Current Understanding of BRAF Alterations in Diagnosis, Prognosis, and Therapeutic Targeting in Pediatric Low-Grade Gliomas
出版年份 2015 全文链接
标题
Current Understanding of BRAF Alterations in Diagnosis, Prognosis, and Therapeutic Targeting in Pediatric Low-Grade Gliomas
作者
关键词
-
出版物
Frontiers in Oncology
Volume 5, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2015-03-03
DOI
10.3389/fonc.2015.00054
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Constitutive Activation of Raf-1 Induces Glioma Formation in Mice
- (2015) Yelena Lyustikman et al. NEOPLASIA
- Childhood Brain Tumor Epidemiology: A Brain Tumor Epidemiology Consortium Review
- (2014) K. J. Johnson et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Analysis of KIAA1549–BRAF fusion gene expression and IDH1/IDH2 mutations in low grade pediatric astrocytomas
- (2014) Gabriela Rampazzo Cruz et al. JOURNAL OF NEURO-ONCOLOGY
- Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study
- (2014) Grant A McArthur et al. LANCET ONCOLOGY
- Vemurafenib in patients with BRAFV600 mutated metastatic melanoma: an open-label, multicentre, safety study
- (2014) James Larkin et al. LANCET ONCOLOGY
- Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas
- (2014) M. A. Karajannis et al. NEURO-ONCOLOGY
- Pilomyxoid astrocytoma treated successfully with vemurafenib
- (2014) Mary Skrypek et al. PEDIATRIC BLOOD & CANCER
- Analysis of the BRAFV600E Mutation in Central Nervous System Tumors
- (2014) Jae Kyung Myung et al. Translational Oncology
- Mutation-specific antibody detects mutant BRAFV600Eprotein expression in human colon carcinomas
- (2013) Frank A. Sinicrope et al. CANCER
- C-RAF Mutations Confer Resistance to RAF Inhibitors
- (2013) R. Antony et al. CANCER RESEARCH
- Upstream mitogen-activated protein kinase (MAPK) pathway inhibition: MEK inhibitor followed by a BRAF inhibitor in advanced melanoma patients
- (2013) Simone M. Goldinger et al. EUROPEAN JOURNAL OF CANCER
- The differential diagnosis of pilocytic astrocytoma with atypical features and malignant glioma: an analysis of 16 cases with emphasis on distinguishing molecular features
- (2013) Matthew D. Cykowski et al. JOURNAL OF NEURO-ONCOLOGY
- BRAF alterations in pediatric low grade gliomas and mixed neuronal–glial tumors
- (2013) Efthymios Dimitriadis et al. JOURNAL OF NEURO-ONCOLOGY
- Trends in childhood brain tumor incidence, 1973–2009
- (2013) Roberta McKean-Cowdin et al. JOURNAL OF NEURO-ONCOLOGY
- CRM1 and BRAF Inhibition Synergize and Induce Tumor Regression in BRAF-Mutant Melanoma
- (2013) R. A. Salas Fragomeni et al. MOLECULAR CANCER THERAPEUTICS
- Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
- (2013) NATURE GENETICS
- BRAF V600E expression and distribution in desmoplastic infantile astrocytoma/ganglioglioma
- (2013) C. Koelsche et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Immunohistochemical Analysis of BRAFV600E Expression of Primary and Metastatic Melanoma and Comparison With Mutation Status and Melanocyte Differentiation Antigens of Metastatic Lesions
- (2012) Klaus J. Busam et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Sensitivity of Glioblastomas to Clinically Available MEK Inhibitors Is Defined by Neurofibromin 1 Deficiency
- (2012) W. L. See et al. CANCER RESEARCH
- The Relationship of the BRAFV600E Mutation and the Established Prognostic Factors in Papillary Thyroid Carcinomas
- (2012) Bülent Kurt et al. ENDOCRINE PATHOLOGY
- Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner
- (2012) A. Kaul et al. GENES & DEVELOPMENT
- Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial
- (2012) Gerald S Falchook et al. LANCET
- Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
- (2012) Axel Hauschild et al. LANCET
- Neuropathology
- (2012) MODERN PATHOLOGY
- Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas
- (2012) C. Horbinski et al. NEURO-ONCOLOGY
- Outcome analysis of childhood pilocytic astrocytomas: a retrospective study of 148 cases at a single institution
- (2012) C. Colin et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- 193 Development of Pediatric Glioma Models for BRAF-targeted Therapy
- (2012) Shih-Shan Lang et al. NEUROSURGERY
- Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
- (2012) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib
- (2012) Jeffrey A. Sosman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy
- (2012) E. Huillard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BRAF, GNAQ, and GNA11 mutations and copy number in pediatric low-grade glioma
- (2012) Yosef Laviv et al. FEBS Open Bio
- Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
- (2011) Huriye Cin et al. ACTA NEUROPATHOLOGICA
- Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
- (2011) Genevieve Schindler et al. ACTA NEUROPATHOLOGICA
- Pathologic Characteristics of Pediatric Intracranial Pilocytic Astrocytomas and Their Impact on Outcome in 3 Countries
- (2011) Tarik Tihan et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- BRAF-KIAA1549 Fusion Predicts Better Clinical Outcome in Pediatric Low-Grade Astrocytoma
- (2011) C. Hawkins et al. CLINICAL CANCER RESEARCH
- Targeted Therapy for BRAFV600E Malignant Astrocytoma
- (2011) T. P. Nicolaides et al. CLINICAL CANCER RESEARCH
- Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas
- (2011) K. Jacob et al. CLINICAL CANCER RESEARCH
- BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model
- (2011) E. H. Raabe et al. CLINICAL CANCER RESEARCH
- GSK1120212 (JTP-74057) Is an Inhibitor of MEK Activity and Activation with Favorable Pharmacokinetic Properties for Sustained In Vivo Pathway Inhibition
- (2011) A. G. Gilmartin et al. CLINICAL CANCER RESEARCH
- An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice
- (2011) Jan Gronych et al. JOURNAL OF CLINICAL INVESTIGATION
- Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling
- (2011) Nikhil Wagle et al. JOURNAL OF CLINICAL ONCOLOGY
- BRAFAlterations in Primary Glial and Glioneuronal Neoplasms of the Central Nervous System With Identification of 2 Novel KIAA1549
- (2011) Alex Lin et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
- (2011) Poulikos I. Poulikakos et al. NATURE
- Vemurafenib for Melanoma Metastases to the Brain
- (2011) Nicole M. Rochet et al. NEW ENGLAND JOURNAL OF MEDICINE
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort
- (2010) Andrew R. J. Lawson et al. ACTA NEUROPATHOLOGICA
- Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K
- (2010) Jessie Villanueva et al. CANCER CELL
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
- (2010) Poulikos I. Poulikakos et al. NATURE
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- (2010) Georgia Hatzivassiliou et al. NATURE
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- (2010) Gideon Bollag et al. NATURE
- COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
- (2010) Cory M. Johannessen et al. NATURE
- Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
- (2010) Ramin Nazarian et al. NATURE
- A multivariate analysis of factors determining tumor progression in childhood low-grade glioma: a population-based cohort study (CCLG CNS9702)
- (2010) T. Stokland et al. NEURO-ONCOLOGY
- Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
- (2010) Margaret J. Dougherty et al. NEURO-ONCOLOGY
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Initial testing (stage 1) of AZD6244 (ARRY-142886) by the pediatric preclinical testing program
- (2010) E. Anders Kolb et al. PEDIATRIC BLOOD & CANCER
- Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma
- (2009) Andrey Korshunov et al. ACTA NEUROPATHOLOGICA
- Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas
- (2009) Craig Horbinski et al. ACTA NEUROPATHOLOGICA
- Duplication of 7q34 in Pediatric Low-Grade Astrocytomas Detected by High-Density Single-Nucleotide Polymorphism-Based Genotype Arrays Results in a NovelBRAFFusion Gene
- (2009) Angela J. Sievert et al. BRAIN PATHOLOGY
- Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours
- (2009) K Jacob et al. BRITISH JOURNAL OF CANCER
- Outcome and prognostic features in pediatric gliomas
- (2009) Ibrahim Qaddoumi et al. CANCER
- Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas
- (2009) Tim Forshew et al. JOURNAL OF PATHOLOGY
- Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma
- (2009) J. Yu et al. NEUROLOGY
- Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
- (2009) D T W Jones et al. ONCOGENE
- MEK1 mutations confer resistance to MEK and B-RAF inhibition
- (2009) C. M. Emery et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tandem Duplication Producing a Novel OncogenicBRAFFusion Gene Defines the Majority of Pilocytic Astrocytomas
- (2008) David T.W. Jones et al. CANCER RESEARCH
- BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
- (2008) Stefan Pfister et al. JOURNAL OF CLINICAL INVESTIGATION
- Frequent Gains at Chromosome 7q34 Involving BRAF in Pilocytic Astrocytoma
- (2008) Eli E. Bar et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
- (2008) Scott M. Wilhelm et al. MOLECULAR CANCER THERAPEUTICS
- Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
- (2008) J. Tsai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now