Article
Chemistry, Analytical
Guanhui Zhao, Yu Du, Nuo Zhang, Chenchen Li, Hongmin Ma, Dan Wu, Wei Cao, Yaoguang Wang, Qin Wei
Summary: This study reported an ECL analytical model using zinc-based metal-organic frameworks of ruthenium hybrid (RuZn MOFs) as the signal emitter for immunoassay. The quenching effect of different noble metal nanoparticles on ECL was investigated. Pd@Ptoct core-shell showed higher activity and improved durability, leading to enhanced quenching ECL. The resonance energy transfer (RET) reaction between noble metal nanoparticles and RuZn MOFs also contributed to the sensitivity improvement.
ANALYTICA CHIMICA ACTA
(2023)
Article
Nanoscience & Nanotechnology
Jun-Mao Wang, Li-Ying Yao, Wei Huang, Yang Yang, Wen-Bin Liang, Ruo Yuan, Dong-Rong Xiao
Summary: By coordinative immobilization of PAHs within metal-organic frameworks, the aggregation-induced quenching effect was eliminated, resulting in increased ECL intensity and efficiency. Utilizing this new ECL emitter combined with dual amplification strategies, an ECL sensor for microRNA-21 detection was constructed with wide signal response and low detection limit.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Shuo Meng, Dongmiao Qin, Yusheng Wu, Guichun Mo, Xiaohua Jiang, Biyang Deng
Summary: Researchers prepared a composite material MnCO3/poly(diallyl dimethyl ammonium chloride) (PDDA)/Ag with excellent electrochemiluminescence (ECL) performance and high biocompatibility by adding MnCO3 and PDDA to silver nanoparticles (AgNPs). MnCO3 and Au@SiO(2)NPs were used as ECL donors and acceptors, respectively, establishing an effective ECL-resonance energy transfer (RET) sensing platform. The system showed good response to the concentration of A beta(42) in serum samples.
Article
Chemistry, Multidisciplinary
Huan Gao, Xuan Wei, Meize Li, Lei Wang, Tianxiang Wei, Zhihui Dai
Summary: By utilizing the co-quenching effect mechanism between LaMOFs and CV, the constructed ECL gene sensor shows good assay performance in the detection range, indicating a promising application prospect in expanding the ECL technology.
Article
Chemistry, Analytical
Jilan Qi, Xiaolei Zhang, Qiangyan Zhang, Ying Xue, Fei Meng, Yuanhua Liu, Gongjun Yang
Summary: This study proposes an electrochemiluminescence (ECL) strategy for detecting the common tumor biomarker Apolipoprotein-A1 (Apo-A1) in bladder cancer. The ECL nanoprobe Ru-MOF, constructed using three-dimensional zinc oxalate metal-organic frameworks (MOFs) and tris(2,2 '-bipyridyl)-ruthenium(II) [Ru(bpy)32+] as the luminophor, is used to detect Apo-A1. Additionally, L-cysteine (L-Cys) is connected to the Pd@Au core-shell nanostructure via Au-S bond and directly modified on the glassy carbon electrode (GCE), reducing the electron transfer distance. The proposed ECL immunosensor shows advantages in terms of simplicity, speed, stability, and selectivity, and has been successfully applied for Apo-A1 determination in real serum and urine samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Yubing Lv, Yanli Zhou, Hui Dong, Maotian Xu, Jing Zhang, Mei Yan
Summary: A new method for electrochemical detection of Alzheimer's disease (AD) biomarkers was developed using a double amplification strategy. The use of titanium carbide (Ti3C2) MXene decorated with gold nanoparticles (Au-MXene) as the electrode substrate, covalent organic frameworks (COFs) modified with aptamers (Apt) and an electron mediator (toluidine blue, TB), resulted in a highly efficient platform for the detection of AD biomarkers.
