Article
Biochemistry & Molecular Biology
Ke Zhang, Chun Chen, Qiang Huang, Chao Li, Xiong Fu
Summary: Sargassum pallidum polysaccharide nanoparticles were successfully prepared using antisolvent precipitation method with optimized conditions. Nanocrystallization did not alter the primary and crystal structures of the polysaccharide, but improved its properties, suggesting nSPP-30's potential as an antioxidant or nano-carrier.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agricultural Engineering
Yi Han, Meng Zhao, Kehui Ouyang, Si Chen, Yang Zhang, Xin Liu, Qi An, Zitong Zhao, Wenjun Wang
Summary: The sulfation derivative of Cyclocarya paliurus polysaccharides showed stronger antioxidant activity compared to the original polysaccharides. The antioxidant effect may be performed via the Keap1-Nrf2 pathway, with Nrf2 proteins increased and Keap1 proteins decreased in response to polysaccharide stimulation.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Food Science & Technology
Hui-Rong Yang, Lian-Hong Chen, Ying-Jie Zeng
Summary: The novel homogeneous polysaccharide extracted from Tricholoma matsutake demonstrated strong antioxidant activity and inhibition on alpha-glucosidase and a-amylase activities. Furthermore, treatment with this polysaccharide significantly improved glucose consumption, glycogen synthesis, and the activities of various enzymes in insulin-resistant-human hepatoma cell line (IR-HepG2), suggesting great potential in managing type 2 diabetes mellitus.
Review
Biochemistry & Molecular Biology
Lais C. G. F. Palhares, James A. London, Aleksandra M. Kozlowski, Emiliano Esposito, Suely F. Chavante, Minghong Ni, Edwin A. Yates
Summary: Glycosaminoglycans (GAGs) are critical in the animal kingdom for developmental processes and the maintenance of healthy tissues. Chemical modification of GAGs is a principal approach for studying the structure-function relationships in these molecules.
Article
Biochemistry & Molecular Biology
Yi Gao, Yizhen Li, Yunze Niu, Hao Ju, Ran Chen, Bin Li, Xiyun Song, Lin Song
Summary: The polysaccharides from Sargassum pallidum (SPPs) exhibit significant antitumor and immune-enhancing activities, inducing cancer cell apoptosis and enhancing immune cell proliferation. Among the fractions, SPP-0.7 was identified as the most active and selected for further purification, with potential as a candidate agent for cancer therapy. Transcriptome sequencing revealed that SPP-0.7 can induce cell apoptosis, cytokine secretion, and inhibit the normal physiological processes of cancer cells.
Article
Biochemistry & Molecular Biology
Dan Yuan, Hecheng Meng, Qiang Huang, Chao Li, Xiong Fu
Summary: The study demonstrated that CH/SPPs-US films prepared via ultrasonication showed improved transparency, mechanical properties, and antioxidant activity. These films effectively extended the shelf life of strawberries and could be developed as a novel edible packaging film.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Zehong Chen, Yuxuan Liu, Dan Wang, Niuniu Wu, Kaiping Wang, Yu Zhang
Summary: In this study, sulfated modification was performed on Grifola frondosa polysaccharide (GFP) using the chlorosulfonic acid-pyridine method. The sulfated GFP (S-GFP) exhibited alpha-glucosidase inhibitory activity and changed the conformation of the enzyme. The results suggest that sulfation alters the structure and inhibitory mechanism of polysaccharides.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Weiyan Quan, Puwang Li, Jinsong Wei, Yuwei Jiang, Yingye Liang, Weilin Zhang, Qizhou Chen, Kefeng Wu, Hui Luo, Qianqian Ouyang
Summary: This study created bio-multifunctional composite sponges with potent hemostatic, antibacterial, anti-inflammatory, and angiogenesis features for treating full-thickness wounds.
Article
Acoustics
Wei Li, Yanqing Zhang, Xiaotong Zhao, Leilei Fang, Tan Yang, Junbo Xie
Summary: This study aimed to improve the extraction rate of Platycodon grandiflorum roots polysaccharides (PGPs) using ultrasound-assisted extraction (UAE) and compared it with heating water extraction (HWE) method. The results showed that UAE had significantly higher polysaccharides content and better antioxidant and hypoglycemic activity compared to HWE. The polysaccharides extracted with UAE and HWE exhibited different molecular weight distribution and monosaccharide composition.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zu-Man Dou, Chun Chen, Qiang Huang, Xiong Fu
Summary: A novel heteropolysaccharide fraction (BBP-24-3) with a relative molecular weight of 145.1 kDa isolated from blackberry fruits showed excellent alpha-glucosidase inhibitory activity. This potential utilization of BBP-24-3 as an alpha-glucosidase inhibitor in healthy food for reducing the postprandial blood glucose level was suggested by the current study.
Article
Food Science & Technology
Tian Wang, Hongying Zhao, Yongguang Bi, Xiaodan Fan
Summary: This study optimized the extraction conditions of Sargassum fusiforme polysaccharides using the response surface method, and successfully prepared SFPS-functionalized nanoselenium. The SFPS-SeNPs showed higher dispersion and stability compared to naked SeNPs, and the SFPS modifier significantly improved the free radical scavenging activity of SeNPs.
JOURNAL OF FOOD SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Hongkun Xue, Zitong Hao, Yuchao Gao, Xu Cai, Jintian Tang, Xiaojun Liao, Jiaqi Tan
Summary: The incidence of diabetes is increasing, leading people to turn to natural active substances for treatment. This paper systematically reviews the hypoglycemic activity of natural polysaccharides, explores their molecular mechanisms, and discusses their potential for improving diabetes complications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Wenyang Cao, Chenxi Wang, Xiayidan Mayhesumu, Le Pan, Yan Dang, Abulimiti Yili, Aytursun Abuduwaili, Sanawar Mansur
Summary: This study investigated the effects of microwave ultrasonic-assisted extraction (MUAE) on the content, structure, and biological functions of Brassica rapa L. polysaccharide (BRP). A neutral polysaccharide named BRP-1-1 was isolated and purified, and its structure was elucidated. The results showed that BRP-1-1 had significant biological activities and could be developed as a functional medicine.
Article
Food Science & Technology
Ke Zhang, Dan Yuan, Chao Li, Xiong Fu
Summary: Three polysaccharides (SPP-30, SPP-60, and SPP-90) were extracted from Sargassum pallidum and their physicochemical properties, antioxidant, and antibacterial activities were compared. SPP-30 and SPP-90 showed stronger antioxidant activities, while SPP-30 and SPP-60 exhibited antibacterial effects against Staphylococcus aureus.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Ben Niu, Simin Feng, Shuangqing Xuan, Ping Shao
Summary: The study found that using maltodextrin as wall materials can reduce moisture adsorption and caking strength of Tremella fuciformis polysaccharides (TPs) microcapsules powder. The administration of TPs microcapsules powder showed hypoglycemic effects and molecular mechanisms related to regulating the PI3K/Akt pathway, leading to decreased blood glucose levels and improved lipid profiles.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Nanoscience & Nanotechnology
Han Li, Linfan Shi, Chao Li, Xiong Fu, Qiang Huang, Bin Zhang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Applied
Dan Yuan, Chao Li, Qiang Huang, Xiong Fu
CARBOHYDRATE POLYMERS
(2020)
Article
Food Science & Technology
Ke Zhang, Dan Yuan, Chao Li, Xiong Fu
Summary: Three polysaccharides (SPP-30, SPP-60, and SPP-90) were extracted from Sargassum pallidum and their physicochemical properties, antioxidant, and antibacterial activities were compared. SPP-30 and SPP-90 showed stronger antioxidant activities, while SPP-30 and SPP-60 exhibited antibacterial effects against Staphylococcus aureus.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Lei Wang, Pan Zhang, Chao Li, Jie Chen
Summary: A new Rosa roxburghii Tratt fruit polysaccharide (RTFP)-iron (III) complex was synthesized and characterized, showing a high iron content and slightly lower antioxidant activity compared to pure RTFP. The release of iron and improved stability and solubility of the complex were observed during simulated gastrointestinal digestion. The RTFP-iron (III) complex could be a promising iron supplement for future pharmaceutical applications.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
Article
Biochemistry & Molecular Biology
Dan Yuan, Hecheng Meng, Qiang Huang, Chao Li, Xiong Fu
Summary: The study demonstrated that CH/SPPs-US films prepared via ultrasonication showed improved transparency, mechanical properties, and antioxidant activity. These films effectively extended the shelf life of strawberries and could be developed as a novel edible packaging film.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Food Science & Technology
Dan Yuan, Chao Li, Qiang Huang, Xiong Fu, Hao Dong
Summary: This review provides an up-to-date overview of the anti-inflammatory effects and mechanisms of natural polysaccharides on acute colitis. The study found that natural polysaccharides can improve clinical symptoms, repair colon tissue, alleviate oxidative stress, inhibit inflammation, regulate immune function, and modulate gut microbiota. In addition, inducible murine models for assessing the anti-inflammatory effects were also discussed.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Chao Li, Shilin Zhou, Xiong Fu, Qiang Huang, Qing Chen
Summary: The study demonstrated that the bioactive polysaccharide MOP-2 from Moringa oleifera leaves could be partially degraded during intestinal digestion but largely utilized during fermentation by human fecal inoculums. Furthermore, MOP-2 showed potential in regulating the structure of the microbial community in the gut, increasing the production of short-chain fatty acids, which indicated its potential as a gut microbiota manipulator for promoting gut health.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Lei Wang, Pan Zhang, Chao Li, Fei Xu, Jie Chen
Summary: The study found that the polysaccharide RTFP can repair intestinal barrier dysfunction, reduce levels of inflammatory cytokines, inhibit intestinal permeability and colonic oxidative stress in mice fed on a high-fat diet.
