Meldonium improves Huntington’s disease mitochondrial dysfunction by restoring peroxisome proliferator-activated receptor γ coactivator 1α expression
出版年份 2018 全文链接
标题
Meldonium improves Huntington’s disease mitochondrial dysfunction by restoring peroxisome proliferator-activated receptor γ coactivator 1α expression
作者
关键词
-
出版物
JOURNAL OF CELLULAR PHYSIOLOGY
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2018-10-26
DOI
10.1002/jcp.27602
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Significance of l -carnitine for human health
- (2017) María M. Adeva-Andany et al. IUBMB LIFE
- Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
- (2017) Luana Naia et al. JOURNAL OF NEUROSCIENCE
- Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent
- (2017) Craig Porter et al. JOURNAL OF PHYSIOLOGY-LONDON
- Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease
- (2017) Chee-Hoe Ng et al. NEUROBIOLOGY OF AGING
- PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis
- (2017) Audrey S. Dickey et al. Science Translational Medicine
- Alterations in the carnitine cycle in a mouse model of Rett syndrome
- (2017) Sabrina Mucerino et al. Scientific Reports
- Erratum: PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
- (2016) Aleksandra Dabrowska et al. Aging-US
- Comment: Meldonium and the WADA Prohibited List
- (2016) David Hughes Australian Prescriber
- Story behind meldonium–from pharmacology to performance enhancement: a narrative review
- (2016) Wolfgang Schobersberger et al. BRITISH JOURNAL OF SPORTS MEDICINE
- Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan
- (2016) Filippo Scialò et al. Cell Metabolism
- Metabolic disturbances in plasma as biomarkers for Huntington's disease
- (2016) Mei-Ling Cheng et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Novel Metabolite Biomarkers of Huntington’s Disease As Detected by High-Resolution Mass Spectrometry
- (2016) Stewart F. Graham et al. JOURNAL OF PROTEOME RESEARCH
- Rosiglitazone activation of PPARγ-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta–induced mitochondrial dysfunction and oxidative stress
- (2016) Ming-Chang Chiang et al. NEUROBIOLOGY OF AGING
- Mitochondrial dynamics and quality control in Huntington's disease
- (2016) Pedro Guedes-Dias et al. NEUROBIOLOGY OF DISEASE
- Response to comment by Sergei V. Jargin: “Meldonium (Mildronate): primum nоn nocere”
- (2016) Maija Dambrova et al. PHARMACOLOGICAL RESEARCH
- Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity
- (2016) Maija Dambrova et al. PHARMACOLOGICAL RESEARCH
- A tennis lesson: sharp practice in the science behind the Sharapova case
- (2016) Arduino Arduini et al. POSTGRADUATE MEDICAL JOURNAL
- VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
- (2016) Xing Guo et al. Nature Communications
- spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster
- (2015) Eric M. Merzetti et al. BMC NEUROSCIENCE
- Mitochondrial modulators improve lipid composition and attenuate memory deficits in experimental model of Huntington’s disease
- (2015) Arpit Mehrotra et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis
- (2014) Amit Kumar et al. DRUG DISCOVERY TODAY
- Targeting Carnitine Biosynthesis: Discovery of New Inhibitors against γ-Butyrobetaine Hydroxylase
- (2014) Kaspars Tars et al. JOURNAL OF MEDICINAL CHEMISTRY
- Adaptive Downregulation of Mitochondrial Function in Down Syndrome
- (2013) Pablo Helguera et al. Cell Metabolism
- PGC-1α, mitochondrial dysfunction, and Huntington's disease
- (2013) Ashu Johri et al. FREE RADICAL BIOLOGY AND MEDICINE
- Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease
- (2013) Jing Jin et al. JOURNAL OF NEUROCHEMISTRY
- Mildronate improves cognition and reduces amyloid-β pathology in transgenic Alzheimer's disease mice
- (2013) Ulrika Beitnere et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntingtons Disease - from Clinical Features to the Bench
- (2012) Tatiana R. Rosenstock et al. CURRENT DRUG TARGETS
- PGC-1 Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
- (2012) T. Tsunemi et al. Science Translational Medicine
- PGC-1 coactivators in the control of energy metabolism
- (2011) C. Liu et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease
- (2011) Ashu Johri et al. HUMAN MOLECULAR GENETICS
- Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease
- (2010) J. Kim et al. HUMAN MOLECULAR GENETICS
- Impaired mitochondrial trafficking in Huntington's disease
- (2009) Xiao-Jiang Li et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondria as the target for mildronate's protective effects in azidothymidine (AZT)‐induced toxicity of isolated rat liver mitochondria
- (2008) Jolanta Pupure et al. CELL BIOCHEMISTRY AND FUNCTION
- Rosiglitazone Treatment Prevents Mitochondrial Dysfunction in Mutant Huntingtin-expressing Cells
- (2008) Rodrigo A. Quintanilla et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart
- (2008) Edgars Liepinsh et al. LIFE SCIENCES
- Analyzing real-time PCR data by the comparative CT method
- (2008) Thomas D Schmittgen et al. Nature Protocols
- Suppression of Neurodegeneration and Increased Neurotransmission Caused by Expanded Full-Length Huntingtin Accumulating in the Cytoplasm
- (2008) Eliana Romero et al. NEURON
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