Article
Chemistry, Analytical
Xiaoyi Lv, Fei Tan, Tian Miao, Jihui Zhang, Zhiwen Zhang, Bo Cui, Yishan Fang
Summary: In this study, a novel organoboron complex microrod with potential-resolved electrochemiluminescence (PRECL) property was synthesized. A competitive potential-resolved differential electrochemiluminescence immunosensor was fabricated using the microrod as a carrier to label competing antigens. The sensor exhibited excellent sensitivity and accuracy and achieved detection of target substances in walnut samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Jiaping Xie, Guomin Yang, Xingrong Tan, Ruo Yuan, Shihong Chen
Summary: This study developed a high-sensitivity detection method for the early diagnosis of Alzheimer's disease using polymeric nanoparticles as coreactant-free electrochemiluminescence emitters. By assembling these nanoparticles, along with gold nanoparticles and antibodies, on a biosensor, a sensitive analytical method for beta-amyloid(1-42) was established.
Article
Chemistry, Analytical
Xiaoyi Lv, Xiaoyun Xu, Tian Miao, Xufeng Zang, Chao Geng, Yanping Li, Bo Cui, Yishan Fang
Summary: Fluorescent dyes are potential candidates for electrochemiluminescence reagents, but their application is limited due to self-absorption effects. A novel ECL emitter BPYHBF was developed for labeling competitors in immunosensors, along with a sensing substrate MWCNTs/Fc-MOF to improve sensor sensitivity and reliability. The ratiometric competitive immunosensor was successfully prepared for ultrasensitive detection of AFB1, with excellent sensitivity, accuracy, and reproducibility demonstrated in actual samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Nanoscience & Nanotechnology
Wanlu Wang, Dexiang Feng, Yuanyuan Wang, Xianwen Kan
Summary: The development of a specifically sensitive approach for CA15-3 detection is important for early diagnosis and treatment monitoring of breast cancer. In this study, an electrochemiluminescence immunosensor with a dual-quenching strategy was constructed for the sensitive and selective detection of CA15-3.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Analytical
Juan Yang, Dongmiao Qin, Na Wang, Yusheng Wu, Kanjun Fang, Biyang Deng
Summary: An electrochemiluminescence resonance energy transfer (ECL-RET) immunosensor was constructed to detect beta-2-microglobulin (B2M) by using carbon nitride nanosheet and nickel- and iron-based organic framework modified with gold nanoparticles. The sandwich immunosensor showed a decrease in ECL intensity with increasing B2M concentration due to low conductivity of B2M. The ECL-RET immunosensor had a linear range of 10 fg/mL to 10 ng/mL and a limit of detection of 2.3 fg/mL (S/N = 3), exhibiting high sensitivity, specificity, and stability for B2M detection.
Article
Biophysics
Chenghui Hong, Pei Zhang, Kening Lu, Yu Ji, Shuang He, Dongqin Liu, Nengqin Jia
Summary: A new type of ECL immunosensor was prepared based on two different luminescence systems, enabling the detection of cTnI biomarker for acute myocardial infarction with high sensitivity and self-calibrating mechanism. This dual signal electrochemiluminescence method offers the advantages of low cost, simple analysis process, wide detection range, and good selectivity, making it a promising analysis protocol for clinical applications.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Haiyun Chen, Jie Huang, Rongjing Zhang, Fei Yan
Summary: In this study, the highly sensitive detection of alphafetoprotein (AFP) was achieved using electrochemiluminescence and electrochemistry. The utilization of vertically ordered mesoporous silica films as a sensing interface resulted in a signal amplification effect and excellent sensitivity. The dual-mode detection of AFP showed a low limit of detection and a wide linear range, with satisfactory results obtained in the analysis of human serum.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Asghar Ali, Jinxiu Zhao, Malik Saddam Khan, Huan Wang, Xiang Ren, Lihua Hu, Romana Manzoor, Dan Wu, Qin Wei
Summary: The study developed a highly efficient dual-quenching electrochemiluminescence immunosensor for sensitive detection of Aβ, utilizing specific nanomaterials with high sensitivity and specificity.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Jie Huang, Tongtong Zhang, Yanyan Zheng, Jiyang Liu
Summary: An ECL-EC dual-mode sensing platform based on vertically-ordered mesoporous silica films (VMSF) modified electrode was designed for the detection of breast cancer biomarker CA 15-3. VMSF was assembled through electrochemically assisted self-assembly and played a crucial role in signal amplification. The immunosensor successfully detected CA 15-3 in human serum without tedious pretreatment.
Article
Chemistry, Analytical
Xue Dong, Guanhui Zhao, Yuyang Li, Qingze Zeng, Hongmin Ma, Dan Wu, Xiang Ren, Qin Wei, Huangxian Ju
Summary: The ECL properties of polyoxomolybdatezirconia (POM-ZrO2) were discovered for the first time in this study, and their luminescence mechanism was explored. A dual-mechanism quenching strategy was successfully applied to the immunoassay of 17 beta-estradiol, demonstrating favorable analytical performance and a wide sensing range.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xinrong Shao, Xianzhen Song, Xin Liu, Liangguo Yan, Lei Liu, Dawei Fan, Qin Wei, Huangxian Ju
Summary: A dual signal-amplified sandwich electrochemiluminescence (ECL) immunosensor was successfully fabricated for highly sensitive detection of procalcitonin (PCT), demonstrating great potential for clinical applications.
Article
Chemistry, Analytical
Tengfei Shi, Lihua Hu, Jiye Chen, Qianqian Cui, Hao Yu, Yuyang Li, Dan Wu, Hongmin Ma, Qin Wei, Huangxian Ju
Summary: This work presents a dual-quenching electrochemiluminescence resonance energy transfer (ECL-RET) immunosensor for sensitive analysis of procalcitonin (PCT). The sensor utilizes polydopamine coated ZnO nanoflowers loaded with small-sized copper oxide nanoparticles to achieve double quenching effects, enhancing the emission performance of g-C3N4. The biosensor showed superior linear detection range and sensitive detection limit, providing a new technical means for the diagnosis of serious diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Tingting Han, Cheng Ma, Leyong Wang, Yue Cao, Hong-Yuan Chen, Jun-Jie Zhu
Summary: A novel electrochemiluminescence (ECL) Janus emitter combining ruthenium (II) complex and luminol polymer doped hemispheres enables dual-mode biosensing for multiple disease-related biomarkers from cells. It eliminates interference between different ECL mono-luminophores, improving ECL efficiency and detection sensitivity. It also enables ratiometric ECL sensing of H2O2 and simultaneous identification and quantification of cancer-related dual microRNAs.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Food Science & Technology
Shasha Feng, Wei Hu, Fubin Pei, Zhiwei Liu, Bin Du, Xihui Mu, Bing Liu, Qingli Hao, Wu Lei, Zhaoyang Tong
Summary: A sensitive dual-readout immunosensor combining fluorescence and electrochemiluminescence (ECL) detection was developed for ricin detection. The sensor utilized CdSe/ZnS quantum dots as dual-signal function probes and a streptavidin-biotin signal amplification system. The sensor exhibited high sensitivity and could successfully detect ricin in complex matrices.
Article
Chemistry, Analytical
Yujie Han, Yu Du, Kun Xu, Xiang Ren, Guanhui Zhao, Zhuangzhuang Ru, Yue Jia, Qin Wei
Summary: An electrochemiluminescence-electrochemistry (ECL-EC) dual-mode biosensing platform was developed to detect Microcystin-LR (MC-LR) with high sensitivity. The platform utilized sulfur quantum dots (SQDs) as an ECL cathode emitter and Ag+ as an ECL signal-amplifying molecule. The biosensor achieved detection in the range of 0.001-100 pg/mL MC-LR concentration with detection limits of 0.17 and 0.24 pg/mL for ECL and EC, respectively.
ANALYTICAL CHEMISTRY
(2023)
Article
Computer Science, Artificial Intelligence
Jiangxin Yang, Lingyu Wang, Lifei Ren, Yanpeng Cao, Yanlong Cao
Summary: This paper proposes an end-to-end light field angular super-resolution network by exploiting structure and scene information to mitigate the trade-off between angular and spatial resolution. It utilizes a Light Field ResBlock to extract epipolar plane image features and scene features, and employs 4D deconvolution to upsample the angular resolution based on these features. The refinement network further exploits LF structure and scene information to alleviate artifacts induced by too little angular information.
APPLIED INTELLIGENCE
(2023)
Article
Meteorology & Atmospheric Sciences
Jing Wang, Jing Chen, Yongzhu Liu, Juanjuan Liu, Bin Wang, Xiaoli Li, FaJing Chen, Zhenhua Huo
Summary: In this study, a moist singular vector (MSV) was developed and evaluated through numerical experiments. The results showed that the linearized moist physical processes have an impact on the spread and structure of MSV, and they can improve the prediction performance of rainfall and atmospheric circulation field.
Article
Pathology
Sung-liang Yu, Yi-jing Hsiao, Wendy A. Cooper, Yoon-la Choi, A. L. E. J. A. N. D. R. O. Aviles-salas, Teh-ying Chou, R. E. N. A. T. A. Coudry, Grigory A. Raskin, Stephen B. Fox, Chao-cheng Huang, Yoon Kyung Jeon, Young-hyeh Ko, Wen-hui Ku, Ghee-young Kwon, C. O. N. N. U. L. L. Leslie, Mei-chun Lin, Pei-jen Lou, C. R. I. S. T. O. V. A. M. Scapulatempo-neto, Saulo Mendoza Ramirez, N. I. K. I. T. A. Savelov, Hyo-sup Shim, Cesar Octavio Lara Torres, Isabela Werneck Cunha, L. A. R. I. S. A. Zavalishina, Yan-ming Chen
Summary: This study assessed the performance of PD-L1 diagnostic assays in NSCLC, HNSCC, and UC. The results showed that the performance of Ventana SP263 and Dako 22C3 assays was comparable in NSCLC and HNSCC. However, in UC, the performance of Ventana SP263 assay was less reliable and may impact treatment decisions.
Article
Engineering, Environmental
Lina Zheng, Ruixue Xu, Jinjin Zhang, Fangyong Yu, Claudia Li, Jaka Sunarso, Weimin Zhang, Xiuxia Meng, Naitao Yang
Summary: Patterned electrolyte surfaces were prepared using stereolithography 3D printing technology to investigate their effects on the cell performance of solid oxide fuel cells. The concavo-convex electrolyte showed significantly higher power density than the planar electrolyte, indicating that the geometry of the electrolyte surface plays a crucial role in enhancing cell performance.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Jingcheng Feng, Yanling Cheng, Chuan Tang, Lei Bai, Fei Liang, Heng Tu, Jun Shen, Haohai Yu, Guochun Zhang, Yicheng Wu
Summary: By investigating the relationship between structure and optical properties, the Nd3+-doped La2CaB8O16 crystal with a long rare-earth ion distance more than 4.27 angstrom was found to allow a high doping concentration and exhibit a weak fluorescence quenching effect. Nd3+-doped La2CaB8O16 crystals with different concentrations were successfully grown by the top seeded solution growth method, showing large size, high optical quality, strong absorption band at 800 nm, and a fluorescence band at 1055 nm. A diode-pumped orthogonally polarized dual-wavelength laser operation at 1052 and 1055 nm was realized, with a slope efficiency of 16.3% and output power of 859 mW. The Nd3+-doped La2CaB8O16 crystal is a promising laser gain medium for 1 μm lasers and possible generation of terahertz radiation.
CHEMISTRY OF MATERIALS
(2023)
Article
Physics, Mathematical
Dongxiang Chen, Xiaoli Li, Xiaoli Chen
Summary: In this paper, we prove the asymptotic stability of a specific stationary solution to 2D magnetohydrodynamic flow without resistivity in an infinite flat strip. Additionally, we establish some explicit decay rates.
JOURNAL OF MATHEMATICAL PHYSICS
(2023)
Correction
Oncology
Yen-Hsiang Huang, Kuo-Hsuan Hsu, Jeng-Sen Tseng, Tsung-Ying Yang, Kun-Chieh Chen, Kang-Yi Su, Sung-Liang Yu, Jeremy J. W. Chen, Gee-Chen Chang
Article
Engineering, Civil
Qingsong Feng, Zhou Yang, Wenjie Guo, Jianfei Lu, Xiaoyan Lei, Jianwei Yan
Summary: This study analyzes the dispersion characteristics of box girder structures by developing a semi-analytical method based on the energy method. The method utilizes virtual springs to simulate Bloch boundaries, addressing the complexity of constructing displacement functions that satisfy the Bloch boundary conditions. By simplifying the box girder structure to a spatial plate coupling model and establishing a dispersion control equation, the propagation characteristics of elastic waves in the box girder are studied.
THIN-WALLED STRUCTURES
(2023)
Article
Cardiac & Cardiovascular Systems
Xuecheng Zhang, Jing Kang, Jingjing Zhang, Ying Chen, Hengheng Dai, Mingzhi Hu, Yan Liu, Hongcai Shang
Summary: This study aims to evaluate the effectiveness of YQFM in patients with AHF in a real-world setting and compare the results with the AUGUST-AHF RCT study. The study will be conducted in 50 secondary and tertiary hospitals in China, including 1,200 AHF patients followed for at least 180 days. The primary outcome is a composite of 90-day all-cause mortality or readmission for heart failure. Cox proportional-hazards regression models will be used to estimate the association between YQFM use and the primary outcome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Health Care Sciences & Services
Tingting Zheng, Wenjuan Hu, Hao Wang, Xiaoli Xie, Lang Tang, Weiyan Liu, Pu-Yeh Wu, Jingjing Xu, Bin Song
Summary: The study aimed to investigate the relationship between texture analysis features based on magnetic resonance imaging (MRI) and BRAF V600E mutation in papillary thyroid carcinoma (PTC). The results showed that MRI-based texture analysis could be a potential method for predicting BRAF V600E mutation in PTC preoperatively.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Article
Computer Science, Artificial Intelligence
Emadeldeen Eldele, Mohamed Ragab, Zhenghua Chen, Min Wu, Chee-Keong Kwoh, Xiaoli Li, Cuntai Guan
Summary: Sleep staging is crucial for diagnosing and treating sleep disorders. Current data-driven deep learning models for automatic sleep staging have limitations when dealing with real-world scenarios. To overcome these limitations, this study proposes a novel adversarial learning framework called ADAST, which addresses the domain shift problem in the unlabeled target domain. The proposed framework outperforms state-of-the-art methods in six cross-domain scenarios.
IEEE TRANSACTIONS ON EMERGING TOPICS IN COMPUTATIONAL INTELLIGENCE
(2023)
Article
Environmental Sciences
Xingming Hao, Xue Fan, Zhuoyi Zhao, Jingjing Zhang
Summary: This study used estimated potential evapotranspiration (PET) and reanalysis data to investigate the changing trends and driving factors of evapotranspiration (ET) in Central Asia. The results showed a generally downward trend in PET and ET, but with opposite trends in 59.41% of the study area. The coupling factor of vegetation-human activity (VH) was the main determinant of ET. The findings of this study can provide scientific support for water resource restoration and sustainability evaluation in the context of global climate change.
Article
Chemistry, Physical
Melissa Guarino-Hotz, Jeremy L. Barnett, Kai-Chun Chou, Allison A. Win, Heng Zhang, Chengyu Song, Scott R. J. Oliver, Jin Z. Zhang
Summary: Metal halide perovskites, such as methylammonium lead bromide (MAPbBr3), have attracted significant attention for their interesting photoelectric properties. In this study, two different types of methylammonium lead bromide magic-sized clusters (MSCs) were synthesized using different methods and their optical properties were characterized. It was found that the heated LARP (HLARP) synthesis method resulted in MSCs with higher photoluminescence (PL) quantum yield and improved stability in both solution and solid state forms. The addition of a non-coordinating matrix, paraffin, further enhanced the stability of the MSCs. The MSCs were analyzed using various techniques, including Raman spectroscopy, X-ray diffraction, and transmission electron microscopy, to confirm their structure and properties.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Medicine, General & Internal
Ping-Yang Hong, Mao-Hong Huang, Feng-Fu Zhan, Yi-Li Lin, Shao-Zhao Qiu, Xiao-Bin Zhang
Summary: The use of Montgomery T-tube is safe and effective for patients with complex subglottic tracheal stenosis.
Article
Medicine, Research & Experimental
Ming Bai, Jingjing Zhang, De Chen, Mengying Lu, Junfen Li, Zheng Zhang, Xiaowei Niu
Summary: This study provides a bibliometric analysis of myocardial ischemia/reperfusion (MI/R) injury research, revealing an increasing trend in publications from 2012 to 2021. China, the USA, Germany, England, and Italy were the top contributors to MI/R studies. The study identifies major research areas and hotspots in MI/R research, including mitochondrial quality control, non-coding RNAs, cell proliferation, and extracellular vesicles.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)