Article
Chemistry, Analytical
Xuyu Feng, Bin Li, Longyi Zhu, Wen Chen, Ying Wu, Yanru Duan, Meiyan Song, Ying Wan, Shengyuan Deng
Summary: The structural characteristics of ECL microreticula allow for flexible designs in probing specific molecules. However, little attention has been paid to the impact of electrolytic carriers on the ECL responsiveness of these grids. This study examines the influences of common cationic species and transition metals on the ECL performance of a zinc porphyrin-organic framework (ZnPOF), demonstrating the adverse effect of divalent metals on ECL brightness and suggesting the need for extra attention in bioassays and mechanistic analyses.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Da Zhu, Yong Zhang, Songsong Bao, Ningning Wang, Siqi Yu, Rengan Luo, Jing Ma, Huangxian Ju, Jianping Lei
Summary: This work introduces a mixed-ligand metal-organic framework for self-enhanced electrochemiluminescence by integrating two ligands that can be oxidized and react with each other on a metal node. The incorporation of both luminophore and coreactant into the MOF framework enhances ECL intensity and allows for stepwise ECL emission, enriching the fundamentals and applications of ECL systems.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Mei-Ling Lu, Xin-Yue Zhang, Jun-Qi Song, Qiu-Yi Peng, Han-Xiao Xiao, Yang Yang, Wen-Bin Liang, Shaoguang Sun, Ruo Yuan, Dong-Rong Xiao
Summary: This research demonstrates that the electrical conductivity of HOF-based ECL materials can be significantly improved, leading to enhanced ECL performance. A conductive HOF composite was prepared by growing H3TATB-HOF on a highly conductive PEDOT:PSS polymer, resulting in a remarkable increase in ECL intensity. By combining this improved ECL property with a 3D DNA walker amplification strategy, an ultrasensitive ECL biosensor for microRNA-21 detection was designed.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Biophysics
Guomin Yang, Yuanyuan Zhang, Jinwen Zhao, Ying He, Ruo Yuan, Shihong Chen
Summary: This study explores the use of poly(styrene-co-maleic anhydride) as a functional reagent to modulate iridium(III) complexes for simultaneous bipolar ECL signals. It also utilizes silver nanoparticles as dual-regulating coreaction accelerators to enhance the bipolar emissions of iridium(III) nanorods. These unique properties provide an interesting mono-luminophore-based ECL ratio sensing platform for biological analysis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Linzhi Li, Xing Liu, Saijun He, Hongmei Cao, Benchao Su, Tianzeng Huang, Qi Chen, Minghuan Liu, Da-Peng Yang
Summary: A novel ultrasensitive electrochemiluminescence (ECL) immunoassay based on Au/CaCO3 nanocomposites synthesized using waste eggshells was developed for detecting ochratoxin A (OTA) in coffee. The sensor showed high sensitivity, selectivity, low detection limit, excellent performance, and stability, with promising practical applicability in analyzing OTA in food samples. This work demonstrates the potential of utilizing natural waste as a source for fabricating nanomaterials in sensor technology for detecting toxic substances in foods.
Article
Chemistry, Analytical
Nuo Zhang, Shanghua Liu, Yue Jia, Guanhui Zhao, Xiaoyi Duan, Yaoguang Wang, Daopeng Zhang, Qin Wei
Summary: A novel electrochemiluminescence immunosensor was developed for sensitive detection of amyloid ss-protein. The sensor showed high signal intensity and low detection limit by using specific materials and labels. This strategy is of great significance for early diagnosis and prevention of Alzheimer's disease and detection of other disease markers.
MICROCHEMICAL JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Rengan Luo, Da Zhu, Huangxian Ju, Jianping Lei
Summary: Electrochemiluminescence (ECL) is a powerful technique that relies on charge transfer between electrochemical intermediates and co-reactants/emitters to form excited emitters. The development of molecular nanocrystals, such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), has allowed for the exploration of ECL mechanisms and enhancement strategies. Reticular crystalline nanoemitters with different topologies provide a platform for understanding ECL fundamentals and designing next-generation ECL devices.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Biophysics
Qingqing Huang, Fang Luo, Cuiying Lin, Jian Wang, Bin Qiu, Zhenyu Lin
Summary: Ru-PEI-L-lys was immobilized on ZIF-8 to form Ru-PEI-L-lys-ZIF-8, which was then mixed with PtNPs to enhance the ECL response. The combination of selective aptamer and RecJf exonuclease in the system resulted in a highly sensitive ECL biosensor for thrombin detection, with a linear response range from 1 fM to 10 pM and a detection limit of 0.02 aM. This work presents a new strategy for designing stable ECL indicators and developing sensitive ECL sensors for biological analysis.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Li-Yan Huang, Xiang Hu, Hong-Yan Shan, Lu Yu, Yi-Xin Gu, Ai-Jun Wang, Dan Shan, Pei-Xin Yuan, Jiu-Ju Feng
Summary: By synthesizing Zn-based metal organic frameworks with pyridine to enhance the electrochemiluminescence response of zinc meso-tetra(4-sulfonatophenyl) porphine, a biosensor with wide linear range and low detection limit was developed in this study. The Zn-TP linked Zn-Bp-MOFs showed significantly improved ECL efficiency compared to free Zn-TP, holding promise for broader applications in the field of photoelectric detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Chuanen Guo, Yingying Wang, Fangzheng Wang, Yaoguang Wang
Summary: This study focused on the preparation of NH2-CoFe2O4/SBA-15 adsorbent for effective removal of Pb2+ from aqueous solution. The adsorption kinetics and isotherms were studied, showing that adsorption followed pseudo-first-order kinetics and Freundlich model. Thermodynamic investigations revealed that the adsorption process was endothermic and spontaneous. The prepared adsorbent exhibited superior anti-interference performance and reusability, indicating potential for practical water treatment applications. This research may also serve as a reference for the study of other heavy metal ions.
Article
Chemistry, Physical
Yaoguang Wang, Yingying Wang, Fangzheng Wang, Hong Chi, Guanhui Zhao, Yong Zhang, Tianduo Li, Qin Wei
Summary: Gold-modified graphene was used to construct an electrochemical aptasensor, while gold-palladium modified metal-organic frameworks nanozyme was employed as a signal enhancer for sensitive detection of mercury ions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Chemistry, Analytical
Xinxiu Yang, Hong Chi, Yong Tian, Tianduo Li, Yaoguang Wang
Summary: This article reviews the application of graphene and its derivatives in gas sensing, including the detection principles, latest methods, and applications in several common gases. It also summarizes the commonly used materials, preparation methods, response mechanisms for gases such as NO, NH3, H2S, and VOCs, and discusses the challenges and prospective applications in this field.
Article
Chemistry, Analytical
Qi Yue, Xuan Li, Jinglong Fang, Min Li, Jingjing Zhang, Guanhui Zhao, Wei Cao, Qin Wei
Summary: Here, a dual-mode quenched electrochemiluminescence immunosensor based on PtPd@PDA was proposed, which provides a new approach for detecting aflatoxin B1.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Guanhui Zhao, Xue Dong, Yu Du, Nuo Zhang, Guozhen Bai, Dan Wu, Hongmin Ma, Yaoguang Wang, Wei Cao, Qin Wei
Summary: This study introduces a novel electrochemiluminescent emitter named NiRu MOFs, which demonstrates high and stable luminous efficiency. The results of an immunoassay model show that it has a strong signal output, making it a meaningful solution for the next-generation ECL emitters.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xue Dong, Guanhui Zhao, Yuyang Li, Qingze Zeng, Hongmin Ma, Dan Wu, Xiang Ren, Qin Wei, Huangxian Ju
Summary: The ECL properties of polyoxomolybdatezirconia (POM-ZrO2) were discovered for the first time in this study, and their luminescence mechanism was explored. A dual-mechanism quenching strategy was successfully applied to the immunoassay of 17 beta-estradiol, demonstrating favorable analytical performance and a wide sensing range.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Chenchen Li, Yunxiao Li, Yong Zhang, Guanhui Zhao, Yaoguang Wang, Huabin Wang, Huan Wang, Rui Xu, Qin Wei
Summary: In this study, a highly efficient and sensitive ECL immunoassay for detecting neuron-specific enolase (NSE) was developed by linking carboxylated Ru(bpy)(3)(2+) to an iron-based metal-organic framework (NH2-MIL-88 (Fe)) and using polyaniline-intercalating vanadium oxide (PVO) nanosheets as the substrate. The NH2-MIL-88 (Fe) and PVO provided abundant amino groups that enhanced the ECL signal by catalyzing the reactions of the co-reactant S2O82-. This research offers an effective strategy for ultrasensitive detection of trace proteins using ECL immunoassays.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Guanhui Zhao, Yu Du, Nuo Zhang, Chenchen Li, Hongmin Ma, Dan Wu, Wei Cao, Yaoguang Wang, Qin Wei
Summary: This study reported an ECL analytical model using zinc-based metal-organic frameworks of ruthenium hybrid (RuZn MOFs) as the signal emitter for immunoassay. The quenching effect of different noble metal nanoparticles on ECL was investigated. Pd@Ptoct core-shell showed higher activity and improved durability, leading to enhanced quenching ECL. The resonance energy transfer (RET) reaction between noble metal nanoparticles and RuZn MOFs also contributed to the sensitivity improvement.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Guanhui Zhao, Yu Du, Nuo Zhang, Yuan Li, Guozhen Bai, Hongmin Ma, Dan Wu, Wei Cao, Qin Wei
Summary: To ensure drinking water quality, the development of rapid and accurate analytical methods is essential. In this study, a highly sensitive electrochemiluminescence (ECL) aptasensor based on a signal on-off-on strategy was developed to detect the water pollutant microcystin-LR (MC-LR). The aptasensor exhibited outstanding sensitivity and stability in MC-LR detection, with a linear detection range of 0.0001-50 ng mL(-1). The study provides valuable directions for the application of alloy nanoparticles of noble metals and bimetallic MOFs in the field of ECL immunoassay.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Guanhui Zhao, Yingying Wang, Huixin Wang, Guozhen Bai, Nuo Zhang, Yaoguang Wang, Qin Wei
Summary: In this work, a highly efficient photoelectrochemical immunosensor based on Bi2S3/Ag2S was constructed for the sensitive detection of procalcitonin (PCT). The immunosensor was simple, convenient, and showed good anti-interference, sensitivity, and specificity. It could provide a meaningful theoretical basis and reference value for the clinical detection of PCT.
Article
Chemistry, Analytical
Yingying Wang, Huixin Wang, Yaliang Bai, Guanhui Zhao, Nuo Zhang, Yong Zhang, Yaoguang Wang, Hong Chi
Summary: In this study, an electrochemical immunoassay method based on molybdenum disulfide (MoS2) was proposed to detect neuron-specific enolase (NSE) sensitively. The MoS2@Au nanozyme, formed by composite MoS2 and Au nanoclusters (Au NCs), was used to catalyze the decomposition of H2O2, which amplified the amperometric response and improved sensitivity. The detection range of this strategy was 0.1 pg·mL(-1)-10 ng·mL(-1) with a limit of detection of 0.05 pg·mL(-1). This sensing strategy showed potential for sensitive detection of NSE and can provide a theoretical basis and technical support for detecting other disease markers.
Review
Chemistry, Analytical
Fangzheng Wang, Yingying Wang, Huixin Wang, Guanhui Zhao, Jihao Li, Yaoguang Wang
Summary: In recent years, nanozyme materials have become a rapidly developing type of new nanomaterials. They have been widely used by researchers in various fields. Nanozymes, a group of inorganic nanomaterials, can mimic the function of real enzymes. They possess the specificity of natural enzymes for catalyzing specific substrates, as well as the unique electrical conductivity and stability of nanomaterials. Single-atom nanozyme materials have gained popularity due to their higher catalytic activity and tunable structure size, which is advantageous for analytical detection in biosensors and advancements in tumor therapy and antimicrobial therapy.
MICROCHEMICAL JOURNAL
(2023)
Review
Chemistry, Inorganic & Nuclear
Yan-Lin Chen, Yao-Guang Wang, Qi Yu
Summary: Photomechanical crystals that can convert light energy directly into mechanical work have gained increasing attention due to their dramatic behaviors and potential applications in photoactuators. One barrier in this field is the need to develop materials with stable, continuous, and reversible response behavior. Various strategies, such as coordination, have been explored to improve the mechanical properties of these crystals. In this review, we summarize recent progress in photomechanical complexes, discuss their possible applications, and address the challenges that still need to be overcome for future practical use.