Article
Food Science & Technology
Ana L. Ramos-Aguilar, Juan Ornelas-Paz, Luis M. Tapia-Vargas, Alfonso A. Gardea-Bejar, Elhadi M. Yahia, Jose de Jesus Ornelas-Paz, Saul Ruiz-Cruz, Claudio Rios-Velasco, Pilar Escalante-Minakata
Summary: The study evaluated the phytochemical composition of 'Hass' and 'Hass' type avocado peels, finding that HT peels showed superiority in certain nutrients such as alpha-tocopherol, beta-sitosterol, perseitol, and cyanidin-3-glucoside. Additionally, some HT peels also had significantly higher levels of phenolic compounds compared to 'Hass' peels.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Plant Sciences
Kaja Kupnik, Mateja Primozic, Vanja Kokol, Zeljko Knez, Maja Leitgeb
Summary: The aim of this research was to extract and quantify biologically active compounds from avocado seeds using different techniques and evaluate their potential applications in various industries. The study revealed that the use of supercritical carbon dioxide resulted in the highest content of total phenols and total proteins, while ethanol extraction had the highest content of proanthocyanidins. The antimicrobial and antioxidant activities of the avocado seed extracts were also evaluated, showing promising results for their potential use in medicine, pharmaceuticals, cosmetics, and other industries.
Article
Biology
Cid-Perez Teresa Soledad, Hernandez-Carranza Paola, Ochoa-Velasco Carlos Enrique, Ruiz-Lopez Irving Israel, Nevarez-Moorillon GuadalupeVirginia, Avila-Sosa Raul
Summary: This study evaluated the volatile chemical profiling and biological activities of avocado seed extracts. Acetone was found to be the best solvent for extracting volatile compounds with high reducing power. The avocado seed extracts showed potential applications as antioxidants and antimicrobial additives.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Thi-Phuong Doan, Mi Zhang, Eun-Jin Park, Jorge-Eduardo Ponce-Zea, Van-Hieu Mai, Hyo-Moon Cho, Ha-Thanh-Tung Pham, Won-Keun Oh
Summary: This study investigated the chemical components of avocado seeds and discovered several new alkaloids. The bioactivities of these compounds on SIRT1 were evaluated, and one compound showed the most potent activation effect, suggesting its potential as an anti-aging agent.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Melinda H. Yin, Ana I. Vargas, Claudia Fuentealba, Muhammad A. Shahid, Elias Bassil, Bruce Schaffer
Summary: This study assessed the differences in physiological and biochemical responses among clonal, non-grafted avocado cultivars of each race to short-term flooding. Guatemalan trees were found to be more sensitive to short-term flooding than Mexican (M) or West Indian (WI) trees based on decreased net CO2 assimilation, stomatal conductance, and transpiration, as well as a lower survival rate of the flooded trees. Different partitioning of sugars and differential responses to flooding among races may explain the greater flooding sensitivity of Guatemalan trees compared to M and WI trees.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Prodromos Skenderidis, Stefanos Leontopoulos, Konstantinos Petrotos, Ioannis Giavasis
Summary: This study optimized the extraction of avocado fruit peels and seeds using vacuum microwave-assisted aqueous extraction for high total phenolic content and antioxidant activity. The results provide a promising solution for avocado processing companies to utilize their waste effectively.
Article
Chemistry, Multidisciplinary
Maria Camila Garcia-Vallejo, Juan Camilo Solarte-Toro, Mariana Ortiz-Sanchez, Leonardo Chamorro-Anaya, Lina Chamorro-Anaya, Pavel Peroza-Pineres, Alexander Perez-Cordero, Carlos Ariel Cardona Alzate
Summary: Research focuses on valorizing avocado residues by extracting bioactive compounds and producing biogas. Avocado peels show higher potential for biogas production compared to seeds, with a yield of 234 Nm3/kg SV. Optimum conditions for bioactive compound extraction from avocado seeds and peels are 45°C for 20 min, with an ethanol concentration of 30% and a solid-to-liquid ratio of 1:20. The rich extracts of avocado seed and peel can be proposed for applications in medical, cosmetic, food, and pharmaceutical industries.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Food Science & Technology
Gustavo R. Velderrain-Rodriguez, Laura Salvia-Trujillo, Gustavo A. Gonzalez-Aguilar, Olga Martin-Belloso
Summary: Phenolic-rich extracts from avocado peels and seeds showed positive effects on the stability of oil-in-water emulsions, reducing oxidation products formation. However, the extracts could lead to instability in nanoemulsions. These findings suggest a potential application of avocado waste.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2021)
Article
Multidisciplinary Sciences
Oluwafemi Adeleke Ojo, Jennifer Chidubem Amanze, Abosede Itunuoluwa Oni, Susan Grant, Matthew Iyobhebhe, Tobiloba Christiana Elebiyo, Damilare Rotimi, Nnaemeka Tobechukwu Asogwa, Babatunji Emmanuel Oyinloye, Basiru Olaitan Ajiboye, Adebola Busola Ojo
Summary: This study explored the potential therapeutic effects of an aqueous extract of Persea americana seeds (AEPAS) on rats with diabetes. The results showed that AEPAS exhibited strong antioxidant and enzyme inhibitory properties. Administration of AEPAS improved insulin sensitivity and regulated glycolipid metabolism.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ghalia Shamlan
Summary: This study aimed to compare the effects of ethanol and water extracts from avocado seeds on doxorubicin-induced cardiotoxicity, finding that the ethanol extract was more effective. Both extracts acted as cardioprotective agents following doxorubicin treatment by mitigating impacts on biochemical markers.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Diana Paola Yepes-Betancur, Carlos Julio Marquez-Cardozo, Edith Marleny Cadena-Chamorro, Jaison Martinez-Saldarriaga, Cristian Torres-Leon, Alberto Ascacio-Valdes, Cristobal N. Aguilar
Summary: The study investigated the effect of solid-state fermentation (SSF) of avocado seed with A. niger GH1 on the release of bioactive compounds with antioxidant capacity, and found that A. niger GH1 has the ability to degrade compounds in avocado seed, enhancing the antioxidant capacity.
FOOD AND BIOPRODUCTS PROCESSING
(2021)
Article
Biochemistry & Molecular Biology
Imen Bettaieb, Mohamed Ali Benabderrahim, Rocio Rodriguez Arcos, Ana Jose Jimenez Araujo, Walid Elfalleh
Summary: This study investigated the antioxidant activities and phenolic profiling of extracts from seven cultivars of date seeds, and found significant variations among cultivars. The total phenolic content, total flavonoid value, and condensed tannin content differed among cultivars, and phloroglucinolysis revealed the presence of phenolic acids and a high amount of flavan-3-ols. Date seeds were identified as a good source of bioactive compounds.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Chemistry, Medicinal
Mariana Garrido-Valdes, Leonor Diaz-Velis, Marisela Valdes-Gonzalez, Barbara B. Garrido-Suarez, Gabino Garrido
Summary: This study systematically reviewed the scientific literature on the gastroprotective role of fruit extracts in gastric ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs) using PRISMA guidelines. The findings suggest that fruit extracts have antiulcer activity, possibly through various mechanisms such as antioxidant, cytoprotective, gastric acid antisecretory, anti-inflammatory, or angiogenesis stimulant effects.
JOURNAL OF MEDICINAL FOOD
(2023)
Article
Chemistry, Multidisciplinary
Abderrahmene Bouaouich, Faiza Bouguerche, Houda Mahiaoui, Gregorio Peron, Hamdi Bendif
Summary: This study characterized fatty acids and secondary metabolites in seeds of three cultivars of Opuntia ficus-indica L. harvested from Algeria. The antioxidant activity of seed extracts was assessed and results showed varying total phenolic content among the cultivars. HPLC and GC analyses revealed the presence of phenolic compounds and essential fatty acids in the seed extracts and oil, respectively. The results highlight the potential of O. ficus-indica seeds as valuable sources of table oil, cooking oil, and antioxidants.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Tarek Hefzalrahman, Mohamed K. S. Morsi, Nashwa F. S. Morsy, Karima S. M. Hammad
Summary: This study evaluated the impact of ultrasound and enzyme-assisted extraction methods on the polyphenols with antioxidant properties in avocado peel. The results showed that ultrasound assisted extraction was more efficient in terms of antioxidant activity compared to enzyme-aided extraction.
ACTA SCIENTIARUM POLONORUM-TECHNOLOGIA ALIMENTARIA
(2022)
Article
Pharmacology & Pharmacy
Leandra de Almeida Ribeiro Oliveira, Arthur Christian Garcia da Silva, Douglas Vieira Thomaz, Fabiana Brandao, Edemilson Cardoso da Conceicao, Marize Campos Valadares, Maria Tereza Freitas Bara, Damaris Silveira
Summary: The aim of this study was to evaluate the anti-inflammatory activity of P. emarginatus oleoresin and isolated diterpenes in in vitro models. The results showed that oleoresin, V2, and V3 inhibited phospholipase A2 activity, and both V1 and V2 inhibited the expression of COX-2. Meanwhile, oleoresin could also inhibit the production of interleukin 6. In conclusion, the results support the ethnomedicinal use of P. emarginatus oleoresin as an anti-inflammatory herbal medicine, and suggest its potential therapeutic use for COVID-19.
ADVANCED PHARMACEUTICAL BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Isaac de Araujo Matos, Ana Carolina Goes Pinto, Matheus Vitor Ferreira Ferraz, Wenny Camilla Santos Adan, Ricardo Pereira Rodrigues, Juliane Xavier dos Santos, Rodrigo Rezende Kitagawa, Roberto Dias Lins, Tiago Branquinho Oliveira, Nivan Bezerra da Costa
Summary: In this study, molecular docking simulations, quantitative structure-activity relationships studies, and ADMETox predictions were used to analyze the molecular recognition and inhibition of Staphylococcus aureus dihydrofolate reductase by a series of 7-aryl-2,4-diaminoquinazoline derivatives. A quantitative structure-activity relationship model was developed, demonstrating the importance of pKa and molar refractivity for inhibitory activity. Virtual screening identified PC-124127620, PC-124127795, and PC-124127805 as promising candidates for SaDHFR inhibitors, with high potency and favorable pharmacokinetics and toxicological profiles. These findings suggest these compounds could be potential antimicrobial agents for treating S. aureus infections.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Polymer Science
Elisabeth Maria Lopez de Prado, Geanne Aparecida de Paula, Jessyca Aparecida Paes Dutra, Daniel Fernandes Cipriano, Rodrigo Rezende Kitagawa, Fabiana Dayse Magalhaes Siman, Eduardo Frizzera Meira, Jair Carlos Checon de Freitas, Juliana Aparecida Severi, Lilian Gasparelli Carreira, Rodrigo Lamberti Orefice, Janaina Cecilia Oliveira Villanova
Summary: This study used crude dry extract from taro rhizome blended with PVA to prepare biomaterials for wound dressing. The films obtained showed good film-forming properties, excellent physicochemical parameters and mechanical properties, as well as in vitro biocompatibility. The presence of taro extract improved the thermal stability, mechanical resistance, and functionality of the films.
Article
Biochemistry & Molecular Biology
Jessyca Aparecida Paes Dutra, Sarah Canal Maximino, Rita de Cassia Ribeiro Goncalves, Pedro Alves Bezerra Morais, William Cezar de Lima Silva, Ricardo Pereira Rodrigues, Alvaro Cunha Neto, Valdemar Lacerda Junior, Warley de Souza Borges, Rodrigo Rezende Kitagawa
Summary: This study evaluated the anti-Candida potential and cytotoxic profile of eugenol derivatives, and found that compound 1b exhibited the strongest antimicrobial activity and has the potential to be a candidate for new anti-Candida drugs.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Chemistry, Medicinal
Jessica Raquel Borges Monteiro, Ricardo Pereira Rodrigues, Ana Carolina Mazzuco, Rita de Cassia Ribeiro Goncalves, Angelo Fraga Bernardino, Ricardo Machado Kuster, Rodrigo Rezende Kitagawa
Summary: It is estimated that there will be nearly 2 million new cases of gastric cancer worldwide in the next two decades, leading to an increased demand for new treatments. Marine algae, such as Laurencia genus, have been found to contain cytotoxic compounds like terpenes and acetogenins. This study identified and tested the cytotoxicity of compounds from Laurencia obtusa, demonstrating their potential for treating gastric adenocarcinoma.
Article
Biochemistry & Molecular Biology
Camilo Di Giulio, Juan Manuel Gonzalez Guzman, Joao Victor Dutra Gomes, Young Hae Choi, Perola O. Magalhaes, Yris M. Fonseca-Bazzo, Damaris Silveira, Omar Estrada
Summary: A new furofuran lignan, esquamosan, was isolated from the leaves of Annona squamosa L. and its structure was determined by spectroscopic methods. Esquamosan showed concentration-dependent inhibition of contraction in rat aortic rings and inhibited vasocontraction of depolarized aorta with high-concentration potassium. The vasorelaxant effect of esquamosan was mainly attributed to the inhibition of calcium influx and increased release of NO. Additionally, esquamosan exhibited antioxidant capacity similar to ascorbic acid.
Article
Chemistry, Applied
Larissa Silva de Souza, Cristina Luz Tosta, Jessica Rodrigues Pereira de Oliveira Borlot, Marcia C. B. N. Varricchio, Rodrigo Rezende Kitagawa, Paulo Roberto Filgueiras, Ricardo Machado Kuster
Summary: The ethanol extract from Euphorbia tirucalli L. and its latex suspended in water are used in Brazil for the treatment of various diseases, including cancer. This study aimed to determine the cytotoxic effects of the ethanol extract on gastric adenocarcinoma cells (AGS) and analyze its chemical composition. Hexane and aqueous fractions of the extract showed higher cytotoxicity on AGS cells. Analysis revealed the presence of triterpene compounds in the hexane fraction and ellagic acid as the main phenolic compound in the aqueous extract, suggesting that these components contribute to the greater cytotoxic activity of the ethanol extract compared to latex.
NATURAL PRODUCT RESEARCH
(2023)
Editorial Material
Plant Sciences
Damaris Silveira, Fabio Boylan
Article
Biochemistry & Molecular Biology
Nataly Senna Gerhardt Barraqui, Jose Aires Ventura, Fabiana Gomes Ruas, Rodrigo Borges de Araujo Gomes, Betina Pires Oliveira Lovatti, Samantha Ribeiro Campos da Silva, Paulo Roberto Filgueiras, Ricardo Machado Kuster
Summary: This study evaluated the quality of Brazilian peppertree fruits at different maturation stages and found that the red fruits had the highest yield of essential oil. The analysis of physical and chemical characteristics of each stage showed distinct profiles, with the pinkish-green and pinkish stages displaying a transition in characteristics. The chromatography data were suitable for chemometric analysis and can contribute to optimizing the harvest time for aroeira fruits.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jessica Rodrigues Pereira de Oliveira Borlot, Luna Schlittler dos Santos, Guilherme Jose Schwarzt Sampaio, Augusto Santos Borges, Ricardo Pereira Rodrigues, Rita de Cassia Ribeiro Goncalves, Reginaldo Bezerra dos Santos, Rodrigo Rezende Kitagawa
Summary: In this study, we synthesized and evaluated a series of 14 chalcones for their anti-H. pylori, NO inhibition, and cytotoxic effects. Compounds 3b and 3h showed good antibacterial activity and demonstrated structure-activity relationships. These compounds also inhibited the production of NO in LPS-stimulated macrophages and showed potential for interaction with the active site of the iNOS enzyme. Additionally, compounds 3b and 3h exhibited high selectivity towards AGS cell lines.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Endocrinology & Metabolism
Priscila M. Coelho, Luisa M. Simmer, Daniel S. da Silva, Matheus C. dos Santos, Rodrigo R. Kitagawa, Mateus F. Pezzin, Camila R. Correa, Jessica G. Leite, Andre S. Leopoldo, Ana Paula Lima-Leopoldo
Summary: This study aimed to investigate whether obesity associated with type 2 diabetes mellitus (T2DM) leads to myocardial contractility dysfunction in cardiomyocytes due to damage in Ca2+ handling, along with increased oxidative stress biomarkers. The results showed that obesity and T2DM are associated, leading to prolonged cardiomyocyte contractile function, protein carbonylation damage, and impairment in Ca2+ handling.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Pharmacology & Pharmacy
Samuel Leite Cardoso, Paula Monteiro Souza, Kelly Rodrigues, Isabella de Souza Mota, Edivaldo Ferreira Filho, Leia Cecilia de Lima Favaro, Felipe Saldanha-Araujo, Mauricio Homem-de-Mello, Adalberto Pessoa, Damaris Silveira, Yris Maria Fonseca-Bazzo, Perola Oliveira Magalhaes
Summary: The search for new drug-producing microorganisms is highly promising in the world of science today. This study successfully cloned and purified L-asparaginase from Fusarium proliferatum in Pichia pastoris, and analyzed its enzymatic activity and predicted its monomeric structure based on the analysis of amino acid residue positions.
Article
Plant Sciences
Gislane dos Santos Ribeiro, Diegue Henrique Nascimento Martins, Joao Victor Dutra Gomes, Noel William Davies, Christopher William Fagg, Luiz Alberto Simeoni, Mauricio Homem-de-Mello, Perola Oliveira Magalhaes, Damaris Silveira, Yris Maria Fonseca-Bazzo
Summary: This study investigated the protective effects of four Cerrado plant species against acetaminophen toxicity in HepG2 cells. The results showed that the extracts could provide cell protection and did not increase the toxic effect of acetaminophen. This protection may be attributed to antioxidant compounds present in the extracts.
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)