Article
Clinical Neurology
Daniel Asby, Delphine Boche, Stuart Allan, Seth Love, J. Scott Miners
Summary: Our study found that multiple brain cytokines were elevated in Alzheimer's disease and vascular dementia, and systemic infection exacerbated cerebral hypoperfusion and blood-brain barrier leakiness associated with these dementias. The level of insoluble amyloid-beta did not seem to play a significant role in these effects.
Review
Biochemistry & Molecular Biology
Stefania Merighi, Manuela Nigro, Alessia Travagli, Stefania Gessi
Summary: Neuroinflammation may be a crucial avenue for treating and preventing Alzheimer's disease, with microglia playing a key role in the disease process but potentially becoming impaired in later stages. It is important to identify new biomarkers to assess microglial activity and develop novel therapies to restore their physiological function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Dieli
Summary: The inflammatory response in Alzheimer's disease has both protective and harmful effects. Microglia initially play a protective role but can become overactivated, leading to impaired clearance of β-amyloid peptides and neurodegeneration. Microglia also contribute to the spread of tau pathology. Elevated levels of soluble TREM2 in cerebrospinal fluid are associated with amyloid plaque burden, neurodegeneration, and cognitive decline. Understanding the relationship between innate immunity and Alzheimer's disease could lead to new diagnostic and therapeutic approaches, but further studies are needed for effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wang
Summary: Alzheimer's disease is a common neurodegenerative disease that leads to cognitive decline and memory loss. Current treatments only provide symptom relief and do not reverse the disease. Studies have shown that TREM2, predominantly expressed in microglia of the central nervous system, plays a protective role by regulating microglial function and promoting the clearance of toxic substances. However, the specific mechanism of action is not fully understood.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Lucia Scipioni, Francesca Ciaramellano, Veronica Carnicelli, Alessandro Leuti, Anna Rita Lizzi, Noemi De Dominicis, Sergio Oddi, Mauro Maccarrone
Summary: This article reviews the role of microglial cells in chronic inflammation in Alzheimer's disease (AD) and the involvement of endocannabinoids in regulating their activity.
Review
Biochemistry & Molecular Biology
Akash Shah, Uday Kishore, Abhishek Shastri
Summary: This article discusses how the complement system plays a role in the functioning of the central nervous system, while also contributing to chronic neuroinflammation leading to neurodegenerative disorders like Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott, M. Kerry O'Banion
Summary: Gas6 overexpression reduces plaque burden but increases pro-inflammatory signaling and worsens behavior in an Alzheimer's disease model. Gas6 overexpression appears to have no effect on phagocytic mechanisms in vitro or in vivo.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Junhua Li, Lin Wang, Qinhua Zeng, Jing He, Qing Tang, Kejian Wang, Guiqiong He
Summary: This study investigates the role of MKP-1 in regulating microglia phenotype and inflammatory factor release in Alzheimer's disease (AD). The findings suggest that MKP-1 can modulate microglia phenotype and inflammatory factor release in AD through the p38 signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Rawan Almarhoumi, Carla Alvarez, Theodore Harris, Christina M. Tognoni, Bruce J. Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci
Summary: In this study, periodontal disease (PD) was induced in mice and it was found that PD leads to activation of microglia and promotes a pro-inflammatory and phagocytic phenotype in the microglia.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Mulan Bao, Rengui Bade, Hua Liu, Battseren Tsambaa, Guo Shao, Almaz Borjigidai, Yong Cheng
Summary: AS-IV from Huangqi may regulate inflammation and microglial activation in AD via EGFR-dependent pathways. EGFR and IL-113 could be important targets that co-regulate downstream molecular functions in the treatment of AD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Immunology
Junhua Xie, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Summary: Alzheimer's disease is an age-related neurodegenerative disorder with increasing prevalence. Current treatments are limited to symptomatic medication, and there is a need for a better understanding of the underlying mechanisms to develop more rational therapies. Peripheral inflammation has been identified as a detrimental factor in AD, and this review provides an overview of the link between peripheral inflammation and AD initiation and progression, contributing to a broader understanding of the disease pathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Yi-He Chen, Rong-Rong Lin, Qing-Qing Tao
Summary: Alzheimer's disease is the most common cause of dementia and is increasing with global aging trends. In addition to the known core pathologies of AD, neuroinflammation has been recognized as playing an important role. Recent evidence has shown that P2X7R plays a critical role in neuroinflammation and AD pathogenesis.
Review
Biochemistry & Molecular Biology
Edward S. Wickstead
Summary: Alzheimer's disease is a common neurodegenerative disorder, especially among the elderly population, with a significant impact on society and the economy. Genome-wide association studies have identified numerous genetic loci that are associated with increased risk of AD. The use of gene editing technology and hiPSCs can provide valuable insights into the role of immune-associated genetic risk variants in AD.
Article
Biotechnology & Applied Microbiology
Liang Tang, Qin Xiang, Ju Xiang, Yan Zhang, Jianming Li
Summary: The study aimed to explore the effect of Tripterygium glycoside (TG) on Alzheimer's disease (AD). The results showed that TG significantly improved spatial memory and learning abilities in AD mice, reduced neuronal damage, and inhibited the release of inflammatory factors and microglial activity.
Article
Materials Science, Multidisciplinary
Ze Li, Zhenyan Song, Chunxiang He, Jialong Fan, Wenjing Yu, Miao Yang, Ping Li, Rongsiqing Luo, Jinyong Zhou, Sijie Xu, Bin Liu, Shaowu Cheng
Summary: This study developed a nano delivery system that can reverse microglia polarization, improve learning and memory, alleviate glial cell activation, and enhance cognitive function in Alzheimer's disease treatment, indicating its promising therapeutic potential.
MATERIALS TODAY ADVANCES
(2022)
Article
Clinical Neurology
Ian Galea, Andrew Durnford, James Glazier, Sophie Mitchell, Suraj Kohli, Lesley Foulkes, Jeanette Norman, Angela Darekar, Seth Love, Diederik O. Bulters, James A. R. Nicoll, Delphine Boche
Summary: Iron deposits in the cortical gray matter after aneurysmal subarachnoid hemorrhage (SAH) and is associated with cognitive outcome. These findings support therapeutic approaches to prevent the permeation of hemoglobin into the cortex after SAH.
Article
Clinical Neurology
Yoshiki Hase, Kamar E. Ameen-Ali, Rachel Waller, Julie E. Simpson, Charlotte Stafford, Ayushi Mahesh, Lucy Ryan, Lucy Pickering, Caroline Bodman, Mai Hase, Delphine Boche, Karen Horsburgh, Stephen B. Wharton, Raj N. Kalaria
Summary: This study assessed the status of perivascular microglia in stroke survivors who develop dementia and found that dementia patients accumulate more activated perivascular CD68+ microglia in white matter, rather than TREM2+ cells. This suggests that CD68+ cells play a differential role in perivascular inflammation within the gliovascular unit of the deep white matter.
Article
Critical Care Medicine
Jonathan R. Weir-McCall, Elise Debruyn, Scott Harris, Nagmi R. Qureshi, Robert C. Rintoul, Fergus Gleeson, Fiona J. Gilbert
Summary: A lung cancer prediction convolutional neural network (LCP-CNN) demonstrates diagnostic performance comparable to PET with CT imaging in the diagnosis of solitary pulmonary nodules. The LCP-CNN outperforms dynamic contrast-enhanced (DCE) CT imaging in accuracy, while being equal to PET with CT imaging.
Article
Cell Biology
Jan N. Hansen, Matthias Brueckner, Marie J. Pietrowski, Jan F. Jikeli, Monika Plescher, Hannes Beckert, Mareike Schnaars, Lorenz Fuelle, Katharina Reitmeier, Thomas Langmann, Irmgard Foerster, Delphine Boche, Gabor C. Petzold, Annett Halle
Summary: In this article, the authors introduce an open-source and freely accessible software called MotiQ for automated quantification of microglial motility and morphology. The software is versatile and can be used with various types of data, and its results can be compared with other analysis methods.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Editorial Material
Clinical Neurology
J. Scott Miners, Robert A. Fisher, Seth Love
Article
Clinical Neurology
Edward B. Lee, Claire Kennedy-Dietrich, Jennian F. Geddes, James A. R. Nicoll, Tamas Revesz, Douglas H. Smith, William Stewart
ACTA NEUROPATHOLOGICA
(2023)
Article
Geriatrics & Gerontology
Bronagh Walsh, Carole Fogg, Scott Harris, Paul Roderick, Simon de Lusignan, Tracey England, Andrew Clegg, Sally Brailsford, Simon D. S. Fraser
Summary: Frailty is common in older adults and is associated with increased health and social care use. Longitudinal information is needed on population-level incidence, prevalence and frailty progression to plan services to meet future population needs.
Article
Clinical Neurology
Hannah M. Tayler, Robert MacLachlan, Ozge Guzel, J. Scott Miners, Seth Love
Summary: Hypertension in midlife is a modifiable risk factor for dementia, and its relationship with cognitive decline is well-established. However, the connection between late-life hypertension and dementia is less clear. This study aimed to investigate the relationship between blood pressure during late life and markers of Alzheimer's disease, vascular function, and cerebral oxygenation. The findings suggest a complex relationship between late-life blood pressure, disease pathology, and vascular function in dementia.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
William Stewart, Michael E. Buckland, Bobak Abdolmohammadi, Andrew J. Affleck, Victor E. Alvarez, Shannon Gilchrist, Bertrand R. Huber, Edward B. Lee, Donald M. Lyall, Christopher J. Nowinski, Emma R. Russell, Thor D. Stein, Catherine M. Suter, Ann C. McKee
ACTA NEUROPATHOLOGICA
(2023)
Review
Immunology
Livia J. De Picker, Manuel Morrens, Igor Branchi, Bartholomeus C. M. Haarman, Tatsuhiro Terada, Min Su Kang, Delphine Boche, Marie-Eve Tremblay, Claire Leroy, Michel Bottlaender, Julie Ottoy
Summary: This study is a transdiagnostic systematic review and meta-analysis of case-control TSPO PET studies in humans for various CNS disorders. The results show robust increases in the TSPO signal for specific types of disorders, which can be widespread or focal. These findings can contribute to future studies in optimizing experimental design and power calculations.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Emma F. Garland, Oliver Dennett, Laurie C. Lau, David S. Chatelet, Michel Bottlaender, James A. R. Nicoll, Delphine Boche
Summary: This study aimed to compare the neuroinflammatory differences between the temporal cortex and cerebellar cortex, including TSPO expression. The results showed that the cerebellum maintains a more homeostatic environment compared to the temporal cortex, with a consistent TSPO expression, supporting its use as a pseudo-reference region for quantification in TSPO PET scans.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Medicine, General & Internal
Emma Rosalyn Russell, Donald M. Lyall, William Stewart
Summary: This study aims to explore the impact of traumatic brain injury (TBI) on the risk of dementia, as well as analyze the differences between a TBI-exposed group and a control group. Existing diagnostic imaging and radiological reports will also be analyzed to identify evidence of specific white matter abnormalities and their potential diagnostic utility.
Review
Cell Biology
Jay Amin, Claire Gee, Kiran Stowell, Daisy Coulthard, Delphine Boche
Summary: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, with a poorer prognosis compared to Alzheimer's disease (AD). Recent research has shown that peripheral inflammation may play a role in dementia, and T lymphocytes may have a potential role in DLB. This review examines the profile of T lymphocytes in DLB and proposes how they may relate to peripheral T lymphocyte characteristics.
Article
Clinical Neurology
Imran Noorani, Kastytis Sidlauskas, Sean Pellow, Reece Savage, Jeannette L. Norman, David S. Chatelet, Mark Fabian, Paul Grundy, Jeng Ching, James A. R. Nicoll, Delphine Boche
Summary: Noorani et al. investigated the immune-phenotype of glioblastoma cores and their invasive margins, discovering correlations between anti-inflammatory macrophages, CD8(+) T cells, and programmed death-ligand 1. They found that high expression of triggering receptor expressed on myeloid cells 2, programmed death-ligand 1, and CD32a at the leading edge of glioblastomas indicated poorer overall survival. These findings have significant clinical implications for targeting microglia/macrophages and immune checkpoint inhibitors in glioblastoma treatment.
BRAIN COMMUNICATIONS
(2023)
Article
Public, Environmental & Occupational Health
E. R. Russell, S. J. Spencer, C. M. Atherton, D. M. Lyall, D. F. Mackay, K. Stewart, J. A. Maclean, J. P. Pell, W. Stewart
Summary: This study found that former professional soccer players have a higher risk of lower limb osteoarthritis compared to the general population. They also have an increased risk of meniscal injury and joint replacement.
OCCUPATIONAL MEDICINE-OXFORD
(2023)