

(2010) P. Xie et al.   JOURNAL OF IMMUNOLOGY

TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40

(2009) H. H. Jabara et al.   INTERNATIONAL IMMUNOLOGY

HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

(2009) Seok-Rae Park et al.   NATURE IMMUNOLOGY

B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers

(2009) Thinh Huy Tran et al.   NATURE IMMUNOLOGY

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

(2008) Sandra Gardam et al.   IMMUNITY