Article
Gastroenterology & Hepatology
Kate Scarlata, Shanti Eswaran, Jason R. Baker, William D. Chey
Summary: The aim of this study was to identify the benefits and barriers of using a gastroenterology (GI) dietitian for irritable bowel syndrome (IBS) care. The results of the survey showed gaps in nutrition-based interventions for IBS care, as well as a significant number of respondents lacking access to a local GI dietitian, despite the majority agreeing that it would be beneficial.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Reena Sidhu, David Turnbull, Hasan Haboubi, John S. Leeds, Chris Healey, Srisha Hebbar, Paul Collins, Wendy Jones, Mohammad Farhad Peerally, Sara Brogden, Laura J. Neilson, Manu Nayar, Jacqui Gath, Graham Foulkes, Nigel J. Trudgill, Ian Penman
Summary: This is a guideline commissioned by the British Society of Gastroenterology, providing detailed information on sedation methods and recent advances in gastrointestinal endoscopy. The guideline covers both elective and emergency procedures, and offers guidance on enhancing safety and minimizing complications.
Article
Gastroenterology & Hepatology
Christopher J. Black, Peter A. Paine, Anurag Agrawal, Imran Aziz, Maria P. Eugenicos, Lesley A. Houghton, Pali Hungin, Ross Overshott, Dipesh H. Vasant, Sheryl Rudd, Richard C. Winning, Maura Corsetti, Alexander C. Ford
Summary: This research aims to review and summarize the current evidence on functional dyspepsia, provide a practical framework for evidence-based diagnosis and treatment of patients, and provide specific recommendations based on the GRADE system. The study also considers the development of novel treatment methods and highlights areas of unmet need and priorities for future research.
Review
Medicine, General & Internal
David Nunan, Ting Cai, Antoni D. Gardener, Jose M. Ordonez-Mena, Nia W. Roberts, Elizabeth T. Thomas, Kamal R. Mahtani
Summary: This study evaluated the benefits and harms of physical activity interventions in adults with irritable bowel syndrome (IBS) based on 11 randomized controlled trials. The results suggest that physical activity may improve symptoms of IBS, but the effects on quality of life and abdominal pain are uncertain. The certainty of evidence is very low, indicating a need for higher quality research in this area.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Gastroenterology & Hepatology
Jochen Kammermeier, Christopher A. Lamb, Kelsey D. J. Jones, Carl A. Anderson, Emma L. Baple, Chrissy Bolton, Helen Braggins, Tanya Coulter, Kimberly C. Gilmour, Vicki Gregory, Sophie Hambleton, David Hartley, A. Barney Hawthorne, Sarah Hearn, Arian Laurence, Miles Parkes, Richard K. Russell, R. Alexander Speight, Simon Travis, David C. Wilson, Holm H. Uhlig
Summary: Genomic medicine enables the identification of rare forms of inflammatory bowel disease (IBD) and supports clinical decision making. More than 100 genetic disorders can present with IBD, requiring adaptive genomic technologies. The aim of this guideline is to ensure appropriate use of genomic technologies in IBD diagnosis and treatment, and to optimize healthcare resources. The guideline provides structural requirements for genomic medicine and outlines the diagnostic care pathway for patients of different age groups.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Article
Gastroenterology & Hepatology
Anjan Dhar, Hasan N. Haboubi, Stephen E. Attwood, Marcus K. H. Auth, Jason M. Dunn, Rami Sweis, Danielle Morris, Jenny Epstein, Marco R. Novelli, Hannah Hunter, Amanda Cordell, Sharon Hall, Jamal O. Hayat, Kapil Kapur, Andrew Robert Moore, Carol Read, Sarmed S. Sami, Paul J. Turner, Nigel J. Trudgill
Summary: This study provides a comprehensive guideline for the evaluation and management of EoE for both pediatric and adult gastroenterologists. The guideline is based on evidence and expert consensus, aiming to assist clinicians in the management of patients with EoE and its complications.
Review
Medicine, General & Internal
Yi-Lin Liu, Jin-Song Liu
Summary: IBS is a common gastrointestinal disease globally, with current guidelines mainly based on western populations. China, with its large population, has a vast literature on IBS, but linguistic variations have caused these studies to be less known in western medical literature. Research on IBS in the Chinese population can benefit understanding and future studies in this area.
