Structure-Guided Engineering of Cytotoxic Cabazitaxel for an Adaptive Nanoparticle Formulation: Enhancing the Drug Safety and Therapeutic Efficacy

Dual-Drug Delivery Using Dextran-Functionalized Nanoparticles Targeting Cardiac Fibroblasts for Cellular Reprogramming

(2018) Mónica P. A. Ferreira et al.   ADVANCED FUNCTIONAL MATERIALS

Tumor Inhibition Achieved by Targeting and Regulating Multiple Key Elements in EGFR Signaling Pathway Using a Self-Assembled Nanoprodrug

(2018) Bowen Li et al.   ADVANCED FUNCTIONAL MATERIALS

Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy

(2018) Jingchao Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced oral absorption and anticancer efficacy of cabazitaxel by overcoming intestinal mucus and epithelium barriers using surface polyethylene oxide (PEO) decorated positively charged polymer-lipid hybrid nanoparticles

(2018) Tianyang Ren et al.   JOURNAL OF CONTROLLED RELEASE

A Tumor-Activatable Theranostic Nanomedicine Platform for NIR Fluorescence-Guided Surgery and Combinatorial Phototherapy

(2018) Xiaoning Li et al.   Theranostics

Evaluation of cabazitaxel's toxicity and tolerance: AC Camargo Cancer Center experience.

(2017) Christiane Silveira Marinho Albuquerque et al.   JOURNAL OF CLINICAL ONCOLOGY

Cabazitaxel Versus Docetaxel As First-Line Therapy for Patients With Metastatic Castration-Resistant Prostate Cancer: A Randomized Phase III Trial—FIRSTANA

(2017) Stéphane Oudard et al.   JOURNAL OF CLINICAL ONCOLOGY

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations

(2017) Hangxiang Wang et al.   Theranostics

Targeted Delivery of Cabazitaxel by Conjugation to Albumin-PEG-folate Nanoparticles Using a Cysteine-acrylate Linker and Simple Synthesis Conditions

(2017) Mohammad Kazem Khoeeniha et al.   Current Drug Delivery

Rethinking cancer nanotheranostics

(2017) Hongmin Chen et al.   Nature Reviews Materials

Cabazitaxel or mitoxantrone with prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel: Final results of a multinational phase III trial (TROPIC).

(2017) J. S. De Bono et al.   JOURNAL OF CLINICAL ONCOLOGY

Well-Defined Polymer-Paclitaxel Prodrugs by a Grafting-from-Drug Approach

(2016) Benoit Louage et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox-Sensitive Citronellol–Cabazitaxel Conjugate: Maintained in Vitro Cytotoxicity and Self-Assembled as Multifunctional Nanomedicine

(2016) Peng Xue et al.   BIOCONJUGATE CHEMISTRY

Mild photothermal therapy/photodynamic therapy/chemotherapy of breast cancer by Lyp-1 modified Docetaxel/IR820 Co-loaded micelles

(2016) WenTing Li et al.   BIOMATERIALS

Oligo(lactic acid)n-Paclitaxel Prodrugs for Poly(ethylene glycol)-block-poly(lactic acid) Micelles: Loading, Release, and Backbiting Conversion for Anticancer Activity

(2016) Yu Tong Tam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improved i.p. drug delivery with bioadhesive nanoparticles

(2016) Yang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy

(2016) Yiming Zhao et al.   Nature Communications

Complete Regression of Xenograft Tumors upon Targeted Delivery of Paclitaxel via Π–Π Stacking Stabilized Polymeric Micelles

(2015) Yang Shi et al.   ACS Nano

Self-Assembling Prodrugs by Precise Programming of Molecular Structures that Contribute Distinct Stability, Pharmacokinetics, and Antitumor Efficacy

(2015) Hangxiang Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Cancer of the prostate: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2015) C. Parker et al.   ANNALS OF ONCOLOGY

Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment

(2014) Mathumai Kanapathipillai et al.   ADVANCED DRUG DELIVERY REVIEWS

Structure-Based Rational Design of Prodrugs To Enable Their Combination with Polymeric Nanoparticle Delivery Platforms for Enhanced Antitumor Efficacy

(2014) Hangxiang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial–mesenchymal transition

(2014) Xian-Shuo Cheng et al.   CANCER LETTERS

Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel

(2014) A. J. M. Nieuweboer et al.   CANCER RESEARCH

Sustained-release from nanocarriers: a review

(2014) Jayaganesh V. Natarajan et al.   JOURNAL OF CONTROLLED RELEASE

Targeting EMT in cancer: opportunities for pharmacological intervention

(2014) Felicity M. Davis et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mesoporous Magnetic Gold “Nanoclusters” as Theranostic Carrier for Chemo-Photothermal Co-therapy of Breast Cancer

(2014) JinRong Peng et al.   Theranostics

Y-Shaped mPEG-PLA Cabazitaxel Conjugates: Well-Controlled Synthesis by Organocatalytic Approach and Self-Assembly into Interface Drug-Loaded Core–Corona Nanoparticles

(2013) Fethi Bensaid et al.   BIOMACROMOLECULES

Real-world cabazitaxel safety: the Italian early-access program in metastatic castration-resistant prostate cancer

(2013) Sergio Bracarda et al.   Future Oncology

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Cabazitaxel: More Than a New Taxane for Metastatic Castrate-Resistant Prostate Cancer?

(2012) A. C. Mita et al.   CLINICAL CANCER RESEARCH

A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases

(2012) Mark J. Ernsting et al.   JOURNAL OF CONTROLLED RELEASE

Preclinical pharmacokinetic, biodistribution, and anti-cancer efficacy studies of a docetaxel-carboxymethylcellulose nanoparticle in mouse models

(2011) Mark J. Ernsting et al.   BIOMATERIALS

Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts

(2011) Hangxiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Time for a Pause

(2011) S. M. Hurtley   Science Signaling

Tumor delivery of macromolecular drugs based on the EPR effect

(2010) Vladimir Torchilin   ADVANCED DRUG DELIVERY REVIEWS

Cabazitaxel for the treatment of castration-resistant prostate cancer

(2010) Neeraj Agarwal et al.   Future Oncology

Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial

(2010) Johann Sebastian de Bono et al.   LANCET

Cabazitaxel

(2010) Matthew D. Galsky et al.   NATURE REVIEWS DRUG DISCOVERY

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Preclinical and clinical studies of anticancer agent-incorporating polymer micelles

(2009) Yasuhiro Matsumura et al.   CANCER SCIENCE

Phase I and Pharmacokinetic Study of XRP6258 (RPR 116258A), a Novel Taxane, Administered as a 1-Hour Infusion Every 3 Weeks in Patients with Advanced Solid Tumors

(2009) A. C. Mita et al.   CLINICAL CANCER RESEARCH

In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration

(2009) Eunhye Lee et al.   JOURNAL OF CONTROLLED RELEASE

Synthetic polymeric nanoparticles by nanoprecipitation

(2009) Stephanie Hornig et al.   JOURNAL OF MATERIALS CHEMISTRY

Ring-Opening Polymerization-Mediated Controlled Formulation of Polylactide−Drug Nanoparticles

(2009) Rong Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection

(2009) J. Andrew MacKay et al.   NATURE MATERIALS

Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles

(2008) Rong Tong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A multicenter phase II study of XRP6258 administered as a 1-h i.v. infusion every 3 weeks in taxane-resistant metastatic breast cancer patients

(2008) X. Pivot et al.   ANNALS OF ONCOLOGY

Nanoparticle formulations in pulmonary drug delivery

(2008) Mark M. Bailey et al.   MEDICINAL RESEARCH REVIEWS