Article
Entomology
Shiming Zhu, Xiaoyi Chen, Sishi Xia, Qin Li, Ziqi Ye, Shaoting Zhao, Kexin Liu, Fangfang Liu
Summary: Reproduction is crucial for the continuation of insect species. Storage proteins, hexamerin and allergen, have been identified in the fat bodies of female American cockroaches, and they play an essential role in promoting vitellogenesis and ovarian maturation. The expression of these proteins is regulated by the juvenile hormone (JH) signaling, with the JH receptor gene Met and the primary response gene Kr-h1 acting as repressors and methoprene, a JH analog, inducing their expression.
Article
Fisheries
Shany Cohen, Omer Ilouz, Rivka Manor, Amir Sagi, Isam Khalaila
Summary: In this study, silencing of the VIH gene alone or in combination with the MIH gene successfully induced ovarian maturation and development in females of Macrobrachium rosenbergii, with more pronounced effects in mature individuals. Additionally, the dsRNA used to silence VIH also affected the expression of MIH, albeit with a delay compared to the dsRNA targeting both VIH and MIH simultaneously.
Article
Endocrinology & Metabolism
Sidney A. Pereira, Fernanda C. B. Oliveira, Lydie Naule, Carine Royer, Francisco A. R. Neves, Ana Paula Abreu, Rona S. Carroll, Ursula B. Kaiser, Michella S. Coelho, Adriana Lofrano-Porto
Summary: Studies have shown that MKRN3 is an inhibitor of GnRH secretion and its loss of function is the most common genetic cause of central precocious puberty in humans. The expression pattern of Mkrn3 in gonads during sexual development was investigated and it was found to be sexually dimorphic between male and female gonads. Mkrn3 is expressed primarily in the interstitial compartment of the testes and its expression increases after puberty and is responsive to luteinizing hormone/hCG stimulation.
Article
Endocrinology & Metabolism
Hao Yu, Bin Yang, Liuhao Wang, Sijia Wang, Kui Wang, Qisheng Song, Hongwei Zhang
Summary: This study investigated the role of neuropeptide hormone bursicon in the ovary development and reproduction of the hemipteran insect, whitefly. The results revealed that bursicon regulates vitellogenesis and reproduction by coordinating with the juvenile hormone signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Barbara Nicol, Martin A. A. Estermann, Humphrey H-C Yao, Namya Mellouk
Summary: This review aims to highlight the conserved and divergent features of ovarian differentiation through an evolutionary perspective, with a focus on ovarian morphogenesis, the evolution of the role of estrogens on ovarian differentiation, and the molecular pathways involved in granulosa cell determination and maintenance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Divya Ramachandran, Kusum Sharma, Vishal Saxena, Niepukolie Nipu, Dinusha C. Rajapaksha, Jan A. Mennigen
Summary: The nonapeptide vasotocin/vasopressin is highly conserved and plays a role as neuromodulator and signaling molecule in vertebrates. Pharmacological studies in several teleost fishes suggest that vasotocin has sex and species-specific reproductive roles. However, comprehensive studies investigating the behavioral and physiological consequences of genetic ablation of vasotocin in a genetically tractable fish model, such as the zebrafish, are currently lacking.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Naira da Silva Mansano, Henrique Rodrigues Vieira, Roberta Araujo-Lopes, Raphael Escorsim Szawka, Jose Donato Jr, Renata Frazao
Summary: This study found that acute fasting can modulate the activity of the HPG axis and has gender-specific effects on Kisspeptin neurons. In female mice, fasting reduces the levels of luteinizing hormone and prolactin, while increasing follicle-stimulating hormone levels. Fasting also reduces Kisspeptin gene expression. Additionally, GABAergic transmission and the effects of neuropeptide Y on ARHKisspeptin neurons show gender differences.
Review
Biology
Muhammad Zaryab Khalid, Sajjad Ahmad, Patrick Maada Ngegba, Guohua Zhong
Summary: Insects possess a highly adaptable reproductive system regulated by their endocrine hormones, with different insect orders showing variations in the regulation of vitellogenesis. Positive and negative interactions between endocrine hormones, such as 20E and JH, play crucial roles in regulating insect reproduction at different stages of their life cycle. Additionally, the impact of microbiomes on the insect endocrine system is also significant, as compounds produced by microbiota can affect hormone synthesis and function.
Article
Toxicology
Julie Boberg, Hanna K. L. Johansson, Delphine Franssen, Monica Kam Draskau, Sofie Christiansen, Johannah Cramer, Mikael Pedersen, Anne-Simone Parent, Terje Svingen
Summary: Inhibiting androgen signaling during critical stages of ovary development may disrupt folliculogenesis and impact reproductive function. Developmental exposure to anti-androgenic chemicals, such as pesticides, can alter hormone profiles and gene expression in female rats, potentially leading to impaired follicle growth. Integrating data from multiple endocrine axes is crucial for investigating the effects of endocrine disruptors on female reproductive development and function.
TOXICOLOGY LETTERS
(2023)
Article
Endocrinology & Metabolism
Melody Wahl, Tom Levy, Rivka Manor, Eliahu D. Aflalo, Amir Sagi, Joseph Aizen
Summary: This study identified and characterized the genes encoding GPA2 (MrGPA2), GPB5 (MrGPB5), and LGR1 (MrLGR1) in the giant freshwater prawn and revealed their spatial expression patterns in females. Loss-of-function experiments demonstrated a possible ligand-receptor interaction between MrGPA2/MrGPB5 and MrLGR1, and the knockdown of MrGPA2/MrGPB5 resulted in reduced MrVg levels in the hepatopancreas. Additionally, loss-of-function of MrLGR1 led to increased MrVgR expression and larger oocytes in the ovary. These findings provide insight into the role of GPA2/GPB5-LGR1 in female reproduction.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Robert T. Rydze, Bethany K. Patton, Shawn M. Briley, Hannia Salazar Torralba, Gregory Gipson, Rebecca James, Aleksandar Rajkovic, Thomas Thompson, Stephanie A. Pangas
Summary: The study on Grem2 (-/-) mice shows that the lack of the BMP antagonist Grem2 leads to a complex reproductive phenotype, primarily resulting from disruptions in the hypothalamic-pituitary-ovarian axis causing irregular estrous cycles.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Cinta Zapater, Ana Rocha, Gregorio Moles, Alessia Mascoli, Soledad Ibanez, Silvia Zanuy, Ana Gomez
Summary: AMH plays a crucial role in teleost gonads, especially in the early stages of germ cell development. The mechanisms involving the interaction of AMH with other growth factors and hormones are not fully understood, but it has been shown to have a significant impact on steroidogenesis in the ovaries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wan-Xin Li, Li-Ting Cai, Yan-Ping Huang, Yuan-Qing Huang, Shu-Hui Pan, Zhi-Long Liu, Charles Brighton Ndandala, Gang Shi, Si-Ping Deng, Hong-Juan Shi, Guang-Li Li, Dong-Neng Jiang
Summary: In this study, it was found that S. argus has two lep genes, with lepa highly expressed in the liver and lepb not detected in any tissue. lepa was found to play a role in regulating female reproduction in S. argus.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Review
Cell Biology
Xiaoyan Sun, Jiafeng Lu, Hong Li, Boxian Huang
Summary: The m(6)A modification plays a crucial role in ovarian development and female reproduction, and dysregulated m(6)A modification is associated with various ovarian diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Annunziata Mauro, Paolo Berardinelli, Valentina Russo, Nicola Bernabo, Alessandra Martelli, Delia Nardinocchi, Oriana Di Giacinto, Maura Turriani, Barbara Barboni
Summary: The development of an adequate blood vessel network is crucial for ovarian follicle growth and ovulation. VEGF and P-4 play roles in ovarian angiogenesis, while RU486 inhibits the signaling of VEGF receptors by downregulating ERKs and AKTs, affecting the microarchitecture of periovulatory follicles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Camila Q. V. Costa, Ines I. Afonso, Sandra Lage, Pedro Reis Costa, Adelino V. M. Canario, Jose P. Da Silva
Summary: The analysis of marine lipophilic toxins in shellfish products is still a challenging task, and liquid chromatography coupled with mass spectrometry is the preferred technique for accurate quantitative measurements. The evaluation and correction of matrix effects (ME) are crucial, with the extent of ME in mussel samples depending on the sample matrix and preparation.
Article
Immunology
Carmen Sousa, Stefan A. Fernandes, Joao C. R. Cardoso, Ying Wang, Wanying Zhai, Pedro M. Guerreiro, Liangbiao Chen, Adelino V. M. Canario, Deborah M. Power
Summary: Toll-like receptors (TLRs) in Antarctic fish show lineage and species-specific changes in the ectodomain and leucine-rich repeats (LRR), possibly associated with the unique Antarctic microbiota. Genes of TLR members in temperate fish are also found in Antarctic Nototheniidae, suggesting a conserved TLR evolution. Exposure to lipopolysaccharide does not affect TLR gene expression, but increased water temperature has a significant effect.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Liliana Anjos, Patricia I. S. Pinto, Soraia Santos, M. Dulce Estevao, Bruno Manadas, Adelino V. M. Canario, Deborah M. Power
Summary: Contamination of aquatic ecosystems with anthropogenic pollutants, including pharmaceutical drugs, is a major concern worldwide. Aquatic organisms such as fish are particularly at risk of exposure to pollutants. This study investigates the impact of pollutants on the skin-scale barrier of fish and provides proteome data on the effects of fluoxetine and estradiol on sea bass skin-scales.
Article
Environmental Sciences
Patricia Pinto, L. Anjos, M. D. Estevao, S. Santos, C. Santa, B. Manadas, T. Monsinjon, Adelino V. M. Canario, D. M. Power
Summary: This study evaluated the impacts of exposure to fluoxetine (FLX) and 17 beta-estradiol (E2) on European sea bass scales and identified the complex disruptive effects of these pollutants on protein synthesis and energy metabolism. The study provides insights into the routes of action and potential biomarkers of pollutant exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Microbiology
Babak Najafpour, Patricia I. S. Pinto, A. V. M. Canario, Deborah M. Power
Summary: This study aimed to design genus-specific primers to evaluate the most abundant bacterial genera in fish-related samples and surrounding water. The designed primers showed high specificity for 11 bacterial genera and can serve as rapid and cost-effective tools for evaluation.
Article
Fisheries
Xueshu Zhang, Bingyan Sun, Yulin Bai, Adelino V. M. Canario, Xiaoyan Xu, Jiale Li
Summary: This study found that lncRNA is involved in regulating immune function in black carp. Specific signaling pathways and genes were identified to be associated with black carp resistance to Aeromonas hydrophila, while other signaling pathways were related to susceptibility.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kuo He, Liulan Zhao, Zihao Yuan, Adelino Canario, Qiao Liu, Siyi Chen, Jiazhong Guo, Wei Luo, Haoxiao Yan, Dongmei Zhang, Lisen Li, Song Yang
Summary: A high-quality chromosome-level reference genome of the largemouth bass was obtained using advanced sequencing technologies, providing a fundamental resource for studying its adaptation to new environments, genetic breeding, and other research.
Article
Endocrinology & Metabolism
Bin Wang, Jose A. Paullada-Salmeron, Alba Verges-Castillo, Ana Gomez, Jose A. Munoz-Cueto
Summary: This study investigates the intracellular signaling pathways of sea bass GnIH and its potential interactions with Kisspeptin. The results suggest that sea bass GnIHR signals are transduced through the PKA and PKC pathways, and GnIH interferes with Kisspeptin actions by reducing its signaling.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Applied
Sandra Lage, Ines I. Afonso, Pedro Reis Costa, Adelino V. M. Canario, Jose P. Da Silva
Summary: TTX and its analogues were found in the tissues of trumpet shell specimens purchased in a market in southern Portugal, suggesting the potential risk of consuming these edible gastropods. Regular monitoring of TTX and analogues in trumpet shell and other edible gastropods is recommended to prevent poisoning incidents.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Horticulture
Melina C. da Silva, Patricia I. S. Pinto, Rui Guerra, Amilcar Duarte, Deborah M. Power, Natalia T. Marques
Summary: This study investigated the transcriptome changes in Citrus macrophylla in response to drought stress and identified thousands of differentially expressed transcripts. The results showed that drought stress can induce the up- and down-regulation of various genes in the stem tissue of Citrus macrophylla, some of which may be associated with drought tolerance in this species.
SCIENTIA HORTICULTURAE
(2023)
Article
Environmental Sciences
M. Connolly, G. Moles, F. Candotto Carniel, M. Tretiach, G. Caorsi, E. Flahaut, B. Soula, E. Pinelli, L. Gauthier, F. Mouchet, J. M. Navas
Summary: Tests using algae and/or cyanobacteria, invertebrates (crustaceans) and fish are crucial for assessing the ecotoxicity of substances and classifying them as hazardous or not to the aquatic environment. However, testing two dimensional (2D) graphene nanoforms requires additional attention and adaptations due to their unique attributes. This review critically analyzes existing studies and approaches to testing, providing important insights for future assessments and regulatory requirements.
Article
Fisheries
Ana Patricia Mateus, Rita A. Costa, Bastien Sadoul, Marie-Laure Begout, Xavier Cousin, Adelino VM. Canario, Deborah M. Power
Summary: Fish skin is a versatile tissue influenced by epigenetic marks during embryonic development. This study examined the effects of egg incubation temperature on the regeneration of skin wounds in juvenile European sea bass. Results showed that fish from eggs incubated at higher temperatures immediately up-regulated the expression of pcna gene after skin damage, while fish from eggs incubated at lower temperatures up-regulated the expression of krt2 gene one day after damage. Regenerated epidermis was thinner in fish from eggs incubated at lower temperatures, with fewer goblet cells and melanomacrophages. Overall, thermal imprinting of eggs altered the damage-repair response in juvenile sea bass skin.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Sandra Lage, Felicitas ten Brink, Adelino V. M. Canario, Jose P. Da Silva
Summary: In a comprehensive project to understand emergent toxins in edible marine organisms, TTX analogues were detected in the soft tissues of European fiddler crabs and green crabs harvested in southern Portugal. No TTX was detected, but three TTX analogues were found. These results emphasize the need to monitor TTX and its analogues in edible marine species to protect consumers and provide information to the European Food Safety Authority.
Article
Chemistry, Analytical
Renato Ferreira, Paulo A. Ribeiro, Adelino V. M. Canario, Maria Raposo
Summary: Prostate cancer is one of the most prevalent tumors in men, and early diagnosis is crucial. In this study, an electronic tongue prototype was developed for detecting prostate cancer.
Article
Fisheries
Carmen S. V. Sousa, Deborah M. Power, Pedro M. Guerreiro, Bruno Louro, Liangbiao Chen, Adelino V. M. Canario
Summary: The environmental conditions and isolation in the Antarctic have driven the evolution of a unique biodiversity. This study investigates the possible adaptation of the Notothenia coriiceps immune system to the cold environment and unique microbial community of the Southern Ocean. The findings suggest that the immune processes in N. coriiceps differ from other teleost fish.