CHINESE MEDICAL JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Gastroenterology & Hepatology
Simon M. Rushbrook, Timothy James Kendall, Yoh Zen, Raneem Albazaz, Prakash Manoharan, Stephen P. Pereira, Richard Sturgess, Brian R. Davidson, Hassan Z. Malik, Derek Manas, Nigel Heaton, K. Raj Prasad, John Bridgewater, Juan W. Valle, Rebecca Goody, Maria Hawkins, Wendy Prentice, Helen Morement, Martine Walmsley, Shahid A. Khan
Summary: These guidelines commissioned by the British Society of Gastroenterology liver section provide guidance for the diagnosis and management of cholangiocarcinoma (CCA). The writing committee includes a multidisciplinary team of experts and patient/public representatives. Quality of evidence is evaluated using the AGREE II format. The recommendations are meant to guide rather than serve as strict references.
Review
Gastroenterology & Hepatology
Edoardo Savarino, Fabiana Zingone, Brigida Barberio, Giovanni Marasco, Filiz Akyuz, Hale Akpinar, Oana Barboi, Giorgia Bodini, Serhat Bor, Giuseppe Chiarioni, Gheorghe Cristian, Maura Corsetti, Antonio Di Sabatino, Anca Mirela Dimitriu, Vasile Drug, Dan L. Dumitrascu, Alexander C. Ford, Goran Hauser, Radislav Nakov, Nisha Patel, Daniel Pohl, Catalin Sfarti, Jordi Serra, Magnus Simren, Alina Suciu, Jan Tack, Murat Toruner, Julian Walters, Cesare Cremon, Giovanni Barbara
Summary: This article summarizes the current state of consensus on the definition, diagnosis, and management of irritable bowel syndrome with diarrhoea (IBS-D) and functional diarrhoea (FDr). Through literature summary and voting, European experts reached a consensus on 31 statements and provided guidance on diagnosis and treatment.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Review
Nutrition & Dietetics
Robin Spiller
Summary: IBS is strongly influenced by diet, but identifying specific food intolerances is difficult due to the complexities of diet. Rapidly fermented carbohydrates and gut-specific mast cell activation may cause symptoms in IBS patients. More research is needed to fully understand the mechanisms of food intolerances and improve personalized medicine approaches to diet in IBS.
Article
Gastroenterology & Hepatology
Jonathon Snook, Neeraj Bhala, Ian L. P. Beales, David Cannings, Chris Kightley, Robert Ph Logan, D. Mark Pritchard, Reena Sidhu, Sue Surgenor, Wayne Thomas, Ajay M. Verma, Andrew F. Goddard
Summary: Iron deficiency anaemia is a major global cause of disease burden, diagnosed through blood testing and treated with iron replacement therapy. Causes include poor diet and gastrointestinal pathologies, with endoscopy and radiological scanning used for diagnosis and assessment in some cases.
Review
Pharmacology & Pharmacy
Esther Colomier, Joost Algera, Chloe Melchior
Summary: Irritable bowel syndrome is a common disorder affecting the gut-brain axis, with four subtypes and a focus on pharmacological treatment for patients with IBS-D. The treatment remains challenging due to the heterogeneous patient population, lack of effective drugs, and multifactorial pathophysiology. Healthcare professionals can use a proposed algorithm for treating individual patients with IBS-D.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Andrew M. Veitch, Franco Radaelli, Raza Alikhan, Jean-Marc Dumonceau, Diane Eaton, Jo Jerrome, Will Lester, David Nylander, Mo Thoufeeq, Geoffroy Vanbiervliet, James R. Wilkinson, Jeanin E. Van Hooft
Summary: This is a collaboration between the British Society of Gastroenterology and the European Society of Gastrointestinal Endoscopy to update the 2016 guideline on endoscopy in patients on antiplatelet or anticoagulant therapy. The development process adhered to AGREE II principles and utilized GRADE methodology to derive the quality of evidence and strength of recommendations. The risk categories for endoscopic procedures and thrombosis have been revised based on evidence, with a particular focus on atrial fibrillation and strengthened recommendations for direct oral anticoagulants.
Review
Oncology
Mary Anne Lagmay Tanay, Jo Armes, Rona Moss-Morris, Anne Marie Rafferty, Glenn Robert
Summary: This study aimed to evaluate the effects of behavioral and exercise interventions on preventing or managing CIPN symptoms. The results showed that exercise interventions have beneficial effects on CIPN symptoms, although higher quality research is needed to confirm this. Behavioral interventions that increase patient's CIPN knowledge and improve self-management capacity can also reduce symptoms.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Review
Gastroenterology & Hepatology
Brigida Barberio, Pierfrancesco Visaggi, Edoardo Savarino, Nicola de Bortoli, Christopher J. Black, Alexander C. Ford
Summary: This study conducted a network meta-analysis to evaluate the efficacy and safety of different medical therapies for endoscopy-negative reflux disease. The results showed that proton pump inhibitors (PPIs) are superior to other drugs in treating this condition. Future research should focus on better patient classification and investigating the efficacy of other drugs.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Maria Rosa Ingrosso, Michael Camilleri, Jan Tack, Gianluca Ianiro, Christopher J. Black, Alexander C. Ford
Summary: This study evaluated the efficacy and safety of drugs for gastroparesis through a network meta-analysis. The results showed that oral dopamine antagonists and tachykinin-1 antagonists were more effective than placebo. For individual symptoms, oral metoclopramide showed good efficacy for nausea, fullness, and bloating. However, the confidence in the evidence for most comparisons was low to moderate, indicating a need for more effective therapies for gastroparesis.
Article
Gastroenterology & Hepatology
Brigida Barberio, David J. Gracie, Christopher J. Black, Alexander C. Ford
Summary: In this study, the authors conducted a systematic review and meta-analysis to evaluate the impact of criteria used to define CD activity at study entry and the time point used to confirm efficacy on the therapeutic gain of active drug over placebo. The results showed that both factors appeared to be important in maximizing the treatment effect of active drug compared to placebo.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
David Gunn, Alexander Ford, Amanda Farrin, Robin Spiller
Summary: This article is related to the papers by Gunn et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Vivek C. Goodoory, Elspeth A. Guthrie, Cho Ee Ng, Christopher J. Black, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Vivek C. Goodoory, Cho E. Ng, Christopher J. Black, Alexander C. Ford
Summary: This article is associated with Goodoory et al papers. Click the link to access these articles.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Alexander C. Ford, Colin W. Howden
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hussain Jaafari, Lesley A. Houghton, Robert M. West, Anurag Agrawal, Imran Aziz, Christopher J. Black, Maura Corsetti, Farag Shuweihdi, Maria Eugenicos, Peter A. Paine, Alexander C. Ford, Peter J. Whorwell, Shrikant I. Bangdiwala, Olafur S. Palsson, Ami D. Sperber, Dipesh H. Vasant
Summary: This study compared the prevalence of disorders of gut brain interaction (DGBI) in the UK with other countries and found that the proportion of DGBI participants was lower in the UK. The prevalence of 14 out of 22 Rome IV DGBI was similar between the UK and other countries, while some specific DGBI were more prevalent in the UK. Differences in opioid prescribing, cultural, dietary, and lifestyle factors may contribute to variations in the prevalence of DGBI between the UK and other countries.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Syed S. Hasan, Sarah Ballou, Laurie Keefer, Dipesh H. Vasant
Summary: Gut-directed hypnotherapy (GDH) is a highly effective behavioral therapy recommended for the treatment of irritable bowel syndrome (IBS). GDH has been recognized as a valuable addition to integrated care alongside medical and dietary approaches. Recent innovations, such as smartphone app-delivered GDH, have improved access to this therapy despite low adherence rates.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Christy Riggott, Keeley M. Fairbrass, Christopher J. Black, David J. Gracie, Alexander C. Ford
Summary: Using latent class analysis, this study identified novel clusters of patients with inflammatory bowel disease (IBD) and found that patients with higher gastrointestinal and psychological symptoms were at a higher risk of adverse disease outcomes and were also high-volume users of healthcare.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Kee-Huat Chuah, Christopher J. Black, Vincent Tee, Sze-Zee Lim, Wen-Xuan Hian, Nur-Fazimah Sahran, Yeong-Yeh Lee, Sanjiv Mahadeva, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Ayodele Sasegbon, Yuying Luo, Laurie A. Keefer, Dipesh H. Vasant
Summary: Despite the high prevalence and burden of disorders of gut-brain interaction (DGBI), there is limited teaching on this topic in medical curricula. This study evaluated the exposure and comfort levels of UK gastroenterology trainees in diagnosing and managing DGBI. Findings suggest that most trainees lack confidence in dealing with DGBI.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Editorial Material
Gastroenterology & Hepatology
Maura Corsetti, Andrea Shin, Christopher Black, Daniel Keszthelyi, Fedias L. Christofi, Frank Zerbib, Kirsteen Browning, Michael Jones
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Neurosciences
Iris Knoop, Annie S. K. Jones, Nicholas Gall, Joseph Chilcot, William Pascoe, Rona Moss-Morris
Summary: This study aims to evaluate the psychometric properties of the OGS and SSS as effective measurement instruments for patients with suspected and confirmed POTS.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2023)