Review
Medicine, General & Internal
Sarah Patel, Bethany Doerfler, Katerine Boutros, Samson Ng, Machelle Manuel, Elayne DeSimone
Summary: IBS-C and CIC are common disorders of gut-brain interaction, presenting with symptoms such as constipation, abdominal pain, and bloating that significantly impact quality of life. Family medicine practitioners are uniquely qualified to diagnose and manage these conditions.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Brooks D. Cash, Amol Sharma, Anna Walker, Adam P. Laitman, Lin Chang
Summary: This study aimed to evaluate the effectiveness of plecanatide in patients with chronic idiopathic constipation (CIC) or irritable bowel syndrome with constipation (IBS-C) with severe constipation. The results showed that plecanatide significantly improved the symptoms of severe constipation in both CIC and IBS-C patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Medicine, General & Internal
Juan J. Sebastian Domingo
Summary: Irritable bowel syndrome is a common functional bowel disorder with significant impact on patients' daily lives and society's economy. It is characterized by abdominal pain, bloating, and altered bowel movements, and its etiology and pathophysiological mechanism are still unknown.
Article
Gastroenterology & Hepatology
Charles Barish, Spencer Dorn, Ronald P. Fogel, Reema Patel, Jonathan Rosenberg
Summary: Plecanatide is an effective and well-tolerated treatment for CIC, relieving symptoms with a low incidence of diarrhea.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Gregory S. Sayuk, Scott A. Waldman, Darren M. Brenner
Summary: This article summarizes the mechanisms of action of commonly used therapies for chronic idiopathic constipation and irritable bowel syndrome with constipation, explaining how these mechanisms contribute to the effectiveness and safety of each treatment option.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Oana-Bogdana Barboi, Ioan Chirila, Irina Ciortescu, Carmen Anton, Vasile-Liviu Drug
Summary: This study suggests that a specific constipation diet combined with inulin, choline, and silymarin can have significant clinical benefits on IBS patients with constipation, improving bowel movement, abdominal pain, and bloating symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Giuseppe Chiarioni, Stefan Lucian Popa, Abdulrahman Ismaiel, Cristina Pop, Dinu Iuliu Dumitrascu, Vlad Dumitru Brata, Traian Adrian Duse, Victor Incze, Teodora Surdea-Blaga, Jose Antonio Uranga
Summary: This systematic review evaluates the efficacy and safety of herbal remedies in the management of IBS-C. The included studies demonstrate some evidence of the beneficial effects of herbal remedies on IBS-C symptoms. However, the heterogeneity of the interventions and outcome measures limits the ability to perform a meta-analysis.
Article
Gastroenterology & Hepatology
Kate Scarlata, Shanti Eswaran, Jason R. Baker, William D. Chey
Summary: The aim of this study was to identify the benefits and barriers of using a gastroenterology (GI) dietitian for irritable bowel syndrome (IBS) care. The results of the survey showed gaps in nutrition-based interventions for IBS care, as well as a significant number of respondents lacking access to a local GI dietitian, despite the majority agreeing that it would be beneficial.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Sameer K. Berry, Rani Berry, David Recker, Jeffrey Botbyl, Lucy Pun, William D. Chey
Summary: Digital gut-directed hypnotherapy (GDH) treatment program can improve symptoms of IBS, including abdominal pain and stool problems. There was no significant difference in effectiveness between digital GDH and digital muscle relaxation (MR), but the GDH treatment group had more abdominal pain responders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Jakub Wlodarczyk, Anna Wasniewska, Jakub Fichna, Adam Dziki, Lukasz Dziki, Marcin Wlodarczyk
Summary: Constipation is a major gastrointestinal disorder in Western countries, affecting almost 20% of the population. The pathophysiology is complex and multifactorial, making diagnosis and treatment challenging. Both nonpharmacological and pharmacological approaches are used, with surgery being a potential solution for refractory cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Theodora Kalli, Tilemachos Koutouratsas, George Karamanolis, Maria Gazouli
Summary: The study found a significant association between the rs696217 genetic polymorphism and IBS susceptibility, with the GG and GT genotypes as well as the G allele being linked to IBS risk, while the T allele may have a protective effect. There was no correlation between ghrelin gene polymorphisms and different IBS subtypes.
Article
Gastroenterology & Hepatology
Dipesh H. Vasant, Peter A. Paine, Christopher J. Black, Lesley A. Houghton, Hazel A. Everitt, Maura Corsetti, Anurag Agrawal, Imran Aziz, Adam D. Farmer, Maria P. Eugenicos, Rona Moss-Morris, Yan Yiannakou, Alexander C. Ford
Summary: This guideline aims to review and summarize current evidence on irritable bowel syndrome (IBS) to inform clinical practice and provide guidance, with specific treatment recommendations based on evidence from a comprehensive search of medical literature. The guideline highlights the efficacy of dietary, pharmacological, and psychological therapies in treating IBS, and provides specific recommendations according to the Grading of Recommendations Assessment, Development, and Evaluation system.
Review
Pharmacology & Pharmacy
Esther Colomier, Joost Algera, Chloe Melchior
Summary: Irritable bowel syndrome is a common disorder affecting the gut-brain axis, with four subtypes and a focus on pharmacological treatment for patients with IBS-D. The treatment remains challenging due to the heterogeneous patient population, lack of effective drugs, and multifactorial pathophysiology. Healthcare professionals can use a proposed algorithm for treating individual patients with IBS-D.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Giovanni Barbara, Cesare Cremon, Massimo Bellini, Maura Corsetti, Giovanni Di Nardo, Francesca Falangone, Lorenzo Fuccio, Francesca Galeazzi, Paola Iovino, Giovanni Sarnelli, Edoardo Vincenzo Savarino, Vincenzo Stanghellini, Annamaria Staiano, Cristina Stasi, Cesare Tosetti, Rossella Turco, Enzo Ubaldi, Rocco Maurizio Zagari, Letizia Zenzeri, Giovanni Marasco
Summary: This study provides consensus on the diagnosis and treatment of irritable bowel syndrome (IBS), suggesting a symptom-based diagnostic strategy and evaluating and recommending different treatment methods.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Meeting Abstract
Gastroenterology & Hepatology
Bryan Love, Christopher Finney, Jill Gaidos
INFLAMMATORY BOWEL DISEASES
(2020)
Article
Multidisciplinary Sciences
Adam G. Pizzuti, Karan H. Patel, Erin K. McCreary, Emily Heil, Christopher M. Bland, Eric Chinaeke, Bryan L. Love, P. Brandon Bookstaver
Correction
Gastroenterology & Hepatology
Lorne J. Hofseth, James R. Hebert, Anindya Chanda, Hexin Chen, Bryan L. Love, Maria M. Pena, E. Angela Murphy, Mathew Sajish, Amit Sheth, Phillip J. Buckhaults, Franklin G. Berger
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Bryan L. Love, Christopher J. Finney, Jill K. J. Gaidos
Summary: This study identified risk factors for severe pneumococcal disease in IBD patients, including having Crohn's disease, more comorbidities, and exposure to combination immunosuppression. Vaccination with pneumococcal vaccines, especially the combination of PCV13 and PPSV23, significantly reduced the risk of severe pneumococcal disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Pharmacology & Pharmacy
Eric E. Chinaeke, Bryan L. Love, Joe Magagnoli, Ismaeel Yunusa, Gene Reeder
Summary: This study demonstrates that the use of statins is associated with a decrease in 30-day ICU mortality, ICU LOS, and 30-day in-hospital mortality among patients with sepsis.