Article
Food Science & Technology
Lei Wang, Yingpeng Tian, Pan Zhang, Chao Li, Jie Chen
Summary: The study demonstrated the synthesis of Ag nanoparticle composites (RP3-AgNPs) using an acidic polysaccharide (RTFP-3) isolated from Rosa roxburghii Tratt fruit. The RP3-AgNPs showed excellent antimicrobial ability and potential for fruit preservation.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2022)
Article
Chemistry, Applied
Dansi Huang, Chao Li, Qing Chen, Xing Xie, Xiong Fu, Chun Chen, Qiang Huang, Zebo Huang, Hao Dong
Summary: Rosa roxburghii Tratt pomace (RRTP) was extracted to obtain free and bound phenolic fractions, which showed dose-dependent scavenging of radicals and improved survival rates in paraquat-exposed nematodes by enhancing SOD and CAT activities. These results suggest RRTP as a good and cost-effective source of natural antioxidants.
Article
Biochemistry & Molecular Biology
Wen-Duo Wang, Chao Li, Chun Chen, Xiong Fu, Rui Hai Liu
Summary: This study investigated the effect of glycation with chitosan oligosaccharide (COS) on the emulsifying properties of lactoferrin (LF). The results showed that glycation with COS led to smaller droplet size and increased stability of LF-stabilized emulsions. Additionally, glycation enhanced the interfacial activity of LF.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Ke Zhang, Chun Chen, Qiang Huang, Chao Li, Xiong Fu
Summary: Sargassum pallidum polysaccharide nanoparticles were successfully prepared using antisolvent precipitation method with optimized conditions. Nanocrystallization did not alter the primary and crystal structures of the polysaccharide, but improved its properties, suggesting nSPP-30's potential as an antioxidant or nano-carrier.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agriculture, Multidisciplinary
Guang Liu, Zhi-ming Wang, Nian Du, Yan Zhang, ZhenCheng Wei, Xiao-Jun Tang, Lei Zhao, Chao Li, Yuan-Yuan Deng, Ming-Wei Zhang
Summary: Recombinant rice quiescin sulfhydryl oxidase (rQSOX) has been found to improve the flour processing quality by promoting gluten protein polymerization and network strengthening.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Applied
Yue Zhang, Chao Li, Xiong Fu, Nan Ma, Xianyang Bao, Hongsheng Liu
Summary: In this study, starch-based foams with a combined function of buffering and controlled release of oxygen were produced using extrusion and coating techniques. The functional foams, coated with poly(vinyl alcohol) solution containing calcium peroxides, exhibited controllable oxygen release under wet conditions and had high compression strength. The foams also showed improved moisture resistance and were effective in reducing physical damage and browning in guavas during simulated food transportation. The starch-based foams have promising potential for fruit and vegetable preservations.
Article
Biochemistry & Molecular Biology
Dan Yuan, Qiang Huang, Chao Li, Xiong Fu
Summary: Sargassum pallidum polysaccharide (SPP) has been shown to have anti-obesity effects in obese mice by suppressing weight gain, reducing blood glucose and lipid levels, and preventing fat accumulation in the liver and hypertrophy of adipocytes. The mechanism involves the down-regulation of adipogenesis genes.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)