SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

(2017) Xingyue He et al.   Nature Chemical Biology

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor–mediated disease

(2015) Jason P. Chua et al.   JOURNAL OF CLINICAL INVESTIGATION

Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure

(2015) Changwon Kho et al.   Nature Communications

The autophagy/lysosome pathway is impaired in SCA7 patients and SCA7 knock-in mice

(2014) Sandro Alves et al.   ACTA NEUROPATHOLOGICA

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

SUMO Chain-Induced Dimerization Activates RNF4

(2014) Alejandro Rojas-Fernandez et al.   MOLECULAR CELL

PML, SUMO, and RNF4: Guardians of Nuclear Protein Quality

(2014) Anne Gärtner et al.   MOLECULAR CELL

A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration

(2014) Lili Guo et al.   MOLECULAR CELL

Identification and analysis of endogenous SUMO1 and SUMO2/3 targets in mammalian cells and tissues using monoclonal antibodies

(2014) Sina V Barysch et al.   Nature Protocols

Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication

(2014) Umut Sahin et al.   Nature Communications

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

SUMO-targeted ubiquitin ligases

(2013) Annie M. Sriramachandran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Interferon beta induces clearance of mutant ataxin 7 and improves locomotion in SCA7 knock-in mice

(2013) Alice Chort et al.   BRAIN

Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies

(2013) Melanie Theodore Malloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detecting endogenous SUMO targets in mammalian cells and tissues

(2013) Janina Becker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

(2013) Jacqueline Gire O’Rourke et al.   Cell Reports

SUMO-1 is Associated with a Subset of Lysosomes in Glial Protein Aggregate Diseases

(2012) Mathew B. Wong et al.   NEUROTOXICITY RESEARCH

Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model

(2011) Yi Chun Chen et al.   HUMAN MOLECULAR GENETICS

SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7

(2009) Alexandre Janer et al.   HUMAN MOLECULAR GENETICS

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

(2009) Leslie Michels Thompson et al.   JOURNAL OF CELL BIOLOGY

Selection of Reference Genes for Quantitative Real-time RT-PCR Studies in Mouse Brain

(2008) Enrica Boda et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Ubiquitin-Proteasome System Is a Key Component of the SUMO-2/3 Cycle

(2008) Joost Schimmel et al.   MOLECULAR & CELLULAR PROTEOMICS

The Fast-Growing Business of SUMO Chains

(2008) Helle D. Ulrich   MOLECULAR CELL

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY