Blood‒Brain Barrier Pathology and CNS Outcomes in Streptococcus pneumoniae Meningitis

Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4

(2018) Kosuke Nagai et al.   CELLULAR IMMUNOLOGY

The Blood Brain Barrier: A Review of its Anatomy and Physiology in Health and Disease

(2018) Yousra Sharif et al.   CLINICAL ANATOMY

The Contribution of Genetic Variation of Streptococcus pneumoniae to the Clinical Manifestation of Invasive Pneumococcal Disease

(2018) Amelieke J H Cremers et al.   CLINICAL INFECTIOUS DISEASES

Enzymatic Hydrolysis of Pneumococcal Capsular Polysaccharide Renders the Bacterium Vulnerable to Host Defense

(2018) Dustin R. Middleton et al.   INFECTION AND IMMUNITY

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

(2018) Kumar Vijay   INTERNATIONAL IMMUNOPHARMACOLOGY

Streptococcus pneumoniae: transmission, colonization and invasion

(2018) Jeffrey N. Weiser et al.   NATURE REVIEWS MICROBIOLOGY

Myeloid Cells in the Central Nervous System

(2017) Jasmin Herz et al.   IMMUNITY

Protective and Pathological Immunity during Central Nervous System Infections

(2017) Robyn S. Klein et al.   IMMUNITY

CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organ

(2017) Neema Negi et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion

(2017) Federico Iovino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis

(2017) Danfeng Xu et al.   Journal of Neuroinflammation

TIGR4 strain causes more severe disease than WU2 strain in a mouse model of Streptococcus pneumoniae meningitis: a common pathogenic role for interferon-γ

(2017) Belinda Yau et al.   MICROBES AND INFECTION

The meteorology of cytokine storms, and the clinical usefulness of this knowledge

(2017) Ian A. Clark et al.   Seminars in Immunopathology

Streptococcus pyogenes Phospholipase A2 Induces the Expression of Adhesion Molecules on Human Umbilical Vein Endothelial Cells and Aorta of Mice

(2017) Masataka Oda et al.   Frontiers in Cellular and Infection Microbiology

Neurological Sequelae of Adult Meningitis in Africa: A Systematic Literature Review

(2017) Drew W Goldberg et al.   Open Forum Infectious Diseases

Host–pathogen interactions in bacterial meningitis

(2016) Kelly S. Doran et al.   ACTA NEUROPATHOLOGICA

Edaravone attenuates hippocampal damage in an infant mouse model of pneumococcal meningitis by reducing HMGB1 and iNOS expression via the Nrf2/HO-1 pathway

(2016) Zheng Li et al.   ACTA PHARMACOLOGICA SINICA

Perivascular Macrophages Limit PermeabilityHighlights

(2016) Huanhuan He et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antibody-induced neutrophil depletion prior to the onset of pneumococcal meningitis influences long-term neurological complications in mice

(2016) Lay Khoon Too et al.   BRAIN BEHAVIOR AND IMMUNITY

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA

(2016) Federico Iovino et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease

(2016) Erika van der Maten et al.   JOURNAL OF INFECTIOUS DISEASES

Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in ExperimentalStreptococcus pneumoniaeMeningitis

(2016) Belinda Yau et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis

(2016) Lea-Jessica Albrecht et al.   MEDIATORS OF INFLAMMATION

The effects of differences in pspA alleles and capsular types on the resistance of Streptococcus pneumoniae to killing by apolactoferrin

(2016) Shaper Mirza et al.   MICROBIAL PATHOGENESIS

Unraveling the Pore-Forming Steps of Pneumolysin from Streptococcus pneumoniae

(2016) Katharina van Pee et al.   NANO LETTERS

Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome

(2016) Bart Ferwerda et al.   EBioMedicine

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Interleukin-1β Receptor Antagonism Prevents Cognitive Impairment Following Experimental Bacterial Meningitis

(2015) Tatiana Barichello et al.   CURRENT NEUROVASCULAR RESEARCH

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targets for adjunctive therapy in pneumococcal meningitis

(2015) Tatiana Barichello et al.   JOURNAL OF NEUROIMMUNOLOGY

The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis

(2015) Fabian D Liechti et al.   Journal of Neuroinflammation

Combined effects of lactoferrin and lysozyme on Streptococcus pneumoniae killing

(2015) G.O. André et al.   MICROBIAL PATHOGENESIS

Role of Microglial Activation in the Pathophysiology of Bacterial Meningitis

(2015) Tatiana Barichello et al.   MOLECULAR NEUROBIOLOGY

Streptococcus pneumoniaesecretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells

(2015) Prashant Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anatomy and physiology of the blood–brain barrier

(2015) Yonatan Serlin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia

(2015) Ji-Yun Kim et al.   Oncotarget

Interferon-γ from Brain Leukocytes Enhances Meningitis by Type 4 Streptococcus pneumoniae

(2015) Elena Pettini et al.   Frontiers in Microbiology

The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis

(2014) L.K. Too et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of matrix metalloproteinases-2 and -9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats

(2014) Tatiana Barichello et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Type I Interferon Signaling Regulates Activation of the Absent in Melanoma 2 Inflammasome during Streptococcus pneumoniae Infection

(2014) R. Fang et al.   INFECTION AND IMMUNITY

Matrix Metalloproteinase Inhibition Lowers Mortality and Brain Injury in Experimental Pneumococcal Meningitis

(2014) Fabian D. Liechti et al.   INFECTION AND IMMUNITY

Conformational Analysis of theStreptococcus pneumoniaeHyaluronate Lyase and Characterization of Its Hyaluronan-specific Carbohydrate-binding Module

(2014) Michael D. L. Suits et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR-Mediated Inflammatory Responses toStreptococcus pneumoniaeAre Highly Dependent on Surface Expression of Bacterial Lipoproteins

(2014) Gillian Tomlinson et al.   JOURNAL OF IMMUNOLOGY

Genomic pneumococcal load and CSF cytokines are not related to outcome in Malawian adults with meningitis

(2014) Emma C. Wall et al.   JOURNAL OF INFECTION

Impact of the pneumococcal conjugate vaccine on serotype distribution and susceptibility trends of pediatric non-invasive Streptococcus pneumoniae isolates in Tokai, Japan over a 5-year period

(2014) Hayato Okade et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

AdjunctiveN-Acetyl-l-Cysteine in Treatment of Murine Pneumococcal Meningitis

(2013) Tobias Högen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis

(2013) Madelijn Geldhoff et al.   BMC INFECTIOUS DISEASES

Cerebrospinal-fluid cytokine and chemokine profile in patients with pneumococcal and meningococcal meningitis

(2013) Leonam G Coutinho et al.   BMC INFECTIOUS DISEASES

The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas

(2013) Helen Könnecke et al.   Clinical & Developmental Immunology

The Core Promoter of the Capsule Operon of Streptococcus pneumoniae Is Necessary for Colonization and Invasive Disease

(2013) Mara G. Shainheit et al.   INFECTION AND IMMUNITY

Caspase-1: The inflammasome and beyond

(2013) Gabriel Sollberger et al.   Innate Immunity

Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches

(2013) Almudena Fuster-Matanzo et al.   MEDIATORS OF INFLAMMATION

The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis

(2013) Denis Grandgirard et al.   MEDIATORS OF INFLAMMATION

Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain

(2013) Geeta Ramesh et al.   MEDIATORS OF INFLAMMATION

The Spr1875 protein confers resistance to the microglia-mediated killing of Streptococcus pneumoniae

(2013) Samuele Peppoloni et al.   MICROBIAL PATHOGENESIS

Pneumococcal IgA1 protease subverts specific protection by human IgA1

(2013) E N Janoff et al.   Mucosal Immunology

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Role of Oxidative Stress in the Pathophysiology of Pneumococcal Meningitis

(2013) Tatiana Barichello et al.   Oxidative Medicine and Cellular Longevity

Parapneumonic Pleural Effusions Caused by Streptococcus pneumoniae Serotype 3 in Children Immunized with 13-Valent Conjugated Pneumococcal Vaccine

(2013) Charalampos Antachopoulos et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Interactions between Blood-Borne Streptococcus pneumoniae and the Blood-Brain Barrier Preceding Meningitis

(2013) Federico Iovino et al.   PLoS One

The Pneumococcus: Epidemiology, Microbiology, and Pathogenesis

(2013) B. Henriques-Normark et al.   Cold Spring Harbor Perspectives in Medicine

Characterization of a pneumococcal meningitis mouse model

(2012) Barry Mook-Kanamori et al.   BMC INFECTIOUS DISEASES

Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality

(2012) E. C. Wall et al.   CLINICAL INFECTIOUS DISEASES

Defense at the border: the blood–brain barrier versus bacterial foreigners

(2012) Nina M van Sorge et al.   Future Microbiology

Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro models

(2012) Yukio Takeshita et al.   IMMUNOLOGICAL REVIEWS

PspK of Streptococcus pneumoniae Increases Adherence to Epithelial Cells and Enhances Nasopharyngeal Colonization

(2012) L. E. Keller et al.   INFECTION AND IMMUNITY

Export Requirements of Pneumolysin in Streptococcus pneumoniae

(2012) K. E. Price et al.   JOURNAL OF BACTERIOLOGY

Changes in Molecular Epidemiology of Streptococcus pneumoniae Causing Meningitis following Introduction of Pneumococcal Conjugate Vaccination in England and Wales

(2012) Bruno Pichon et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Inflammasome-Dependent IFN-  Drives Pathogenesis in Streptococcus pneumoniae Meningitis

(2012) A. J. Mitchell et al.   JOURNAL OF IMMUNOLOGY

CXCL12-Induced Monocyte-Endothelial Interactions Promote Lymphocyte Transmigration Across an in Vitro Blood-Brain Barrier

(2012) S. Man et al.   Science Translational Medicine

Proinflammatory activity and the sensitization of depressive-like behavior during maternal separation.

(2011) Michael B. Hennessy et al.   BEHAVIORAL NEUROSCIENCE

Pathogenesis and Pathophysiology of Pneumococcal Meningitis

(2011) B. B. Mook-Kanamori et al.   CLINICAL MICROBIOLOGY REVIEWS

Long-term outcomes of pneumococcal meningitis in childhood and adolescence

(2011) Deborah Christie et al.   EUROPEAN JOURNAL OF PEDIATRICS

Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema

(2011) Sabrina Hupp et al.   GLIA

Streptococcus pneumoniae Stimulates a STING- and IFN Regulatory Factor 3-Dependent Type I IFN Production in Macrophages, which Regulates RANTES Production in Macrophages, Cocultured Alveolar Epithelial Cells, and Mouse Lungs

(2011) U. Koppe et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

(2011) M. Witzenrath et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release

(2011) Tobias Hoegen et al.   JOURNAL OF IMMUNOLOGY

Transcellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with Streptococcus suis

(2011) Corinna Wewer et al.   Journal of Neuroinflammation

Bacterial Meningitis Impairs Hippocampal Neurogenesis

(2011) Sandra Hofer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Oxidative Stress, Cytokine/Chemokine and Disruption of Blood–Brain Barrier in Neonate Rats After Meningitis by Streptococcus agalactiae

(2011) Tatiana Barichello et al.   NEUROCHEMICAL RESEARCH

African meningitis belt pneumococcal disease epidemiology indicates a need for an effective serotype 1 containing vaccine, including for older children and adults

(2010) Bradford D Gessner et al.   BMC INFECTIOUS DISEASES

A conceptual revolution in the relationships between the brain and immunity

(2010) Michal Schwartz et al.   BRAIN BEHAVIOR AND IMMUNITY

Streptococcus pneumoniae: virulence factors and variation

(2010) A.M. Mitchell et al.   CLINICAL MICROBIOLOGY AND INFECTION

TNF-α, IL-1β, IL-6, and cinc-1 levels in rat brain after meningitis induced by Streptococcus pneumoniae

(2010) Tatiana Barichello et al.   JOURNAL OF NEUROIMMUNOLOGY

Interaction of pneumococcal phase variation, host and pressure/gas composition: Virulence expression of NanA, HylA, PspA and CbpA in simulated otitis media

(2010) Ha-Sheng Li-Korotky et al.   MICROBIAL PATHOGENESIS

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

(2010) Edel A. McNeela et al.   PLoS Pathogens

Risk factors for nasopharyngeal carriage of drug-resistant Streptococcus pneumoniae: data from a nation-wide surveillance study in Greece

(2009) Ioannis Katsarolis et al.   BMC INFECTIOUS DISEASES

Emerging pneumococcal carriage serotypes in a high-risk population receiving universal 7-valent pneumococcal conjugate vaccine and 23-valent polysaccharide vaccine since 2001

(2009) Amanda J Leach et al.   BMC INFECTIOUS DISEASES

Sequelae due to bacterial meningitis among African children: a systematic literature review

(2009) Meenakshi Ramakrishnan et al.   BMC Medicine

Toll-Like Receptor Stimulation Enhances Phagocytosis and Intracellular Killing of Nonencapsulated and Encapsulated Streptococcus pneumoniae by Murine Microglia

(2009) S. Ribes et al.   INFECTION AND IMMUNITY

Mechanisms for transcellular diapedesis: probing and pathfinding by `invadosome-like protrusions'

(2009) C. V. Carman   JOURNAL OF CELL SCIENCE

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

(2009) Satoshi Uchiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates

(2009) James P Watt et al.   LANCET

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

Health related quality of life in survivors of pneumococcal meningitis

(2008) Rosa Legood et al.   ACTA PAEDIATRICA

Dexamethasone regulation of matrix metalloproteinase expression in experimental pneumococcal meningitis

(2008) Xinjie Liu et al.   BRAIN RESEARCH

Epidemiology of Invasive Pneumococcal Disease among Adult Patients in Barcelona Before and After Pediatric 7‐Valent Pneumococcal Conjugate Vaccine Introduction, 1997–2007

(2008) Carmen Ardanuy et al.   CLINICAL INFECTIOUS DISEASES

Pneumolysin: A Double-Edged Sword During the Host-Pathogen Interaction

(2008) Helen Marriott et al.   CURRENT MOLECULAR MEDICINE

Use of antibiotics and risk factors for carriage of Streptococcus pneumoniae: a longitudinal household study in the United Kingdom

(2008) R. G. PEBODY et al.   EPIDEMIOLOGY AND INFECTION

Pneumolysin Released during Streptococcus pneumoniae Autolysis Is a Potent Activator of Intracellular Oxygen Radical Production in Neutrophils

(2008) A. Martner et al.   INFECTION AND IMMUNITY

A Second Pilus Type in Streptococcus pneumoniae Is Prevalent in Emerging Serotypes and Mediates Adhesion to Host Cells

(2008) F. Bagnoli et al.   JOURNAL OF BACTERIOLOGY

Streptococcus pneumoniaeDeficient in Pneumolysin or Autolysin Has Reduced Virulence in Meningitis

(2008) Robert A. Hirst et al.   JOURNAL OF INFECTIOUS DISEASES

Role of Glial Cells in the Functional Expression of LL-37/Rat Cathelin-Related Antimicrobial Peptide in Meningitis

(2008) Lars-Ove Brandenburg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The diagnosis and management of acute bacterial meningitis in resource-poor settings

(2008) Matthew Scarborough et al.   LANCET NEUROLOGY

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY