Article
Cell Biology
Saikat Bhattacharya, Divya Reddy, Ning Zhang, Hua Li, Jerry L. L. Workman
Summary: The methyltransferase SETD2 plays a crucial role in regulating transcription, splicing, and other processes through the deposition of the H3K36me3 histone mark. Its stability is controlled by proteasome-mediated degradation to maintain low levels. Excessive SETD2 leads to upregulation of cell cycle-associated pathways, resulting in increased cell proliferation and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Andrew R. Leitch, Lu Ma, Steven Dodsworth, Joerg Fuchs, Andreas Houben, Ilia J. Leitch
Summary: Angiosperm genomes consist of genes and their regulatory regions, repeats, semi-degraded repeats, and "dark matter". This study compares the histone modifications associated with chromatin packaging of these different genomic components in two species with significantly different genome sizes. The results reveal distinct associations between certain histone marks and different genomic features, providing insights into epigenetic profiles and chromatin organization.
Review
Genetics & Heredity
Vincenzo Cavalieri
Summary: The emergence of a nucleosome-based chromatin structure during the evolutionary transition from prokaryotes to eukaryotes plays a crucial role in adaptive responses to environmental influence through epigenetic mechanisms involving histones. The overwhelming number of post-translational modifications at multiple residues of histones and their implications in nucleosome dynamics and chromatin processes are discussed in this review.
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Cell Biology
Faith M. Joseph, Nicolas L. Young
Summary: Post-translational modifications (PTMs) of histones play a key role in DNA-based processes and contribute to cell differentiation and gene function by adding an extra layer of regulation. Variations in histone sequences within each family of histones expand the chromatin repertoire and provide further mechanisms for regulation and signaling. However, much remains unknown about variant-specific PTMs and their role in regulating chromatin due to limited technologies and appropriate reagents.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Microbiology
Samuel S. Porter, Jennifer C. Liddle, Kristen Browne, Diana Pastrana, Benjamin A. Garcia, Christopher B. Buck, Matthew D. Weitzman, Alison A. McBride
Summary: Papillomaviruses package their genomes with host histones into virions, with specific histone modifications being acquired late in infection that benefit viral replication and gene expression. The viral minichromosome is enriched in posttranslational modifications associated with active chromatin, potentially aiding in evasion of detection and promoting early infection stages.
Review
Endocrinology & Metabolism
Lindsay Moritz, Saher Sue Hammoud
Summary: This article explores the molecular mechanisms underlying male fertility and the process of chromatin remodeling. It points out the current gaps in understanding of the chromatin remodeling process and suggests future research directions to enhance our knowledge of the histone-to-protamine exchange and the etiology of idiopathic male infertility.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Kayleigh J. A. Orchard, Moeed Akbar, Lindsay A. N. Crowe, John Cole, Neal L. Millar, Stuart M. Raleigh
Summary: The development and progression of rotator cuff tendinopathy (RCT) is influenced by multiple factors, including genetics and epigenetics. This study investigated the role of histone modifications in RCT using chromatin immunoprecipitation sequencing. The findings suggest that epigenetic control, particularly through histone modifications, plays a role in the development and progression of RCT.
Review
Cell Biology
Isa Ozdemir, Florian A. Steiner
Summary: The article reviews the recent advances in understanding the transmission of histone variants and histone PTM patterns across generations in C. elegans and discusses the interplay among different histone PTMs as well as the impact of soma-germ line communication on the inheritance of epigenetic traits.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yulei Shi, Wei Qi
Summary: Nonalcoholic fatty liver disease (NAFLD) is a progressive liver condition associated with high energy-density diets and sedentary lifestyles. It is closely linked to metabolic disorders like obesity and hyperlipidemia. The epigenetic regulation, particularly histone modifications, plays a crucial role in the initiation and progression of NAFLD, offering potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hitoshi Kurumizaka, Tomoya Kujirai, Yoshimasa Takizawa
Summary: Chromatin compacts genomic DNA through nucleosome core particles, with versatile structure and dynamics for epigenetic regulation of genomic DNA. Histone variants in higher eukaryotes contribute to nucleosome diversity and play important roles in chromatin epigenetic regulation.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qingyun Yang, Yingxiao Gao, Xia Liu, Yihang Xiao, Mingxuan Wu
Summary: A new method for editing the N-tail of histone H3 using sortase mediated metathesis (SMM) is reported. This method expands the application scope of sortase and offers a strategy for precise editing of PTMs of cellular histone H3.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Cell Biology
Pe'era Wasserzug Pash, Gilad Karavani, Eli Reich, Lital Zecharyahu, Zehava Kay, Dvora Bauman, Talya Mordechai-Daniel, Tal Imbar, Michael Klutstein