Letter
Medicine, General & Internal
Ismaeel Yunusa, Bryan L. Love, Chao Cai, Tessa Hastings, Claiborne E. Reeder, Elizabeth W. Blake, Cynthia Phillips
Summary: This cross-sectional study compares the number of insulin prescriptions filled before and during the COVID-19 pandemic to understand the influencing factors.
Article
Public, Environmental & Occupational Health
Chao Cai, Bryan L. Love, Ismaeel Yunusa, Claiborne E. Reeder
Summary: Standard survival models may bias the estimation of medication persistence if there is a high rate of long-term persistent patients. In this study, a mixture cure model was introduced to improve the estimation of medication persistence.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Health Care Sciences & Services
Chelsea L. Richard, Bryan L. Love, Nansi Boghossian, James Hardin, Suzanne McDermott
Summary: This study examines the difference in opioid prescribing during pregnancy by disability status among Medicaid beneficiaries in South Carolina. The findings indicate that women with disabilities, particularly those with physical, inflammatory, and psychiatric disabilities, are prescribed more opioids and at higher dosages during pregnancy compared to women without disabilities.
DISABILITY AND HEALTH JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Ismaeel Yunusa, Bryan L. Love
Summary: This study evaluated the economic and clinical implications of using vonoprazan-based and rifabutin-based regimens compared to other existing prepackaged first-line treatment options for eradicating Helicobacter pylori (H. pylori) in the United States. The findings suggest that vonoprazan triple therapy provides the greatest net health and monetary benefit for US healthcare payers.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Mohiuddin Ahsanul Kabir Chowdhury, James W. Hardin, Bryan L. Love, Anwar T. Merchant, Suzanne McDermott
Summary: The study examined the association between nonsteroidal anti-inflammatory drug (NSAID) use during pregnancy and autism spectrum disorder (ASD) and intellectual disability (ID) in children. A retrospective cohort study was conducted using multiple datasets in South Carolina between 2010 and 2017. Results showed that NSAID use during pregnancy was associated with ID only, but not with ASD.
JOURNAL OF WOMENS HEALTH
(2023)
Letter
Gastroenterology & Hepatology
Ismaeel Yunusa, Bryan L. Love
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Clinical Neurology
Margaret A. Turk, Suzanne McDermott, Wanfang Zhang, Bo Cai, Bryan L. Love, NaTasha Hollis
Summary: The purpose of this study was to investigate the association between filling opioid prescriptions and healthcare service utilization among adults with disability. The results showed that a higher proportion of adults with inflammatory conditions or longstanding physical disability filled opioid prescriptions compared to those without these conditions. Additionally, individuals who filled opioid prescriptions were more likely to have higher rates of emergency department visits and hospitalizations.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Health Care Sciences & Services
Rouen Brockmann, Joanna Nixon, Bryan L. Love, Ismaeel Yunusa
Summary: In 2021, the FDA approved aducanumab for early-stage Alzheimer's disease without clear clinical evidence of cognitive benefits. The initial price of the drug was $56,000 per year, later reduced to $28,200. However, CMS will only cover individuals in clinical trials and limit coverage for future antiamyloid antibodies, causing confusion and concerns. These decisions raise questions about the approval process and accessibility of the drug, impacting future Alzheimer's treatments. Stakeholders need to work together to address these challenges and ensure access to effective and affordable treatments.
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Health Policy & Services
Eric E. Chinaeke, Minghui Li, Bryan L. Love, Brandon Bookstaver, Xiaoming Li, Gene Reeder, Kevin Lu
Summary: The comorbidity of Type-II Diabetes Mellitus imposes a significant economic burden on HIV/AIDS patients and Medicare, especially among African Americans.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Health Policy & Services
Eric E. Chinaeke, Minghui Li, Brandon Bookstaver, Bryan L. Love, Xiaoming Li, Gene Reeder, Kevin Lu
Summary: This study found an association between the use of protease inhibitors (PI) in HIV/AIDS patients and an increased risk of developing type II diabetes mellitus (T2DM), with African Americans having a higher risk compared to Caucasians.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)