期刊
JOURNAL OF ONCOLOGY
卷 2009, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2009/491985
关键词
-
类别
资金
- American Institute for Cancer Research [441450-58819-OH]
- University of California Iris Cantor Women's Health Center,
- UCLA Clinical Nutrition Research Unit
- NATIONAL CANCER INSTITUTE [R01CA028868] Funding Source: NIH RePORTER
CXCR4 is a chemokine receptor frequently overexpressed on primary tumor cells. Organs to which these cancers metastasize secrete CXCL12, the unique ligand for CXCR4, which stimulates invasion and metastasis to these sites. Similar to our previous work with the chemoprotective phytochemical, 3,3' -diindolylmethane (DIM), we show here that genistein also downregulates CXCR4 and CXCL12 and subsequently lowers the migratory and invasive potentials of breast and ovarian cancer cells. Moreover, genistein and DIM elicit a significantly greater cumulative effect in lowering CXCR4 and CXCL12 levels than either compound alone. Our data suggest a novel mechanism for the protective effects of phytochemicals against cancer progression and indicate that in combination, these compounds may prove even more efficacious. Copyright (C) 2009 Erin L. Hsu et al.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据