期刊
FEBS LETTERS
卷 592, 期 23, 页码 3921-3942出版社
WILEY
DOI: 10.1002/1873-3468.13275
关键词
acquired immunity; glycosphingolipid; innate immunity; intracellular parasitism; lipid raft; neutrophil; phagocytosis; T cell activation; T cell selection
资金
- Foundation of Strategic Research Projects in Private Universities [S1201013, S1311011, S1201031]
- MEXT KAKENHI [16017293, 24659293, 25860831, 15K19592, 16H04767]
- AMED [JP17g-m0910006]
- Naito Foundation
- Mizutani Foundation for Glycoscience
- ONO Medical Research Foundation
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [15K19592, 16H04767, 25860831, 16017293, 24659293] Funding Source: KAKEN
Lipid rafts formed by glycosphingolipids (GSLs) on cellular membranes play important roles in innate and adaptive immunity. Lactosylceramide (LacCer) forms lipid rafts on plasma and granular membranes of human neutrophils. These LacCer-enriched lipid rafts bind directly to pathogenic components, such as pathogenic fungi-derived beta-glucan and Mycobacteria-derived lipoarabinomannan via carbohydrate-carbohydrate interactions, and mediate innate immune responses to these pathogens. In contrast, a-series and o-series gangliosides form distinct rafts on CD4(+) and CD8(+) T cell subsets, respectively, contributing to the respective functions of these cells and stimulating adaptive immune responses through T cell receptors. These findings suggest that gangliosides play indispensable roles in T cell selection and activation. This Review introduces the involvement of GSL-enriched lipid rafts in innate and adaptive immunity.
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