Eomesodermin controls a unique differentiation program in human IL-10 and IFN-γ coproducing regulatory T cells

Intestinal IFN-γ–producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease

(2018) Johanna Sophie Alfen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eomes controls the development of Th17-derived (non-classic) Th1 cells during chronic inflammation

(2018) Alessio Mazzoni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.

(2016) Jens Geginat et al.   CYTOKINE & GROWTH FACTOR REVIEWS

IL-10 promotes homeostatic proliferation of human CD8+memory T cells and, when produced by CD1c+DCs, shapes naive CD8+T-cell priming

(2016) Giulia Nizzoli et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-10–producing forkhead box protein 3–negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus

(2016) Federica Facciotti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expanding antigen-specific regulatory networks to treat autoimmunity

(2016) Xavier Clemente-Casares et al.   NATURE

Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells

(2015) Ilko Kastirr et al.   JOURNAL OF IMMUNOLOGY

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

(2015) Nicola Gagliani et al.   NATURE

TGF-β3-expressing CD4+CD25−LAG3+ regulatory T cells control humoral immune responses

(2015) Tomohisa Okamura et al.   Nature Communications

Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets

(2015) Jens Geginat et al.   Frontiers in Immunology

Role of Blimp-1 in programing Th effector cells into IL-10 producers

(2014) Christian Neumann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes

(2014) N. E. Humphreys et al.   JOURNAL OF IMMUNOLOGY

Interleukin-4 Regulates Eomesodermin in CD8+ T Cell Development and Differentiation

(2014) Shannon A. Carty et al.   PLoS One

Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells

(2014) Rosa Bacchetta et al.   Frontiers in Immunology

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

(2013) G. Nizzoli et al.   BLOOD

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

CD4 CTL: Living up to the challenge

(2013) Hilde Cheroutre et al.   SEMINARS IN IMMUNOLOGY

The CD4-centered universe of human T cell subsets

(2013) J. Geginat et al.   SEMINARS IN IMMUNOLOGY

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

(2012) Pierre Desreumaux et al.   GASTROENTEROLOGY

Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells

(2011) S. Steinfelder et al.   BLOOD

Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin

(2011) Kenji Ichiyama et al.   IMMUNITY

Unexpected Role for Granzyme K in CD56bright NK Cell-Mediated Immunoregulation of Multiple Sclerosis

(2011) W. Jiang et al.   JOURNAL OF IMMUNOLOGY

CCR6 is expressed on an IL-10–producing, autoreactive memory T cell population with context-dependent regulatory function

(2010) Laura Rivino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells

(2010) Roopali Gandhi et al.   NATURE IMMUNOLOGY

Identification and characterization of IL-10/IFN-γ–producing effector-like T cells with regulatory function in human blood

(2009) Barbara Häringer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Plasmacytoid Dendritic Cells Induce IL-10 Production in T Cells via the Delta-Like-4/Notch Axis

(2009) N. Kassner et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY