期刊
DRUG DISCOVERY TODAY
卷 19, 期 9, 页码 1498-1502出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2014.07.009
关键词
-
资金
- Prostate Cancer Foundation
- NIH [K99/R00, K99CA160640]
Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that is frequently mutated in prostate and endometrial cancers. All the cancer-associated SPOP mutations reported to date are clustered in the meprin and TRAF (Tumor necrosis factor receptor-associated factor) homology (MATH) domain, presumably affecting substrate binding. SPOP mutations in prostate cancer are mutually exclusive with the ETS (Erythroblast transformation-specific) family gene rearrangements and define a distinct molecular subclass of prostate cancer. SPOP mutations contribute to prostate cancer development by altering the steady-state levels of key components in the androgen-signaling pathway.
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