Article
Oncology
Min Jee Jo, Bu Gyeom Kim, Woo Young Kim, Dae-Hee Lee, Hye Kyeong Yun, Soyeon Jeong, Seong Hye Park, Bo Ram Kim, Jung Lim Kim, Dae Yeong Kim, Sun Il Lee, Sang Cheul Oh
Summary: CBD has been shown to suppress angiogenesis and stem cell-like properties of breast cancer by interfering with the Src/VHL/HIF-1a signaling pathway. This suggests that CBD may have potential for the treatment of refractory or recurrent breast cancer.
Article
Oncology
Hongyu Yuan, Zitong Zhao, Jing Xu, Ruiping Zhang, Liying Ma, Jing Han, Weihong Zhao, Mingzhou Guo, Yongmei Song
Summary: This study elucidated the molecular mechanism of TMTC3 in regulating tumor angiogenesis and identified the potential therapeutic combination of TMTC3 inhibitor and cisplatin, providing a promising strategy for the treatment of esophageal squamous cell carcinoma (ESCC).
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Agnes Bocian-Jastrzebska, Anna Malczewska-Herman, Beata Kos-Kudla
Summary: This review comprehensively summarizes the role of leptin and adiponectin in different stages of cancer development, focusing on their interactions with the tumor microenvironment, epithelial-mesenchymal transition, and angiogenesis. Understanding these mechanisms is crucial for the potential use of these adipokines in cancer diagnostics and therapeutics.
Article
Genetics & Heredity
Brian M. Ortmann, Natalie Burrows, Ian T. Lobb, Esther Arnaiz, Niek Wit, Peter S. J. Bailey, Louise H. Jordon, Olivia Lombardi, Ana Penalver, James McCaffrey, Rachel Seear, David R. Mole, Peter J. Ratcliffe, Patrick H. Maxwell, James A. Nathan
Summary: The histone H3K4 methyltransferase SET1B plays a crucial role in the transcriptional activity of HIF target genes, and its loss results in impaired cell growth and tumor formation. Experimental findings demonstrate that SET1B accumulates on chromatin in hypoxia and is recruited to HIF target genes by the HIF complex.
Review
Pharmacology & Pharmacy
Shuang Luo, Yu Jiang, Anfu Zheng, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Shuai Deng, Meijuan Chen, Wanping Li, Xiaobing Li, Li Gu, Yuhong Sun, Zhangang Xiao, Jing Shen
Summary: Hypoxia-inducible factors (HIFs), central regulators in the adaptation of cells to low oxygen levels, are frequently overexpressed and activated in breast cancer. They influence various processes related to cancer development, such as glycolysis, angiogenesis, and metastasis, thus affecting the prognosis of breast cancer patients. Targeting HIFs specifically could potentially enhance the efficiency of cancer therapy. Additionally, drug delivery systems (DDSs) for HIF targeting, including liposomes, polymers, and nanoparticles, are being developed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yuanyu Zhao, Fang Liu, Junfeng Dong, Hong Fu, Jianhua Luo, Junsong Ji, Xiaogang Gao, Wenyuan Guo
Summary: It has been found that the expression of miR-93 is significantly downregulated in innate cells and in patients infected with RNA viruses, including influenza virus. It has been shown that miR-93 inhibits the antiviral activity of type I interferons by targeting JAK1. Antagomirs of miR-93 can reduce influenza virus replication and prevent death in mice, suggesting miR-93 as a potential therapeutic target for RNA virus infection.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xianjie Jiang, Xiangying Deng, Jie Wang, Yongzhen Mo, Lei Shi, Fang Wei, Shanshan Zhang, Zhaojian Gong, Yi He, Fang Xiong, Yumin Wang, Can Guo, Bo Xiang, Ming Zhou, Qianjin Liao, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
Summary: BPIFB1, highly expressed in nasopharyngeal epithelium, is downregulated in NPC and associated with poor prognosis; BPIFB1 inhibits vasculogenic mimicry by regulating metabolic reprogramming in NPC; These findings provide a new therapeutic target for NPC diagnosis and treatment.
Article
Pharmacology & Pharmacy
Jie Li, Hui Lv, Yuqin Che, Jianhua Fan
Summary: The study demonstrated that Serenoa repens extract has anti-tumor effects on glioblastoma in BALB/c nude mice, prolonging survival and reducing tumor infiltration by modulating the NF-kappa B/Cox-2 signaling pathway.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Elizabeth E. Wicks, Gregg L. Semenza
Summary: This review presents the mechanisms and consequences of hypoxia-inducible factor (HIF) activation in cancer cells, and discusses the current status and future prospects of small-molecule HIF inhibitors as cancer therapeutics.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Environmental Sciences
Huang-Ming Hu, Hsiang-Lin Lee, Chung-Jung Liu, Yi-Hsien Hsieh, Yong-Syuan Chen, Kuan-Chun Hsueh
Summary: The study found that MTA2 regulates HCC progression through the MTA2-FAK-MMP7 pathway. PTK7, as a downstream factor of MTA2, affects the migration and invasion abilities of HCC cells by regulating MMP7 expression. The expression level of PTK7 is correlated with tumor stage, grade, and overall survival in HCC patients, and may have diagnostic value for HCC patients.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Marina Roy-Luzarraga, Louise E. Reynolds, Beatriz de Luxan-Delgado, Oscar Maiques, Laura Wisniewski, Emma Newport, Vinothini Rajeeve, Rebecca J. G. Drake, Jesus Gomez-Escudero, Frances M. Richards, Celine Weller, Christof Dormann, Ya-Ming Meng, Peter B. Vermeulen, Dieter Saur, Victoria Sanz-Moreno, Ping-Pui Wong, Cyrill Geraud, Pedro R. Cutillas, Kairbaan Hodivala-Dilke
Summary: This study reveals that endothelial cell focal adhesion kinase (FAK) plays a role in regulating pancreatic ductal adenocarcinoma (PDAC) metastasis and impacting the outcome of gemcitabine treatment. The findings suggest the potential clinical utility of combinatorial endothelial cell FAK targeting with gemcitabine in controlling metastasis in PDAC patients.
Article
Pharmacology & Pharmacy
Fares Hezam Al-Ostoot, Ankith Sherapura, V. Vigneshwaran, Giridhara Basappa, H. K. Vivek, B. T. Prabhakar, Shaukath Ara Khanum
Summary: The study synthesized and validated new IPA (8a-n) analogs, with IPA (8k) identified as a lead molecule with anti-proliferative and anti-angiogenic activities. By targeting HIF-1α, it modulates downstream genes and exhibits anti-tumor activity both in vitro and in vivo.
PHARMACOLOGICAL REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Brianna Guarino, Venkatesh Katari, Ravi Adapala, Neha Bhavnani, Julie Dougherty, Mahmood Khan, Sailaja Paruchuri, Charles Thodeti
Summary: This study demonstrates that t-EVs induce endothelial cell phenotypic transition and abnormal angiogenesis through post-translational downregulation of TRPV4 and activation of the Rho/Rho kinase/YAP/VEGFR2 pathways. Furthermore, t-EVs can induce abnormal vessel formation in vivo independently of tumors, suggesting their potential as novel targets for vascular normalization and cancer therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
Sharareh Bordbari, Britta Morchen, Ekaterina Pylaeva, Elena Siakaeva, Ilona Spyra, Maksim Domnich, Freya Droege, Oliver Kanaan, Karl Sebastian Lang, Dirk Schadendorf, Stephan Lang, Iris Helfrich, Jadwiga Jablonska
Summary: This study reveals that Type I interferon-deficient tumor-associated neutrophils play a significant role in promoting angiogenesis in tumors by releasing pro-angiogenic factors and activating the transcription factor FOXO3a. The post-translational modifications of FOXO3a control its transcriptional activity, which ultimately regulates the expression of pro-angiogenic factors. Targeting FOXO3a activity could be a potential strategy for antiangiogenic targeted therapy in cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemical Research Methods
James R. Byrnes, Amy M. Weeks, Eric Shifrut, Julia Carnevale, Lisa Kirkemo, Alan Ashworth, Alexander Marson, James A. Wells
Summary: Immunosuppressive factors in the tumor microenvironment impair T cell function. This study examines how regulatory T cells (Tregs) and hypoxia affect the surface proteome of primary human T cells. The results show that Tregs have only a modest effect on the surface proteome, while hypoxia drastically alters it, inducing an immunosuppressed state.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Editorial Material
Endocrinology & Metabolism
Ranyao Yang, Aimin Xu, Alexei Kharitonenkov
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Howell Leung, Xiaoxue Long, Yueqiong Ni, Lingling Qian, Emmanouil Nychas, Sara Leal Siliceo, Dennis Pohl, Kati Hanhineva, Yan Liu, Aimin Xu, Henrik B. Nielsen, Eugeni Belda, Karine Clement, Rohit Loomba, Huating Li, Weiping Jia, Gianni Panagiotou
Summary: A growing body of evidence suggests that the gut microbiota plays a role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study found that machine learning models integrating microbial signatures were able to accurately classify individuals based on their NAFLD status and liver fat accumulation, outperforming other clinical models. These findings raise the possibility of using gut microbiota for early clinical warning of NAFLD development.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Juanying Zhen, Shuyun Liu, Ryan Yan Lam Kam, Guoru Zhao, Hao Peng, Jianguo Liang, Aimin Xu, Chao Li, Lijie Ren, Jun Wu, Bernard Man Yung Cheung
Summary: We aimed to investigate the relationship of B2M, cystatin C, and LCN-2 with stroke risk in a general Chinese population. Elevated levels of serum B2M, cystatin C, and LCN-2 were significantly associated with stroke risk. These biomarkers may serve as useful tools for clinicians to assess stroke risk.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hui Liu, Yueqin Zhu, Kevin Tak-Pan Ng, Chung-Mau Lo, Kwan Man
Summary: The application of steatotic liver graft has been increased due to donor shortage and prevalence of non-alcoholic fatty liver disease. However, steatotic livers are vulnerable to inflammatory injury, which may lead to cancer recurrence. This study identified differential alternative splicing events (ASEs) in steatotic liver grafts and their association with tumor recurrence. The differential ASEs were associated with HCC patients' survival and were enriched in metabolic pathways and immune cell distribution. The cancer hallmarks were also enriched in steatotic liver grafts and linked to differential ASEs. This work provides new insights into the relationship between steatotic liver graft injury and tumor recurrence, as well as potential markers for prognosis and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Chi-Ho Lee, David Tak-Wai Lui, Chloe Yu-Yan Cheung, Carol Ho-Yi Fong, Michele Mae-Ann Yuen, Yu-Cho Woo, Wing-Sun Chow, Ian Yat-Hin Wong, Aimin Xu, Karen Siu-Ling Lam
Summary: This study evaluated the associations of three diabetes-related biomarkers (AFABP, FGF21, and PEDF) with the development of sight-threatening diabetic retinopathy (STDR). The results showed that serum AFABP level was independently associated with incident STDR and its addition to a clinical model improved the prediction of STDR among participants without baseline retinopathy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Transplantation
Chi-Ho Lee, David Tak-Wai Lui, Chloe Yu-Yan Cheung, Carol Ho-Yi Fong, Michele Mae-Ann Yuen, Wing-Sun Chow, Aimin Xu, Karen Siu-Ling Lam
Summary: This study aimed to investigate the association between serum TSP2 level and kidney function decline in patients with type 2 diabetes. The results showed that serum TSP2 level was independently associated with incident eGFR decline and could predict a rapidly declining trajectory. This finding is of great importance for the renal health management of patients with diabetes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kangmin Yang, Srividya Velagapudi, Alexander Akhmedov, Simon Kraler, Tetiana Lapikova-Bryhinska, Martin O. Schmiady, Xiaoping Wu, Leiluo Geng, Giovanni G. Camici, Aimin Xu, Thomas F. Luscher
Summary: This study aimed to investigate the therapeutic potential of chronic recombinant murine SIRT1 (rmSIRT1) supplementation to alleviate endothelial and vascular dysfunction in diabetic mice. The results showed that arterial SIRT1 levels were significantly reduced in diabetic conditions, while rmSIRT1 supplementation restored SIRT1 levels and improved endothelial function and vascular compliance. The study suggests that SIRT1 supplementation may represent a novel therapeutic strategy to prevent and treat diabetic vascular disease by enhancing eNOS activity and suppressing NOX-related oxidative stress.
CARDIOVASCULAR RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Kevin Tak-Pan Ng, Jiang Liu, Oscar Wai-Ho Yeung, Li Pang, Hoi Chung Shiu, Hui Liu, Xin Xiang Yang, Albert Chi-Yan Chan, Tiffany Cho-Lam Wong, Chung Mau Lo, Kwan Man
Summary: This study found that post-transplant cytokines CCL11, IFN alpha 2, and IL17A are significant predictors of tumor recurrence and survival after liver transplantation for hepatocellular carcinoma. A prediction model including these cytokines, the UCSF criteria, and pre-transplant AFP accurately predicted post-transplant tumor recurrence and guided refinements in surveillance and therapeutic strategies.
HEPATOLOGY INTERNATIONAL
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Xinxiang Yang, Jinyang Li, Rongrong Zhong, Rui Shen, Jiaqi Wang, Congwen Bian, Kevin Tak-Pan Ng, Kwan Man
Article
Primary Health Care
Juanying Zhen, Shuyun Liu, Guoru Zhao, Hao Peng, Aimin Xu, Chao Li, Jun Wu, Bernard Man Yung Cheung
Summary: This study investigates the relationship between lifestyle and hypertension in a Chinese population and finds that a healthy lifestyle score is inversely related to the risk of hypertension. This highlights the importance of addressing lifestyle to reduce the risk of hypertension.
Article
Oncology
Victor Chun -Lam Wong, Ming-In Wong, Victor Ho-Fun Lee, Kwan Man, Kevin Tak-Pan Ng, Tan To Cheung
Summary: This study aimed to develop liquid biopsy assays for early HCC diagnosis and prognosis. A panel of 23 microRNAs (HCCseek-23 panel) was consolidated based on their reported functions in HCC development. Serum samples were collected from 103 early-stage HCC patients before and after hepatectomy. Quantitative PCR and machine learning random forest models were applied to develop diagnostic and prognostic models.
Article
Gastroenterology & Hepatology
Hui Liu, Wai Ho Oscar Yeung, Li Pang, Jiang Liu, Xiao Bing Liu, Kevin Tak Pan Ng, Qingmei Zhang, Wen Qi Qiu, Yueqin Zhu, Tao Ding, Zhe Wang, Ji Ye Zhu, Chung Mau Lo, Kwan Man
Summary: During fatty liver graft injury, arachidonic acid activates NLRP3 inflammasome in MDSCs through FATP2, which subsequently stimulates CD4+ T cells producing IL-17 to promote tumor recurrence post transplantation.
Meeting Abstract
Gastroenterology & Hepatology
Tao Ding, Li Pang, Jiang Liu, Kevin Tak-Pan Ng, Oscar Wai-Ho Yeung, Hui Liu, Zhe Wang, Shinuan Zeng, Jinyang Li, Kwan Man
Meeting Abstract
Gastroenterology & Hepatology
Jiang Liu, Li Pang, Oscar Wai-Ho Yeung, Kevin Tak-Pan Ng, Chung-Mau Lo, Jia-Hong Dong, Kwan Man
Meeting Abstract
Gastroenterology & Hepatology
Wenqi Qiu, Xinxiang Yang, Zhe Wang, Kwan Man, Kevin Tak-Pan Ng