Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs)

Modulation of Liver Fibrosis by Adipokines

(2017) Fabio Marra et al.   DIGESTIVE DISEASES

Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

(2016) Nikolaos Stefanou et al.   BMC CANCER

Differential Roles of Insulin-like Growth Factor Receptor- and Insulin Receptor-mediated Signaling in the Phenotypes of Hepatocellular Carcinoma Cells

(2015) Ya-Wen Chen et al.   NEOPLASIA

Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma

(2013) K. Muir et al.   CANCER RESEARCH

Epidemiology and Natural History of Patients with NAFLD

(2013) Neeraj Bhala et al.   CURRENT PHARMACEUTICAL DESIGN

From NAFLD to NASH and HCC: Pathogenetic Mechanisms and Therapeutic Insights

(2013) Samuele De Minicis et al.   CURRENT PHARMACEUTICAL DESIGN

Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

(2013) Susan K. Murphy et al.   GASTROENTEROLOGY

Liver fatty acid binding protein (L-Fabp) modulates murine stellate cell activation and diet-induced nonalcoholic fatty liver disease

(2013) Anping Chen et al.   HEPATOLOGY

Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: Role of the S100A4-miR155-SOCS1-MMP9 axis

(2013) Xin-Long Yan et al.   HEPATOLOGY

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice

(2013) Guanhua Xie et al.   HEPATOLOGY

Selective hepatic insulin resistance in a murine model heterozygous for a mitochondrial trifunctional protein defect

(2013) R. Scott Rector et al.   HEPATOLOGY

Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice

(2013) Ziyan Wang et al.   HEPATOLOGY

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Role of Hepatic Progenitor Cells in Nonalcoholic Fatty Liver Disease Development: Cellular Cross-Talks and Molecular Networks

(2013) Guido Carpino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis

(2013) Yusaku Shirai et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver

(2013) Hiroyuki Motoyama et al.   LABORATORY INVESTIGATION

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Convergent pathways that cause hepatic fibrosis in NASH

(2013) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

Engineered SIRP  Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies

(2013) K. Weiskopf et al.   SCIENCE

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Introduction: MMPs, ADAMs/ADAMTSs Research Products to Achieve Big Dream

(2012) Isao Okazaki et al.   Anti-Cancer Agents in Medicinal Chemistry

Novel Strategies for Hepatocellular Carcinoma Based on MMPs Science

(2012) Isao Okazaki et al.   Anti-Cancer Agents in Medicinal Chemistry

Mechanisms of Disease Progression in NASH

(2012) Brittany N. Bohinc et al.   Clinics in Liver Disease

Hepatic progenitor cells activation, fibrosis, and adipokines production in pediatric nonalcoholic fatty liver disease

(2012) Valerio Nobili et al.   HEPATOLOGY

Fibrosis-dependent mechanisms of hepatocarcinogenesis

(2012) David Y. Zhang et al.   HEPATOLOGY

Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?

(2012) David van der Poorten et al.   HEPATOLOGY

Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice

(2012) Heng Lin et al.   HEPATOLOGY

Hepatic Stellate Cell-derived Delta-like Homolog 1 (DLK1) Protein in Liver Regeneration

(2012) Nian-Ling Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the stromal-derived factor-1 (SDF-1)–CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma

(2012) Alessandra Gentilini et al.   JOURNAL OF HEPATOLOGY

Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury

(2012) Ismail Syed et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver Fibrogenesis in Non-Alcoholic Steatohepatitis

(2012) Zhaolian Bian et al.   Frontiers in Physiology

Fascin-1 expression correlates with repression of E-cadherin expression in hepatocellular carcinoma cells and augments their invasiveness in combination with matrix metalloproteinases

(2011) Yoshihiro Hayashi et al.   CANCER SCIENCE

Pathophysiology of Non-Alcoholic Steatohepatitis and Basis for Treatment

(2011) Massimo Pinzani   DIGESTIVE DISEASES

MMP-9 activity is increased by adiponectin in primary human hepatocytes but even negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

(2011) Josef Wanninger et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

(2011) Toshiaki Teratani et al.   GASTROENTEROLOGY

Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression

(2011) Jingjing Jiao et al.   HEPATOLOGY

Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis

(2011) Núria Tarrats et al.   HEPATOLOGY

MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression

(2011) Jian-Hong Fang et al.   HEPATOLOGY

Nuclear receptors in liver disease

(2011) Martin Wagner et al.   HEPATOLOGY

Nuclear factor high-mobility group box1 mediating the activation of toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice

(2011) Liang Li et al.   HEPATOLOGY

Reactive oxygen species and NADPH oxidase 4 induced by transforming growth factor β1 are the therapeutic targets of polyenylphosphatidylcholine in the suppression of human hepatic stellate cell activation

(2011) Remina Ikeda et al.   INFLAMMATION RESEARCH

Reactive Oxygen Species Released from Hypoxic Hepatocytes Regulates MMP-2 Expression in Hepatic Stellate Cells

(2011) Jing Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

(2011) Hasan Korkaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production

(2011) Karen McLean et al.   JOURNAL OF CLINICAL INVESTIGATION

Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration and collagen gene expression through the FAK-PI3K-Akt pathway

(2011) Naoki Uyama et al.   LABORATORY INVESTIGATION

Full-spectrum antioxidant therapy featuring astaxanthin coupled with lipoprivic strategies and salsalate for management of non-alcoholic fatty liver disease

(2011) Mark F. McCarty   MEDICAL HYPOTHESES

Matrix Metalloproteinase-13 Promotes Recovery from Experimental Liver Cirrhosis in Rats

(2011) Hitoshi Endo et al.   PATHOBIOLOGY

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Pioglitazone in the treatment of NASH: the role of adiponectin

(2010) A. Gastaldelli et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Inhibition of Na+/H+ exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility

(2010) Xuekang Yang et al.   CANCER LETTERS

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Suppression of Liver Tumor Growth and Metastasis by Adiponectin in Nude Mice through Inhibition of Tumor Angiogenesis and Downregulation of Rho Kinase/IFN-Inducible Protein 10/Matrix Metalloproteinase 9 Signaling

(2010) K. Man et al.   CLINICAL CANCER RESEARCH

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways

(2010) Jing Fu et al.   HEPATOLOGY

Fitness versus fatness: Moving beyond weight loss in nonalcoholic fatty liver disease

(2010) Nathan A. Johnson et al.   HEPATOLOGY

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver

(2010) Kumaravelu Jagavelu et al.   HEPATOLOGY

The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

(2010) Mustafa S. Ascha et al.   HEPATOLOGY

Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis

(2010) Judith Ertle et al.   INTERNATIONAL JOURNAL OF CANCER

Leptin Promotes the Myofibroblastic Phenotype in Hepatic Stellate Cells by Activating the Hedgehog Pathway

(2010) Steve S. Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Soluble Leptin Receptor Levels in Morbidly Obese Patients With Insulin Resistance and Nonalcoholic Fatty Liver Disease

(2010) Valentina Medici et al.   Obesity

Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression

(2010) S Y Park et al.   ONCOGENE

The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective

(2010) A. P. Venook et al.   ONCOLOGIST

Liver immunolocalization and plasma levels of MMP-9 in non-alcoholic steatohepatitis (NASH) and hepatitis C infection

(2009) Fabio D’Amico et al.   ACTA HISTOCHEMICA

Expression ofKiSS-1Gene and its Role in Invasion and Metastasis of Human Hepatocellular Carcinoma

(2009) Zang Shengbing et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

NASH and HCC

(2009) John M. Page et al.   Clinics in Liver Disease

Liver expression of matrix metalloproteases and their inhibitors in hepatocellular carcinoma

(2009) A. Altadill et al.   DIGESTIVE AND LIVER DISEASE

Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production During Hepatic Fibrogenesis in Mice

(2009) Reiichi Higashiyama et al.   GASTROENTEROLOGY

Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis

(2009) Valérie Paradis et al.   HEPATOLOGY

Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial

(2009) Vlad Ratziu et al.   HEPATOLOGY

Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury

(2009) Noémi K. M. Van Hul et al.   HEPATOLOGY

Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

(2009) Etsuko Hashimoto et al.   JOURNAL OF GASTROENTEROLOGY

Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis

(2009) Takeharu Asano et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Distinction of hepatocellular adenoma from hepatocellular carcinoma with and without cirrhosis using E-cadherin and matrix metalloproteinase immunohistochemistry

(2009) Maria S Tretiakova et al.   MODERN PATHOLOGY

TGFβ-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

(2009) B Wang et al.   ONCOGENE

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

(2009) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Hepatocyte Growth Factor Suppresses Profibrogenic Signal Transduction via Nuclear Export of Smad3 With Galectin-7

(2008) Yutaka Inagaki et al.   GASTROENTEROLOGY

Visceral fat: A key mediator of steatohepatitis in metabolic liver disease

(2008) David van der Poorten et al.   HEPATOLOGY

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY

Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis

(2008) Tadashi Moro et al.   LIFE SCIENCES