Editorial Material
Infectious Diseases
Xiaoning Liu, Zheng Zhu, Yun He, Jia Wen Lim, Bethany Lane, Hui Wang, Qiaoli Peng, Liqin Sun, Hongzhou Lu
Summary: Monkeypox, which was previously confined to Western and Central African countries, has now seen a changing trend with a multinational outbreak in Europe. The outbreak has affected men who have sex with men (MSM), with many cases displaying atypical clinical symptoms and co-infection with other sexually transmitted diseases.
INFECTIOUS DISEASES OF POVERTY
(2022)
Review
Medicine, General & Internal
Wilson M. Compton, Christopher M. Jones
Summary: Among men who have sex with men, bisexual men have a higher rate of substance use compared to other subgroups, and methamphetamine use is associated with high-risk sexual behaviors and HIV transmission.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Maria Xiridou, Fuminari Miura, Philippe Adam, Eline op de Coul, John de Wit, Jacco Wallinga
Summary: The decline in mumps cases among MSM in the Netherlands was primarily due to infection-induced immunity among those with high sexual activity levels and accelerated by behavioral adaptions. The outbreak could have faded even without vaccination.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Candice J. McNeil, Robert D. Kirkcaldy, Kimberly Workowski
Summary: Transmission of enteric pathogens may occur through direct or indirect oral-anal contact in sexual networks of men who have sex with men (MSM). Observational data suggests that Campylobacter, Giardia lamblia, and Shigella (particularly antimicrobial-resistant strains) can be sexually transmitted in MSM networks. Providers are recommended to consider enteritis or proctocolitis in MSM as possible sexually transmitted infections and encourage targeted testing. Further research is needed to understand the transmission and prevention of enteric pathogens in MSM.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Management
Eduardo Ibanez-Tomas, Angel Gasch-Gallen
Summary: The study aimed to determine the frequency of sexual practices leading to hepatitis A infection in the population of men who have sex with men in Spain. High rates of unsafe sexual practices associated with hepatitis A were found, with sociodemographic and contextual factors of sexual behavior playing a significant role.
JOURNAL OF NURSING MANAGEMENT
(2021)
Article
Immunology
Jelle Koopsen, Edyth Parker, Alvin X. Han, Thijs van de Laar, Colin Russell, Elske Hoornenborg, Maria Prins, Marc van der Valk, Janke Schinkel
Summary: This study on HCV transmission among MSM in Amsterdam showed that most transmission clusters were introduced between the late 1990s and early 2010s, with no new clusters introduced after 2012. The proportion of unclustered sequences of subtype 1a fluctuated over time, increasing from 0% in 2012 to 50% in 2018. The rise in external introductions of HCV infections among MSM in Amsterdam in recent years, despite high DAA uptake, suggests that international collaboration is necessary for effective local microelimination efforts.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Kenneth H. Mayer, LaRon Nelson, Lisa Hightow-Weidman, Matthew J. Mimiaga, Leandro Mena, Sari Reisner, Demetre Daskalakis, Steven A. Safren, Chris Beyrer, Patrick S. Sullivan
Summary: Men who have sex with men (MSM) in the USA face ongoing high risk of HIV acquisition, with factors including role versatility, biological, individual, social, and structural elements affecting the epidemic. Racial and ethnic minority men may be further concentrated in high-prevalence networks due to assortative mixing and adverse life experiences. Young MSM have additional HIV risks due to impulse control issues and lack of familiarity with serostatus discussions, while digital technologies could be beneficial for prevention efforts. Older and transgender MSM also face unique challenges requiring tailored HIV prevention information and culturally responsive programmes. Training of healthcare providers in culturally competent care is essential for optimizing HIV care and prevention.
Article
Immunology
Ying Guo, Xiaojie Huang, Xintong Sun, Yixi Yu, Yan Wang, Baojin Zhang, Jie Cao, Shuo Wen, Yuchen Li, Xin Wang, Siyu Cai, Wei Xia, Feili Wei, Junyi Duan, Haozhi Dong, Shan Guo, Fengqiu Zhang, Dongxiang Zheng, Zheng Sun
Summary: The study aimed to investigate salivary virome composition and functional genes in HIV-negative and -positive MSM individuals. Results showed that salivary virobiota composition in individuals with mild immunosuppression was most similar to that in healthy individuals, while severe immunosuppression resulted in suppressed virus genera. Analysis revealed changes in KEGG Pathways related to HIV progression, immune function, and oral health in different HIV infection stages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Brendan L. Harney, Rachel Sacks-Davis, Daniela K. van Santen, Michael Traeger, Anna L. Wilkinson, Jason Asselin, Carol El-Hayek, Christopher K. Fairley, Norman Roth, Mark Bloch, Gail Matthews, Basil Donovan, Rebecca Guy, Mark Stoove, Margaret E. Hellard, Joseph S. Doyle
Summary: The study found that in Australia, the incidence of HCV has decreased among HIV-positive gay, bisexual, and other men who have sex with men, while it has remained stable among HIV-negative individuals in this group. Among HIV-negative gay, bisexual, and other men who have sex with men using preexposure prophylaxis, the incidence of HCV has decreased since its implementation in Australia in 2016.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Diego Cerecero-Garcia, Heleen Vermandere, Ietza Bojorquez, Jose Gomez-Castro, Jose Arturo Sanchez-Ochoa, Araczy Martinez-Davalos, Ivonne Huerta-Icelo, Sergio Bautista-Arredondo
Summary: The study found that during the COVID-19 pandemic, over half of MSM and TGW in Mexico experienced significant depressive symptoms, with the majority of participants being impacted by COVID-19 to varying degrees, especially in terms of anxiety and economic stress. The results emphasize the need for targeted psychological interventions to minimize the impacts of COVID-19 on mental health.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Gastroenterology & Hepatology
Fengyi Jin, Gregory J. Dore, Gail Matthews, Niklas Luhmann, Virginia Macdonald, Sahar Bajis, Rachel Baggaley, Bradley Mathers, Annette Verster, Andrew E. Grulich
Summary: A global systematic review and meta-analysis showed that the prevalence of HCV among men who have sex with men is high, with the highest rates in Africa and Southeast Asia. HIV-positive MSM have a significantly higher HCV prevalence compared to HIV-negative MSM, and the burden of HCV varies considerably by region.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Virology
Eisuke Adachi, Makoto Saito, Tadashi Kikuchi, Kazuhiko Ikeuchi, Michiko Koga, Takeya Tsutsumi, Hiroshi Yotsuyanagi
Summary: Although the prevalence of hepatitis C virus (HCV) infection has decreased significantly with the advent of direct-acting antiviral agents, HCV is still prevalent among men who have sex with men (MSM) in Japan. This study found that regular testing at outpatient visits may lead to a higher HCV prevalence rate among MSM than reported.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Christine M. Khosropour, Olusegun O. Soge, Matthew R. Golden, James P. Hughes, Lindley A. Barbee
Summary: Pharyngeal chlamydia has a low incidence and duration, but its contribution to population-level transmission remains unclear.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Cheng Wang, Peizhen Zhao, Ann Marie Weideman, Wenqian Xu, Jason J. Ong, Muhammad S. Jamil, Bin Yang, Joseph D. Tucker
Summary: This study evaluated the effectiveness and cost of providing HCV self-testing (HCVST) among MSM in China, and found that HCVST significantly increased the proportion of MSM testing for HCV and was cost-effective.
Article
Infectious Diseases
Ana Rita C. Motta-Castro, Ligia Kerr, Carl Kendall, Rosa S. S. Mota, Mark Drew C. Guimaraes, Andrea Fachel Leal, Edgar Merchan-Hamann, Ines Dourado, Maria Amelia Veras, Ana Maria de Brito, Alexandre Kerr Pontes, Raimunda Hermelinda M. Macena, Daniela Knauth, Luana N. G. C. Lima, Socorro Cavalcante, Ximena P. Diaz-Bermudez, Lisangela C. Oliveira, Laio Magno, Ana Claudia Camillo, Marcilio F. Lemos, Vanessa Cristina M. Silva, Adriana P. P. Compri, Regina Celia Moreira
Summary: The prevalence of HBV infection among MSM in Brazil is high, with a low positivity index for the serological marker of HBV vaccine immunity. These findings are important for preventing hepatitis B and promoting vaccination in this key population.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Immunology
Kaori Mukai, Takuya Miyagi, Kumiko Nishio, Yoshinobu Yokoyama, Teppei Yoshioka, Yoshinobu Saito, Satoshi Tanaka, Minoru Shigekawa, Takatoshi Nawa, Hayato Hikita, Ryotaro Sakamori, Harumasa Yoshihara, Yasuharu Imai, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
JOURNAL OF IMMUNOLOGY
(2016)
Article
Gastroenterology & Hepatology
Satoshi Tanaka, Hayato Hikita, Tomohide Tatsumi, Ryotaro Sakamori, Yasutoshi Nozaki, Sadatsugu Sakane, Yuto Shiode, Tasuku Nakabori, Yoshinobu Saito, Naoki Hiramatsu, Keisuke Tabata, Tsuyoshi Kawabata, Maho Hamasaki, Hidetoshi Eguchi, Hiroaki Nagano, Tamotsu Yoshimori, Tetsuo Takehara
Article
Biochemistry & Molecular Biology
Yoshinobu Saito, Hayato Hikita, Yasutoshi Nozaki, Yugo Kai, Yuki Makino, Tasuku Nakabori, Satoshi Tanaka, Ryoko Yamada, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Gastroenterology & Hepatology
Tsukasa Kawaguchi, Takahiro Kodama, Hayato Hikita, Yuki Makino, Yoshinobu Saito, Satoshi Tanaka, Satoshi Shimizu, Ryotaro Sakamori, Takuya Miyagi, Hiroshi Wada, Hiroaki Nagano, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
HEPATOLOGY RESEARCH
(2015)
Article
Multidisciplinary Sciences
Tasuku Nakabori, Hayato Hikita, Kazuhiro Murai, Yasutoshi Nozaki, Yugo Kai, Yuki Makino, Yoshinobu Saito, Satoshi Tanaka, Hiroshi Wada, Hidetoshi Eguchi, Takeshi Takahashi, Hiroshi Suemizu, Ryotaro Sakamori, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
SCIENTIFIC REPORTS
(2016)
Article
Gastroenterology & Hepatology
Hisashi Ishida, Akio Ishihara, Satoshi Tanaka, Tetsuya Iwasaki, Hiroko Hasegawa, Tomofumi Akasaka, Yuko Sakakibara, Shoichi Nakazuru, Tomoko Uehira, Takuma Shirasaka, Eiji Mita
HEPATOLOGY RESEARCH
(2019)
Article
Multidisciplinary Sciences
Yuto Shiode, Hayato Hikita, Satoshi Tanaka, Kumiko Shirai, Akira Doi, Sadatsugu Sakane, Yugo Kai, Tasuku Nakabori, Ryoko Yamada, Takahiro Kodama, Ryohei Narumi, Ryotaro Sakamori, Hidetoshi Eguchi, Takeshi Tomonaga, Tomohide Tatsumi, Tetsuo Takehara
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Yuta Myojin, Takahiro Kodama, Kazuki Maesaka, Daisuke Motooka, Yu Sato, Satoshi Tanaka, Yuichi Abe, Kazuyoshi Ohkawa, Eiji Mita, Yoshito Hayashi, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Ayumu Taguchi, Hidetoshi Eguchi, Tetsuo Takehara
Summary: The study identified FGF19 as a tumor biomarker indicating susceptibility to lenvatinib in HCC, and ST6GAL1 as a potential novel biomarker for identifying FGF19-driven HCC that is responsive to lenvatinib. Among patients with high serum ST6GAL1 levels undergoing TKI therapy, lenvatinib showed significantly better survival outcomes compared to sorafenib.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yasutoshi Nozaki, Hayato Hikita, Satoshi Tanaka, Kenji Fukumoto, Makiko Urabe, Katsuhiko Sato, Yuta Myojin, Akira Doi, Kazuhiro Murai, Sadatsugu Sakane, Yoshinobu Saito, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Summary: This study found that enhanced tumor formation from DEN-transformed hepatocytes by persistent hepatocyte apoptosis is mediated by increased oxidative stress, independent of compensatory liver regeneration. Controlling oxidative stress may play a critical role in suppressing hepatocarcinogenesis for patients with livers harboring transformed cells.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Aya Ishizaka, Michiko Koga, Taketoshi Mizutani, Lay Ahyoung Lim, Eisuke Adachi, Kazuhiko Ikeuchi, Ryuta Ueda, Haruyo Aoyagi, Satoshi Tanaka, Hiroshi Kiyono, Tetsuro Matano, Hideki Aizaki, Sachiyo Yoshio, Eiji Mita, Masamichi Muramatsu, Tatsuya Kanto, Takeya Tsutsumi, Hiroshi Yotsuyanagi
Summary: This study comprehensively observed the amount of virus excreted into the intestinal tract, changes in the intestinal microbiome, and the level of inflammation during the healing process in patients with HAV infection. The results showed that the virus could be shed for more than 150 days post-infection, pro-inflammatory cytokines were elicited immediately after infection and dysbiosis of the intestinal microbiome occurred and continued for a long time after healing.
Article
Oncology
Yuta Myojin, Takahiro Kodama, Ryotaro Sakamori, Kazuki Maesaka, Takayuki Matsumae, Yoshiyuki Sawai, Yasuharu Imai, Kazuyoshi Ohkawa, Masanori Miyazaki, Satoshi Tanaka, Eiji Mita, Seiichi Tawara, Takayuki Yakushijin, Yasutoshi Nozaki, Hideki Hagiwara, Yuki Tahata, Ryoko Yamada, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara
Summary: The study found that circulating IL-6 levels may serve as a novel prognostic biomarker for predicting therapeutic response in advanced HCC patients who undergo combined immunotherapy with Atezolizumab/bevacizumab (Atezo/Bev) therapy.
Review
Medicine, General & Internal
Yoshifumi Fujii, Ryotaro Sakamori, Ryoko Yamada, Teppei Yoshioka, Takahiro Kodama, Minoru Shigekawa, Hayato Hikita, Satoshi Tanaka, Hisashi Ishida, Eiji Mita, Hidenari Hongyo, Hiroki Higashihara, Takehiro Noda, Hidetoshi Eguchi, Tomohide Tatsumi, Tetsuo Takehara
Summary: Transileocolic obliteration (TIO) is an effective treatment for gastric, duodenal, or rectal varices, but its application for esophageal varices has not been reported. In this study, successful TIO was performed for refractory esophageal varices with a large paraesophageal vein, with no recurrence observed afterwards.
Article
Gastroenterology & Hepatology
Yusuke Seiki, Satoshi Tanaka, Seiya Kato, Akio Ishihara, Shoichi Nakazuru, Hisashi Ishida, Eiji Mita
ACG CASE REPORTS JOURNAL
(2020)
Article
Gastroenterology & Hepatology
Hiroki Bessho, Satoshi Tanaka, Akio Ishihara, Shinya Kato, Reishi Toshiyama, Naoki Hama, Kiyoshi Mori, Masayuki Mano, Atsushi Miyamoto, Hisashi Ishida, Motohiro Hirao, Eiji Mita