Article
Immunology
Pan Fu, Xinpeng Luo, Jun Shen, Leiyan He, Hua Rong, Chunling Li, Saige Chen, Lei Zhang, Aimin Wang, Chuanqing Wang
Summary: This study investigated carbapenemase-producing Enterobacteriaceae (CPE) strains isolated from children in Shanghai, China from 2016 to 2021. The results showed that NDM was the primary carbapenemase in children (67.6%), followed by KPC (26.4%), IMP (5.3%), and OXA-48 (0.6%). NDM-Kpn posed the most serious threat to infants, especially neonates, and the high-risk clone ST11 KPC-Kpn should be continuously monitored in children.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Public, Environmental & Occupational Health
Adriana Jimenez, Kristopher Fennie, L. Silvia Munoz-Price, Boubakari Ibrahimou, Vukosava Pekovic, Lilian M. Abbo, Octavio Martinez, Gemma Rosello, Kathleen Sposato, Yohei Doi, Mary Jo Trepka
Summary: The study found that patients with immunocompromised, mechanical ventilation exposure, or exposure to carbapenems have a higher risk of prolonged CPE carriage. Patients with CPE isolated from multiple body sites had a higher probability of clearing their CPE-carrier status. Infection prevention programs should consider these factors to prevent horizontal transmission and outbreaks.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Food Science & Technology
Jiayi Wang, Yue Lei, Yougui Yu, Lebin Yin, Yangyang Zhang
Summary: This study demonstrates that a mixture of lactic acid and acetic acid can achieve similar inhibitory effects on Escherichia coli O157:H7 while reducing costs. Proteomics analysis and cell membrane permeability experiments reveal distinct mechanisms of action between 1% lactic acid and 0.8% lactic acid + 0.2% acetic acid, providing a theoretical basis for using acid mixtures for produce decontamination.
Article
Infectious Diseases
Sarah Jolivet, Jeanne Couturier, Xavier Vuillemin, Cyril Gouot, Didier Nesa, Marine Adam, Eolia Brissot, Mohamad Mohty, Remy A. Bonnin, Laurent Dortet, Frederic Barbut
Summary: This study investigated a persistent outbreak of OXA-48 carbapenemase-producing Enterobacterales (CPE) in a haematological ward of a French teaching hospital, primarily Citrobacter freundii. Whole genome comparisons identified clonal dissemination from hospital environment to patients. Strict routine infection control measures and an intensive cleaning program helped to contain the outbreak.
Article
Medicine, General & Internal
Yong Kyun Kim, In Bok Chang, Han Sung Kim, Wonkeun Song, Seung Soon Lee
Summary: The study found that OXA-48-like and Klebsiella pneumoniae are associated with prolonged carriage of CPE. Additionally, patients with CP-K. pneumoniae, positive clinical specimen of CPE, and concurrent Clostridioides difficile infection are more likely to have prolonged carriage of CPE.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Eleni Xenofontos, Georgios Renieris, Maria Kalogridi, Dionyssia-Eirini Droggiti, Kalliopi Synodinou, Georgia Damoraki, Panagiotis Koufargyris, Labros Sabracos, Evangelos J. Giamarellos-Bourboulis
Summary: Current research shows that gut colonization often precedes infection by carbapenem-resistant enterobacteria. Rifaximin has been found to effectively inhibit CRKP isolates and reduce KPC-KP gut colonization.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Tom J. B. de Man, Anna Q. Yaffee, Wenming Zhu, Dhwani Batra, Efe Alyanak, Lori A. Rowe, Gillian McAllister, Heather Moulton-Meissner, Sandra Boyd, Andrea Flinchum, Rachel B. Slayton, Steven Hancock, Maroya Spalding Walters, Alison Laufer Halpin, James Kamile Rasheed, Judith Noble-Wang, Alexander J. Kallen, Brandi M. Limbago
Summary: This investigation identified the largest known outbreak of VIM-producing CRE in the United States, showcasing evidence of in-hospital plasmid transmission and environmental contamination.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Engineering, Multidisciplinary
Beiwen Zheng, Hao Xu, Lihua Guo, Xiao Yu, Jinru Ji, Chaoqun Ying, Yunbo Chen, Ping Shen, Huiming Han, Chen Huang, Shuntian Zhang, Tao Lv, Yonghong Xiao
Summary: This study investigates the population structure and genetic characteristics of carbapenemase-producing Enterobacteriaceae (CPE) isolates among bloodstream infections (BSIs) in China. The research reveals a high prevalence of ESBLs and wide dissemination of CPE in BSIs, with the clonal spread of KPC2-producing K. pneumoniae ST11 and NDM-5-producing E. coli ST167 being of particular concern.
Article
Microbiology
Diego Cuicapuza, Luis Alvarado, Norah Tocasca, Daniel Aguilar, Juan Carlos Gomez-de-la-Torre, Guillermo Salvatierra, Pablo Tsukayama, Jesus Tamariz
Summary: We identified five carbapenemase-producing Enterobacterales (CPE) isolates from two healthcare institutions in Lima, Peru. All isolates were carriers of the bla(OXA-48)-like gene and had the bla(OXA-181) gene as the only carbapenemase gene. Other resistance genes and the IncX3 plasmid were also found. This study highlights the increasing public health problem of CPE isolates harboring bla(OXA)-like genes and the wide dissemination of bla(OXA-181) in Peru.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Chendi Zhu, Carmen Li, Christopher K. C. Lai, Rita Ng, Ka Yee Chau, Kam Tak Wong, Norman W. S. Lo, Nilakshi Barua, Ying Yang, Veranja Liyanapathirana, Mamie Hui, Raymond W. Lai, Kitty S. C. Fung, Dominic N. Tsang, I. P. Margaret
Summary: This study describes the molecular epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in patients from Hong Kong hospitals, with increasing isolation rates and dominance of bla(NDM) and bla(IMP) genes. Enhanced containment strategies are required to mitigate the rising trend of CPE in healthcare settings.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Hye-Jin Kim, JungHee Hyun, Hyo-Seon Jeong, Yeon-Kyeng Lee
Summary: This study aimed to describe the clinical and epidemiological characteristics and risk factors of CPE infection in terms of acquisition and colonization. The results showed that CPE acquisition was significantly associated with ICU treatment and holding gastrointestinal tubes. Active CPE screening should be implemented for high-risk patients.
Article
Infectious Diseases
Ryuichiro Abe, Yukihiro Akeda, Tetsuya Iida, Shigeyuki Hamada
Summary: The article discusses the validity of population analysis profiling (PAP) for determining carbapenem heteroresistance. The authors found that some isolates did not exhibit heteroresistance despite meeting PAP criteria. It was discovered that bacterial cells that were originally non-viable could occasionally become viable due to the hydrolysis of carbapenems by carbapenemases produced by dying cells, mimicking the emergence of subpopulations with enhanced resistance. As a result, PAP for carbapenemase-producing Enterobacteriaceae (CPE) may be influenced by dying populations and may not accurately detect heterogeneity in carbapenem resistance among seemingly isogenic clones.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Microbiology
Xiaopeng Jing, Yanyan Hu, Tingting Wu, Xing Zhang, Shaofeng Luo, Wei Wang, Xiaochun Min, Ruiling Sun, Ji Zeng
Summary: A method using MALDI-TOF MS with EDTA and PB was established to distinguish metallo-beta-lactamase and serine carbapenemases. The method showed high sensitivity and specificity, making it helpful for antibiotic selection in clinical practice.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Rita Elias, Anton Spadar, Antoni P. A. Hendrickx, Remy A. Bonnin, Laurent Dortet, Margarida Pinto, Jody E. Phelan, Isabel Portugal, Susana Campino, Gabriela Jorge da Silva, Taane G. Clark, Aida Duarte, Joao Perdigao
Summary: This study characterized the genomic diversity and international dissemination of CRKP strains from tertiary care hospitals in Lisbon, Portugal. Two genomic clusters, ST13/GC1 and ST17/GC2, were identified. Additionally, an emerging OXA-181/ST17-producing strain in Portugal and the ongoing international dissemination of a KPC-3/ST13-producing clone were highlighted.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Cecile Emeraud, Aba Mahamat, Agnes B. Jousset, Sandrine Bernabeu, Tania Goncalves, Camille Pommier, Delphine Girlich, Aurelien Birer, Christophe Rodriguez, Jean-Michel Pawlotsky, Thierry Naas, Remy A. Bonnin, Laurent Dorte
Summary: Since 2021, the rapid spread of highly resistant NDM-14 producing Klebsiella pneumoniae has been identified in hospitals in France. This strain, primarily imported from Morocco, is highly resistant to most antimicrobials and belongs to a single clone. However, it remains susceptible to colistin, cefiderocol, and the combination of aztreonam/avibactam.