Summary: Pre-pubertal oocytes are dormant and do not undergo meiotic divisions naturally. Pubertal transition triggers molecular changes and epigenetic events in oocytes. Our study shows that pubertal transition leads to reorganization of oocyte chromatin and elevation of histone methylation levels. Understanding these changes is important for developing methods to mature pre-pubertal oocytes for fertility preservation in young cancer survivors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zihang Huang, Shuai Song, Xiaokai Zhang, Linqi Zeng, Aijun Sun, Junbo Ge
Summary: This review summarizes the impact of cardiac metabolism disorder on histone modifications and gene expression, as well as the dual role of metabolic substrates in regulating cardiac hypertrophy. The article suggests the therapeutic supplementation of metabolic substrates as a potential approach to restore histone modifications.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Article
Biochemistry & Molecular Biology
Dharmendra Kashyap, Rajarshi Roy, Parimal Kar, Hem Chandra Jha
Summary: This study screened seven active compounds of plant origins using molecular docking, which showed strong binding affinity with the nucleocapsid protein of SARS-CoV-2 and exhibited good properties. Further research is needed to validate their suitability for clinical trials.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Deeksha Tiwari, Gaurava Srivastava, Omkar Indari, Vijay Tripathi, Mohammad Imran Siddiqi, Hem Chandra Jha
Summary: Recent reports suggest that persistent Epstein-Barr virus infection could lead to the formation of proteinaceous plaques in the brain, a hallmark of Alzheimer's disease. The apolipoprotein E (ApoE), a major genetic risk factor for AD, may also affect the outcome of EBV infection. This study investigates the interactions between ApoE and various EBV proteins, and finds possible stable interactions between the C-terminal domain of ApoE3 and EBV proteins EBNA1 and BZLF1. These interactions may interfere with the clearance of amyloid fragments from the brain, contributing to the development of AD.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Immunology
Omkar Indari, Annu Rani, Budhadev Baral, Suleyman Ergun, Kiran Bala, Srikanth Karnati, Hem Chandra Jha
Summary: Viruses exploit peroxisomal compartment for successful infection. This study investigates the modulation of peroxisomal proteins in EBV transformed cell lines and during acute EBV infection. The results reveal distinct regulation of peroxisomal proteins in EBV infected cells and highlight the importance of investigating the manipulation of the peroxisomal compartment in EBV pathologies.
MICROBIAL PATHOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Priyanka Patra, Annu Rani, Neha Sharma, Chandrachur Mukherjee, Hem Chandra Jha
Summary: This study demonstrates a direct connection between Epstein-Barr virus (EBV) and its peptide gM(146-157) with neurological illnesses. It suggests that the peptide may enhance aggregation of A beta(42) and induce neuroinflammatory responses, leading to mitochondrial and calcium ion imbalances, neurodegeneration, and demyelination.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Microbiology
Dharmendra Kashyap, Samiksha Rele, Pranit Hemant Bagde, Vaishali Saini, Debi Chatterjee, Ajay Kumar Jain, Rajan Kumar Pandey, Hem Chandra Jha
Summary: Cancer is characterized by mutagenic events that disrupt cell signaling and functions. Pathogens, especially Helicobacter pylori and Epstein-Barr virus (EBV), have been associated with human cancer development. Co-infection of these pathogens can lead to gastric cancer by causing DNA damage and dysregulating cellular signaling pathways related to growth, apoptosis, and DNA repair. This review focuses on the oncogenic roles of H. pylori, EBV, and associated signaling cascades in various cancers, providing insights for preventing and treating H. pylori and EBV-associated cancers.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Computer Science, Information Systems
Budhadev Baral, Kartik Muduli, Shweta Jakhmola, Omkar Indari, Jatin Jangir, Ashraf Haroon Rashid, Suchita Jain, Amrut Kumar Mohapatra, Shubhransu Patro, Preetinanda Parida, Namrata Misra, Ambika Prasad Mohanty, Bikash R. Sahu, Ajay Kumar Jain, Selvakumar Elangovan, Hamendra Singh Parmar, M. Tanveer, Nirmal Kumar Mohakud, Hem Chandra Jha
Summary: During the COVID-19 pandemic, qRT-PCR, CT scans, and biochemical parameters were used to study the physiological changes and disease progression of patients. Among the patients studied, C-reactive protein (CRP) was found to be the most critical parameter for classifying symptomatic and asymptomatic groups. Elevated CRP levels were associated with increased D-dimer, GGT, and urea levels in COVID-19 patients.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Chemistry, Multidisciplinary
Bhumika Sahu, Tanushree Ghosh, Suchita Kandpal, Love Bansal, Chanchal Rani, Hem Chandra Jha, Rajesh Kumar
Summary: Herbal electronics is an emerging field that focuses on the optical and electrical properties of herbal materials for potential electronic applications. This study investigates the optical properties of turmeric and henna extract solutions through absorption and luminescence spectroscopies. The analysis reveals that when the two solutions are mixed and excited by a blue/UV LED, they emit yellow light. The emission color is quantitatively evaluated using CIE color chart and the PL quantum yield is calculated. A simple setup demonstrates the yellow emission using a blue LED (400 nm) and the mixture solution, achieving a quantum yield of approximately 5%.
Review
Cell Biology
Yuvraj Anandrao Jagtap, Prashant Kumar, Sumit Kinger, Ankur Rakesh Dubey, Akash Choudhary, Ravi Kumar Gutti, Sarika Singh, Hem Chandra Jha, Krishna Mohan Poluri, Amit Mishra
Summary: Disturbance in mitochondrial functions is a defining characteristic of neurodegenerative diseases, such as Parkinson's, ALS, and Alzheimer's. Misfolded proteins play a role in the impairment of mitochondrial pathways, exacerbating disease progression. However, the impact of mitochondrial dysfunction on other organelles and cellular processes remains understudied. Investigating the interplay between mitochondria and neurodegeneration can provide valuable insights for targeted therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Budhadev Baral, Dharmendra Kashyap, Nidhi Varshney, Tarun Prakash Verma, Ajay Kumar Jain, Debi Chatterji, Vinod Kumar, Amit Mishra, Awanish Kumar, Hem Chandra Jha
Summary: This study investigates the association between Helicobacter pylori infection and various gastrointestinal diseases and gastric cancer. Isolates from gastric epithelium and gastric juice were examined to determine their pathogenic potential and carcinogenic ability. The study also assessed the effects of different durations of H. pylori infection on cell migration ability, proliferation status, and genomic instability.
Review
Biochemistry & Molecular Biology
Annu Rani, Vaishali Saini, Priyanka Patra, Tanish Prashar, Rajan Kumar Pandey, Amit Mishra, Hem Chandra Jha
Summary: EGCG, a polyphenolic compound in green tea, has pleiotropic bioactivities to combat neurological diseases and inhibit the effects of neurotropic viruses.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Budhadev Baral, Vaishali Saini, Akrati Tandon, Siddharth Singh, Samiksha Rele, Amit Kumar Dixit, Hamendra Singh Parmar, Ajay Kumar Meena, Hem Chandra Jha
Summary: The study investigates the role of SARS-CoV-2 Envelope protein (E) in cell death and inflammation in lung and gastrointestinal epithelium, as well as its impact on the gastrointestinal-lung axis. The results show that transfection of E protein increases lysosomal pH, induces inflammation, and leads to necrotic cell death. Inhibition of RIPK1, a marker of necroptosis, reduces cell death and inflammation. The conditioned media from E-transfected cells induces inflammation in the gastrointestinal-lung axis.
Article
Virology
Nidhi Varshney, Sneha Murmu, Budhadev Baral, Dharmendra Kashyap, Siddharth Singh, Meenakshi Kandpal, Vasundhra Bhandari, Anurag Chaurasia, Sunil Kumar, Hem Chandra Jha
Summary: This study explores the relationship between EBV protein EBNA1 and AURKA in gastric cancer. It found that EBV infection enhances cell proliferation and migration, and upregulates AURKA levels. Knockdown of AURKA reduces the expression of EBNA1 and promotes apoptosis in EBV-infected gastric cancer cells.
Article
Immunology
Annu Rani, Manushree Tanwar, Tarun Prakash Verma, Priyanka Patra, Pankaj Trivedi, Rajesh Kumar, Hem Chandra Jha
Summary: Our study highlights the crucial role of membrane cholesterol in the entry and pathogenesis of EBV in astroglial cells, which in turn triggers/exacerbates virus-associated neuropathologies. These findings may contribute to the prognosis of neurological diseases like MS.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Omkar Indari, Suleyman Ergun, Srikanth Karnati, Hem Chandra Jha
Article
Nanoscience & Nanotechnology
Vidhi Agarwal, Nidhi Varshney, Surbhi Singh, Nitin Kumar, Amrita Chakraborty, Bhagwati Sharma, Hem Chandra Jha, Tridib K. Sarma
Summary: Self-assembled metal-ion cross-linked multifunctional hydrogels have significant potential in the fields of biomedicine and biocatalysis. This study presents a heat-triggered metallogel formed by the self-assembly of adenosine 5'-monophosphate (AMP) and cobalt chloride, displaying enzyme-mimicking and catalytic activities under different pH conditions. The metallogel shows stability in a wide pH range and can effectively degrade hydrogen peroxide and scavenge reactive oxygen species. It demonstrates promising applications in biomedical fields.
ACS APPLIED BIO MATERIALS
(2023)