Palladium-Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature

Decarbonylative Cross-Couplings: Nickel Catalyzed Functional Group Interconversion Strategies for the Construction of Complex Organic Molecules

(2018) Lin Guo et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium-Catalyzed Decarbonylative Trifluoromethylation of Acid Fluorides

(2018) Sinead T. Keaveney et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition-Metal-Catalyzed Decarbonylative Coupling Reactions: Concepts, Classifications, and Applications

(2018) Lin Guo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ligand-Controlled Chemoselective C(acyl)–O Bond vs C(aryl)–C Bond Activation of Aromatic Esters in Nickel Catalyzed C(sp2)–C(sp3) Cross-Couplings

(2018) Adisak Chatupheeraphat et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone

(2018) Wenjun Miao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Switchable Selectivity in the Pd-Catalyzed Alkylative Cross-Coupling of Esters

(2018) Jeanne Masson-Makdissi et al.   ORGANIC LETTERS

Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

(2018) Jie Sheng et al.   Organic Chemistry Frontiers

Metallaphotoredox Difluoromethylation of Aryl Bromides

(2018) Vlad Bacauanu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional Group Transposition: A Palladium-Catalyzed Metathesis of Ar–X σ-Bonds and Acid Chloride Synthesis

(2018) Maximiliano De La Higuera Macias et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis

(2017) Ryosuke Takise et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CF2H, a Hydrogen Bond Donor

(2017) Chanan D. Sessler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium

(2017) Zhang Feng et al.   Nature Chemistry

A General Approach to Quaternary Center Construction from Couplings of Unactivated Alkenes and Acyl Xanthates

(2017) Ernest N. Jenkins et al.   ORGANIC LETTERS

Nickel-Catalyzed C–CN Bond Formation via Decarbonylative Cyanation of Esters, Amides, and Intramolecular Recombination Fragment Coupling of Acyl Cyanides

(2017) Adisak Chatupheeraphat et al.   ORGANIC LETTERS

Palladium- and Nickel-Catalyzed Decarbonylative C–S Coupling to Convert Thioesters to Thioethers

(2017) Naoko Ichiishi et al.   ORGANIC LETTERS

Pd-Catalyzed Decarbonylative Cross-Couplings of Aroyl Chlorides

(2017) Christian A. Malapit et al.   ORGANIC LETTERS

Synthesis, Reactivity, and Catalytic Applications of Isolable (NHC)Cu(CHF2) Complexes

(2017) James R. Bour et al.   ORGANOMETALLICS

Nickel-Catalyzed C–O Bond-Cleaving Alkylation of Esters: Direct Replacement of the Ester Moiety by Functionalized Alkyl Chains

(2017) Xiangqian Liu et al.   ACS Catalysis

Site-Selective C–H/C–N Activation by Cooperative Catalysis: Primary Amides as Arylating Reagents in Directed C–H Arylation

(2017) Guangrong Meng et al.   ACS Catalysis

Metal-Catalyzed Direct Difluoromethylation Reactions

(2017) Jian Rong et al.   Asian Journal of Organic Chemistry

China's flourishing synthetic organofluorine chemistry: innovations in the new millennium

(2017) Qinghe Liu et al.   National Science Review

Synthesis of Biaryls through Nickel-Catalyzed Suzuki-Miyaura Coupling of Amides by Carbon-Nitrogen Bond Cleavage

(2016) Shicheng Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Decarbonylative Borylation of Amides: Evidence for Acyl C−N Bond Activation

(2016) Jiefeng Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Biaryl Ketones by Suzuki-Miyaura Cross-Coupling of Organotrifluoroborates and Acyl Chlorides

(2016) Alaina M. Forbes et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

N-Acylsaccharins as Amide-Based Arylating Reagents via Chemoselective N–C Cleavage: Pd-Catalyzed Decarbonylative Heck Reaction

(2016) Chengwei Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

(2016) Long Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Difluoromethylation of Aryl Iodides with (Difluoromethyl)zinc Reagent

(2016) Hiroki Serizawa et al.   ORGANIC LETTERS

Palladium-Catalyzed Negishi Cross-Coupling Reaction of Aryl Halides with (Difluoromethyl)zinc Reagent

(2016) Kohsuke Aikawa et al.   ORGANIC LETTERS

Pd-Catalyzed Transfer of Difluorocarbene

(2016) Xiao-Yun Deng et al.   ORGANIC LETTERS

Nickel-Catalyzed Deamidative Step-Down Reduction of Amides to Aromatic Hydrocarbons

(2016) Aniruddha Dey et al.   ACS Catalysis

General Olefin Synthesis by the Palladium-Catalyzed Heck Reaction of Amides: Sterically Controlled Chemoselective NC Activation

(2015) Guangrong Meng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-Catalyzed Difluoromethylation of Vinyl Bromides, Triflates, Tosylates, and Nonaflates

(2015) Dalu Chang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Acid Chloride Synthesis by the Palladium-Catalyzed Chlorocarbonylation of Aryl Bromides

(2015) Jeffrey S. Quesnel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp2) and C(sp) Centers

(2015) Marie-Charlotte Belhomme et al.   CHEMISTRY-A EUROPEAN JOURNAL

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nickel-catalysed Suzuki–Miyaura coupling of amides

(2015) Nicholas A. Weires et al.   Nature Chemistry

Decarboxylative functionalization of cinnamic acids

(2015) Arun Jyoti Borah et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Access to Difluoromethylated Arenes by Pd-Catalyzed Reaction of Arylboronic Acids with Bromodifluoroacetate

(2015) Zhang Feng et al.   ORGANIC LETTERS

Well-Defined, Shelf-Stable (NHC)Ag(CF2H) Complexes for Difluoromethylation

(2015) Yang Gu et al.   ORGANOMETALLICS

Decarbonylative organoboron cross-coupling of esters by nickel catalysis

(2015) Kei Muto et al.   Nature Communications

Silver-Catalyzed Oxidative Activation of Benzylic CH Bonds for the Synthesis of Difluoromethylated Arenes

(2014) Peng Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stable but Reactive Perfluoroalkylzinc Reagents: Application in Ligand-Free Copper-Catalyzed Perfluoroalkylation of Aryl Iodides

(2014) Kohsuke Aikawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Sandmeyer Difluoromethylation of (Hetero-)Arenediazonium Salts

(2014) Christian Matheis et al.   ORGANIC LETTERS

Catalytic Cycle for Palladium-Catalyzed Decarbonylative Trifluoromethylation using Trifluoroacetic Esters as the CF3 Source

(2014) Ansis Maleckis et al.   ORGANOMETALLICS

Copper-Catalyzed Aerobic C–H Trifluoromethylation of Phenanthrolines

(2014) Hao Xu et al.   SYNLETT

Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides

(2014) Yang Gu et al.   Nature Communications

Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature

(2014) Xue-Liang Jiang et al.   Organic Chemistry Frontiers

Nickel-Catalyzed Decarbonylative CH Coupling Reactions: A Strategy for Preparing Bis(heteroaryl) Backbones

(2013) Arkaitz Correa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Green and sustainable manufacture of chemicals from biomass: state of the art

(2013) Roger A. Sheldon   GREEN CHEMISTRY

A Palladium-Catalyzed Carbonylation Approach to Acid Chloride Synthesis

(2013) Jeffrey S. Quesnel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible Light-Promoted Metal-Free C–H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination

(2013) Ji-Bao Xia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Suzuki-Miyaura Cross-Coupling in Acylation Reactions, Scope and Recent Developments

(2013) Marco Blangetti et al.   MOLECULES

Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes

(2013) Satoshi Mizuta et al.   ORGANIC LETTERS

Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane

(2012) G. K. Surya Prakash et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reactions of Hydridoirida-β-diketones with Amines or with 2-Aminopyridines: Formation of Hydridoirida-β-ketoimines, PCN Terdentate Ligands, and Acyl Decarbonylation

(2012) Roberto Ciganda et al.   INORGANIC CHEMISTRY

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical and innate carbon–hydrogen functionalization of heterocycles

(2012) Yuta Fujiwara et al.   NATURE

Carboxylates as sources of carbon nucleophiles and electrophiles: comparison of decarboxylative and decarbonylative pathways

(2012) Wojciech I. Dzik et al.   Chemical Science

Decarbonylative Cycloaddition of Phthalic Anhydrides with Allenes

(2011) Yosuke Ochi et al.   ORGANIC LETTERS

Synthesis of Celecoxib Analogues Possessing aN-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity

(2009) Morshed A. Chowdhury et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iridium-Catalyzed Addition of Acid Chlorides to Terminal Alkynes

(2009) Tomohiro Iwai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Suzuki−Miyaura Cross-Coupling Reactions Employing Dialkylbiaryl Phosphine Ligands

(2008) Ruben Martin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Carboxylic Acids as Substrates in Homogeneous Catalysis

(2008) Lukas J. Gooßen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Decarbonylative Addition of Anhydrides to Alkynes

(2008) Yuichi Kajita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium-Catalyzed Regioselective C−H Functionalization via Decarbonylation of Acid Chlorides and C−H Bond Activation under Phosphine-Free Conditions

(2008) Xiaodan Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS