Current Challenges in Glioblastoma: Intratumour Heterogeneity, Residual Disease, and Models to Predict Disease Recurrence

Liquid biopsies in patients with diffuse glioma

(2015) Myron G. Best et al.   ACTA NEUROPATHOLOGICA

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

(2015) Hoon Kim et al.   GENOME RESEARCH

Deep learning

(2015) Yann LeCun et al.   NATURE

Molecular Heterogeneity in Glioblastoma: Potential Clinical Implications

(2015) Nicole Renee Parker et al.   Frontiers in Oncology

A Multilayer Grow-or-Go Model for GBM: Effects of Invasive Cells and Anti-Angiogenesis on Growth

(2014) Olivier Saut et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Contributions to Drug Resistance in Glioblastoma Derived from Malignant Cells in the Sub-Ependymal Zone

(2014) S. G. M. Piccirillo et al.   CANCER RESEARCH

Detection of Brain Tumor Cells in the Peripheral Blood by a Telomerase Promoter-Based Assay

(2014) Kelly M. MacArthur et al.   CANCER RESEARCH

Dynamics of Leukemia Stem-like Cell Extinction in Acute Promyelocytic Leukemia

(2014) B. Werner et al.   CANCER RESEARCH

A step towards clinical blood biomarkers of glioblastoma

(2014) Matthias Preusser   Nature Reviews Neurology

Circulating glioma biomarkers

(2014) J. M. Kros et al.   NEURO-ONCOLOGY

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples

(2014) Laura E. MacConaill et al.   PLoS One

Effects of Anti-Angiogenesis on Glioblastoma Growth and Migration: Model to Clinical Predictions

(2014) Elizabeth Scribner et al.   PLoS One

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Hematogenous dissemination of glioblastoma multiforme

(2014) C. Muller et al.   Science Translational Medicine

Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression

(2014) J. P. Sullivan et al.   Cancer Discovery

Glioblastoma Multiforme: A Look Inside Its Heterogeneous Nature

(2014) Maria-del-Mar Inda et al.   Cancers

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

(2013) B. E. Johnson et al.   SCIENCE

Evolutionary dynamics of cancer in response to targeted combination therapy

(2013) Ivana Bozic et al.   eLife

Glioblastoma-Initiating Cells: Relationship with Neural Stem Cells and the Micro-Environment

(2013) Nicolas Goffart et al.   Cancers

Role of Mismatch Repair and MGMT in Response to Anticancer Therapies

(2012) Ida Casorelli et al.   Anti-Cancer Agents in Medicinal Chemistry

Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

(2012) K. C. A. Chan et al.   CLINICAL CHEMISTRY

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Evolution of the cancer genome

(2012) Lucy R. Yates et al.   NATURE REVIEWS GENETICS

Characterizing Mutational Heterogeneity in a Glioblastoma Patient with Double Recurrence

(2012) Gabrielle C. Nickel et al.   PLoS One

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240

(2012) T. R. Fenton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

(2012) N. J. Szerlip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

(2012) R. J. Leary et al.   Science Translational Medicine

Intratumor Heterogeneity: Seeing the Wood for the Trees

(2012) T. A. Yap et al.   Science Translational Medicine

Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma

(2011) Matija Snuderl et al.   CANCER CELL

Targeted Therapy for BRAFV600E Malignant Astrocytoma

(2011) T. P. Nicolaides et al.   CLINICAL CANCER RESEARCH

Next-generation sequencing applied to molecular diagnostics

(2011) Rachael Natrajan et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Glioblastoma survival in the United States before and during the temozolomide era

(2011) Derek R. Johnson et al.   JOURNAL OF NEURO-ONCOLOGY

Detecting Heteroplasmy from High-Throughput Sequencing of Complete Human Mitochondrial DNA Genomes

(2010) Mingkun Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors

(2010) Cristina Patru et al.   BMC CANCER

The Next Generation of Glioma Biomarkers: MGMT Methylation, BRAF Fusions and IDH1 Mutations

(2010) Andreas Von Deimling et al.   BRAIN PATHOLOGY

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

(2010) A. Sottoriva et al.   CANCER RESEARCH

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Incorporation of Biomarker Assessment in Novel Clinical Trial Designs: Personalizing Brain Tumor Treatments

(2010) Evanthia Galanis et al.   Current Oncology Reports

The subependymal zone neurogenic niche: a beating heart in the centre of the brain: How plastic is adult neurogenesis? Opportunities for therapy and questions to be addressed

(2009) I. Kazanis   BRAIN

Migration rules: tumours are conglomerates of self-metastases

(2009) H Enderling et al.   BRITISH JOURNAL OF CANCER

Peptide screening of cerebrospinal fluid in patients with glioblastoma multiforme

(2009) M.U. Schuhmann et al.   EJSO

Mathematical Models of Cancer Stem Cells

(2008) Franziska Michor   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE