Article
Chemistry, Physical
Janice Caroline Hardt, Michelly Cristina Galdioli Pella, Ana Caroline Reis Meira, Andressa Giombelli Rosenberger, Josiane Caetano, Douglas Cardoso Dragunski
Summary: This study evaluated the potential application of silver sulfadiazine loaded PBAT/PCL microfibers as wound dressings, which exhibited antimicrobial activity and controlled release. The results showed that the fiber diameter and crystallinity were concentration-dependent on the silver sulfadiazine, and the release profile was biphasic with both fast and sustained release.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Polymer Science
Guiting Liu, Yuan Zhou, Hongxun Zhou, Rong Chen, Shaoyun Guo
Summary: A novel thermo-responsive drug release material was fabricated in this study, achieving controlled release of drugs by changing temperature. The experimental results showed that this material can accelerate drug release at specific temperatures, indicating its potential application in bone tissue engineering.
Article
Materials Science, Multidisciplinary
Thannaphat Jenvoraphot, Boontharika Thapsukhon, Donraporn Daranarong, Robert Molloy, Chayarop Supanchart, Suttichai Krisanaprakornkit, Paul D. Topham, Brian Tighe, Anisa Mahomed, Winita Punyodom
Summary: In this research, a periodontal membrane with nanoporous structure and tetracycline drug loading was designed and fabricated to improve periodontal regeneration and anti-inflammatory effect.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Composites
Danilo D. Siqueira, Carlos B. B. Luna, Edcleide Maria Araujo, Thercio Henrique de Carvalho Costa, Renate M. R. Wellen
Summary: Biocomposites of poly(e-caprolactone) (PCL) with macaiba fiber (MF) showed promising biodegradability and performance, with plasma-treated fibers exhibiting lower elastic modulus compared to PCL.
POLYMER COMPOSITES
(2022)
Article
Engineering, Environmental
Jiqian Li, Hezhi He, Zhiwen Zhu, Mohong Xu, Junfei Gao, Qun Gu, Bin Tan
Summary: In this study, PLA/PCL blends were extruded using eccentric rotor extruder (ERE) and twin-screw extruder (TSE), and their morphologies and properties were investigated. The results showed that ERE provided better dispersion and compatibility, as well as less polymer chain scission. Additionally, ERE promoted the crystallinity of PLA.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
J. Huang, J. Jacobsen, N. Genina, S. W. Larsen, H. M. Nielsen, A. Mullertz, H. Mu
Summary: This study investigated the effect of graphene oxide (GO) and the composition of excipients on the release and antifungal activities of clotrimazole-loaded buccal foams. The results showed that the addition of GO increased the mechanical strength of the foams and accelerated the release of clotrimazole. However, it did not significantly affect the antifungal activity of clotrimazole-loaded foams.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Sarah A. Stewart, Juan Dominguez-Robles, Emilia Utomo, Camila J. Picco, Francesca Corduas, Elena Mancuso, Muh. Nur Amir, Muh. Akbar Bahar, Sumarheni Sumarheni, Ryan F. Donnelly, Andi Dian Permana, Eneko Larran
Summary: The study developed a subcutaneous implant for prolonged delivery of LEVO to treat hypothyroidism, with in vitro experiments showing good release efficiency. In vivo experiments demonstrated that these implants were capable of providing stable LEVO plasma levels throughout the entire experimental period.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Materials Science, Multidisciplinary
Miguel Lorente, Gustavo Gonzalez-Gaitano, Margarita Valero, Javier Gonzalez-Benito
Summary: Fibrous materials based on poly(ethyleneoxide) (PEO), poly-ε-caprolactone (PCL), and a mixture of them (PEO/PCL) were prepared by solution blow spinning (SBS). The morphology, structure, thermal and mechanical properties, dissolution, and drug release of the materials were investigated. The results showed that the rotation speed of the collector affected the morphology, which in turn influenced the mechanical behavior, dissolution process, and drug release of the materials. These findings are important for the development of controlled release materials for biomedical applications.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Biochemistry & Molecular Biology
Jakia Khanom, Abdelrahman I. Rezk, Chan Hee Park, Cheol Sang Kim
Summary: This study combines hyperthermia and chemotherapy by attaching pyrrole to the surface of nanofibers, achieving localized cancer treatment. The increase in pyrrole concentration under NIR irradiation leads to a rise in local temperature, accelerating drug release and enhancing cytotoxicity.
Article
Chemistry, Multidisciplinary
Chonghui Fan, Jieyu Huang, Alfred Mensah, Zhiwen Long, Jianguo Sun, Qufu Wei
Summary: By utilizing a low-cost and biodegradable tribopositive material, we have developed a high-performance TENG for wearable applications, reducing environmental impact.
CELL REPORTS PHYSICAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Safiullah Khan, Muhammad Naeem Aamir, Asadullah Madni, Nasrullah Jan, Arshad Khan, Abdul Jabar, Hassan Shah, Muhammad Abdur Rahim, Ahsan Ali
Summary: The study successfully developed lipid polymer hybrid nanoparticles for delivering 5-fluorouracil, demonstrating sustained release and enhanced anti-cancer efficacy. The system shows potential for targeted chemotherapy delivery and minimizing toxic side effects.
Article
Polymer Science
Carmen R. Tubio, Xabier Valle, Estela Carvalho, Joana Moreira, Pedro Costa, Daniela M. Correia, Senentxu Lanceros-Mendez
Summary: Poly(hydroxybutyrate-co-hidroxyvalerate) (PHBV) is a biodegradable polymer that can be used as a substitute for plastics made from fossil resources. By blending PHBV with poly(caprolactone) (PCL) and poly(lactic acid) (PLA), its properties can be improved, including morphology, wetting, structure, thermal, mechanical, and electrical characteristics. The addition of PCL and PLA also enhances the antibacterial activity of PHBV. This study demonstrates the potential of developing PHBV blends with PCL or PLA for specific applications.
Article
Materials Science, Multidisciplinary
Huanhuan Liu, Adrianus C. Laan, Jeroen Plomp, Steven R. Parnell, Yongjun Men, Robert M. Dalgliesh, Rienk Eelkema, Antonia G. Denkova
Summary: Polymeric micelles are widely used as carriers for chemotherapeutic drugs due to their easy preparation and versatile properties. Controlled drug release using internal or external stimuli can improve the safety of drug delivery processes. Research on using ionizing radiation as a trigger for drug release from micelles loaded with photosensitizer and drugs showed that release occurred under radiation exposure, with the exact mechanism remaining unclear. Additionally, different drugs showed varied release profiles under radiation exposure.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Eduardo Galdon, Monica Millan-Jimenez, Gloria Mora-Castano, Antxon Martinez de Ilarduya, Isidoro Caraballo
Summary: A biodegradable copolyester, poly(butylene succinate-co-epsilon-caprolactone) (PBS_CL), was successfully utilized as an excipient for pharmaceutical dosage forms using hot processing techniques such as ultrasound-assisted compression (USAC) and hot melt extrusion (HME). Controlled release of the drug was achieved with varying amounts of PBS_CL, with a percolation threshold around 23% v/v estimated.
Article
Pharmacology & Pharmacy
Mohammad Mofidfar, Mark R. Prausnitz
CURRENT DRUG DELIVERY
(2019)
Article
Chemistry, Analytical
Mohammad Mofidfar, Eun Seon Kim, Emily L. Larkin, Lisa Long, Wayne D. Jennings, Samad Ahadian, Mahmoud A. Ghannoum, Gary E. Wnek
Review
Materials Science, Multidisciplinary
Elham Davoodi, Einollah Sarikhani, Hossein Montazerian, Samad Ahadian, Marco Costantini, Wojciech Swieszkowski, Stephanie Michelle Willerth, Konrad Walus, Mohammad Mofidfar, Ehsan Toyserkani, Ali Khademhosseini, Nureddin Ashammakhi
ADVANCED MATERIALS TECHNOLOGIES
(2020)
Review
Pharmacology & Pharmacy
Samad Ahadian, Joel A. Finbloom, Mohammad Mofidfar, Sibel Emir Diltemiz, Fatemeh Nasrollahi, Elham Davoodi, Vahid Hosseini, Ioanna Mylonaki, Sivakoti Sangabathuni, Hossein Montazerian, Kirsten Fetah, Rohollah Nasiri, Mehmet Remzi Dokmeci, Molly M. Stevens, Tejal A. Desai, Ali Khademhosseini
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Review
Pharmacology & Pharmacy
Mohammad Mofidfar, Behnam Abdi, Samad Ahadian, Ebrahim Mostafavi, Tejal A. Desai, Farhang Abbasi, Yang Sun, Edward E. Manche, Christopher N. Ta, Charles W. Flowers
Summary: Research in ophthalmic drug formulations has focused on improving drug penetration and bioavailability in the eye, as well as developing technologies to overcome physiological and anatomical barriers. Innovative technologies and formulations have been developed to extend the duration of drug action and enhance therapeutic effects for patients.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Xiaowei Song, Mohammad Mofidfar, Richard N. Zare
Summary: In this study, Nafion was introduced into the ambient ionization technique of spray mass spectrometry for in situ desalting and direct analysis of biological fluids. The Nafion coating enhanced the ionization efficiency and reduced ion suppression, significantly improving the accuracy of qualitative profiling or quantitative measurement of the target analyte.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xiaowei Song, Jia Li, Mohammad Mofidfar, Richard N. Zare
Summary: Isobaric ions with the same mass-to-charge ratio can be differentiated using hydrogen-deuterium exchange in microdroplets, producing unique MS spectral patterns without the need for MS/MS experiments or ion mobility measurements. This approach has been successfully used to identify isobaric ions in urinary metabolic profiles and distinguish between healthy individuals and those with bladder cancer.
Review
Engineering, Biomedical
Sara Nadine, Ada Chung, Sibel Emir Diltemiz, Brooke Yasuda, Charles Lee, Vahid Hosseini, Solmaz Karamikamkar, Natan Roberto de Barros, Kalpana Mandal, Shailesh Advani, Benjamin Behnam Zamanian, Marvin Mecwan, Yangzhi Zhu, Mohammad Mofidfar, Mohammad Reza Zare, Joao Mano, Mehmet Remzi Dokmeci, Farshid Alambeigi, Samad Ahadian
Summary: This article reviews various microfabrication technologies used in tissue engineering and discusses their advantages, drawbacks, and areas for further research.
Article
Chemistry, Multidisciplinary
Anubhav Kumar, Supratim Mondal, Mohammad Mofidfar, Richard N. Zare, Shibdas Banerjee
Summary: Carbanions, which are transient intermediates in organic or biological reactions, are difficult to observe directly. This study demonstrates that aqueous microdroplets can capture and stabilize carbanion intermediates from various reactions, allowing for their detection and providing insights into reaction mechanisms. The composition of the microdroplets, specifically water-methanol, plays a crucial role in the efficiency of carbanion capture.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Masoud A. Mehrgardi, Mohammad Mofidfar, Richard N. Zare
Summary: Water has the ability to produce hydrogen peroxide when sprayed to form microdroplets, and gas-surface interactions increase the concentration of hydrogen peroxide.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Mohammad Mofidfar, Xiaowei Song, John T. T. Kelly, Mitchell H. H. Rubenstein, Richard N. N. Zare
Summary: Using silicone wristband electrospray ionization mass spectrometry (SWESI-MS), the internal surface of a wristband can be exposed to sweat metabolites and the external surface can be exposed to environmental factors. A small amount of a water:methanol solution can effectively extract metabolites and chemicals from various sources. This method allows for onsite sampling, simple testing, and automatic data searching, making it suitable for monitoring hazardous chemical contamination and sweat-secreted metabolites.
ISRAEL JOURNAL OF CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Behnam Abdi, Mohammad Mofidfar, Fatemeh Hassanpour, Emel Kirbas Cilingir, Sepideh K. Kalajahi, Paria H. Milani, Mahsa Ghanbarzadeh, Daddi Fadel, Melissa Barnett, Christopher N. Ta, Roger M. Leblanc, Anuj Chauhan, Farhang Abbasi
Summary: The eye is crucial for providing information on the environment, but corneal diseases can lead to vision loss. Ophthalmic drug delivery has been a challenge, but contact lenses offer a potential solution for enhancing drug bioavailability in ocular tissues. This review discusses various techniques for sustained drug release, including soaking, multilayered lenses, vitamin E barriers, molecular imprinting, nanoparticles, micelles, and liposomes. The review also highlights the benefits of contact lenses over eye drops, strategies for incorporating drugs into lenses, clinical results, and recent advances in therapeutic contact lenses for allergic conjunctivitis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Xiaowei Song, Chanbasha Basheer, Yu Xia, Juan Li, Ismail Abdulazeez, Abdulaziz Al-Saadi, Mohammad Mofidfar, Mohammed Altahir Suliman, Richard Zare
Summary: This study develops a new catalytic system that utilizes a graphite mesh covered with a CuBi2O4 coating and a mixture of N-2 and CO2 as the nebulizing gas to synthesize urea in water microdroplets. The reaction converts greenhouse gases into a value-added product in an ecofriendly process.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Max L. Wang, Christian F. Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P. Annes, Richard N. Zare, Amin Arbabian
Summary: On-demand drug delivery systems combined with wireless implants can control drug release, reducing dosage and side effects. Researchers designed a release system based on a modified electroresponsive polypyrrole nanoparticulate film for negatively charged compounds. They also developed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system in vivo. The feasibility of wireless, controllable drug release was demonstrated through in vitro and in vivo characterization using fluorescein as a model drug.
Proceedings Paper
Computer Science, Information Systems
Max L. Wang, Pyungwoo Yeon, Christian F. Chamberlayne, Mohammad Mofidfar, Haixia Xu, Justin P. Annes, Richard N. Zare, Amin Arbabian
Summary: This study presents an ultrasonically powered implantable potentiostat for programmable drug delivery control. The system is complex, consisting of multiple functional modules for bidirectional communication and drug release. The wireless powered and controlled fluorescein release successfully demonstrates the system's effectiveness.
2021 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (IEEE BIOCAS 2021)
(2021)