SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model

Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation

(2011) Chung-Lan Kao et al.   Journal of Atherosclerosis and Thrombosis

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1

(2010) Ting Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD

(2010) Jae-woong Hwang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues

(2010) Marcella Fulco et al.   CELL CYCLE

Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells

(2010) Brittney Jung-Hynes et al.   CELL CYCLE

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

AMP-activated protein kinase and its downstream transcriptional pathways

(2010) Carles Cantó et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells

(2010) Yi Zu et al.   CIRCULATION RESEARCH

An Energy-Sensor Network Takes Center Stage During Endothelial Aging

(2010) Michael Potente   CIRCULATION RESEARCH

Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation

(2010) Jinling Hou et al.   CURRENT NEUROVASCULAR RESEARCH

SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol

(2010) M. D. Fullerton et al.   DIABETES

Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

(2010) Zhenggang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

(2010) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

Sirtuin 1 regulation of developmental genes during differentiation of stem cells

(2010) V. Calvanese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shear stress, SIRT1, and vascular homeostasis

(2010) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

Aging: Central role for autophagy and the lysosomal degradative system

(2009) Yogendra S. Rajawat et al.   AGEING RESEARCH REVIEWS

Signaling mechanisms of angiotensin II in regulating vascular senescence

(2009) Li-Juan Min et al.   AGEING RESEARCH REVIEWS

AMPK and the biochemistry of exercise: implications for human health and disease

(2009) Erik A. Richter et al.   BIOCHEMICAL JOURNAL

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

SIRT1: Regulation of longevity via autophagy

(2009) Antero Salminen et al.   CELLULAR SIGNALLING

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirolimus and Everolimus Induce Endothelial Cellular Senescence Via Sirtuin 1 Down-Regulation

(2009) Hidetaka Ota et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3  Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway

(2009) S. M. Shin et al.   MOLECULAR PHARMACOLOGY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

(2008) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of Lkb1 Provokes Highly Invasive Endometrial Adenocarcinomas

(2008) C. M. Contreras et al.   CANCER RESEARCH

Unexpected Pieces to the Senescence Puzzle

(2008) Karen Cichowski et al.   CELL

Conserved Metabolic Regulatory Functions of Sirtuins

(2008) Bjoern Schwer et al.   Cell Metabolism

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells

(2008) Zhonglin Xie et al.   CIRCULATION

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Senescence: the good the bad and the dysfunctional

(2008) Ermira Pazolli et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Regulation of SIRT1 protein levels by nutrient availability

(2008) Yariv Kanfi et al.   FEBS LETTERS

Premature aging in mice activates a systemic metabolic response involving autophagy induction

(2008) Guillermo Mariño et al.   HUMAN MOLECULAR GENETICS

Vascular endothelial senescence: from mechanisms to pathophysiology

(2008) Jorge D. Erusalimsky   JOURNAL OF APPLIED PHYSIOLOGY

AMP-activated Protein Kinase Contributes to UV- and H2O2-induced Apoptosis in Human Skin Keratinocytes

(2008) Cong Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rosiglitazone Stimulates Nitric Oxide Synthesis in Human Aortic Endothelial Cells via AMP-activated Protein Kinase

(2008) James G. Boyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Nitrogen Species Is Required for the Activation of the AMP-activated Protein Kinase by Statinin Vivo

(2008) Hyoung Chul Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage, vascular senescence and atherosclerosis

(2008) Maria Grazia Andreassi   JOURNAL OF MOLECULAR MEDICINE-JMM

Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

(2008) A. F. Hezel et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity

(2008) Swami R. Narala et al.   MOLECULAR BIOLOGY OF THE CELL

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

(2008) Patrick Narbonne et al.   NATURE

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers

(2008) Anna Nogalska et al.   NEUROBIOLOGY OF AGING

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

(2008) Jing Huang et al.   PLoS One

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LKB1 and AMPK in cell polarity and division

(2008) Tyisha Williams et al.   TRENDS IN CELL BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

(2007) Antero Salminen et al.   AGEING RESEARCH REVIEWS

SNF1/AMPK pathways in yeast

(2007) Kristina Hedbacker   Frontiers in Bioscience-Landmark