Ancestral diterpene cyclases show increased thermostability and substrate acceptance

Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability

(2017) Pascal Leuenberger et al.   SCIENCE

Terpene Cyclases from Social Amoebae

(2016) Patrick Rabe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis

(2016) Johan Andersen-Ranberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering ancestral protein hyperstability

(2016) M. L. Romero-Romero et al.   BIOCHEMICAL JOURNAL

Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the 'retro approach to protein engineering

(2016) Y. Gumulya et al.   BIOCHEMICAL JOURNAL

Evolution of Enzyme Superfamilies: Comprehensive Exploration of Sequence–Function Relationships

(2016) F. Baier et al.   BIOCHEMISTRY

Ancestral protein reconstruction: techniques and applications

(2016) Rainer Merkl et al.   BIOLOGICAL CHEMISTRY

Multi-domain terpenoid cyclase architecture and prospects for proximity in bifunctional catalysis

(2016) Mengbin Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Catalytic Promiscuity of Ancestral Esterases and Hydroxynitrile Lyases

(2016) Titu Devamani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins

(2016) Devin L. Trudeau et al.   MOLECULAR BIOLOGY AND EVOLUTION

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

(2016) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Sustainable polymers from renewable resources

(2016) Yunqing Zhu et al.   NATURE

Evolutionary drivers of thermoadaptation in enzyme catalysis

(2016) Vy Nguyen et al.   SCIENCE

Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution

(2015) Hans Renata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New Generation of Biocatalysts for Organic Synthesis

(2014) Bettina M. Nestl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Induced-Fit Mechanism in Class I Terpene Cyclases

(2014) Philipp Baer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hedycaryol Synthase in Complex with Nerolidol Reveals Terpene Cyclase Mechanism

(2014) Philipp Baer et al.   CHEMBIOCHEM

High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase

(2013) Ryan Lauchli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future

(2013) Manfred T. Reetz   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

(2013) Valeria A. Risso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Building Phylogenetic Trees from Molecular Data with MEGA

(2013) B. G. Hall   MOLECULAR BIOLOGY AND EVOLUTION

Unipro UGENE: a unified bioinformatics toolkit

(2012) Konstantin Okonechnikov et al.   BIOINFORMATICS

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Terpene Biosynthesis: Modularity Rules

(2011) Eric Oldfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Bifunctional Triterpene/Sesquarterpene Cyclase: Tetraprenyl-β-curcumene Cyclase Is Also Squalene Cyclase in Bacillus megaterium

(2011) Tsutomu Sato et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Improved General Amino Acid Replacement Matrix

(2008) S. Q. Le et al.   MOLECULAR BIOLOGY AND EVOLUTION

Terpenoid biomaterials

(2008) Jörg Bohlmann et al.   PLANT JOURNAL