Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload

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Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia

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A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

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Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

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HIF2 α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling

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Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils

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Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

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(2015) Antonello Pietrangelo   GASTROENTEROLOGY

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease

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Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

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Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice

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Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

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Identification of erythroferrone as an erythroid regulator of iron metabolism

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PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2

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IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2  mRNA translation

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The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

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Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

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Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

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Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

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Intestinal HIF2  promotes tissue-iron accumulation in disorders of iron overload with anemia

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Hepcidin and iron homeostasis

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Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

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Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination

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Deletion of HIF-2  in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice

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Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

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Intestinal Hypoxia-inducible Factor-2α (HIF-2α) Is Critical for Efficient Erythropoiesis

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Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

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Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

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A Ferroportin Transcript that Lacks an Iron-Responsive Element Enables Duodenal and Erythroid Precursor Cells to Evade Translational Repression

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HIF-2α, but not HIF-1α, promotes iron absorption in mice

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