Intercalated discs: cellular adhesion and signaling in heart health and diseases

Desmosomes in Human Disease

(2018) Nicole A. Najor   Annual Review of Pathology-Mechanisms of Disease

Frequency of genetic variants associated with arrhythmogenic right ventricular cardiomyopathy in the genome aggregation database

(2018) Charlotte L Hall et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

GJA1 gene variations in sudden unexplained nocturnal death syndrome in the Chinese Han population

(2017) Qiuping Wu et al.   FORENSIC SCIENCE INTERNATIONAL

Regulation of cardiac gap junctions by protein phosphatases

(2017) Ashleigh R. Hood et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells

(2017) Katharina Hütz et al.   MOLECULAR CARCINOGENESIS

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective

(2017) Matthias Rübsam et al.   Cold Spring Harbor Perspectives in Biology

Whole exome sequencing with genomic triangulation implicatesCDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy

(2017) Kari L. Turkowski et al.   Congenital Heart Disease

Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis

(2017) Zackie Aktary et al.   Oncotarget

Identification of Cadherin 2 ( CDH2 ) Mutations in Arrhythmogenic Right Ventricular CardiomyopathyCLINICAL PERSPECTIVE

(2017) Bongani M. Mayosi et al.   Circulation-Cardiovascular Genetics

Unique genetic background and outcome of non-Caucasian Japanese probands with arrhythmogenic right ventricular dysplasia/cardiomyopathy

(2017) Yuko Wada et al.   Molecular Genetics & Genomic Medicine

A novel heterozygous mutation in desmoplakin gene in a Lebanese patient with Carvajal syndrome and tooth agenesis

(2016) F. Bitar et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

A Proteomics Approach to Identify New Putative Cardiac Intercalated Disk Proteins

(2016) Siddarth Soni et al.   PLoS One

Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair

(2016) Joell L. Solan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Gap junction mediated miRNA intercellular transfer and gene regulation: A novel mechanism for intercellular genetic communication

(2016) Liang Zong et al.   Scientific Reports

Homozygous Desmocollin-2 Mutations and Arrhythmogenic Cardiomyopathy

(2015) Alessandra Lorenzon et al.   AMERICAN JOURNAL OF CARDIOLOGY

Novel frame-shift mutation in PKP2 associated with arrhythmogenic right ventricular cardiomyopathy: a case report

(2015) Teresa Trenkwalder et al.   BMC Medical Genetics

Arrhythmogenic Right Ventricular Cardiomyopathy with Left Ventricular Involvement: A Novel Splice Site Mutation in the DSG2 Gene

(2015) Marina Pereira Fernandes et al.   CARDIOLOGY

New functions for alpha-catenins in health and disease: from cancer to heart regeneration

(2015) Alexia Vite et al.   CELL AND TISSUE RESEARCH

Desmosome regulation and signaling in disease

(2015) Joshua A. Broussard et al.   CELL AND TISSUE RESEARCH

Comprehensive analysis of desmosomal gene mutations in Han Chinese patients with arrhythmogenic right ventricular cardiomyopathy

(2015) Xiujuan Zhou et al.   European Journal of Medical Genetics

Role of connexin 43 in cardiovascular diseases

(2015) Pecoraro Michela et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mutations of desmoglein-2 in sudden death from arrhythmogenic right ventricular cardiomyopathy and sudden unexplained death

(2015) Mingchang Zhang et al.   FORENSIC SCIENCE INTERNATIONAL

Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of Mitogen-activated Protein Kinase/Serum-response Factor and β-Catenin/GSK-3β Protein Signaling

(2015) Ashraf Yusuf Rangrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Crosstalk Between WNT Signaling and Tyrosine Kinase Signaling in Cancer

(2015) Jaimie N. Anastas   SEMINARS IN ONCOLOGY

Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function

(2014) Angela Schlipp et al.   CARDIOVASCULAR RESEARCH

Arrhythmogenic cardiomyopathy: a disease of intercalated discs

(2014) Martina Calore et al.   CELL AND TISSUE RESEARCH

Plakophilins in Desmosomal Adhesion and Signaling

(2014) Mechthild Hatzfeld et al.   CELL COMMUNICATION AND ADHESION

N-Cadherin/Catenin Complex as a Master Regulator of Intercalated Disc Function

(2014) Alexia Vite et al.   CELL COMMUNICATION AND ADHESION

α-catenin

(2014) Yutong Sun et al.   CELL CYCLE

Hippo Activation in Arrhythmogenic Cardiomyopathy

(2014) Yong Hu et al.   CIRCULATION RESEARCH

Intercalated Discs and Arrhythmogenic Cardiomyopathy

(2014) A. Rampazzo et al.   Circulation-Cardiovascular Genetics

Truncating Plakophilin-2 Mutations in Arrhythmogenic Cardiomyopathy Are Associated With Protein Haploinsufficiency in Both Myocardium and Epidermis

(2014) T. B. Rasmussen et al.   Circulation-Cardiovascular Genetics

Atlas of the clinical genetics of human dilated cardiomyopathy

(2014) Jan Haas et al.   EUROPEAN HEART JOURNAL

Arrhythmogenic cardiomyopathy and Brugada syndrome: Diseases of the connexome

(2014) Esperanza Agullo-Pascual et al.   FEBS LETTERS

Calpain-dependent Cleavage of N-cadherin Is Involved in the Progression of Post-myocardial Infarction Remodeling

(2014) Yoko Kudo-Sakamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin–EB1 interactions

(2014) Dipal M. Patel et al.   JOURNAL OF CELL BIOLOGY

Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions

(2014) Jennifer L. Bays et al.   JOURNAL OF CELL BIOLOGY

Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes

(2014) A. E. Zemljic-Harpf et al.   JOURNAL OF CELL SCIENCE

Plakoglobin but Not Desmoplakin Regulates Keratinocyte Cohesion via Modulation of p38MAPK Signaling

(2014) Volker Spindler et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy

(2014) Derk Frank et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Plakophilin-2 Promotes Tumor Development by Enhancing Ligand-Dependent and -Independent Epidermal Growth Factor Receptor Dimerization and Activation

(2014) K.-i. Arimoto et al.   MOLECULAR AND CELLULAR BIOLOGY

Desmosomes: Regulators of Cellular Signaling and Adhesion in Epidermal Health and Disease

(2014) J. L. Johnson et al.   Cold Spring Harbor Perspectives in Medicine

Coxsackievirus-Induced miR-21 Disrupts Cardiomyocyte Interactions via the Downregulation of Intercalated Disk Components

(2014) Xin Ye et al.   PLoS Pathogens

Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes

(2013) Rashmi Ram et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Wnt/β-catenin signalling: from plasma membrane to nucleus

(2013) Wantae Kim et al.   BIOCHEMICAL JOURNAL

Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque

(2013) Esperanza Agullo-Pascual et al.   CARDIOVASCULAR RESEARCH

Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy

(2013) Peter M Benz et al.   Cell Communication and Signaling

Cardiomyocyte growth and sarcomerogenesis at the intercalated disc

(2013) Amanda J. Wilson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adrenergic Nervous System in Heart Failure

(2013) Anastasios Lymperopoulos et al.   CIRCULATION RESEARCH

The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

(2013) Suet Nee Chen et al.   CIRCULATION RESEARCH

Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size

(2013) C. A. Dunn et al.   JOURNAL OF CELL SCIENCE

Plakoglobin as a Regulator of Desmocollin Gene Expression

(2013) Etienne Tokonzaba et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Down-regulated desmocollin-2 promotes cell aggressiveness through redistributing adherens junctions and activating beta-catenin signalling in oesophageal squamous cell carcinoma

(2013) Wang-Kai Fang et al.   JOURNAL OF PATHOLOGY

Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy

(2013) Frank I. Marcus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Loss of the desmosomal cadherin desmoglein-2 suppresses colon cancer cell proliferation through EGFR signaling

(2013) R Kamekura et al.   ONCOGENE

Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes

(2012) Satoko Ishikawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Molecular Insights into Arrhythmogenic Right Ventricular Cardiomyopathy Caused by Plakophilin-2 Missense Mutations

(2012) Florian Kirchner et al.   Circulation-Cardiovascular Genetics

Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy

(2012) Jolanda van Hengel et al.   EUROPEAN HEART JOURNAL

Xin proteins and intercalated disc maturation, signaling and diseases

(2012) Qinchuan Wang   Frontiers in Bioscience-Landmark

Multimarker Approach for the Prediction of Cardiovascular Events in Patients With Mild to Moderate Coronary Artery Lesions

(2012) Min Zhang et al.   International Heart Journal

The C-terminal unique region of desmoglein 2 inhibits its internalization via tail–tail interactions

(2012) Jing Chen et al.   JOURNAL OF CELL BIOLOGY

MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins

(2012) Laura Leitner et al.   JOURNAL OF CELL SCIENCE

The DSPII splice variant is crucial for desmosome-mediated adhesion in HaCaT keratinocytes

(2012) Rita M. Cabral et al.   JOURNAL OF CELL SCIENCE

Loss of Cadherin-Binding Proteins  -Catenin and Plakoglobin in the Heart Leads to Gap Junction Remodeling and Arrhythmogenesis

(2012) D. Swope et al.   MOLECULAR AND CELLULAR BIOLOGY

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

(2012) A. von Gise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele

(2011) Katja Gehmlich et al.   CARDIOVASCULAR PATHOLOGY

Interactions Between Ankyrin-G, Plakophilin-2, and Connexin43 at the Cardiac Intercalated Disc

(2011) Priscila Y. Sato et al.   CIRCULATION RESEARCH

Nuclear Plakoglobin Is Essential for Differentiation of Cardiac Progenitor Cells to Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy

(2011) Raffaella Lombardi et al.   CIRCULATION RESEARCH

A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions

(2011) Katja Gehmlich et al.   HEART RHYTHM

Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy

(2011) Deqiang Li et al.   HUMAN MOLECULAR GENETICS

Cardiac Tissue-Restricted Deletion of Plakoglobin Results in Progressive Cardiomyopathy and Activation of  -Catenin Signaling

(2011) J. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling

(2011) Keli Kolegraff et al.   MOLECULAR BIOLOGY OF THE CELL

Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1

(2011) J. Matthew Rhett et al.   MOLECULAR BIOLOGY OF THE CELL

Pathophysiology of arrhythmogenic cardiomyopathy

(2011) Cristina Basso et al.   Nature Reviews Cardiology

Molecular Genetics and Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy: A Disease of Cardiac Stem Cells

(2011) Raffaella Lombardi et al.   PEDIATRIC CARDIOLOGY

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development

(2011) Richard P. Davis et al.   TRENDS IN MOLECULAR MEDICINE

Arrhythmogenic Cardiomyopathy: Etiology, Diagnosis, and Treatment

(2010) Srijita Sen-Chowdhry et al.   Annual Review of Medicine

Myozap, a Novel Intercalated Disc Protein, Activates Serum Response Factor–Dependent Signaling and Is Required to Maintain Cardiac Function In Vivo

(2010) Thalia S. Seeger et al.   CIRCULATION RESEARCH

WNT Signaling in Adult Cardiac Hypertrophy and Remodeling

(2010) Martin W. Bergmann   CIRCULATION RESEARCH

The Cardiac Desmosome and Arrhythmogenic Cardiomyopathies

(2010) Mario Delmar et al.   CIRCULATION RESEARCH

Desmosomal gene analysis in arrhythmogenic right ventricular dysplasia/cardiomyopathy: spectrum of mutations and clinical impact in practice

(2010) Veronique Fressart et al.   EUROPACE

Novel missense mutations in exon 15 of desmoglein-2: Role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy?

