In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds

Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

(2018) F. Oesch et al.   ARCHIVES OF TOXICOLOGY

Determination of flutamide and two major metabolites using HPLC–DAD and HPTLC methods

(2018) Nada S. Abdelwahab et al.   Chemistry Central Journal

Transport–Glucuronidation Classification System and PBPK Modeling: New Approach To Predict the Impact of Transporters on Disposition of Glucuronides

(2017) Shufan Ge et al.   MOLECULAR PHARMACEUTICS

From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling

(2017) Alicia Paini et al.   TOXICOLOGY IN VITRO

Use of physiologically based kinetic modeling-facilitated reverse dosimetry of in vitro toxicity data for prediction of in vivo developmental toxicity of tebuconazole in rats

(2017) Hequn Li et al.   TOXICOLOGY LETTERS

Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols

(2016) Marije Strikwold et al.   ARCHIVES OF TOXICOLOGY

Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict in Vivo Toxicity from in Vitro Data

(2016) Jochem Louisse et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predicting points of departure for risk assessment based on in vitro cytotoxicity data and physiologically based kinetic (PBK) modeling: The case of kidney toxicity induced by aristolochic acid I

(2016) Rozaini Abdullah et al.   FOOD AND CHEMICAL TOXICOLOGY

Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations

(2015) Floris A. Groothuis et al.   TOXICOLOGY

Evaluation of physiologically based toxicokinetic (PBTK) modelling for reverse dosimetry approaches

(2015) E. Fabian et al.   TOXICOLOGY LETTERS

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

(2014) Jochem Louisse et al.   ARCHIVES OF TOXICOLOGY

Extrahepatic metabolism at the body's internal–external interfaces

(2014) Ursula Gundert-Remy et al.   DRUG METABOLISM REVIEWS

Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol in rat and human

(2013) Marije Strikwold et al.   ARCHIVES OF TOXICOLOGY

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

CROSS-SPECIES CONSERVATION OF ENDOCRINE PATHWAYS: A CRITICAL ANALYSIS OF TIER 1 FISH AND RAT SCREENING ASSAYS WITH 12 MODEL CHEMICALS

(2013) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Pyrethroid and their metabolite, 3-phenoxybenzoic acid showed similar (anti)estrogenic activity in human and rat estrogen receptor α-mediated reporter gene assays

(2013) Hong Sun et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

Quantitative analysis of acetaminophen and its six metabolites in rat plasma using liquid chromatography/tandem mass spectrometry

(2012) Ji Hye An et al.   BIOMEDICAL CHROMATOGRAPHY

A testing strategy for the identification of mammalian, systemic endocrine disruptors with particular focus on steroids

(2012) Susanne N. Kolle et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Alternative long-term markers for the detection of methyltestosterone misuse

(2012) C. Gómez et al.   STEROIDS

Human and Rat ABC Transporter Efflux of Bisphenol A and Bisphenol A Glucuronide: Interspecies Comparison and Implications for Pharmacokinetic Assessment

(2012) Christopher S. Mazur et al.   TOXICOLOGICAL SCIENCES

Effect of combining in vitro estrogenicity data with kinetic characteristics of estrogenic compounds on the in vivo predictive value

(2012) Ans Punt et al.   TOXICOLOGY IN VITRO

Compilation of 222 drugs’ plasma protein binding data and guidance for study designs

(2011) Fengling Zhang et al.   DRUG DISCOVERY TODAY

Efflux Transport Is an Important Determinant of Ethinylestradiol Glucuronide and Ethinylestradiol Sulfate Pharmacokinetics

(2011) M. J. Zamek-Gliszczynski et al.   DRUG METABOLISM AND DISPOSITION

In vitro–in vivo correlation: Perspectives on model development

(2011) Ying Lu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tutorial on physiologically based kinetic modeling in molecular nutrition and food research

(2011) Ivonne M. C. M. Rietjens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chemical toxicity testing in vitro using cytochrome P450–expressing cell lines, such as human CYP1B1

(2011) Robert Landsiedel et al.   Nature Protocols

Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice

(2011) Ans Punt et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals

(2011) Caroline Bauch et al.   TOXICOLOGY IN VITRO

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man

(2010) Jochem Louisse et al.   TOXICOLOGICAL SCIENCES

A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes

(2010) Alicia Paini et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In house validation of recombinant yeast estrogen and androgen receptor agonist and antagonist screening assays

(2010) S.N. Kolle et al.   TOXICOLOGY IN VITRO

Prediction of Vss from In Vitro Tissue-Binding Studies

(2009) L. M. Berry et al.   DRUG METABOLISM AND DISPOSITION

A stereospecific high-performance liquid chromatographic assay for the determination of ketoconazole enantiomers in rat plasma

(2008) Dalia A. Hamdy et al.   BIOMEDICAL CHROMATOGRAPHY

Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data

(2008) P. J. Kilford et al.   DRUG METABOLISM AND DISPOSITION

Endocrine-disrupting properties in vivo of widely used azole fungicides

(2008) C. Taxvig et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding

(2008) Nigel J. Waters et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

4-Alkylphenols and related chemicals show similar effect on the function of human and rat estrogen receptor α in reporter gene assay

(2007) Hong Sun et al.   CHEMOSPHERE

Enzyme-assisted synthesis and structure characterization of glucuronide conjugates of eleven anabolic steroid metabolites

(2007) Laura Hintikka et al.   STEROIDS