Article
Immunology
Jialong Chen, Kanmin Mao, Honglin Yu, Yue Wen, Hua She, He Zhang, Linhua Liu, Mingque Li, Wenjun Li, Fei Zou
Summary: The study found that the p38-TFEB signaling pathway promotes neuroinflammation in Parkinson's disease by inhibiting CMA-mediated NLRP3 degradation. Inhibition of p38 has a protective effect in PD models, preventing neurodegeneration and alleviating movement impairments. This research suggests that targeting the p38-TFEB pathway could be a potential therapeutic strategy for Parkinson's disease.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Medicine, General & Internal
Masresha Ahmed Assaye, Solomon T. Gizaw
Summary: Proteostasis, or protein homeostasis, is crucial for cell survival. Among the different forms of autophagy, chaperone-mediated autophagy (CMA) plays a distinct role in maintaining cellular homeostasis. Dysfunction in CMA has been associated with neurodegenerative diseases and cancer, highlighting its importance in these conditions.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar de Rojasj, Thiago Peixoto Leal, Akinori Miyashita, Celine Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier-Boley, Tatsuhiko Naito, Fahri Kucukali, Seth D. Talyansky, Selina Maria Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Alvarez, Beatrice Arosio, Michael E. Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, Maria J. Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stephanie Debette, Jean-Francois Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Duzel, Daniela Galimberti, Guillermo Garcia-Ribas, Jose Maria Garcia-Alberca, Pablo Garcia-Gonzalez, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grunblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jurgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonca, Merce Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gael Nicolas, Shumpei Niida, Borge G. Nordestgaard, Goran Papenberg, Janne Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A. L. Pijnenburg, Gerard Pinol-Ripoll, Julius Popp, Laura Molina Porcel, Raquel Puertaj Jordi Perez-Tur, Innocenzo Rainero, Inez Ramakers, Luis M. Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Owen A. Ross, Jose Luis Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John van Swieten, Raquel Sanchez-Valle, Eng-King Tan, Thomas Tegos, Charlotte Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans Verhey, Margda Waern, Jens Wiltfang, Jing Zhangc, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G. Kehoe, Ole A. Andreassen, Cornelia Van Duin, Magda Tsolaki, Pascual Sanchez-Juan, Ruth Frikke-Schmidt, Kristel Sleegers, Tatsushi Todau, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje van der Fliere, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustin Ruiz, Ziv Gan-Or, Jean-Charles Lambert, Michael D. Greicius, Emmanuel Mignot
Summary: We analyzed the HLA associations in individuals with Parkinson's disease and Alzheimer's disease across different ancestry groups and found that these two diseases share a common protective association at the HLA locus. Fine-mapping showed that specific subtypes of HLA-DRB1*04 were responsible for this association, with HLA-DRB1*04:04 and HLA-DRB1*04:07 showing the strongest association. This protective effect was also associated with decreased neurofibrillary tangles in the brain and reduced levels of tau protein in cerebrospinal fluid.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biology
Trae Carroll, Sanjib Guha, Keith Nehrke, Gail V. W. Johnson
Summary: The spatial progression of Alzheimer's Disease cases in the brain follows a well-defined route, and recent research suggests that certain neurons may be more vulnerable to AD stress, potentially leading to selective vulnerability. Modifications of tau protein have been implicated in this selective vulnerability, with specific phosphorylation sites disrupting proper tau function and initiating early pathological changes.
Article
Pharmacology & Pharmacy
H. Cui, S. Norrbacka, T. T. Myohanen
Summary: Previous studies have shown that the PREP inhibitor KYP-2047 can promote the degradation of alpha-syn through the activation of the CMA pathway, leading to disease-modifying effects in PD treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Danail Minchev, Maria Kazakova, Victoria Sarafian
Summary: Parkinson's disease is a neurodegenerative disorder characterized by neuronal degeneration and the accumulation of alpha-Synuclein aggregates. Neuroinflammation and autophagy are crucial processes implicated in the development of Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Michal Rakowski, Szymon Porebski, Agnieszka Grzelak
Summary: This review focuses on the modulation of autophagy by selected vitamins and nutraceuticals, and their potential value in the treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sung Wook Kim, Jun Ho Lee, Bumjung Kim, Gabsik Yang, Jong Uk Kim
Summary: Alzheimer's disease and Parkinson's disease are the most common neurodegenerative diseases worldwide, with increasing incidence rates due to population aging. The exact cause and treatment methods are unknown, but research suggests specific proteins play a role in these diseases. Medications available currently only delay disease progression and have adverse effects, increasing interest in natural products with fewer side effects. This study reviewed 16 papers and found promising mechanisms of action for natural products in treating these diseases, such as antioxidant and anti-inflammatory effects, suggesting their potential as alternative treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Yi-Ting Wang, Jia-Hong Lu
Summary: Chaperone-mediated autophagy (CMA) is a protein degradation mechanism associated with neurodegenerative diseases (NDs). Modulating CMA has been shown to promote the degradation of ND-associated proteins and alleviate ND phenotypes, making it a potential therapeutic strategy for ND.
Review
Cell Biology
Virginie Hubert, Sebastian Weiss, Andrew Jackson Rees, Renate Kain
Summary: Autophagy is a central mechanism for maintaining cellular homeostasis. Chaperone-mediated autophagy (CMA) is a selective degradation pathway for soluble cytosolic proteins. Altered levels of CMA are associated with various diseases, but its therapeutic potential is still limited.
Review
Geriatrics & Gerontology
Ranran Lu, Lijie Zhang, Xinling Yang
Summary: Autophagy is crucial for maintaining cellular homeostasis by degrading damaged organelles, misfolded proteins, and pathogens. Autophagy has a complex interaction with neuroinflammation. Strengthening autophagy can reduce neuroinflammation and protect neurons. Clearance of protein aggregates through autophagy activation can delay the progression of neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jing Liu, Lijuan Wang, Hua He, Yueying Liu, Yiqun Jiang, Jinfeng Yang
Summary: Chaperone-mediated autophagy (CMA) is a process that degrades proteins labeled with KFERQ-like motifs within cells to terminate their functioning. CMA plays a crucial role in cell proliferation and apoptosis. Its relationship with cancer is complex, with contradictory effects in cancer cells and untransformed cells, leading to interest in regulating CMA activity for cancer therapy.
Review
Biochemistry & Molecular Biology
Zhong-Xuan Wang, Yao-Lin Li, Jia-Li Pu, Bao-Rong Zhang
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, and the role of DNA damage and repair deficiency in its pathogenesis has been increasingly recognized. This review provides an overview of the current understanding of DNA damage and repair in PD, including the evidence and causes of DNA damage, the potential pathways linking DNA damage to neurotoxicity, and possible interventions targeting DNA damage and repair. Future research should focus on addressing key issues to further elucidate the role of DNA damage in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Sachchida Nand Rai, Neeraj Tiwari, Payal Singh, Divya Mishra, Anurag Kumar Singh, Etrat Hooshmandi, Emanuel Vamanu, Mohan P. Singh
Summary: Autophagy is essential for cellular homeostasis, and dysregulation in this pathway is implicated in neurodegenerative disorders. TFEB, a key regulator of autophagy and lysosomal biogenesis, is considered a potential therapeutic target for treating these disorders. Studies have shown that targeting TFEB may help alleviate neurotoxicity and rescue neurodegeneration in animal models, providing insights for potential therapeutic strategies in neurodegenerative disorders.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Xiaoyan Xu, Yaqin Sun, Xufeng Cen, Bing Shan, Qingwei Zhao, Tingxue Xie, Zhe Wang, Tingjun Hou, Yu Xue, Mengmeng Zhang, Di Peng, Qiming Sun, Cong Yi, Ayaz Najafov, Hongguang Xia
Summary: The study reveals that Metformin can induce CMA through activating the TAK1-IKKα/β signaling pathway to improve the pathogenesis of neurodegenerative diseases. Additionally, Metformin can reduce amyloid-beta plaques in the brain and reverse the molecular and behavioral phenotypes of Alzheimer's disease.
Article
Chemistry, Multidisciplinary
Qian Zhang, Qingxiang Song, Xiao Gu, Mengna Zheng, Antian Wang, Gan Jiang, Meng Huang, Huan Chen, Yu Qiu, Bin Bo, Shanbao Tong, Rong Shao, Binyin Li, Gang Wang, Hao Wang, Yongbo Hu, Hongzhuan Chen, Xiaoling Gao
Summary: The multifunctional nanostructure RAP-RL developed in this study accelerates Aβ clearance and restores cerebral vasculature function, resulting in improved learning and memory abilities in AD mice.
Article
Clinical Neurology
Ru-Jing Ren, Qiang Huang, Gang Xu, Kai Gu, Eric B. Dammer, Chun-Fang Wang, Xin-Yi Xie, Wen Chen, Zhen-Yi Shao, Sheng-Di Chen, Gang Wang
Summary: The study found that patients with Alzheimer's disease in the Chinese population had a lower risk of developing certain cancers, including lung cancer and prostate and testicular cancer, but a positive association with a higher incident rate of lymphoma was observed.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Hualong Wang, Ying Xu, Rujing Ren, Feng Yao, Mei Chen, Zhihua Sheng, Xin Guo, Yan Li, Shengdi Chen, Gang Wang
Summary: The study on 106 Alzheimer's disease patients revealed different blood pressure characteristics in patients at different stages, with some having high blood pressure or low blood pressure, which correlated with cognitive performance. Additionally, patients in the mild stage showed a higher prevalence in certain characteristics compared to those in the severe stage.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Xin-Yi Xie, Guo-zhen Lin, Qiang Huang, Chun-Bo Li, Mark Hallett, Valerie Voon, Ru-jing Ren, Sheng-di Chen, Gang Wang
Summary: The survey found that Chinese clinicians consider atypical movement disorders, multiple somatizations, and emotional disturbance to be essential for the diagnosis of functional movement disorders (FMD). However, lack of guidelines, physician knowledge, and training often limit their ability to manage patients with FMD. Efforts are needed to promote related research and establish practice guidelines in China in the future.
Article
Geriatrics & Gerontology
Qiang Huang, Yong-Fang Zhang, Lin-Jie Li, Eric B. Dammer, Yong-Bo Hu, Xin-Yi Xie, Ran Tang, Jian-Ping Li, Jin-Tao Wang, Xiang-Qian Che, Gang Wang, Ru-Jing Ren
Summary: Neuronal ceroid lipofuscinosis (NCL) is a group of inherited neurodegenerative diseases characterized by the presence of lipofuscin deposits in the lysosomal lumen. In this study, a novel C128Y mutation in the DNAJC5 gene was identified in a young Chinese female with adult-onset NCL, leading to abnormal palmitoylation and lipofuscin deposits.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jin-Tao Wang, Gang Xu, Ru-Jing Ren, Ying Wang, Ran Tang, Qiang Huang, Jian-Ping Li, Murad Al-Nusaif, Wei-Dong Le, Gang Wang
Summary: This study investigates the impact of health insurance and resources on the burden of Alzheimer's disease and related dementias (ADRD). The findings suggest that ADRD has an increasing burden on patients globally, both physically and economically. Moreover, health resources are negatively associated with certain burden factors, such as disability-adjusted life years (DALY) and death, but positively associated with years of life lived with disability (YLD).
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Yisong Hu, Wenjia Peng, Rujing Ren, Ying Wang, Gang Wang
Summary: This study found a clear association between sarcopenia and mild cognitive impairment (MCI) among elderly adults in China, based on a large-scale survey. The longitudinal study confirmed the link between sarcopenia and cognitive decline.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Hua-Long Wang, Ran Tang, Ru-Jing Ren, Eric B. Dammer, Qi-Hao Guo, Guo-Ping Peng, Hai-Lun Cui, You-Min Zhang, Jin-Tao Wang, Xin-Yi Xie, Qiang Huang, Jian-Ping Li, Fu-Hua Yan, Sheng-Di Chen, Na-Ying He, Gang Wang
Summary: Language deficits often occur during the early stages of Alzheimer's disease (AD), and the percentage of silence duration (PSD) has been found to be a reliable diagnostic biomarker for early-stage AD and amnestic mild cognitive impairment (aMCI). The brain's response to fluency tasks is significantly inhibited in the aMCI/AD group, which partially explains the elevated PSD.
Article
Biochemistry & Molecular Biology
Xin-Yi Xie, Qian-Hua Zhao, Qiang Huang, Eric Dammer, Sheng-di Chen, Ru-Jing Ren, Gang Wang, Alzheimer's Dis Neuroimaging Initiat
Summary: Compared with early-onset familial Alzheimer's disease, the heritability of most familial late-onset Alzheimer's disease remains unclear. In this study, targeted sequencing of selected candidate genes was conducted for Chinese Han individuals with familial late-onset Alzheimer's disease, revealing the most frequent variants in CR1, TREM2, and ACE. Additionally, novel pathogenic mutations in ACE were found to be associated with familial late-onset Alzheimer's disease.
Article
Medicine, General & Internal
Xiehe Kong, Zhao Ma, Ran Tang, Xuejun Wang, Kai Wei, Guang Yang, Yanting Yang, Yue Zhao, Dan Zhang, Chen Xie, Gang Wang, Xiaopeng Ma
Summary: This study aims to confirm the efficacy of acupuncture as an adjunctive treatment for mild AD and explore the relationship between clinical efficacy and shifts in gut microbiota.
FRONTIERS IN MEDICINE
(2023)
Article
Neurosciences
Xiang-Qian Che, Guo-Zhen Lin, Xiao-Hong Liu, Gang Wang, Qian-Hua Zhao, Ru-Jing Ren
Summary: This study identified a novel SIGMAR1 gene variant independent of C9orf72 gene status, which is associated with semantic dementia. Further MR imaging showed that this variant is related to pathological progression and is predicted to affect normal splicing.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Editorial Material
Clinical Neurology
Yue Huang, Qiao-Xin Li, Ling-Xiao Cao, Gang Wang, Daniel Kam Yin Chan, Conceicao Bettencourt, Adrienne E. Milward
FRONTIERS IN NEUROLOGY
(2023)
Article
Psychiatry
Xinyi Xie, Qingxiang Song, Chengxiang Dai, Shishuang Cui, Ran Tang, Suke Li, Jing Chang, Ping Li, Jintao Wang, Jianping Li, Chao Gao, Hongzhuan Chen, Shengdi Chen, Rujing Ren, Xiaoling Gao, Gang Wang
Summary: This study conducted a phase I/II clinical trial with three dosage groups to explore the safety and efficacy of allogenic human adipose MSCs-Exos in patients with mild to moderate AD. The results showed that intranasal administration of ahaMSCs-Exos was safe and well tolerated, and a specific dosage was recommended for further clinical trials.
GENERAL PSYCHIATRY
(2023)
Review
Health Care Sciences & Services
Ling-Xiao Cao, Gang Wang, Qi-Hao Guo, Wei Zhang, Thomas Bak, Yue Huang
Summary: Addenbrooke's cognitive examination (ACE) is an effective cognitive screening tool that shows better performance than other tests in detecting mild cognitive impairment in various neurological disorders. The Chinese version of ACE has been translated into multiple languages and can facilitate early identification and management of cognitive impairment in China.
Review
Psychiatry
Rujing Ren, Jinlei Qi, Shaohui Lin, Xinya Liu, Peng Yin, Zhihui Wang, Ran Tang, Jintao Wang, Qiang Huang, Jianping Li, Xinyi Xie, Yongbo Hu, Shishuang Cui, Yuan Zhu, Xiaoping Yu, Pengfei Wang, Yikang Zhu, Yiran Wang, Yanyan Huang, Yisong Hu, Ying Wang, Chunbo Li, Maigeng Zhou, Gang Wang
Summary: China's aging population and the increasing prevalence of neurodegenerative disorders, particularly Alzheimer's disease and related dementias, have led to an urgent need for healthcare resources to support the affected individuals and their families. This report provides an overview of the epidemiological trends, economic burden, clinical diagnosis and treatment status, and available public health resources for these diseases in China. It also highlights the public health impact of Alzheimer's disease and related dementias, including prevalence, mortality, costs, and the overall effect on caregivers and society. Furthermore, it offers technical guidance and support for prevention and treatment, and emphasizes the importance of international exchange and cooperation in addressing this issue.
GENERAL PSYCHIATRY
(2022)