(2010) Katja Gehmlich et al.   HEART RHYTHM

N-cadherin Regulates p38 MAPK Signaling via Association with JNK-associated Leucine Zipper Protein

(2010) Koichi Ando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ordered Assembly of the Adhesive and Electrochemical Connections within Newly Formed Intercalated Disks in Primary Cultures of Adult Rat Cardiomyocytes

(2010) Sarah B. Geisler et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium

(2010) James W. Smyth et al.   JOURNAL OF CLINICAL INVESTIGATION

A New Hypo/Oligodontia Syndrome

(2010) L. Chalabreysse et al.   JOURNAL OF DENTAL RESEARCH

Cardiomyocyte-targeted overexpression of the coxsackie–adenovirus receptor causes a cardiomyopathy in association with β-catenin signaling

(2010) Laura Caruso et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Plakophilin 2 Couples Actomyosin Remodeling to Desmosomal Plaque Assembly via RhoA

(2010) Lisa M. Godsel et al.   MOLECULAR BIOLOGY OF THE CELL

Cell-Cell Connection to Cardiac Disease

(2010) Farah Sheikh et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Structural and Molecular Mechanisms of Gap Junction Remodeling in Epicardial Border Zone Myocytes following Myocardial Infarction

(2009) Fabien Kieken et al.   CIRCULATION RESEARCH

Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes

(2009) Priscila Y. Sato et al.   CIRCULATION RESEARCH

Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK

(2009) Charlotte Farmer et al.   EXPERIMENTAL CELL RESEARCH

A genetic variants database for arrhythmogenic right ventricular dysplasia/cardiomyopathy

(2009) Paul A. van der Zwaag et al.   HUMAN MUTATION

Interactions of Plakoglobin and β-Catenin with Desmosomal Cadherins

(2009) Hee-Jung Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK MAP kinase-activated Arf6 trafficking directs coxsackievirus type B3 into an unproductive compartment during virus host-cell entry

(2009) D. Marchant et al.   JOURNAL OF GENERAL VIROLOGY

Cardiac cell–cell junctions in health and disease: Electrical versus mechanical coupling

(2009) Maartje Noorman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Prostaglandin Promotion of Osteocyte Gap Junction Function through Transcriptional Regulation of Connexin 43 by Glycogen Synthase Kinase 3/ -Catenin Signaling

(2009) X. Xia et al.   MOLECULAR AND CELLULAR BIOLOGY

Connexin43 interacts with Caveolin-3 in the heart

(2009) Limei Liu et al.   MOLECULAR BIOLOGY REPORTS

A microRNA regulatory mechanism of osteoblast differentiation

(2009) H. Inose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connexin-Caused Genetic Diseases and Corresponding Mouse Models

(2008) Radoslaw Dobrowolski et al.   ANTIOXIDANTS & REDOX SIGNALING

Homozygous Mutation of Desmocollin-2 in Arrhythmogenic Right Ventricular Cardiomyopathy with Mild Palmoplantar Keratoderma and Woolly Hair

(2008) M.A. Simpson et al.   CARDIOLOGY

Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant

(2008) Janet L. Manias et al.   CARDIOVASCULAR RESEARCH

Remodelling of gap junctions and connexin expression in diseased myocardium

(2008) N. J. Severs et al.   CARDIOVASCULAR RESEARCH

Heterocellular interaction enhances recruitment of α and β-catenins and ZO-2 into functional gap-junction complexes and induces gap junction-dependant differentiation of mammary epithelial cells

(2008) Rabih S. Talhouk et al.   EXPERIMENTAL CELL RESEARCH

Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen

(2008) J. Gilleron et al.   JOURNAL OF CELL SCIENCE

Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart

(2008) Byung-Kwan Lim et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of Zonula Occludens-1 Causes Embryonic Lethal Phenotype Associated with Defected Yolk Sac Angiogenesis and Apoptosis of Embryonic Cells

(2008) Tatsuya Katsuno et al.   MOLECULAR BIOLOGY OF THE CELL

A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy

(2008) Maximilian G. Posch et al.   MOLECULAR GENETICS AND METABOLISM

Local effects and mechanisms of antiarrhythmic peptide AAP10 in acute regional myocardial ischemia: electrophysiological and molecular findings

(2008) Joanna Jozwiak et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Desmosome structure, composition and function

(2007) David Garrod et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES