Oxidative Damage to RNA in Aging and Neurodegenerative Disorders

The Earliest Stage of Cognitive Impairment in Transition From Normal Aging to Alzheimer Disease Is Marked by Prominent RNA Oxidation in Vulnerable Neurons

(2012) Akihiko Nunomura et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Greater nucleic acids oxidation in the temporal lobe than the frontal lobe in SAMP8

(2012) Fei Shi et al.   NEUROREPORT

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Quantification of oxidized levels of specific RNA species using an aldehyde reactive probe

(2011) Mikiei Tanaka et al.   ANALYTICAL BIOCHEMISTRY

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

(2011) Vittorio Calabrese et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Urinary Markers of Nucleic Acid Oxidation and Long-Term Mortality of Newly Diagnosed Type 2 Diabetic Patients

(2011) K. Broedbaek et al.   DIABETES CARE

Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a

(2011) Qingli Shi et al.   JOURNAL OF NEUROCHEMISTRY

Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain

(2011) Mark A. Lovell et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Oxidative Damage to RNA and Expression Patterns of MTH1 in the Hippocampi of Senescence-Accelerated SAMP8 Mice and Alzheimer’s Disease Patients

(2011) Xiao-Ning Song et al.   NEUROCHEMICAL RESEARCH

RNA Oxidation Adducts 8-OHG and 8-OHA Change with Aβ42 Levels in Late-Stage Alzheimer's Disease

(2011) Adam M. Weidner et al.   PLoS One

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

(2010) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress

(2010) Hiroshi Hayakawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis

(2010) William H. Hoffman et al.   BRAIN RESEARCH

Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease

(2010) M.A. Bradley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reference ranges of urinary biomarkers of oxidized guanine in (2′-deoxy)ribonucleotides and nucleic acids

(2010) Roberta Andreoli et al.   FREE RADICAL BIOLOGY AND MEDICINE

An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe

(2010) Mikiei Tanaka et al.   FREE RADICAL RESEARCH

Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy

(2010) Boris Görg et al.   HEPATOLOGY

Reimagining Alzheimer's Disease--An Age-Based Hypothesis

(2010) K. Herrup   JOURNAL OF NEUROSCIENCE

Direct Strand Scission from a Nucleobase Radical in RNA

(2010) Aaron C. Jacobs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Preclinical Alzheimer disease: Brain oxidative stress, Aβ peptide and proteomics

(2010) Christopher D. Aluise et al.   NEUROBIOLOGY OF DISEASE

Occupational exposure to low levels of benzene: Biomarkers of exposure and nucleic acid oxidation and their modulation by polymorphic xenobiotic metabolizing enzymes

(2010) Paola Manini et al.   TOXICOLOGY LETTERS

Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis

(2009) Kasper Broedbaek et al.   FREE RADICAL BIOLOGY AND MEDICINE

Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice

(2009) Mark A. Lovell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nature of Guanine Oxidation in RNA via the Flash-Quench Technique versus Direct Oxidation by a Metal Oxo Complex

(2009) Dana R. Holcomb et al.   INORGANIC CHEMISTRY

APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

(2009) C. Vascotto et al.   MOLECULAR AND CELLULAR BIOLOGY

Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease

(2009) Akihiko Nunomura et al.   NEUROBIOLOGY OF DISEASE

Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers

(2009) Paola Manini et al.   TOXICOLOGY LETTERS

Mitochondrial iron accumulation with age and functional consequences

(2008) Arnold Y.  Seo et al.   AGING CELL

Human polynucleotide phosphorylase reduces oxidative RNA damage and protects HeLa cell against oxidative stress

(2008) Jinhua Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNAs (miRNAs) in Neurodegenerative Diseases

(2008) Peter T. Nelson et al.   BRAIN PATHOLOGY

Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy

(2008) Tim Hofer et al.   EXPERIMENTAL GERONTOLOGY

Nucleic acid oxidation in Alzheimer disease

(2008) Paula I. Moreira et al.   FREE RADICAL BIOLOGY AND MEDICINE

Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain

(2008) Changxing Shao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ammonia induces RNA oxidation in cultured astrocytes and brainin vivo

(2008) Boris Görg et al.   HEPATOLOGY

Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS

(2008) Yueming Chang et al.   PLoS One

Long-Term Effects of Caloric Restriction or Exercise on DNA and RNA Oxidation Levels in White Blood Cells and Urine in Humans

(2008) Tim Hofer et al.   REJUVENATION RESEARCH

Oxidative stress in neurodegeneration in dentatorubral-pallidoluysian atrophy

(2007) Rie Miyata et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Comparison of lifelong and late life exercise on oxidative stress in the cerebellum

(2007) Li Cui et al.   NEUROBIOLOGY OF AGING

Oxidatively modified RNA in mild cognitive impairment

(2007) Mark A. Lovell et al.   NEUROBIOLOGY OF DISEASE