CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis

T Cell–Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses

(2017) Rachel E. O’Neill et al.   JOURNAL OF IMMUNOLOGY

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

Therapeutic targeting of CD70 and CD27

(2016) Harald Wajant   EXPERT OPINION ON THERAPEUTIC TARGETS

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy

(2016) Vanessa Sue Wacleche et al.   Retrovirology

Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation

(2015) Catherine Larochelle et al.   ANNALS OF NEUROLOGY

Cerebrospinal fluid markers reveal intrathecal inflammation in progressive multiple sclerosis

(2015) Mika Komori et al.   ANNALS OF NEUROLOGY

Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis

(2015) Priscilla W. Lee et al.   BRAIN BEHAVIOR AND IMMUNITY

Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells

(2015) M. Dhainaut et al.   EMBO JOURNAL

Focal disturbances in the blood–brain barrier are associated with formation of neuroinflammatory lesions

(2015) Jorge Ivan Alvarez et al.   NEUROBIOLOGY OF DISEASE

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

(2015) Yonghao Cao et al.   Science Translational Medicine

TGF-β upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin’s lymphoma

(2014) Z-Z Yang et al.   LEUKEMIA

CD70-expressing CD4 T cells produce IFN-γ and IL-17 in rheumatoid arthritis

(2014) Jin Kyun Park et al.   RHEUMATOLOGY

The CD70-CD27 Axis, a New Brake in the T Helper 17 Cell Response

(2013) Xiaohu Wang et al.   IMMUNITY

Modulation of Regulatory T Cell Function by Monocyte-Derived Dendritic Cells Matured through Electroporation with mRNA Encoding CD40 Ligand, Constitutively Active TLR4, and CD70

(2013) J. J. Pen et al.   JOURNAL OF IMMUNOLOGY

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system

(2012) Catherine Larochelle et al.   BRAIN

The CD27 and CD70 Costimulatory Pathway Inhibits Effector Function of T Helper 17 Cells and Attenuates Associated Autoimmunity

(2012) Jonathan M. Coquet et al.   IMMUNITY

Enhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice

(2012) G. FrancoSalinas et al.   JOURNAL OF NEUROIMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on  4 integrin

(2011) I. Ifergan et al.   BRAIN

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Function of CD27 in helper T cell differentiation

(2011) Sten Libregts et al.   IMMUNOLOGY LETTERS

CD70 Is Selectively Expressed on Th1 but Not on Th2 Cells and Is Required for Th1-Type Immune Responses

(2011) Tatsuyoshi Kawamura et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

In vivo imaging of lymphocytes in the CNS reveals different behaviour of naïve T cells in health and autoimmunity

(2011) Josephine Herz et al.   Journal of Neuroinflammation

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Disruption of central nervous system barriers in multiple sclerosis

(2010) Jorge Ivan Alvarez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TGF-  Enhances Effector Th1 Cell Activation but Promotes Self-Regulation via IL-10

(2010) D. J. Huss et al.   JOURNAL OF IMMUNOLOGY

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells

(2009) Bernadette Pöllinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand

(2009) A. Wyzgol et al.   JOURNAL OF IMMUNOLOGY

Soluble CD70: a novel immunotherapeutic agent for experimental glioblastoma

(2009) James Miller et al.   JOURNAL OF NEUROSURGERY

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system

(2009) Ulf Schulze-Topphoff et al.   NATURE MEDICINE

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells

(2007) I. Ifergan et al.   BRAIN