Review
Biotechnology & Applied Microbiology
Nejla Cini, Ferah Calisir
Summary: Recent advances in the design of nanosized drug delivery systems (NDDS) using layer-by-layer (LbL) self-assembled therapeutic vehicles have provided new possibilities. The LbL method offers a cost-effective and easy-to-apply strategy for loading individual or multiple drugs. Microcapsules and core-shell structures formed by highly charged particles (polyelectrolyte multilayers; PEMs) have been proposed as versatile vehicles for NDDS. This review provides an overview of LbL-PEMs in NDDS, focusing on emerging drug loading and release strategies in the last five years.
Article
Pharmacology & Pharmacy
Victoria A. Guarino, Adam Blau, Jack Alvarenga, Joseph Loscalzo, Ying-Yi Zhang
Summary: A stable form of XDSCS NPs has been developed, which can rapidly and efficiently incorporate heparin-binding proteins while maintaining their full biological activity in vivo. XDSCS NPs exhibit high stability in physiological salt solutions and have potential for therapeutic delivery of heparin-binding proteins.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Polymer Science
Faeze Kazemi-Andalib, Maryam Mohammadikish, Adeleh Divsalar, Unes Sahebi
Summary: The utilization of hollow structures for drug encapsulation and controlled release has gained attention. The layer-by-layer assembly of oppositely charged polymers is important, especially for pH-responsive capsules in cancer drug delivery. pH-sensitive and biodegradable capsules were prepared, showing high encapsulation and releasing efficiency for anticancer drugs and high cytotoxicity on colorectal carcinoma cells.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Zheng Wu, Jun Shi, Pingan Song, Jingguo Li, Shaokui Cao
Summary: In this study, a pH/NIR multi-responsive drug delivery platform was successfully fabricated using a layer-by-layer approach, consisting of hollow hydroxyapatite, chitosan/hyaluronic acid multilayers, gold nanorods, and MXene. The system exhibited excellent photothermal conversion efficiency and biocompatibility, with outstanding drug release performance under acidic conditions and effective activation by near-infrared light.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Gongshuai Song, Jiayuan Liu, Qi Wang, Danli Wang, Bingquan Chu, Ling Li, Gongnian Xiao, Jinyan Gong, Fuping Zheng
Summary: The study demonstrated that hollow dextran sulfate/chitosan-coated zein nanoparticles loaded with crocin can serve as a promising delivery system for effective treatment of Alzheimer's disease, showing better controlled release behavior and antioxidant activity.
FOOD HYDROCOLLOIDS
(2022)
Article
Pharmacology & Pharmacy
Naoto Ono, Tomoya Iibuchi, Hiroaki Todo, Shoko Itakura, Hirotoshi Adachi, Kenji Sugibayashi
Summary: Thermalporation is an effective method for improving skin permeation of middle and high molecular weight biopharmaceuticals. The study showed that using the PassPort(R) system can significantly enhance the skin permeation of FD-4 and insulin, with improved relative bioavailability of insulin. Additionally, the skin resistance value decreased immediately after the PS treatment but returned to the initial level within 12 hours.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Food Science & Technology
Manita Adhikari, Sushil Koirala, Anil Kumar Anal
Summary: This study successfully developed an edible multilayer coating using chitosan-pectin biopolymers deposited by electrostatic layer-by-layer deposition (LbL) to extend the shelf life of strawberries. The application of this coating on strawberries at room temperature was able to significantly prolong their shelf life while maintaining their texture and color.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jean Schoeller, Fabian Itel, Karin Wuertz-Kozak, Sandra Gaiser, Nicolas Luisier, Dirk Hegemann, Stephen J. Ferguson, Giuseppino Fortunato, Rene M. Rossi
Summary: Surface functionalization of electrospun nanofibers allows for the introduction of additional functionalities while retaining high porosity and surface-to-volume ratio. In this study, chitosan and alginate were sequentially deposited on PLGA nanofibers to form a polyelectrolyte complex for controlled release of ibuprofen. Chitosan with a positive surface charge regulated the interactions between the drug and the coating, resulting in slower release at acidic pH compared to neutral pH.
Article
Biochemistry & Molecular Biology
Sergey O. Solomevich, Uladzislau E. Aharodnikau, Egor I. Dmitruk, Pavel A. Nikishau, Pavel M. Bychkovsky, Daria A. Salamevich, Guohua Jiang, Kirill I. Pavlov, Yanfang Sun, Tatiana L. Yurkshtovich
Summary: In this study, all-polysaccharide biodegradable polyelectrolyte complex hydrogels (DPCS) based on dextran phos-phate carbamate (DP) and chitosan (CS) were developed for controlled co-delivery of the anticancer drug doxorubicin (DOX) and the non-steroidal anti-inflammatory drug indomethacin (IND). The release profile of both drugs from the hydrogels was tuned by changing the molecular weight and functional groups content of the polysaccharides. The optimized DPCS showed a steady release of DOX both in vitro and in vivo, and a gradual release of IND, making it a promising long-acting polysaccharide-based antitumor platform.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Sagar R. Pardeshi, Mahesh P. More, Chandrakantsing V. Pardeshi, Prashant J. Chaudhari, Amol D. Gholap, Ankit Patil, Pritam B. Patil, Jitendra B. Naik
Summary: Glaucoma is a condition characterized by damage to the optic nerve and high intraocular pressure, affecting 12 million people in India. The use of dorzolamide hydrochloride eye drops has limitations in terms of residence time and bioavailability. To overcome these limitations, chitosan oligosaccharide-dextran sulfate crosslinked nanoparticles were developed to improve the mucoadhesion, penetration, and ocular delivery of dorzolamide. The formulated nanoparticles showed promising results in terms of particle size, zeta potential, entrapment efficiency, prolonged release, and ocular hypotensive activity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
J. B. M. Rocha Neto, G. G. Lima, A. Fiamingo, L. G. L. Germiniani, T. B. Taketa, R. A. Bataglioli, G. A. T. da Silveira, J. V. L. da Silva, S. P. Campana-Filho, O. N. Oliveira Jr, M. M. Beppu
Summary: By adjusting the degree of deacetylation of chitosans and the pH of the solution, the properties of HA/CHI LbL films can be controlled, providing tailored film materials for various applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Parisa Maleki Dana, Jamal Hallajzadeh, Zatollah Asemi, Mohammad Ali Mansournia, Bahman Yousefi
Summary: Osteosarcoma is prevalent in children and adolescents with ineffective conventional treatments, necessitating the development of novel drugs and bone-repairing methods. Chitosan, a natural compound, exhibits anti-tumor activities and can be utilized in drug delivery and diagnostic techniques.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Ceramics
Shirin Khanmohammadi, Hossein Aghajani, Morteza Farrokhi-Rad
Summary: In this study, vancomycin-loaded mesoporous bioglass/hydroxyapatite whiskers/chitosan composite coatings were fabricated on titanium substrate using electrophoretic deposition. The coatings exhibited good drug delivery capability and antibacterial potency, without toxic effects on osteoblast cells.
CERAMICS INTERNATIONAL
(2022)
Article
Polymer Science
Muhammad Imran Azman, Jirasuta Chungprempree, Jitima Preechawong, Pornsri Sapsrithong, Manit Nithitanakul
Summary: In this study, amines electrolyte solution was used with layer-by-layer technique to modify highly porous polymer, increasing its CO2 adsorption capacity. By utilizing polyHIPE prepared from styrene and divinylbenzene with varying ratios and modifying the surface with LbL technique, improvements were made in surface area, thermal properties, and mechanical properties. The modified material showed the highest CO2 adsorption capacity with the use of PEI, maintaining an open cell structure suitable for adsorption technology.
Article
Chemistry, Applied
Mengying Zhang, Yijing Huang, Wenhao Pan, Xianqin Tong, Qiankun Zeng, Ting Su, Xiaoliang Qi, Jianliang Shen
Summary: The study introduces an effective method for fabricating polysaccharide hydrogels for controlled release of antibiotics, with promising biocompatibility and antibacterial properties. By systematically evaluating the physicochemical properties, the hydrogels exhibited good biocompatibility and antibacterial performance. The properties of the hydrogels can be controlled by adjusting the composition ratio.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Zaoxue Yan, Chengjing Dai, Xiaomeng Lv, Mingmei Zhang, Xinhong Zhao, Jimin Xie
JOURNAL OF ALLOYS AND COMPOUNDS
(2019)
Article
Materials Science, Multidisciplinary
Yuanguo Xu, Nabi Ullah, Linlin Chen, Wei Wei, Chidinma Judith Oluigbo, Meng Xie, Mingmei Zhang, Jimin Xie
MATERIALS CHEMISTRY AND PHYSICS
(2019)
Article
Chemistry, Physical
Nabi Ullah, Sayyar Ali Shah, Meng Xie, Haroon Ur Rasheed, Chidinma Judith Oluigbo, Di Jiang, Yuanguo Xu, Jimin Xie
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2019)
Article
Chemistry, Physical
Huihui Hu, Nan Chen, Wei Wei, Hui Li, Zhifeng Jiang, Yuanguo Xu, Jimin Xie
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2019)
Article
Engineering, Environmental
Duidui Wang, Yuanguo Xu, Liquan Jing, Meng Xie, Yanhua Song, Hui Xu, Huaming Li, Jimin Xie
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Chemistry, Organic
Yongwei Zhao, Robert J. A. Goode, Ralf B. Schittenhelm, Julien Tailhades, Max J. Cryle
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Julien Tailhades, Yongwei Zhao, Y. T. Candace Ho, Anja Greule, Iftekhar Ahmed, Melanie Schoppet, Ketav Kulkarni, Rob J. A. Goode, Ralf B. Schittenhelm, James J. De Voss, Max J. Cryle
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Review
Biochemistry & Molecular Biology
Yongwei Zhao, Y. T. Candace Ho, Julien Tailhades, Max Cryle
Summary: Researchers are intrigued by the complex biosynthesis of glycopeptide antibiotics, particularly the role of the X-domain in recruiting P450 enzymes. In vitro studies have provided insights into the tolerances and limitations of the GPA cyclisation cascade, paving the way for future reengineering of this important antibiotic class.
Article
Chemistry, Analytical
Bashir Adegbemiga Yusuf, Yuanguo Xu, Nabi Ullah, Meng Xie, Chidinma Judith Oluigbo, Waleed Yaseen, Jagadeesh Kumar Alagarasan, Kanagaraj Rajalakshmi, Jimin Xie
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2020)
Article
Nanoscience & Nanotechnology
Wei Wei, Huihui Hu, Linlin Chen, Zaoxue Yan, Xuelin Fan, Junjie Wang, Yuanguo Xu, Jimin Xie
Article
Chemistry, Multidisciplinary
Yongwei Zhao, Edward Marschall, Maxine Treisman, Alasdair McKay, Leo Padva, Max Crusemann, David R. Nelson, David L. Steer, Ralf B. Schittenhelm, Julien Tailhades, Max J. Cryle
Summary: This study investigates the use of peptide crosslinking cytochrome P450 enzymes in generating cyclic tripeptides from simple synthons. The enzymes produced both tyrosine-histidine and tyrosine-tryptophan crosslinked tripeptides, the latter being a rare example of phenolic crosslinking to an indole moiety. The tripeptides can be easily isolated after removing the leader peptide and can include a wide range of amino acids. This research suggests that P450 enzymes have the potential to play a significant role in the synthesis of high-value cyclic tripeptides, which can be further diversified using selective chemical techniques.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Bashir Adegbemiga Yusuf, Meng Xie, Waleed Yaseen, Jimin Xie, Yuanguo Xu
Summary: The as-fabricated CoFe2O4@BC nanoflowers exhibit remarkable electrocatalytic activity, providing an effective approach to enhance the performance and stability of transition metal-boride electrocatalysts. The unique flower-like nanoarchitecture, exposure of active sites, boron doping-driven electrical conductivity, defects in porous structures, and synergy between Co and Fe metals and boron contribute to the enhanced HER activity of the CoFe2O4@BC nanoflowers. This work presents a strategic plan for designing efficient and stable B-doped electrocatalysts in an alkaline solution.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Wei Sun, Wei Wei, Nan Chen, Linlin Chen, Yin Xu, Chidinma Judith Oluigbo, Zhifeng Jiang, Zaoxue Yan, Jimin Xie
Article
Chemistry, Inorganic & Nuclear
Yuanguo Xu, Jie Liu, Meng Xie, Wei Wei, Ting Zhou, Jia Yan, Hui Xu, Haiyan Ji, Huaming Li, Jimin Xie
INORGANIC CHEMISTRY FRONTIERS
(2019)