Article
Biochemistry & Molecular Biology
Elhan Khan, Mahvish Khan, Saif Khan, Mohtashim Lohani, Nashwa Zaki Ali Bushara, Hussein Abdul Aziz Marouf, Kurian Punnoose, Iffat Zareen Ahmad
Summary: Melanoma is a dangerous and complex disease, making diagnosis and treatment difficult. Marine biomass plays a crucial role in preserving biodiversity. Research suggests that TLR activation, in addition to its role in innate immunity, may be connected to the development of cancer, making TLR agonists potential candidates for cancer medications. Scytonemin shows significant binding potential to TLR3 and TLR4, indicating its potential as a therapeutic agent.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Yu Chen, Xiao Xiao Wang, Corrie H. C. Ng, Sai Wah Tsao, Wai Keung Leung
Summary: Transcripts and proteins of TLR1/2/4/5/6, NOD1/2 and NLRP1/2 were expressed in human periodontal tissue in health and disease, with NOD2 possibly considered as a key damage-associated molecular pattern sensor on periodontal resident cells.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Alessio Borio, Aurora Holgado, Christina Passegger, Herbert Strobl, Rudi Beyaert, Holger Heine, Alla Zamyatina
Summary: The TLR4/MD-2 complex is a crucial receptor in the innate immune system and plays a major role in inflammation, but dysregulation in its signaling can lead to uncontrolled inflammation and disease. Targeting this receptor complex with anti-inflammatory therapies is promising, but the complexity of ligand recognition and species-specificity presents challenges. Researchers have developed glycolipids that mimic lipid A and inhibit TLR4-mediated inflammation, and these glycolipids were evaluated for their activity in human and murine immune cells. A bis-phosphorylated glycolipid was found to have antagonist activity on human TLR4, but acted as a partial agonist on murine TLR4.
Article
Chemistry, Medicinal
Olivia Slater, Kapur B. Dhami, Ganesh Shrestha, Maria Kontoyianni, Michael R. Nichols, Alexei V. Demchenko
Summary: This study reports the development of a new Lipid-A analogue lacking a disaccharide core but still exhibiting potent antagonistic activity against LPS-induced inflammation. Computational, synthetic, and biological studies revealed new structural determinants of these simplified analogues.
ACS INFECTIOUS DISEASES
(2022)
Article
Food Science & Technology
Hinda Allaoui, Nedra Rached, Naziha Marrakchi, Ameur Cherif, Amor Mosbah, Erij Messadi
Summary: The natriuretic-like peptide Lebetin 2 (L2) has been found to exert potent cardioprotection in myocardial infarction, with stronger effects than B-type natriuretic peptide (BNP). Through molecular modeling and simulation, it was discovered that L2 exhibited higher affinity for NP receptors (NPRs), particularly NPR-A and NPR-C, compared to BNP. The stronger interaction between L2 and NPR-C suggests a potential new signaling pathway. Overall, L2 shows promise as a therapeutic approach for myocardial infarction and highlights the importance of further research.
Article
Immunology
Andrea N. Loes, Melissa N. Hinman, Dylan R. Farnsworth, Adam C. Miller, Karen Guillemin, Michael J. Harms
Summary: The zebrafish is a powerful model organism for studying the innate immune system. Recent findings suggest that zebrafish share an LPS-sensitive Tlr4/Md-2 complex with mammals, rather than a new invention in tetrapods. The discovery of the Ly96 gene in zebrafish and functional assays further support this hypothesis, indicating a low-sensitivity ancestral Tlr4/Md-2 complex retained by zebrafish.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Fisheries
Raja Aadil Hussain Bhat, Ritesh Shantilal Tandel, Pragyan Dash, Mir Ishfaq Nazir, Dar Jaffer Yousuf, Irfan Ahmad Bhat, Parvaiz Ahmad Ganie, Pankaj Gargotra, C. Siva
Summary: In this study, the full-length TLR4 gene was cloned and characterized in Tor putitora, and its phylogenetic relationship, localization, and binding affinity with ligands were investigated. The results suggest that TpTLR4 plays an important role in sensing pathogen-associated molecular patterns, particularly of viral origin.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Yongsheng Zhang, Xinjie Liang, Xuefei Bao, Wei Xiao, Guoliang Chen
Summary: This review discusses TLR4 inhibitors that can bind directly to TLR4 or the TLR4/MD2 complex, as well as compounds that can downregulate the expression of TLR4. The involvement of specific residues in the binding of antagonistic ligands to the TLR4/MD2 complex provides useful information for structure-based TLR4 inhibitor design.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biology
Xuan Jiang, Shuxiang Li, Hongbin Zhang, Liang-Liang Wang
Summary: Opioids are known for their potent analgesic effects and severe side effects. TRV130, a biased ligand for the G-protein-dependent pathway of the mu-opioid receptor, shows high analgesia and fewer side effects. Through structure similarity search and molecular dynamics simulations, four candidate molecules with potential MOR agonist activity were identified.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Review
Immunology
Cassio Luiz Coutinho Almeida-da-Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva, David M. Ojcius
Summary: The innate immune system in vertebrates and invertebrates relies on conserved receptors and ligands, and pathways to initiate a rapid response against microbial infections and other sources of stress and danger. Research on NOD-like receptors (NLRs) has advanced in the past two decades, providing insight into the ligands and conditions that activate NLRs, as well as the outcomes of NLR activation in cells and animals. NLRs play crucial roles in diverse functions, such as transcription of MHC molecules and initiation of inflammation, and their activation can be direct or indirect depending on the ligands involved. Future discoveries will contribute to a better understanding of the molecular details and physiological consequences of NLR activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chiagoziem A. Otuechere, Adewale Adewuyi, Netra Prasad Neupane, Sharon Ofure Eromosele, Onyinye M. Ibekwe, Adriel Ekozin, Oluwadamilare Iyapo, Amita Verma
Summary: This study investigates the action of vanillin-spiked Zinc ferrite nanoparticles (VMN) on biochemical markers and histopathology of the hepatic tissue in rats exposed to Cadmium (Cd). It shows that VMN can alleviate Cd-induced liver injury and interact with specific proteins such as Toll-like receptor 8, AKT serine/threonine kinase 1, and B-cell lymphoma 2. This study highlights the hepatoprotective potential of VMN and provides a basis for further mechanistic studies.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Fei Han, Yuan Zhang, Anle Xu, Na Song, Geng Qin, Xiaoyan Wang, Siqing Chen, Li Bian, Tianxiang Gao
Summary: The black scraper is a significant commercial species in China, but it is susceptible to infectious diseases during aquaculture. Researchers have identified and characterized eight Toll-like receptor genes in the black scraper, which play vital roles in immune defense and can be utilized for disease prevention and vaccine development.
MARINE BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Alejandra Matamoros-Recio, Juan Felipe Franco-Gonzalez, Lucia Perez-Regidor, Jean-Marc Billod, Joan Guzman-Caldentey, Sonsoles Martin-Santamaria
Summary: This study provides a realistic and complete 3D model of the TLR4 complex, revealing its behavior in different membrane environments, offering insights into the signal transduction mechanism, and promoting the discovery of new TLR4 modulators.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Yingqi Qiu, Yuanmeng Wang, Jiahao Lu, Qinghua Zhu, Li Jia, Fuhou Lei, Liqun Shen, Lihe Jiang, Aiqun Wu
Summary: This study involved the chemical modification of curcumin to obtain tetrahydrocurcumin and demonstrated its enhanced physiological and antioxidant activities compared to curcumin. The computational pharmacology techniques provided a theoretical basis for the development and modification of high-efficiency, low-toxicity drugs that interact with various targets of curcumin in the future.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Uxia Regueiro, Maite Lopez-Lopez, Ruben Varela-Fernandez, Tomas Sobrino, Elio Diez-Feijoo, Isabel Lema
Summary: Keratoconus (KC) is a corneal disorder closely related to dysregulation of Lactoferrin (LTF) and overexpression of Toll-like Receptors 2 (TLR2). This study explores the association between these two biomarkers, providing insights into KC pathophysiology and potential therapeutic approaches. The study quantified LTF concentrations in serum and tear samples from KC patients and controls, and conducted correlation analysis with immunoinflammatory mediators and KC-associated tomographic parameters. In vitro experiments using cell cultures were also conducted to investigate the impact of LTF treatment on TLR2 expression and functionality. The results showed decreased LTF levels in KC patients compared to controls, indicating a strong correlation with TLR2 overexpression, inflammatory mediator upregulation, and KC severity. In stimulated cell cultures, TLR2 expression was reduced after LTF treatment, along with decreased secretion of SEAP and IL-8. Overall, the dysregulation of LTF and TLR2 in the ocular surface of KC patients contributes to KC severity by maintaining a chronic immune-inflammatory state, suggesting the potential of LTF as a therapeutic approach for KC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
A. M. Shehata, L. Quintanilla-Fend, S. Bettio, J. Jauch, T. Scior, W. A. Scherbaum, H. P. T. Ammon
HORMONE AND METABOLIC RESEARCH
(2015)
Review
Plant Sciences
Quoc Tuan Do, Jose L. Medina-Franco, Thomas Scior, Philippe Bernard
Article
Biochemistry & Molecular Biology
Thomas Scior, Bertin Paiz-Candia, Angel A. Islas, Alfredo Sanchez-Solano, Lourdes Millan-Perez Pena, Claudia Mancilla-Simbro, Eduardo M. Salinas-Stefanon
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2015)
Review
Biochemistry & Molecular Biology
Thomas Scior, Jose Antonio Guevara-Garcia, Quoc-Tuan Do, Philippe Bernard, Stefan Laufer
CURRENT MEDICINAL CHEMISTRY
(2016)
Article
Biophysics
Alfredo Sanchez-Solano, Angel A. Islas, Thomas Scior, Bertin Paiz-Candia, Lourdes Millan-PerezPena, Eduardo M. Salinas-Stefanon
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
Article
Pharmacology & Pharmacy
Bertin Paiz-Candia, Angel A. Islas, Alfredo Sanchez-Solano, Claudia Manilla-Simbro, Thomas Scior, Lourdes Millan-PerezPena, Eduardo M. Salinas-Stefanon
EUROPEAN JOURNAL OF PHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Gloria Komazin, Michael Maybin, Ronald W. Woodard, Thomas Scior, Dominik Schwudke, Ursula Schombel, Nicolas Gisch, Uwe Mamat, Timothy C. Meredith
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Chemistry, Physical
Lisset Noriega, Maria Eugenia Castro, Jose Manuel Perez-Aguilar, Norma A. Caballero, Thomas Scior, Ramses E. Ramirez, Enrique Gonzalez-Vergara, Francisco Javier Melendez
THEORETICAL CHEMISTRY ACCOUNTS
(2019)
Article
Biochemistry & Molecular Biology
Jorge Lozano-Aponte, Thomas Scior, Francisco Noe Mendoza Ambrosio, Minerva Gonzalez-Melchor, Christian Alexander
Article
Cardiac & Cardiovascular Systems
Rafael Gustavo Vila-Casahonda, Jorge Lozano-Aponte, Carlos Enrique Guerrero-Beltran
Summary: The TLR signaling pathway is crucial in immune defense, but overactivation can lead to inflammation. Research suggests that HSP60 peptides have potential in regulating TLR4-mediated diseases, protecting against cardiac inflammation, and may serve as a new innovative therapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
K. Kuchta, M. Thomsen, T. Scior, M. Schmidt
Article
Chemistry, Medicinal
Israel Quiroga, Thomas Scior
Article
Chemistry, Multidisciplinary
Israel Quiroga, Thomas Scior
JOURNAL OF THE MEXICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Medicinal
Blanca Colin-Lozano, Ismael Leon-Rivera, Manuel Jesus Chan-Bacab, Benjamin Otto Ortega-Morales, Rosa Moo-Puc, Vanessa Lopez-Guerrero, Emanuel Hernandez-Nunez, Raul Arguello-Garcia, Thomas Scior, Elizabeth Barbosa-Cabrera, Gabriel Navarrete-Vazquez
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2017)