Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

(2018) Bradley R. Groveman et al.   Acta Neuropathologica Communications

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

(2018) Benjamin Falcon et al.   ACTA NEUROPATHOLOGICA

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease

(2017) Christina D. Orrú et al.   Science Translational Medicine

Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples

(2017) Matilde Bongianni et al.   JAMA Neurology

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

(2017) Mohammad Shahnawaz et al.   JAMA Neurology

Widespread tau seeding activity at early Braak stages

(2016) Jennifer L. Furman et al.   ACTA NEUROPATHOLOGICA

Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

(2016) Shuko Takeda et al.   ANNALS OF NEUROLOGY

The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases

(2016) Matthias Schmitz et al.   Nature Protocols

Advanced tests for early and accurate diagnosis of Creutzfeldt–Jakob disease

(2016) Gianluigi Zanusso et al.   Nature Reviews Neurology

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

(2016) Graham Fairfoul et al.   Annals of Clinical and Translational Neurology

Deep clinical and neuropathological phenotyping of Pick disease

(2015) David J. Irwin et al.   ANNALS OF NEUROLOGY

Rapid and Sensitive RT-QuIC Detection of Human Creutzfeldt-Jakob Disease Using Cerebrospinal Fluid

(2015) Christina D. Orrú et al.   mBio

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains

(2015) Christina D. Orrú et al.   PLoS Pathogens

Amplification of Tau Fibrils from Minute Quantities of Seeds

(2014) Virginia Meyer et al.   BIOCHEMISTRY

Characteristic CSF Prion Seeding Efficiency in Humans with Prion Diseases

(2014) Maria Cramm et al.   MOLECULAR NEUROBIOLOGY

A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings

(2014) Christina D. Orrú et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prions in the Urine of Patients with Variant Creutzfeldt–Jakob Disease

(2014) Fabio Moda et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of Misfolded Aβ Oligomers for Sensitive Biochemical Diagnosis of Alzheimer’s Disease

(2014) Natalia Salvadores et al.   Cell Reports

Conformational Features of Tau Fibrils from Alzheimer’s Disease Brain Are Faithfully Propagated by Unmodified Recombinant Protein

(2013) Olga A. Morozova et al.   BIOCHEMISTRY

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease

(2012) Lynne I. McGuire et al.   ANNALS OF NEUROLOGY

New generation QuIC assays for prion seeding activity

(2012) Christina D. Orru et al.   Prion

Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion

(2011) Ryuichiro Atarashi et al.   NATURE MEDICINE

Rapid End-Point Quantitation of Prion Seeding Activity with Sensitivity Comparable to Bioassays

(2010) Jason M. Wilham et al.   PLoS Pathogens