Article
Biochemistry & Molecular Biology
Feng Tang, Hua Yu, Xia Wang, Jiageng Shi, Zhizhuang Chen, Hao Wang, Ziyu Wan, Qiqi Fu, Xuan Hu, Yisha Zuhaer, Tao Liu, Zhonghua Yang, Jianping Peng
Summary: NCAPG is overexpressed in bladder cancer, and its knockdown can inhibit cell proliferation through the inhibition of the NF-kappa B signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Huangheng Tao, Yixiang Liao, Youji Yan, Zhiwen He, Jiajie Zhou, Xinghuan Wang, Jianping Peng, Shangze Li, Tao Liu
Summary: This study revealed that high expression of BRCC3 in bladder cancer promotes tumorigenesis by targeting the TRAF2 protein, while genetic ablation of BRCC3 significantly blocks proliferation and migration of bladder cancer cells. RNA-Seq analysis shows down-regulation of NF-kappa B signaling in BRCC3-deficient cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Yong Cai, Zhaoying Sheng, Jiying Wang
Summary: Xanthorrhizol, a sesquiterpenoid agent isolated from Curcuma xanthorrhiza, has shown anti-cancer properties by inducing oxidative stress, altering mitochondrial membrane potential, and modulating apoptotic signaling events in non-small cell lung carcinoma cells.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yingchun Zhao, Xinglong Liu, Chuanbo Ding, Yan Gu, Wencong Liu
Summary: The study demonstrated that DHM treatment significantly inhibited liver fibrosis in mice induced by TAA, with decreased ALT and AST activities, increased SOD and GSH levels, and reversed MDA levels. DHM also inhibited hepatocyte apoptosis and hepatic stellate cell activation, and regulated the expression of TGF-beta 1, showing its potential hepatoprotective effects in treating liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tuoyang Li, Junyi Zhou, Yingming Jiang, Yandong Zhao, Jintuan Huang, Weiyao Li, Zhenze Huang, Zijian Chen, Xiaocheng Tang, Hao Chen, Zuli Yang
Summary: This study investigated the role of ADAMTS16 in gastric cancer and found that it promotes cell migration, invasion, and proliferation by targeting IFI27 through the NF-kappa B pathway. ADAMTS16 may serve as a potential biomarker for the progression and survival of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lingya Yao, Xiaoli Chen, Manlu Shen, Yuan Zhao, Qian Cao
Summary: In this study, the anti-inflammatory effects and mechanisms of isosteviol (IS) against intestinal inflammation were investigated. IS was found to alleviate DSS-induced colitis by reducing inflammation and preserving intestinal barrier function through the PDK1/AKT/NF-kappa B signaling pathway. These findings highlight the potential of IS as a therapeutic agent for inflammatory bowel diseases (IBD).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Veterinary Sciences
Yi-Lei Liu, Kang-Ning Ding, Xing-Ling Shen, Han-Xiao Liu, Yi-An Zhang, Yu-Qing Liu, Yong-Ming He, Lu-Ping Tang
Summary: The study revealed that chronic heat stress in broilers leads to decreased growth performance, liver damage, and inflammation. Heat stress induced infiltration of neutrophils and lymphocytes in the liver, activating multiple inflammation signaling pathways.
BMC VETERINARY RESEARCH
(2022)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Minggang Che, Qing Lan
Summary: RIT1 is upregulated in glioma and associated with poor prognosis. Manipulating RIT1 levels inhibits glioma cell proliferation and invasion. RIT1 contributes to the development and metastasis of glioma via activation of the AKT/ERK/NF-kappa B pathway.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Review
Gastroenterology & Hepatology
Qianhui Chen, Xinyu Lu, Xiaoyong Zhang
Summary: The noncanonical NF-kappa B signaling pathway plays a crucial role in regulating inflammation and immune response, showing potential therapeutic value against liver diseases. Activation of this pathway may contribute to viral clearance, with specific inhibitors and antibodies currently under development and testing.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Genetics & Heredity
Huajie Mao, Ya Zhao, Li Lei, Yanxia Hu, Hangrui Zhu, Runzhi Wang, Dongsheng Ni, Jianing Liu, Lei Xu, Hua Xia, Zaikuan Zhang, Meng Ma, Zheng Pan, Qin Zhou, Yajun Xie
Summary: SELS is highly expressed in clear cell renal cell carcinoma (ccRCC) and associated with multiple pathological features. SELS overexpression promotes cell proliferation and inhibits apoptosis, while silence of SELS has the opposite effect. Mechanistically, SELS activates AKT/GSK3 beta/NF-kappa B signaling pathway to enhance cell proliferation and inhibit apoptosis, and stabilizes c-Myc by preventing ubiquitin-proteasome-mediated degradation. Furthermore, SELS inhibits ccRCC cell migration likely through repressing epithelial-mesenchymal transition (EMT).
Article
Immunology
Xiaohe Li, Qing Liang, Shaoyan Gao, Qiuyan Jiang, Fangxia Zhang, Ruiqin Zhang, Hao Ruan, Shuangling Li, Jiaoyan Luan, Ruxia Deng, Honggang Zhou, Hui Huang, Cheng Yang
Summary: Lenalidomide has potential anti-fibrotic effects by suppressing inflammation-related signaling pathways, thereby reducing pulmonary fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peng Han, Jin Shang, Dan-Ling Chen, Si-Yang Li, Rui Fan, Rui-Han Li, Hui-Qi Li, Shi-Yang Zhang, Dong-Yan Shen
Summary: Baicalein, derived from Scutellaria baicalensis Georgi, shows anticancer effects on cholangiocarcinoma cells by inhibiting cell viability and proliferation, inducing apoptosis and cell cycle arrest, suppressing migration and invasion, reducing aerobic glycolysis, and inhibiting tumor growth through regulating protein expression and signaling pathways both in vitro and in vivo.
PROCESS BIOCHEMISTRY
(2021)
Article
Oncology
Shayi Wu, Miao Chen, Jiao Huang, Feifei Zhang, Zhaojie Lv, Yongxu Jia, Yu-Zhu Cui, Liang-Zhan Sun, Ying Wang, Ying Tang, Krista R. Verhoeft, Yan Li, Yanru Qin, Xiang Lin, Xin-Yuan Guan, Ka-On Lam
Summary: This study reveals the upregulation of ORAI2 in lymph node metastasis of gastric cancer, and its role in cell proliferation and migration. Clinical data shows a correlation between ORAI2-positive cells in gastric cancer tissues and poor prognosis. ORAI2 promotes metastasis of gastric cancer cells through activation of PI3K/Akt signaling pathway and focal adhesion disassembly at the cell's rear-edge.
Article
Pharmacology & Pharmacy
Zhen Ye, Yuzheng Li, Yingqi She, Mingquan Wu, Yu Hu, Kaihua Qin, Linzhen Li, Han Yu, Qian Zhao, Zhao Jin, Fating Lu, Qiaobo Ye
Summary: This study investigated the potential active components and molecular mechanisms of Renshen Baidu powder (RSBDP) for the treatment of ulcerative colitis. Results showed that RSBDP could ameliorate disease activity index, colon weight, colon shortening, and histology in TNBS-induced colitis rats. Furthermore, RSBDP inhibited the PI3K/Akt/NF-kappa B signaling pathway to effectively alleviate colitis in rats.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiao-ping Tan, Kai Zhou, Qing-li Zeng, Yun-fei Yuan, Wei Chen
Summary: This study compared the clinical and prognostic features of non-B non-C alpha-fetoprotein (AFP)(-)-hepatocellular carcinoma (HCC) patients with other groups. The study found that non-B non-C alpha-fetoprotein (AFP)(-)-HCC patients had a favorable prognosis and could serve as a marker for predicting the risk of tumor recurrence in the early stages.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Xuexian Fang, Hossein Ardehali, Junxia Min, Fudi Wang
Summary: Iron homeostasis is crucial for proper cardiac function, and iron imbalance is a common factor in various cardiovascular diseases. Ferroptosis, an iron-dependent regulated cell death, has been increasingly recognized as an important process underlying the pathogenesis and progression of cardiovascular diseases. Understanding the mechanisms of iron metabolism and ferroptosis regulation in cardiomyocytes may lead to improvements in disease management.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Neurosciences
Danyang Li, Qizhong Qin, Yinyin Xia, Shuqun Cheng, Jun Zhang, Xinhao Duan, Xia Qin, Xin Tian, Lejiao Mao, Jingfu Qiu, Xuejun Jiang, Zhen Zou, Chengzhi Chen
Summary: Arsenite, a common neurotoxicant, affects neurological functions through mechanisms not fully understood. This study investigated the role of autophagy in arsenite neurotoxicity using beclin 1(+/+) and beclin 1(+/-) mice. The results showed that arsenite exposure caused cognitive impairment, anxiety-like behavior, and motor coordination disorder in beclin 1(+/+) mice, accompanied by morphological and electrophysiological changes in cortical tissues. Heterozygous disruption of beclin 1 attenuated these neurotoxic effects, suggesting that regulating autophagy through beclin 1 may be a potential therapeutic approach against arsenite neurotoxicity.
Article
Integrative & Complementary Medicine
Fengxiao Wang, Pinwei Peng, Yixin Zheng, Shuqun Cheng, Yunfei Chen
Summary: This study aimed to evaluate the efficacy and safety of acupuncture compared to parecoxib sodium on postoperative pain, postoperative nausea and vomiting, and the Bruggemann Comfort Scale in patients following laparoscopic cholecystectomy. The results showed that the pain score in the acupuncture group was lower than the control group at 6 h and 9 h after the operation, and the number of patients requesting parecoxib sodium was also lower in the acupuncture group. The acupuncture group also had lower levels of postoperative nausea and vomiting at 6 h after the operation. Acupuncture may be a potential method for treating postoperative pain following laparoscopic cholecystectomy.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ying Cheng, Yuan Gao, Jing Li, Tongyu Rui, Qianqian Li, Huan Chen, Bowen Jia, Yiting Song, Zhiya Gu, Tao Wang, Cheng Gao, Ying Wang, Zufeng Wang, Fudi Wang, Luyang Tao, Chengliang Luo
Summary: Ferroptosis, a form of regulated cell death triggered by iron-dependent lipid peroxidation, is involved in the pathophysiology of traumatic brain injury (TBI). N-acetyl serotonin (NAS), an agonist of TrkB and precursor of melatonin, has beneficial effects on TBI by suppressing ferroptosis through the activation of the TrkB/PI3K/Akt/Nrf2 pathway. NAS shows promise as an anti-ferroptosis agent for TBI treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Qian Wu, Euclides Sacomboio, Lara Valente de Souza, Rui Martins, Jamil Kitoko, Silvia Cardoso, Temitope W. Ademolue, Tiago Paixao, Jaakko Lehtimaki, Ana Figueiredo, Caren Norden, Pierre-Louis Tharaux, Guenter Weiss, Fudi Wang, Susana Ramos, Miguel P. Soares
Summary: Iron recycling is important in preventing anemia, and its role in preventing anemia during infection is unclear. In severe Plasmodium falciparum malaria, acute kidney injury (AKI) is associated with life-threatening anemia. A study using a rodent model shows that renal proximal tubule epithelial cells (RPTECs) have the ability to store and recycle iron during P. chabaudi chabaudi (Pcc) infection, preventing the onset of life-threatening malarial anemia.
Article
Multidisciplinary Sciences
Na Li, Bowen Wu, Jifeng Wang, Yumeng Yan, Peng An, Yuezhen Li, Yuning Liu, Yanfei Hou, Xiaoqing Qing, Lili Niu, Xiang Ding, Zhensheng Xie, Mengmeng Zhang, Xiaojing Guo, Xiulan Chen, Tanxi Cai, Jianming Luo, Fudi Wang, Fuquan Yang
Summary: New diagnostic strategies are needed to determine the subtypes of beta-thalassemia and facilitate personalized therapeutic regimens. This study explored the characteristics and potential biomarkers of beta-thalassemia subtypes using quantitative proteomics of plasma-derived extracellular vesicles. The findings showed that the proteomic patterns of extracellular vesicles were consistent with, but more distinct than, those of plasma, and they had superior discriminatory ability for beta-thalassemia subtypes.
Editorial Material
Biochemistry & Molecular Biology
Chang-Zhou Feng, Ning-Zhe Li, Xi-Bo Hu, Yin -Yin Xie, Qiu-Hua Huang, Jianming Zhang, Zhu Chen, Sai-Juan Chen, Fudi Wang, Xiao-Jian Sun
Article
Biochemistry & Molecular Biology
Yuan Gao, Tao Wang, Ying Cheng, Yumin Wu, Luwen Zhu, Zhiya Gu, Youzhuang Wu, Luwei Cai, Yimin Wu, Yidan Zhang, Cheng Gao, Lili Li, Jing Li, Qianqian Li, Zufeng Wang, Ying Wang, Fudi Wang, Chengliang Luo, Luyang Tao
Summary: TBI is a common cause of death and disability, but there is a lack of effective drugs. The study shows that post-TBI, genes Mt1, Mt2, Il33, and Fth1 are upregulated and enriched in pathways associated with inflammation, oxidative phosphorylation, and ferroptosis. Melatonin confers neuroprotective effects by inhibiting inflammation and ferroptosis mainly through the MT2/IL-33 pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Huiwen Zheng, Xin Guo, Shaomeng Kang, Zhongda Li, Tian Tian, Jianhua Li, Fudi Wang, Peng Yu, Shiyang Chang, Yan-zhong Chang
Summary: Ischemic stroke is a common and severe disease that leads to high mortality and morbidity rates worldwide. The molecular mechanisms underlying the neuronal damage in stroke victims are not well understood. This study found that the iron export protein FPN1 in brain microvascular endothelial cells plays a role in brain iron homeostasis and neuronal damage in ischemic stroke.
CELL DEATH & DISEASE
(2023)
Review
Chemistry, Inorganic & Nuclear
Shuying Shen, Jie Shen, Zhong Luo, Fudi Wang, Junxia Min
Summary: Auranofin (AUR) is a lipophilic gold-based compound used for rheumatoid arthritis treatment. It exhibits diverse biological properties, including antibacterial, antiviral, antifungal, antiparasitic, and anticancer activities. Mechanistically, AUR regulates cellular redox homeostasis by inhibiting thioredoxin reductase activity and affects multiple signaling pathways related to cell proliferation, apoptosis, and ferroptosis. Advances in stereospecific chemistry of AUR have identified new targets, offering potential for its use in various clinical indications.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Jie Fu, Xin Zong, Mingliang Jin, Junxia Min, Fudi Wang, Yizhen Wang
Summary: As cationic host defense peptides, defensins are synthesized by various cells and serve as crucial components of host defense. Recent research has focused on their biological functions, structure-activity relationships, mechanisms of action, and therapeutic potential. This review provides an overview of the roles of defensins in immune homeostasis, mucosal barrier function, gut microbiota regulation, and various diseases, as well as their regulation by nutrients. It offers important insights into the biology and potential clinical applications of defensins.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Urology & Nephrology
Xihao Cheng, Chao Yu, Xinquan Yang, Fudi Wang, Junxia Min
Summary: A review of the latest progress in the field of ferroptosis in cardiovascular disease (CVD) reveals that ferroptosis plays a pathogenic role in various forms of CVD, and targeting ferroptosis through modulation of iron metabolism, lipid metabolism, and oxidative metabolism represents a promising approach for the prevention and treatment of CVD.
Review
Cell & Tissue Engineering
Qin Ru, Yusheng Li, Wenqing Xie, Yilan Ding, Lin Chen, Guodong Xu, Yuxiang Wu, Fudi Wang
Summary: Ferroptosis, a unique form of cell death driven by iron accumulation and lipid peroxidation, is closely associated with iron metabolism, polyunsaturated fatty acid metabolism, and antioxidant pathways. Recent research has revealed a potential link between ferroptosis and age-related orthopedic diseases, such as osteoporosis and osteoarthritis. Understanding the regulatory mechanisms of ferroptosis in these diseases could lead to improved treatment and prevention strategies.
Article
Gastroenterology & Hepatology
Qiuyuan Yang, Yue Wu, Wei Liu, Xiaojuan Ou, Wei Zhang, Jianning Wang, Yanzhong Chang, Fudi Wang, Ming Gao, Sijin Liu
Summary: Our study explores the role of iron in liver lipid metabolism and finds that iron overload can disrupt the normal distribution of lipids within the liver, particularly in the periportal zone. Through gene expression analysis in both the pericentral and periportal zones, we identify pyruvate carboxylase (PC) as a key regulator in iron overload-induced lipid accumulation. We also reveal that the activation of cyclic adenosine monophosphate response element binding protein (CREB) is essential for Pc gene expression in response to iron overload.
LIVER INTERNATIONAL
(2023)