Mechanisms and Therapeutic Implications of Cell Death Induction by Indole Compounds

Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells

(2011) Bin Bao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine

(2011) Keisuke Shimamoto et al.   TOXICOLOGY

miR-146a Suppresses Invasion of Pancreatic Cancer Cells

(2010) Y. Li et al.   CANCER RESEARCH

Anticancer Properties of Indole Compounds: Mechanism of Apoptosis Induction and Role in Chemotherapy

(2010) Aamir Ahmad et al.   CURRENT DRUG TARGETS

Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance

(2010) Zhiwei Wang et al.   DRUG RESISTANCE UPDATES

3,3′-diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1

(2010) Aamir Ahmad et al.   INTERNATIONAL JOURNAL OF CANCER

3,3′-diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model

(2010) Han Jin Cho et al.   MOLECULAR CARCINOGENESIS

3,3′-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators

(2010) Eun Ji Kim et al.   MOLECULAR CARCINOGENESIS

Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species

(2010) Mohammad F. Ullah et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Activation of Checkpoint Kinase 2 by 3,3'-Diindolylmethane Is Required for Causing G2/M Cell Cycle Arrest in Human Ovarian Cancer Cells

(2010) P. K. Kandala et al.   MOLECULAR PHARMACOLOGY

Pancreatic cancer: understanding and overcoming chemoresistance

(2010) Zhiwei Wang et al.   Nature Reviews Gastroenterology & Hepatology

Nanochemoprevention: Sustained Release of Bioactive Food Components for Cancer Prevention

(2010) Imtiaz A. Siddiqui et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

RETRACTED ARTICLE: FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors

(2009) Aamir Ahmad et al.   BREAST CANCER RESEARCH AND TREATMENT

Peroxisome proliferator-activated receptor γ-dependent activity of indole ring-substituted 1,1-bis(3′-indolyl)-1-(p-biphenyl)methanes in cancer cells

(2009) Jingjing Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

RETRACTED: Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agents

(2009) Shadan Ali et al.   CANCER LETTERS

3,3'-Diindolylmethane Enhances the Efficacy of Butyrate in Colon Cancer Prevention through Down-Regulation of Survivin

(2009) N. Bhatnagar et al.   Cancer Prevention Research

3,3'-Diindolylmethane Induction of p75NTR-Dependent Cell Death via the p38 Mitogen-Activated Protein Kinase Pathway in Prostate Cancer Cells

(2009) F. S. Khwaja et al.   Cancer Prevention Research

3,3'-Diindolylmethane Enhances Taxotere-Induced Apoptosis in Hormone-Refractory Prostate Cancer Cells through Survivin Down-regulation

(2009) K. W. Rahman et al.   CANCER RESEARCH

Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells

(2009) Y. Li et al.   CANCER RESEARCH

3,3′-Diindolylmethane Enhances Chemosensitivity of Multiple Chemotherapeutic Agents in Pancreatic Cancer

(2009) Sanjeev Banerjee et al.   CANCER RESEARCH

Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics

(2009) Fazlul H. Sarkar et al.   CANCER TREATMENT REVIEWS

Cellular signaling perturbation by natural products

(2009) Fazlul H. Sarkar et al.   CELLULAR SIGNALLING

Chemosensitization and Immunosensitization of Resistant Cancer Cells to Apoptosis and Inhibition of Metastasis by the Specific NF-κB Inhibitor DHMEQ

(2009) Alina Katsman et al.   CURRENT PHARMACEUTICAL DESIGN

Down-regulation of uPA and uPAR by 3,3′-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells

(2009) Aamir Ahmad et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inactivation of uPA and its receptor uPAR by 3,3′-diindolylmethane (DIM) leads to the inhibition of prostate cancer cell growth and migration

(2009) Aamir Ahmad et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Oral Administration of 3,3′-Diindolylmethane Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells in BALB/c Mice

(2009) Eun Ji Kim et al.   JOURNAL OF NUTRITION

Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals

(2009) Erin L. Hsu et al.   Journal of Oncology

CXCR4 and CXCL12 down-regulation: A novel mechanism for the chemoprotection of 3,3′-diindolylmethane for breast and ovarian cancers

(2008) Erin L. Hsu et al.   CANCER LETTERS

Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs

(2008) Stephen Safe et al.   CANCER LETTERS

Mammalian Target of Rapamycin Repression by 3,3'-Diindolylmethane Inhibits Invasion and Angiogenesis in Platelet-Derived Growth Factor-D-Overexpressing PC3 Cells

(2008) D. Kong et al.   CANCER RESEARCH

The IκB kinase – a bridge between inflammation and cancer

(2008) Michael Karin   CELL RESEARCH

Survivin: Key Regulator of Mitosis and Apoptosis and Novel Target for Cancer Therapeutics

(2008) A. C. Mita et al.   CLINICAL CANCER RESEARCH

Targeting survivin in cancer therapy

(2008) Marzia Pennati et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

NF-κB Signaling Pathway and Its Therapeutic Implications in Human Diseases

(2008) Fazlul H. Sarkar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

PI3K/Akt inhibition modulates multidrug resistance and activates NF-κB in murine lymphoma cell lines

(2008) Mariana G. García et al.   LEUKEMIA RESEARCH

Induction of growth arrest and apoptosis in human breast cancer cells by 3,3-diindolylmethane is associated with induction and nuclear localization of p27kip

(2008) Z. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3′-indoly)-1-(p-substituted phenyl)methanes

(2008) Ping Lei et al.   MOLECULAR CANCER THERAPEUTICS

Apoptosis-inducing effect of erlotinib is potentiated by 3,3′-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer

(2008) Shadan Ali et al.   MOLECULAR CANCER THERAPEUTICS