Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors

Therapeutic Efficacy of a Family of pHLIP–MMAF Conjugates in Cancer Cells and Mouse Models

(2017) Kelly E. Burns et al.   MOLECULAR PHARMACEUTICS

PET Imaging of Extracellular pH in Tumors with 64Cu- and 18F-Labeled pHLIP Peptides: A Structure–Activity Optimization Study

(2016) Dustin Wayne Demoin et al.   BIOCONJUGATE CHEMISTRY

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

(2016) M. C. Lloyd et al.   CANCER RESEARCH

Comparative Study of Tumor Targeting and Biodistribution of pH (Low) Insertion Peptides (pHLIP® Peptides) Conjugated with Different Fluorescent Dyes

(2016) Ramona-Cosmina Adochite et al.   MOLECULAR IMAGING AND BIOLOGY

Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo

(2016) Jovana Golijanin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probe for the measurement of cell surface pH in vivo and ex vivo

(2016) Michael Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates

(2016) Kelly E. Burns et al.   Scientific Reports

Novel pH-Sensitive Cyclic Peptides

(2016) Dhammika Weerakkody et al.   Scientific Reports

Noncanonical Amino Acids to Improve the pH Response of pHLIP Insertion at Tumor Acidity

(2015) Joab O. Onyango et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Down-regulation of PAR1 activity with a pHLIP-based allosteric antagonist induces cancer cell death

(2015) K. E. Burns et al.   BIOCHEMICAL JOURNAL

A Novel Soluble Peptide with pH-Responsive Membrane Insertion

(2015) Vanessa P. Nguyen et al.   BIOCHEMISTRY

Conformational Fine-Tuning of Pore-Forming Peptide Potency and Selectivity

(2015) Aram J. Krauson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Cancer Cell Proliferation and Breast Tumor Targeting of pHLIP–Monomethyl Auristatin E Conjugates

(2015) Kelly E. Burns et al.   MOLECULAR PHARMACEUTICS

The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions

(2015) Thomas T. Tapmeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Breast Tumors with pH (Low) Insertion Peptides

(2014) Ramona-Cosmina Adochite et al.   MOLECULAR PHARMACEUTICS

MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

(2014) Christopher J. Cheng et al.   NATURE

Targeting Pancreatic Ductal Adenocarcinoma Acidic Microenvironment

(2014) Zobeida Cruz-Monserrate et al.   Scientific Reports

Antiproliferative Effect of pHLIP-Amanitin

(2013) Anna Moshnikova et al.   BIOCHEMISTRY

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

pHLIP®-mediated delivery of PEGylated liposomes to cancer cells

(2013) Lan Yao et al.   JOURNAL OF CONTROLLED RELEASE

Family of pH (low) insertion peptides for tumor targeting

(2013) D. Weerakkody et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of the pHLIP Transmembrane Helix Insertion Pathway

(2012) Alexander G. Karabadzhak et al.   BIOPHYSICAL JOURNAL

In Vivo pH Imaging with 99mTc-pHLIP

(2012) Sven Macholl et al.   MOLECULAR IMAGING AND BIOLOGY

pHLIP peptide targets nanogold particles to tumors

(2012) L. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning a Polar Molecule for Selective Cytoplasmic Delivery by a pH (Low) Insertion Peptide

(2011) Dayanjali Wijesinghe et al.   BIOCHEMISTRY

Roles of Carboxyl Groups in the Transmembrane Insertion of Peptides

(2011) Francisco N. Barrera et al.   JOURNAL OF MOLECULAR BIOLOGY

Imaging pH and metastasis

(2011) Arig Ibrahim Hashim et al.   NMR IN BIOMEDICINE

Tumor pH and Its Measurement

(2010) X. Zhang et al.   JOURNAL OF NUCLEAR MEDICINE

Measuring Tumor Aggressiveness and Targeting Metastatic Lesions with Fluorescent pHLIP

(2010) Yana K. Reshetnyak et al.   MOLECULAR IMAGING AND BIOLOGY

pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation

(2010) M. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane

(2008) Y. K. Reshetnyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA