Glioblastoma Multiforme: A Look Inside Its Heterogeneous Nature

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The roots of cancer: Stem cells and the basis for tumor heterogeneity

(2012) Maho Shibata et al.   BIOESSAYS

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

Receptor Tyrosine Kinase Genes Amplified in Glioblastoma Exhibit a Mutual Exclusivity in Variable Proportions Reflective of Individual Tumor Heterogeneity

(2012) S. E. Little et al.   CANCER RESEARCH

The Life History of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterizing Mutational Heterogeneity in a Glioblastoma Patient with Double Recurrence

(2012) Gabrielle C. Nickel et al.   PLoS One

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

(2012) N. J. Szerlip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumor Heterogeneity: Seeing the Wood for the Trees

(2012) T. A. Yap et al.   Science Translational Medicine

Quantitative analysis of matrix metalloproteinase-2 mRNA expression in central and peripheral regions of gliomas

(2011) Marta Brell et al.   Brain Tumor Pathology

Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma

(2011) Matija Snuderl et al.   CANCER CELL

Heterogeneity Maintenance in Glioblastoma: A Social Network

(2011) R. Bonavia et al.   CANCER RESEARCH

Intratumor Heterogeneity in Evolutionary Models of Tumor Progression

(2011) Rick Durrett et al.   GENETICS

Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma

(2011) Barbara S. Paugh et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

(2011) R Bonavia et al.   ONCOGENE

Evolutionary Dynamics of Intratumor Heterogeneity

(2011) Yoh Iwasa et al.   PLoS One

Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized

(2010) Elsa Quintana et al.   CANCER CELL

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

A Microfluidic Platform for Systems Pathology: Multiparameter Single-Cell Signaling Measurements of Clinical Brain Tumor Specimens

(2010) J. Sun et al.   CANCER RESEARCH

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy

(2010) Masayuki Nitta et al.   PLoS One

Cancer stem cells: Back to Darwin?

(2010) Mel Greaves   SEMINARS IN CANCER BIOLOGY

MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance

(2009) S. Yip et al.   CLINICAL CANCER RESEARCH

Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancers Dependent on the Epidermal Growth Factor Receptor Pathway

(2009) Kim-Son H. Nguyen et al.   Clinical Lung Cancer

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Intratumoral patterns of clonal evolution in gliomas

(2009) Ana Luísa Vital et al.   NEUROGENETICS

Genetically Engineered Mouse Models of Brain Cancer and the Promise of Preclinical Testing

(2008) Jason T. Huse et al.   BRAIN PATHOLOGY

Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib

(2008) Kazuya Taniguchi et al.   CANCER SCIENCE

Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT Activity

(2008) Monika E. Hegi et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE