The role of hydrophobic /hydrophilic balance in the activity of structurally flexible vs. rigid cytolytic polypeptides and analogs developed on their basis

Antifungal activity of Latarcin 1 derived cell-penetrating peptides against Fusarium solani

(2018) Deepthi Poornima Budagavi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Comparison of lipid-dependent bilayer insertion of pHLIP and its P20G variant

(2018) Victor Vasquez-Montes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Improved antibacterial activity of a marine peptide-N2 against intracellular Salmonella typhimurium by conjugating with cell-penetrating peptides-bLFcin 6 /Tat 11

(2018) Zhanzhan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial properties of Latarcin 1 derived cell-penetrating peptides

(2018) Deepthi Poornima Budagavi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Elucidating the biogeographical variation of the venom of Naja naja (spectacled cobra) from Pakistan through a venom-decomplexing proteomic study

(2018) Kin Ying Wong et al.   Journal of Proteomics

Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity

(2018) Andrea Sala et al.   PLoS One

Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors

(2018) Linden C. Wyatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving therapeutic potential of antibacterial spider venom peptides: coarse-grain molecular dynamics guided approach

(2018) Peter V Dubovskii et al.   Future Medicinal Chemistry

Cell-penetrating and cargo-delivery ability of a spider toxin-derived peptide in mammalian cells

(2017) Nisha Ponnappan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

An overview of antimicrobial peptides and the latest advances in their development

(2017) Josep M Sierra et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15–34), antimicrobial peptides from rattlesnake venom

(2017) Clara Pérez-Peinado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of membrane partitioning on the spatial structure of an S-type cobra cytotoxin

(2017) Peter V. Dubovskii et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Cardiotoxins: Functional Role of Local Conformational Changes

(2017) Anastasia G. Konshina et al.   Journal of Chemical Information and Modeling

Proteomic analysis to unravel the complex venom proteome of eastern India Naja naja: Correlation of venom composition with its biochemical and pharmacological properties

(2017) Sumita Dutta et al.   Journal of Proteomics

Antimicrobial activity predictors benchmarking analysis using shuffled and designed synthetic peptides

(2017) William F. Porto et al.   JOURNAL OF THEORETICAL BIOLOGY

MLACP: machine-learning-based prediction of anticancer peptides

(2017) Balachandran Manavalan et al.   Oncotarget

Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design

(2017) Jianguo Li et al.   Frontiers in Neuroscience

Peptides with Dual Antimicrobial and Anticancer Activities

(2017) Mário R. Felício et al.   Frontiers in Chemistry

Lachesana tarabaevi, an expert in membrane-active toxins

(2016) A. I. Kuzmenkov et al.   BIOCHEMICAL JOURNAL

Molecular mechanisms of membrane targeting antibiotics

(2016) Richard M. Epand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Comparison of the primary structures, cytotoxicities, and affinities to phospholipids of five kinds of cytotoxins from the venom of Indian cobra, Naja naja

(2016) Mieko Suzuki-Matsubara et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Antimicrobial Peptides: Mechanisms of Action and Resistance

(2016) B. Bechinger et al.   JOURNAL OF DENTAL RESEARCH

Unveiling the elusive and exotic: Venomics of the Malayan blue coral snake (Calliophis bivirgata flaviceps)

(2016) Choo Hock Tan et al.   Journal of Proteomics

An Evaluation on Different Machine Learning Algorithms for Classification and Prediction of Antifungal Peptides

(2016) Maryam Mousavizadegan et al.   Medicinal Chemistry

Mapping membrane activity in undiscovered peptide sequence space using machine learning

(2016) Ernest Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

(2016) Margit Mahlapuu et al.   Frontiers in Cellular and Infection Microbiology

A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code

(2015) Dolores Solís et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Dynamic Structural/Amphiphilic “Portrait” of Biomembranes as their Fundamental Property Relevant to Function: Results of Atomistic Simulations

(2015) Roman G. Efremov et al.   BIOPHYSICAL JOURNAL

Latarcins: versatile spider venom peptides

(2015) Peter V. Dubovskii et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Machine Learning in the Rational Design of Antimicrobial Peptides

(2015) Paola Rondon-Villarreal et al.   Current Computer-Aided Drug Design

Antiproliferative Activity of Cobra Venom Cytotoxins

(2015) Peter Dubovskii et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Venomics, lethality and neutralization of Naja kaouthia (monocled cobra) venoms from three different geographical regions of Southeast Asia

(2015) Kae Yi Tan et al.   Journal of Proteomics

Cobra cytotoxins: determinants of antibacterial activity

(2015) Peter V. Dubovskii et al.   MENDELEEV COMMUNICATIONS

Cobra venom cytotoxins; apoptotic or necrotic agents?

(2015) Karim Ebrahim et al.   TOXICON

Resurrecting Inactive Antimicrobial Peptides from the Lipopolysaccharide Trap

(2014) Harini Mohanram et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptide-based cancer therapy: Opportunity and challenge

(2014) Dongdong Wu et al.   CANCER LETTERS

Novel Formulations for Antimicrobial Peptides

(2014) Ana Carmona-Ribeiro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deciphering Fine Molecular Details of Proteins’ Structure and Function with a Protein Surface Topography (PST) Method

(2014) Anna D. Koromyslova et al.   Journal of Chemical Information and Modeling

Small cationic antimicrobial peptides delocalize peripheral membrane proteins

(2014) M. Wenzel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PREDDIMER: a web server for prediction of transmembrane helical dimers

(2013) Anton A. Polyansky et al.   BIOINFORMATICS

Cobra Cardiotoxins: Membrane Interactions and Pharmacological Potential

(2013) P. Dubovskii et al.   CURRENT MEDICINAL CHEMISTRY

A common landscape for membrane-active peptides

(2013) Nicholas B. Last et al.   PROTEIN SCIENCE

Imaging the membrane lytic activity of bioactive peptide latarcin 2a

(2012) Amy Won et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure and Dynamics of Cardiotoxins

(2012) Anastasia G. Konshina et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Dynamic clustering of lipids in hydrated two-component membranes: results of computer modeling and putative biological impact

(2012) Darya V. Pyrkova et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

2H Solid-State Nuclear Magnetic Resonance Investigation of Whole Escherichia coli Interacting with Antimicrobial Peptide MSI-78

(2011) James Pius et al.   BIOCHEMISTRY

Membrane-active host defense peptides – Challenges and perspectives for the development of novel anticancer drugs

(2011) Sabrina Riedl et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Antimicrobial peptides with cell-penetrating peptide properties and vice versa

(2011) Katrin Splith et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin

(2011) Peter V. Dubovskii et al.   FEBS Journal

Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells

(2010) Lucia Kuhn-Nentwig et al.   AMINO ACIDS

Damage of the Bacterial Cell Envelope by Antimicrobial Peptides Gramicidin S and PGLa as Revealed by Transmission and Scanning Electron Microscopy

(2010) M. Hartmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Modeling of the Endosomolytic Activity of HA2-TAT Peptides with Red Blood Cells and Ghosts

(2010) Ya-Jung Lee et al.   BIOCHEMISTRY

Haemolytic and cytotoxic action of latarcin Ltc2a

(2010) Olga V. Vorontsova et al.   BIOCHIMIE

Snake Venomics of African Spitting Cobras: Toxin Composition and Assessment of Congeneric Cross-Reactivity of the Pan-African EchiTAb-Plus-ICP Antivenom by Antivenomics and Neutralization Approaches

(2010) Daniel Petras et al.   JOURNAL OF PROTEOME RESEARCH

Structure of an analog of fusion peptide from hemagglutinin

(2010) Peter V. Dubovskii et al.   PROTEIN SCIENCE

Interaction of Naja naja atra cardiotoxin 3 with H-trisaccharide modulates its hemolytic activity and membrane-damaging activity

(2010) Pei-Hsiu Kao et al.   TOXICON

Structure, function and evolution of three-finger toxins: Mini proteins with multiple targets

(2010) R. Manjunatha Kini et al.   TOXICON

Alpha-helical cationic antimicrobial peptides: relationships of structure and function

(2010) Yibing Huang et al.   Protein & Cell

PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes

(2009) Timothy V. Pyrkov et al.   BIOINFORMATICS

N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: A case study in latarcins

(2009) Anton A. Polyansky et al.   FEBS LETTERS

Adaptation of a Membrane-active Peptide to Heterogeneous Environment. II. The Role of Mosaic Nature of the Membrane Surface

(2009) Anton A. Polyansky et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Adaptation of a Membrane-active Peptide to Heterogeneous Environment. I. Structural Plasticity of the Peptide

(2009) Anton A. Polyansky et al.   JOURNAL OF PHYSICAL CHEMISTRY B

CAMP: a useful resource for research on antimicrobial peptides

(2009) Shaini Thomas et al.   NUCLEIC ACIDS RESEARCH

Three-Dimensional Structure/Hydrophobicity of Latarcins Specifies Their Mode of Membrane Activity†,‡

(2008) Peter V. Dubovskii et al.   BIOCHEMISTRY

Control of cell selectivity of antimicrobial peptides

(2008) Katsumi Matsuzaki   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Bacterial Membranes as Predictors of Antimicrobial Potency

(2008) Richard M. Epand et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY