Autosomal dominant polycystic kidney disease: Disrupted pathways and potential therapeutic interventions

Monoallelic Mutations to DNAJB11 Cause Atypical Autosomal-Dominant Polycystic Kidney Disease

(2018) Emilie Cornec-Le Gall et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Polycystin and calcium signaling in cell death and survival

(2018) Fernanda O. Lemos et al.   CELL CALCIUM

Bone marrow–mesenchymal stromal cell infusion in patients with chronic kidney disease: A safety study with 18 months of follow-up

(2018) Atieh Makhlough et al.   CYTOTHERAPY

The vasopressin system: new insights for patients with kidney diseases

(2017) W. F. Clark et al.   JOURNAL OF INTERNAL MEDICINE

Polycystic Kidney Disease without an Apparent Family History

(2017) Ioan-Andrei Iliuta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bosutinib versus Placebo for Autosomal Dominant Polycystic Kidney Disease

(2017) Vladimir Tesar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

Safety and tolerability of autologous bone marrow mesenchymal stromal cells in ADPKD patients

(2017) Atieh Makhlough et al.   Stem Cell Research & Therapy

Mutations in GANAB , Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease

(2016) Binu Porath et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autosomal Dominant Polycystic Kidney Disease: Core Curriculum 2016

(2016) Fouad T. Chebib et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2

(2016) Yifei Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Challenges and opportunities for stem cell therapy in patients with chronic kidney disease

(2016) LaTonya J. Hickson et al.   KIDNEY INTERNATIONAL

Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease

(2016) Liudmila Cebotaru et al.   KIDNEY INTERNATIONAL

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR

(2016) Marilena Gregorini et al.   PLoS One

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ouabain Enhances ADPKD Cell Apoptosis via the Intrinsic Pathway

(2016) Jessica Venugopal et al.   Frontiers in Physiology

Vasopressin Receptor Antagonists, Heart Failure, and Polycystic Kidney Disease

(2015) Vicente E. Torres   Annual Review of Medicine

Human mesenchymal stem cells - current trends and future prospective

(2015) Imran Ullah et al.   BIOSCIENCE REPORTS

Mesenchymal Stromal Cells Improve Renovascular Function in Polycystic Kidney Disease

(2015) Federico Franchi et al.   CELL TRANSPLANTATION

Chloride secretion by renal collecting ducts

(2015) Madhumitha Rajagopal et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Autologous transplantation of mesenchymal stromal cells tends to prevent progress of interstitial fibrosis in a rhesus Macaca mulatta monkey model of chronic kidney disease

(2015) Reza Moghadasali et al.   CYTOTHERAPY

Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease

(2015) Li Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease

(2015) C. S. Pinto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vasopressin and disruption of calcium signalling in polycystic kidney disease

(2015) Fouad T. Chebib et al.   Nature Reviews Nephrology

Molecular Pathways and Therapies in Autosomal-Dominant Polycystic Kidney Disease

(2015) Takamitsu Saigusa et al.   PHYSIOLOGY

Cyclooxygenase product inhibition with acetylsalicylic acid slows disease progression in the Han:SPRD-Cy rat model of polycystic kidney disease

(2015) Naser H.M. Ibrahim et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Treatment of chronic kidney diseases with histone deacetylase inhibitors

(2015) Na Liu et al.   Frontiers in Physiology

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

(2015) Elisa Nigro et al.   Cells

Intra-renal arterial injection of autologous bone marrow mesenchymal stromal cells ameliorates cisplatin-induced acute kidney injury in a rhesus Macaque mulatta monkey model

(2014) Reza Moghadasali et al.   CYTOTHERAPY

Polycystins and partners: proposed role in mechanosensitivity

(2014) Kevin Retailleau et al.   JOURNAL OF PHYSIOLOGY-LONDON

Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease

(2014) Robert W. Schrier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal Stem Cells Modulate Albumin-Induced Renal Tubular Inflammation and Fibrosis

(2014) Hao Jia Wu et al.   PLoS One

Polycystin-1: a master regulator of intersecting cystic pathways

(2014) Sorin V. Fedeles et al.   TRENDS IN MOLECULAR MEDICINE

Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease

(2013) Xia Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Smac-Mimetic-Induced Epithelial Cell Death Reduces the Growth of Renal Cysts

(2013) L. X. Fan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity

(2013) G. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

(2013) Ming Ma et al.   NATURE GENETICS

Diagnosis and management of polycystic liver disease

(2013) Tom J. G. Gevers et al.   Nature Reviews Gastroenterology & Hepatology

Mesenchymal Stem Cells (MSC) Prevented the Progression of Renovascular Hypertension, Improved Renal Function and Architecture

(2013) Elizabeth B. Oliveira-Sales et al.   PLoS One

Therapeutic Potential of Mesenchymal Stem Cells in Regenerative Medicine

(2013) Devang M. Patel et al.   Stem Cells International

Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity

(2012) Reza Moghadasali et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

c-Met and NF- B-Dependent Overexpression of Wnt7a and -7b and Pax2 Promotes Cystogenesis in Polycystic Kidney Disease

(2012) S. Qin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Celecoxib inhibits growth of human autosomal dominant polycystic kidney cyst-lining epithelial cells through the VEGF/Raf/MAPK/ERK signaling pathway

(2012) Tao Xu et al.   MOLECULAR BIOLOGY REPORTS

Angiogenesis and autosomal dominant polycystic kidney disease

(2012) Jennifer L. Huang et al.   PEDIATRIC NEPHROLOGY

The long-term outcome of patients with polycystic liver disease treated with lanreotide

(2011) M. Chrispijn et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Cilium, centrosome and cell cycle regulation in polycystic kidney disease

(2011) Kyung Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aliskiren corrects recurrent hyperreninemia and hyperaldosteronism in autosomaldominant polycystic kidney disease

(2011) P. Amico et al.   CLINICAL NEPHROLOGY

Inhibition of Cdc25A Suppresses Hepato-renal Cystogenesis in Rodent Models of Polycystic Kidney and Liver Disease

(2011) Tatyana V. Masyuk et al.   GASTROENTEROLOGY

Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways

(2011) Ayumi Takakura et al.   HUMAN MOLECULAR GENETICS

Cystogenic potential of CD133+ progenitor cells of human polycystic kidneys

(2011) Raquel Carvalhosa et al.   JOURNAL OF PATHOLOGY

Calcimimetics inhibit renal pathology in rodent nephronophthisis

(2011) Neal X. Chen et al.   KIDNEY INTERNATIONAL

Short-term effects of tolvaptan on renal function and volume in patients with autosomal dominant polycystic kidney disease

(2011) Maria V. Irazabal et al.   KIDNEY INTERNATIONAL

Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation

(2011) Lucy X. Fan et al.   KIDNEY INTERNATIONAL

Therapeutic potential of vasopressin V2 receptor antagonist in a mouse model for autosomal dominant polycystic kidney disease: optimal timing and dosing of the drug

(2011) E. Meijer et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis

(2011) B. Buchholz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Inhibition of the p38 MAPK pathway ameliorates renal fibrosis in an NPHP2 mouse model

(2011) Noriyuki Sugiyama et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis

(2011) V. Takiar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment Strategies and Clinical Trial Design in ADPKD

(2010) Vicente E. Torres   ADVANCES IN CHRONIC KIDNEY DISEASE

Rosiglitazone Inhibits Cell Proliferation by Inducing G1 Cell Cycle Arrest and Apoptosis in ADPKD Cyst-Lining Epithelia Cells

(2010) Yawei Liu et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Cyclic AMP-mediated cyst expansion

(2010) Darren P. Wallace   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells

(2010) Nadezhda N. Zheleznova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reducing Polycystic Liver Volume in ADPKD: Effects of Somatostatin Analogue Octreotide

(2010) A. Caroli et al.   Clinical Journal of the American Society of Nephrology

Novel targets for the treatment of autosomal dominant polycystic kidney disease

(2010) Franck A Belibi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD

(2010) Sergio A. Gradilone et al.   GASTROENTEROLOGY

Randomized Clinical Trial of Long-Acting Somatostatin for Autosomal Dominant Polycystic Kidney and Liver Disease

(2010) M. C. Hogan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

mTOR Inhibitors in Polycystic Kidney Disease

(2010) Terry Watnick et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease

(2010) Andreas L. Serra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

(2010) Gerd Walz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chronic treatment with lisinopril decreases proliferative and apoptotic pathways in autosomal recessive polycystic kidney disease

(2010) Guangfu Jia et al.   PEDIATRIC NEPHROLOGY

Carboxy Terminal Tail of Polycystin-1 Regulates Localization of TSC2 to Repress mTOR

(2010) Ruhee Dere et al.   PLoS One

ERK Regulates Renal Cell Proliferation and Renal Cyst Expansion in inv Mutant Mice

(2009) Yasuko Okumura et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Lanreotide Reduces the Volume of Polycystic Liver: A Randomized, Double-Blind, Placebo-Controlled Trial

(2009) Loes van Keimpema et al.   GASTROENTEROLOGY

Calcimimetic Inhibits Late-Stage Cyst Growth in ADPKD

(2009) V. H. Gattone et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models

(2009) Y. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

(2008) Sekiya Shibazaki et al.   HUMAN MOLECULAR GENETICS

Caspase-3 Gene Deletion Prolongs Survival in Polycystic Kidney Disease

(2008) Y. Tao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Small-Molecule CFTR Inhibitors Slow Cyst Growth in Polycystic Kidney Disease

(2008) B. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Src Inhibition Ameliorates Polycystic Kidney Disease

(2008) W. E. Sweeney et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Triptolide Reduces Cystogenesis in a Model of ADPKD

(2008) S. J. Leuenroth et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Increased Expression of Secreted Frizzled-Related Protein 4 in Polycystic Kidneys

(2008) D. Romaker et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease

(2008) Mamdouh Albaqumi et al.   KIDNEY INTERNATIONAL

Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease

(2008) X. Wang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION