Review
Endocrinology & Metabolism
Haiyan Zhu, Xin Wang, Shihao Lu, Kongbo Ou
Summary: Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming, which provides potential targets for therapeutic interventions. This review summarizes recent discoveries of metabolic alterations in ccRCC, including changes in glucose, lipid, and amino acid metabolism. It also discusses the development of metabolic drugs targeting these pathways and proposes future trends in drug development. Overall, this review highlights the potential for developing new treatments for ccRCC based on metabolic alterations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
David F. McDermott, Jae-Lyun Lee, Georg A. Bjarnason, James M. G. Larkin, Rustem A. Gafanov, Mark D. Kochenderfer, Niels Viggo Jensen, Frede Donskov, Jahangeer Malik, Alexandr Poprach, Scott S. Tykodi, Teresa Alonso-Gordoa, Daniel C. Cho, Poul F. Geertsen, Miguel Angel Climent Duran, Christopher DiSimone, Rachel Kloss Silverman, Rodolfo F. Perini, Charles Schloss, Michael B. Atkins
Summary: Single-agent pembrolizumab demonstrated promising antitumor activity as a first-line treatment in untreated patients with advanced ccRCC, with durable responses observed across different categories. The safety and tolerability profile of pembrolizumab monotherapy was consistent with what has been observed in other tumor types.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
David F. McDermott, Jae-Lyun Lee, Marek Ziobro, Cristina Suarez, Przemyslaw Langiewicz, Vsevolod Borisovich Matveev, Pawel Wiechno, Rustem Airatovich Gafanov, Piotr Tomczak, Frederic Pouliot, Frede Donskov, Boris Yakovlevich Alekseev, Sang Joon Shin, Georg A. Bjarnason, Daniel Castellano, Rachel Kloss Silverman, Rodolfo F. Perini, Charles Schloss, Michael B. Atkins
Summary: First-line pembrolizumab monotherapy demonstrated promising antitumor activity in patients with nccRCC, showing similar efficacy and safety profile to other tumor types.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Cell Biology
Fan Zhang, Junyu Lin, Dechao Feng, Jiayu Liang, Yiping Lu, Zhihong Liu, Xianding Wang
Summary: This study explored the correlation between cuprotosis and clear cell renal cell carcinoma (ccRCC) and developed a cuprotosis-related signature to predict the prognosis of patients with ccRCC. The signature risk score was significantly associated with tumor stage, histological grade, and immune cell infiltrates in ccRCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Lilong Liu, Yaxin Hou, Junyi Hu, Lijie Zhou, Ke Chen, Xiong Yang, Zhengshuai Song
Summary: The study identified SLC39A8 as a key gene of the ZIP family in ccRCC, showing that its low expression is associated with poorer prognosis in patients. Moreover, overexpression of SLC39A8 or treatment with low concentration zinc chloride effectively inhibits proliferation, migration, and invasion of ccRCC cells. This study provides new insights into the role of SLC39A8/zinc in regulating ccRCC progression, offering potential directions for drug development and combination therapy strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zuhu Yu, Chong Lu, Bin Lu, Hong Gao, Rongfang Liang, Wuxing Xiang
Summary: This study identified necroptosis-related microRNAs (miRNAs) associated with the prognosis of clear cell renal cell carcinoma (ccRCC), and developed a prognostic signature to predict overall survival in ccRCC patients. The targeted genes of these miRNAs were predicted using miRNA databases, and their functional and pathway associations with ccRCC prognosis were investigated. The differential expression of the three miRNAs in the signature was validated in ccRCC tissues.
Article
Biochemistry & Molecular Biology
Yawei Xu, Jingcheng Zhou, Lei Li, Wuping Yang, Zedan Zhang, Kenan Zhang, Kaifang Ma, Haibiao Xie, Zheng Zhang, Lin Cai, Yanqing Gong, Kan Gong
Summary: The m6A modification is suppressed and closely related to autophagic flux in ccRCC. Elevated FTO is inhibited, leading to increased autophagic flux and impaired growth and metastasis of ccRCC. SIK2 is identified as a functional target of m6A-mediated autophagy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Bao Yuan, Jin Zhou
Summary: Emerging research has revealed that N6-methyladenosine (m6A) modification plays a crucial role in the tumorigenesis of clear-cell renal cell carcinoma (ccRCC). However, the regulatory mechanisms of m6A reader IGF2BP1 in ccRCC tumor energy metabolism are still unclear. The results showed that IGF2BP1 exhibited significantly higher expression in ccRCC cells. Functional assays demonstrated that IGF2BP1 promoted glycolytic characteristics in ccRCC cells. Mechanistically, IGF2BP1 recognized m6A modified sites on LDHA mRNA and enhanced its stability, thereby accelerating tumor energy metabolism. This study provides new insights into the functional importance of IGF2BP1 as an m6A reader in post-transcriptional gene regulation.
Article
Immunology
Mancheng Gong, Yongxiang Li, Erlin Song, Miaoyuan Li, Shaopeng Qiu, Wenjing Dong, Runqiang Yuan
Summary: Our study found a correlation between OIP5 expression and immune cell infiltration level in ccRCC. Analysis based on RNA-seq data showed that OIP5 has an impact on immune activity. Additionally, OIP5 was associated with several immunomodulators and involved in multiple immune signaling pathways. We constructed a multiple-gene risk prediction signature, providing a potential target for immunotherapy in ccRCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Lauren E. Langbein, Rayan El Hajjar, Shen He, Eleonora Sementino, Zhijiu Zhong, Wei Jiang, Benjamin E. Leiby, Li Li, Robert G. Uzzo, Joseph R. Testa, Haifeng Yang
Summary: In clear cell renal cell carcinomas (ccRCC), loss of BAP1 reduces type I interferon signaling, and reactivating this pathway may be a novel therapeutic strategy for treating this cancer.
Article
Oncology
Songchen Han, Wenbo Yang, Caipeng Qin, Yiqing Du, Mengting Ding, Huaqi Yin, Tao Xu
Summary: Intratumoral fibrosis in renal clear cell carcinoma (ccRCC) is found to be associated with the immune infiltration of the tumor. The study identifies proteins involved in immunity and tumor-infiltrating lymphocytes that are associated with intratumoral fibrosis. Additionally, the study reveals a negative correlation between the expression of CTLA4 protein and collagen level in ccRCC.
Article
Multidisciplinary Sciences
Lucile Massenet-Regad, Justine Poirot, Margaret Jackson, Caroline Hoffmann, Elise Amblard, Fanny Onodi, Fatiha Bouhidel, Malika Djouadou, Idir Ouzaid, Evanguelos Xylinas, Jasna Medvedovic, Vassili Soumelis
Summary: This study used single-cell RNA sequencing data to characterize the communication networks in human clear cell renal cell carcinoma (ccRCC). The study identified 50 communication channels used by cancer cells to interact with other cells, including two novel angiogenin-mediated interactions. The expression of angiogenin and its receptors was validated at the protein level in primary ccRCC. This study provides new insights into the molecular mechanisms of ccRCC and suggests angiogenin and its receptors as potential therapeutic targets.
Article
Immunology
Gang Wang, Panhong Liu, Jiangfeng Li, Ke Jin, Xiangyi Zheng, Liping Xie
Summary: This study constructed an immune-related long non-coding RNA (irlncRNA) prognosis model for clear cell renal cell carcinoma (ccRCC) that is independent of gene expression levels. The paired irlncRNA model showed promising clinical prediction value, allowing for better prediction of patient survival, pathological characteristics, and immune-related factors.
Article
Oncology
Chuanjie Zhang, Feng Qi, Yuxiao Zheng, Xin Xia, Xiao Li, Xinwei Wang
Summary: This study systematically investigated the characterization of tumor microenvironment in clear cell renal cell carcinoma (ccRCC), and found that the TMEscore has promising significance for predicting prognosis and immunotherapy responses, making it an essential biomarker and drug indicator.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Fahui Liu, Ping Wang, Wenjuan Sun, Yan Jiang, Qiming Gong
Summary: This study characterizes the tumour microenvironment (TME) of clear cell renal cell carcinoma (ccRCC) and identifies ligand-receptor (LR) pairs that could serve as effective biomarkers and predictors for molecular subtyping and immunotherapy effects in ccRCC. The study analyzes single-cell sequencing data and proposes a new molecular subtyping model based on LR-pairs. The study shows significant differences in prognosis, clinicopathological features, mutational, pathway, and immune signatures among different molecular subtypes. The LR.score model accurately predicts the prognosis of ccRCC patients. Targeting LR-pairs could have clinical benefit in immunotherapy regimens and prognostic evaluations in ccRCC.
FRONTIERS IN IMMUNOLOGY
(2022)
