Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination

A TLR/AKT/FoxO3 immune tolerance–like pathway disrupts the repair capacity of oligodendrocyte progenitors

(2018) Taasin Srivastava et al.   JOURNAL OF CLINICAL INVESTIGATION

Teriflunomide promotes oligodendroglial differentiation and myelination

(2018) Peter Göttle et al.   Journal of Neuroinflammation

Muscarinic receptor M3R signaling prevents efficient remyelination by human and mouse oligodendrocyte progenitor cells

(2018) R. Ross Welliver et al.   JOURNAL OF NEUROSCIENCE

Human Endogenous Retroviruses in Neurological Diseases

(2018) Patrick Küry et al.   TRENDS IN MOLECULAR MEDICINE

PRMT5-mediated regulation of developmental myelination

(2018) Antonella Scaglione et al.   Nature Communications

The function of contactin-2/TAG-1 in oligodendrocytes in health and demyelinating pathology

(2017) Lida Zoupi et al.   GLIA

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination

(2017) Yongfeng Chen et al.   PLoS One

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis

(2017) Eva María Medina-Rodríguez et al.   Scientific Reports

Ratiometric fluorescence imaging of cell surface pH by poly(ethylene glycol)-phospholipid conjugated with fluorescein isothiocyanate

(2017) Ryuichi Ohgaki et al.   Scientific Reports

Pushing Forward: Remyelination as the New Frontier in CNS Diseases

(2016) David Kremer et al.   TRENDS IN NEUROSCIENCES

Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis

(2016) Jack van Horssen et al.   Multiple Sclerosis and Related Disorders

Intracellular Protein Shuttling: A Mechanism Relevant for Myelin Repair in Multiple Sclerosis?

(2015) Peter Göttle et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling

(2015) P. Gottle et al.   JOURNAL OF NEUROSCIENCE

A splice site mutation in ATP6AP2 causes X-linked intellectual disability, epilepsy, and parkinsonism

(2015) Harsh V. Gupta et al.   PARKINSONISM & RELATED DISORDERS

Protein–protein interactions within the ensemble, eukaryotic V-ATPase, and its concerted interactions with cellular machineries

(2015) Asha Manikkoth Balakrishna et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Recent Insights into the Structure, Regulation, and Function of the V-ATPases

(2015) Kristina Cotter et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mapping the H+ (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation

(2015) Maria Merkulova et al.   Scientific Reports

Novel techniques in the development of osteoporosis drug therapy: the osteoclast ruffled-border vacuolar H+-ATPase as an emerging target

(2014) Norbert Kartner et al.   Expert Opinion on Drug Discovery

The neutralizing antibody GNbAC1 abrogates HERV-W envelope protein-mediated oligodendroglial maturation blockade

(2014) David Kremer et al.   Multiple Sclerosis Journal

Megalencephalic leukoencephalopathy with subcortical cysts protein-1 modulates endosomal pH and protein trafficking in astrocytes: Relevance to MLC disease pathogenesis

(2014) Maria S. Brignone et al.   NEUROBIOLOGY OF DISEASE

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

(2013) David Kremer et al.   ANNALS OF NEUROLOGY

Neuron-oligodendrocyte myelination co-culture derived from embryonic rat spinal cord and cerebral cortex

(2013) Yi Pang et al.   Brain and Behavior

GNbAC1, a Humanized Monoclonal Antibody Against the Envelope Protein of Multiple Sclerosis—Associated Endogenous Retrovirus: A First-in-Humans Randomized Clinical Study

(2012) François Curtin et al.   CLINICAL THERAPEUTICS

Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

(2012) Hervé Perron et al.   Multiple Sclerosis Journal

The complex world of oligodendroglial differentiation inhibitors

(2011) David Kremer et al.   ANNALS OF NEUROLOGY

Enhancing remyelination in disease--can we wrap it up?

(2011) M. R. Kotter et al.   BRAIN

TLR Signaling Is Required for Salmonella typhimurium Virulence

(2011) Nicholas Arpaia et al.   CELL

Activation of CXCR7 receptor promotes oligodendroglial cell maturation

(2010) Peter Göttle et al.   ANNALS OF NEUROLOGY

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

Imaging outcomes for neuroprotection and repair in multiple sclerosis trials

(2009) Frederik Barkhof et al.   Nature Reviews Neurology

p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation

(2009) D. Kremer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages

(2008) Sandeepa M. Eswarappa et al.   Innate Immunity