Review
Biochemistry & Molecular Biology
Yin-Qiao Liu, Hai-Ying Zou, Jian-Jun Xie, Wang-Kai Fang
Summary: Desmosomes, intercellular adhesion complexes, play paradoxical roles in tumor suppression and promotion in the context of head and neck cancer, with abnormal expression of desmosomal components being associated with tumor progression and poor survival. The signaling functions of desmosomes in regulating cancer cell behavior offer valuable insights for HNC diagnosis and therapeutics development.
Review
Pathology
Marihan Hegazy, Abbey L. Perl, Sophia A. Svoboda, Kathleen J. Green
Summary: Desmosomal cadherins are a recently evolved adhesive substance that forms the core of desmosomes, which are crucial for tissue integrity. They not only resist mechanical stress, but also promote tissue differentiation and morphogenesis. Interfering with desmosomal cadherin function can lead to various diseases. Our understanding of their regulation and function is still limited, but new directions for combating desmosome-related diseases are emerging.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
(2022)
Article
Cell Biology
Marcin Moch, Jana Schieren, Rudolf E. Leube
Summary: Mechanical stress affects the plasticity of desmosomes and regulates the turnover of desmosomal proteins, suggesting the existence of a yet unknown mechanosensing pathway in desmosomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michal Kielbik, Izabela Szulc-Kielbik, Magdalena Klink
Summary: SNAIL1, rather than SNAIL2, is implicated in cisplatin resistance of ovarian cancer cells. STAT3 serves as a universal regulator for the expression of SNAIL1/2 in ovarian cancer cells, regardless of their chemoresistance or invasive capabilities. The expression of SNAIL1 and N-cadherin is associated with cisplatin resistance, while SNAIL2 and E-cadherin levels are related to sensitivity to cisplatin in ovarian cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Carolina Noronha, Ana Sofia Ribeiro, Ricardo Taipa, Diogo S. Castro, Joaquim Reis, Claudia Faria, Joana Paredes
Summary: Cadherins play a crucial role in cell adhesion and tissue homeostasis, with implications in cancer cell invasiveness and dissemination. Cadherin switch signifies the epithelial to mesenchymal transition, a key process in cancer progression.
Correction
Plant Sciences
Ivan Kulich, Frank Vogler, Andrea Bleckmann, Philipp Cyprys, Maria Lindemeier, Ingrid Fuchs, Laura Krassini, Thomas Schubert, Jens Steinbrenner, Jim Beynon, Pascal Falter-Braun, Gernot Langst, Thomas Dresselhaus, Stefanie Sprunck
Summary: A correction to the paper has been published and the details can be found at the provided link.
Article
Immunology
Xue Wang, Rui Wang, Dingfang Bu, Leyi Wang, Yuexin Zhang, Yuan Chang, Chenyang Zhang, Xixue Chen, Xuejun Zhu, Zhi Liu, Mingyue Wang
Summary: The study suggests that autoantibodies against the C-terminus of desmoplakin might be pathogenic in PNP.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Collin R. Nisler, Yoshie Narui, Emily Scheib, Deepanshu Choudhary, Jacob D. Bowman, Harsha Mandayam Bharathi, Vincent J. Lynch, Marcos Sotomayor
Summary: The complex inner ear of modern vertebrates has evolved over 500 million years, resulting in diverse inner-ear adaptations. Cadherin-23 and protocadherin-15 are essential molecules for hearing in vertebrates, acting as the focal point of force transmission when converting sound waves into electrical signals. This study characterizes the evolution of the interaction between these proteins, showing how sequence changes affect their biophysical properties, and how variations in interaction strength and dynamics exist among vertebrate lineages. The findings also suggest that the biophysical properties of the complex constrain its evolution, providing a possible explanation for the increased presence of deafness-causing mutants in cadherin-23 compared to protocadherin-15.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Review
Biochemistry & Molecular Biology
Fiyaz Mohammed, Martyn Chidgey
Summary: This review focuses on the structural characteristics of desmosomal proteins, their interactions with each other and the intermediate filament cytoskeleton. By examining representative examples of missense mutations, the authors demonstrate how such variants could affect the structural fold of desmosomal proteins expressed in the heart, potentially compromising desmosomal adhesion and leading to life-threatening diseases like arrhythmogenic right ventricular cardiomyopathy.
JOURNAL OF STRUCTURAL BIOLOGY
(2021)
Article
Cell Biology
Evelyn C. Aviles, Alexandra Krol, Steven J. Henle, Jessica Burroughs-Garcia, Michael R. Deans, Lisa Goodrich
Summary: The polarized flow of information in neural circuits relies on the organization of neurons, their processes, and their synapses. Fat3, a protein similar to Fat cadherins, plays a crucial role in the development of polarized circuits in the mouse retina. It binds to cytoskeletal regulators and synaptic proteins, coordinating different cell behaviors and regulating synapse localization.
Article
Biotechnology & Applied Microbiology
Yunhao Gan, Fuxin Zhong, Hao Wang, Lingyu Li
Summary: The study found that ARMC1 expression was significantly higher in tumor samples compared to normal tissues, and higher expression was associated with lower survival rates and the stage and histological characteristics of breast cancer. Additionally, ARMC1 mutations were common in BRCA and may be involved in the cell cycle. Confirmatory experiments validated the increased expression of ARMC1 in clinical breast carcinoma tissues.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Hoyee Tsui, Sebastiaan Johannes van Kampen, Su Ji Han, Viviana Meraviglia, Willem B. van Ham, Simona Casini, Petra van der Kraak, Aryan Vink, Xiaoke Yin, Manuel Mayr, Alexandre Bossu, Gerard A. Marchal, Jantine Monshouwer-Kloots, Joep Eding, Danielle Versteeg, Hesther de Ruiter, Karel Bezstarosti, Judith Groeneweg, Sjoerd J. Klaasen, Linda W. Van Laake, Jeroen A. A. Demmers, Geert J. P. L. Kops, Christine L. Mummery, Toon A. B. Van Veen, Carol Ann Remme, Milena Bellin, Eva van Rooij
Summary: Arrhythmogenic cardiomyopathy (ACM) is a progressive cardiac disease caused by inherited mutations, such as plakophilin-2 (PKP2), which lead to decreased expression of desmosomal and adherens junction (AJ) proteins. In vitro and in vivo experiments demonstrated impaired contractility, cardiac dysfunction, and fibrosis associated with PKP2 mutations. Proteomics analysis revealed the involvement of the ubiquitin-proteasome system (UPS) in ACM pathogenesis, and inhibition of UPS improved cardiomyocyte function. The study highlights the potential therapeutic strategy of targeting protein degradation and improving desmosomal protein stability for ACM treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biology
Sanja Jasek, Csaba Veraszto, Emelie Brodrick, Reza Shahidi, Tom Kazimiers, Alexandra Kerbl, Gaspar Jekely, Kristin Tessmar-Raible
Summary: Cells in animal tissues form networks through synaptic, chemical, and adhesive links. Muscle cells in invertebrates are often connected to other cells through desmosomes. By analyzing electron microscopy data, researchers found that muscle cells in the larva of the annelid Platynereis adhere to other cells and form a connectome of over 2000 cells.
Article
Cell Biology
Sonia Ratajczyk, Corinne Drexler, Reinhard Windoffer, Rudolf E. Leube, Peter Fuchs
Summary: Epiplakin (EPPK1) dynamically relocalizes and associates with keratin filaments to stabilize the keratin network under stress conditions, which involves an increase in cytoplasmic Ca2+ levels.
Article
Cardiac & Cardiovascular Systems
Enrico Ammirati, Francesca Raimondi, Nicolas Piriou, Loren Sardo Infirri, Saidi A. Mohiddin, Andrea Mazzanti, Chetan Shenoy, Ugo A. Cavallari, Massimo Imazio, Giovanni Donato Aquaro, Iacopo Olivotto, Patrizia Pedrotti, Neha Sekhri, Caroline M. Van de Heyning, Glenn Broeckx, Giovanni Peretto, Oliver Guttmann, Santo Dellegrottaglie, Alessandra Scatteia, Piero Gentile, Marco Merlo, Randal I. Goldberg, Alex Reyentovich, Christopher Sciamanna, Sabine Klaassen, Wolfgang Poller, Cory R. Trankle, Antonio Abbate, Andre Keren, Smadar Horowitz-Cederboim, Julia Cadrin-Tourigny, Rafik Tadros, Giuseppe A. Annoni, Emanuela Bonoldi, Claire Toquet, Lara Marteau, Vincent Probst, Jean Noel Trochu, Antheia Kissopoulou, Aurelia Grosu, Deni Kukavica, Alessandro Trancuccio, Cristina Gil, Matteo Pedrazzini, Margherita Torchio, Gianfranco Sinagra, Juan Ramon Gimeno, Davide Bernasconi, Maria Grazia Valsecchi, Karin Klingel, Eric D. Adler, Paolo G. Camici, Leslie T. Cooper
Summary: This study found that patients with acute myocarditis and desmosomal gene variants have a higher incidence of adverse cardiovascular events, indicating the need for further prospective research to determine if genetic testing can improve risk stratification for AM patients considered low risk.
JACC-HEART FAILURE
(2022)
