Eph Receptors and Ephrin Ligands: Important Players in Angiogenesis and Tumor Angiogenesis

EphA2 overexpression promotes ovarian cancer growth

(2010) Chunhua Lu et al.   CANCER BIOLOGY & THERAPY

Dasatinib

(2009) Susan J Keam   BIODRUGS

Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors

(2009) Yongmun Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures

(2009) O. Salvucci et al.   BLOOD

Activity of the multikinase inhibitor dasatinib against ovarian cancer cells

(2009) G E Konecny et al.   BRITISH JOURNAL OF CANCER

Dasatinib synergizes with doxorubicin to block growth, migration and invasion of breast cancer cells

(2009) C S Pichot et al.   BRITISH JOURNAL OF CANCER

Transcriptional Switch of Dormant Tumors to Fast-Growing Angiogenic Phenotype

(2009) N. Almog et al.   CANCER RESEARCH

Over-expression of EphB3 enhances cell–cell contacts and suppresses tumor growth in HT-29 human colon cancer cells

(2009) Sou-Tyau Chiu et al.   CARCINOGENESIS

Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-κB signaling pathway

(2009) Yu-Xiong Feng et al.   HEPATOLOGY

Soluble ephrin-B2 mediates apoptosis in retinal neovascularization and in endothelial cells

(2009) Michael H. Davies et al.   MICROVASCULAR RESEARCH

Bidirectional signaling of ErbB and Eph receptors at synapses

(2009) Yu Chen et al.   Neuron Glia Biology

Chronic Hypoxia and Rat Lung Development: Analysis by Morphometry and Directed Microarray

(2009) William E Truog et al.   PEDIATRIC RESEARCH

Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines

(2008) Catherine Bardelle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines

(2008) Catherine Bardelle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade

(2008) J. S. Scehnet et al.   BLOOD

Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer

(2008) Q Chang et al.   BRITISH JOURNAL OF CANCER

Eph Receptors and Ephrins in Cancer: Common Themes and Controversies

(2008) J. Chen et al.   CANCER RESEARCH

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

(2008) Elena B. Pasquale   CELL

Eph/Ephrin Signalling and Function in Oncogenesis: Lessons from Embryonic Development

(2008) Peter Janes et al.   CURRENT CANCER DRUG TARGETS

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis

(2008) Y. H. Kim et al.   DEVELOPMENT

Eph/ephrin signaling: networks

(2008) D. Arvanitis et al.   GENES & DEVELOPMENT

Aberrant methylation ofEphA7in human prostate cancer and its relation to clinicopathologic features

(2008) Ming Guan et al.   INTERNATIONAL JOURNAL OF CANCER

Hypoxia-inducible Transcription Factor-2α in Endothelial Cells Regulates Tumor Neovascularization through Activation of Ephrin A1

(2008) Toshiharu Yamashita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors

(2008) Roberta Noberini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration

(2008) Noretta Clifford et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

(2008) Dana M. Brantley-Sieders et al.   JOURNAL OF CLINICAL INVESTIGATION

Signaling through ephrin-A ligand leads to activation of Src-family kinases, Akt phosphorylation, and inhibition of antigen receptor-induced apoptosis

(2008) Halvor L. Holen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis

(2008) Yingchun Dong et al.   MODERN PATHOLOGY

Inhibition of Src Family Kinases with Dasatinib Blocks Migration and Invasion of Human Melanoma Cells

(2008) R. Buettner et al.   MOLECULAR CANCER RESEARCH

The EphA2 Receptor and EphrinA1 Ligand in Solid Tumors: Function and Therapeutic Targeting

(2008) J. Wykosky et al.   MOLECULAR CANCER RESEARCH

Bidirectional modulation of synaptic functions by Eph/ephrin signaling

(2008) Rüdiger Klein   NATURE NEUROSCIENCE

Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor

(2008) J Wykosky et al.   ONCOGENE

Expression of EphA2 and VEGF in squamous cell carcinoma of the tongue: Correlation with the angiogenesis and clinical outcome

(2008) Zhe Shao et al.   ORAL ONCOLOGY

Comparative 3'UTR Analysis Allows Identification of Regulatory Clusters that Drive Eph/ephrin Expression in Cancer Cell Lines

(2008) Jennifer Winter et al.   PLoS One

RNA interference targeting EphA2 inhibits proliferation, induces apoptosis, and cooperates with cytotoxic drugs in human glioma cells

(2008) Zhangming Zhou et al.   SURGICAL NEUROLOGY