Article
Engineering, Biomedical
Zhouguang Wang, Yan Huang, Yan He, Sinan Khor, Xingxing Zhong, Jian Xiao, Qingsong Ye, Xiaokun Li
Summary: The use of an injectable coacervate to protect growth factor FGF10 has shown to significantly improve heart condition in a mouse acute myocardial infarction model, with better outcomes compared to free FGF10 or heparin+FGF10 treatment, especially in the long term. The coacervate treatment effectively inhibited cardiac deterioration, reduced myocardial inflammation and fibrosis, improved arterioles and capillaries stabilization, and activated signaling pathways related to cardiac function and angiogenesis.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Environmental
Bin Wang, Chengfan Wu, Shufang He, Yaguang Wang, Di Wang, Hui Tao, Chenchen Wang, Xiaoxi Pang, Fei Li, Yue Yuan, Eric R. Gross, Gaolin Liang, Ye Zhang
Summary: In this study, a new supramolecular hydrogel V1-Cal/NapFFY was developed, which significantly enhanced the therapeutic effects of V1-Cal on myocardial infarction and improved cardiac function. The hydrogel demonstrated sustained release of V1-Cal for more than two weeks and effectively reduced TRPV1 expression, apoptosis, and inflammatory factors in vivo experiments.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Di Wang, Yang Hu, Lili Zhang, Haijian Cai, Yaguang Wang, Ye Zhang
Summary: Anti-inflammatory strategies have the potential to be a definitive treatment for ventricular remodeling post myocardial infarction. The SN50/IL-10/NapFFY hydrogel can sustainably release IL-10 and SN50, improving myocardial fibrosis and promoting cardiac function recovery in the treatment of myocardial infarction.
ACTA BIOMATERIALIA
(2023)
Review
Immunology
Shuwan Xu, Jishou Zhang, Jianfang Liu, Jing Ye, Yao Xu, Zhen Wang, Junping Yu, Di Ye, Mengmeng Zhao, Yongqi Feng, Wei Pan, Menglong Wang, Jun Wan
Summary: Members of the IL-10 cytokine family, such as IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29, play critical roles in regulating inflammation, which is closely associated with the occurrence and progression of cardiovascular diseases. Studies have focused on the relationship between the IL-10 cytokine family and cardiovascular diseases, aiming to determine their contribution to disease regulation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Environmental
Shu-yi He, Lin-yu Long, Zhi-cun Wang, Wen-qi Liu, Wen Zhang, Cheng Hu, Xiao-feng Wu, Ruiqi Dong, Hong-song Fan, Qing Jiang, Ying-ying Tong, Guang-hua Yang, Li Yang, Yun-bing Wang
Summary: In this study, an injectable self-doping conductive hydrogel was developed for delivering human umbilical cord mesenchymal stem cell secretome to protect cardiac function after myocardial infarction. The conductive hydrogel showed good biocompatibility and conductivity consistent with the natural myocardium, and the secretome was able to promote cell proliferation, migration, and angiogenesis. In a rat MI model, hydrogel injection improved ejection fraction and fraction shortening, and decreased susceptibility to arrhythmia.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Yang Liu, Rui Guo, Tengling Wu, Yuanning Lyu, Meng Xiao, Binbin He, Guanwei Fan, Jianhai Yang, Wenguang Liu
Summary: A cell-free and therapeutic drug-free injectable zwitterionic hydrogel with antioxidant ability and intrinsic conductive properties was fabricated, showing positive effects such as promoting cardiovascular growth and reducing cardiac fibrosis after injection into the infarcted region of rats.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Amirala Bakhshian Nik, Santiago Alvarez-Argote, Caitlin C. O'Meara
Summary: IL4 and IL13 play a significant role in cardiac regeneration and repair following injury, leading to beneficial outcomes. However, there is still a lack of comprehensive understanding about their molecular and cellular actions in the heart.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
S-H Li, Y-Y Zhang, Y-L Sun, H-J Zhao, Y. Wang
Summary: The study showed that miR-802-5p expression increased in myocardial infarction and its silencing could inhibit apoptosis by activating the Sonic Hedgehog signaling pathway, reducing myocardial injury and improving cardiac function in rats with myocardial infarction.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Mingyu Lee, Junggeon Park, Goeun Choe, Sanghun Lee, Bo Gyeong Kang, Ju Hee Jun, Yoonmin Shin, Min Chul Kim, Yong Sook Kim, Youngkeun Ahn, Jae Young Lee
Summary: Myocardial infarction (MI) is a major cause of death worldwide. We developed a hydrogel cardiac patch that provides mechanical support, electrical conduction, and tissue adhesiveness to aid in the recovery of an infarcted heart function. The MXene-based conductive and adhesive hydrogel (CAH) showed promising results in in vitro and in vivo studies, improving cardiac function and alleviating pathological remodeling of an infarcted heart.
Article
Chemistry, Multidisciplinary
Cagla Eren Cimenci, Nick J. R. Blackburn, Veronika Sedlakova, Justina Pupkaite, Marcelo Munoz, Benjamin H. Rotstein, David A. Spiegel, Emilio I. Alarcon, Erik J. Suuronen
Summary: The study demonstrates that fisetin-collagen hydrogel therapy can reduce the negative effects of MG post-MI by increasing glyoxalase-1 levels, decreasing MG-AGE accumulation, and reducing oxidative stress, leading to improved cardiac function. Additionally, the therapy promotes neovascularization, increases pro-healing macrophages, and decreases pro-inflammatory macrophages in the infarct area.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Biomedical
Linghong Zhang, Tao Li, Yan Yu, Kun Shi, Zhongwu Bei, Yongjun Qian, Zhiyong Qian
Summary: Researchers have developed a self-healing conductive hydrogel by grafting polypyrrole onto gelatin, which shows good biocompatibility and electrical conductivity. Injection of this hydrogel after myocardial infarction improves cardiac function, reduces the occurrence of arrhythmias, and decreases inflammation in the infarcted area.
BIOACTIVE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Yi Zhou, Lunan Yang, Zhen Liu, Yang Sun, Junfei Huang, Bingcheng Liu, Quan Wang, Leyu Wang, Yong Miao, Malcolm Xing, Zhiqi Hu
Summary: We developed a switchable hydrogel film adhesive with pattern-tunable wrinkles to control adhesion, addressing the challenges of on-demand adherence and detachment from tissue surfaces. The generated compressive stress from the bilayer system leads to self-similar wrinkling patterns at different wavelengths, regulating interfacial adhesion. We demonstrated the application of our adhesive in a random skin flap model, showing its potential for tissue sealing, neovascularization promotion, and gradual detachment through dynamic wrinkling pattern transition.
Article
Biochemistry & Molecular Biology
Yangjin Dong, Shanshan Li, Xiaoyun Li, Xiaoying Wang
Summary: In this study, two-dimensional MXene nanosheets with high photothermal conversion efficiency and stability were successfully prepared and applied to a hydrogel drug delivery system, providing a new approach for localized cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Xiaofang Hu, Peng Zhang, Jianing Liu, Haien Guan, Ruihong Xie, Liu Cai, Jiasong Guo, Leyu Wang, Ye Tian, Xiaozhong Qiu
Summary: A self-association crosslinked conductive zwitterionic hydrogel was developed, and it showed excellent ionic conductivity and suitable plasticity, promoting the functionalization of cardiomyocytes and the restoration of cardiac function.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Yong Wu, Tianqi Chang, Weiqian Chen, Xiaoyu Wang, Jingjing Li, Yueqiu Chen, You Yu, Zhenya Shen, Qian Yu, Yanxia Zhang
Summary: Myocardial infarction is a serious cardiovascular disease with complex pathophysiology. Treatment with injectable composite hydrogel for dual-release of VEGF and BMP9 shows a collaborative effect in promoting angiogenesis and inhibiting myocardial fibrosis, demonstrating significant potential for cardiac clinical application.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Andre Hemmler, Andrew Lin, Nikolaus Thierfelder, Thomas Franz, Michael W. Gee, Deon Bezuidenhout
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2020)
Article
Engineering, Biomedical
Kevin L. Sack, Eric Aliotta, Jenny S. Choy, Daniel B. Ennis, Neil H. Davies, Thomas Franz, Ghassan S. Kassab, Julius M. Guccione
ACTA BIOMATERIALIA
(2020)
Article
Cardiac & Cardiovascular Systems
Hugo Krynauw, Jannik Buescher, Josepha Koehne, Loes Verrijt, Georges Limbert, Neil H. Davies, Deon Bezuidenhout, Thomas Franz
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Peter Zilla, Manfred Deutsch, Deon Bezuidenhout, Neil H. Davies, Tim Pennel
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
Article
Engineering, Biomedical
Rushdi Hendricks, Elena Hofmann, Jade Peres, Sharon Prince, Jos Hille, Neil H. Davies, Deon Bezuidenhout
Summary: Obstructive sleep apnoea is a serious condition affecting nearly one billion adults globally, with CPAP being the gold standard treatment. A study on tongue tethering devices implanted in sheep showed a hybrid biological tendon-like tether formed after 32 weeks, with a break-strength of 60 N exceeding the force needed to prevent upper airway collapse.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Cell & Tissue Engineering
Candice de Boer, Bridget Calder, Dee Blackhurst, David Marais, Jonathan Blackburn, Martina Steinmaurer, Nicholas J. Woudberg, Sandrine Lecour, Jason Lovett, Kathy Myburgh, Deon Bezuidenhout, Paul Human, Neil H. Davies
Summary: This study aimed to develop a multi-step purification protocol to isolate serum exosomes and evaluate their regenerative potential. The purification process of UC DG SEC significantly improved the removal of lipoproteins from serum exosomes, leading to enhanced cellular proliferation and potential angiogenic response in vivo. The purified exosomes showed increased levels of exosome-related proteins and reduced amounts of lipoproteins, indicating a more accurate identification of serum exosome functional activity and composition.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Computer Science, Interdisciplinary Applications
Tamer Abdalrahman, Neil H. Davies, Thomas Franz
Summary: This study proposes a micromechanical hierarchical approach to capture the mechanical contribution of actin stress fibres in single cells, employing the Mori-Tanaka homogenization method. By utilizing a finite element model, the impact of stress fibre volume fractions and substrate elastic modulus on strain in cell membrane, cytoplasm, and nucleus was assessed, showing changes in peak strain in these regions.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Article
Engineering, Chemical
Harry Ngwangwa, Fulufhelo Nemavhola, Thanyani Pandelani, Makhosasana Msibi, Israel Mabuda, Neil Davies, Thomas Franz
Summary: This study evaluates the passive mechanical property differences in the three main walls of the rat heart based on biaxial tensile test data. The findings suggest that there are variations in the mechanical properties of different ventricle walls, including differences in the toe region strain range, strain energy storage, and anisotropy. These findings emphasize the importance of considering wall-specific material parameters to accurately model ventricular mechanics.
Article
Biophysics
Riham K. Ahmed, Tamer Abdalrahman, Neil H. Davies, Fred Vermolen, Thomas Franz
Summary: Cells mechanically interact with their environment to sense various mechanical cues and this has profound effects on cellular behavior, including motility. This study aims to develop a mathematical model to predict the motility of individual cells in a colony on planar elastic substrates. The model takes into account cell-substrate interaction, substrate deformation from neighboring cells, and other factors such as friction, randomness, and cell death and division. The model can accurately simulate collective cell motility on planar elastic substrates and has the potential to be extended to other cell and substrate shapes and the inclusion of chemotactic cues.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Materials Science, Biomaterials
Ellen Ngarande, Emma Doubell, Ousman Tamgue, Manuel Mano, Paul Human, Mauro Giacca, Neil Hamer Davies
Summary: This study investigates the use of a modified fibrin hydrogel combined with Invivofectamine((R)) 3.0 as a delivery system for small interfering RNA (siRNA). PEGylation of the fibrin hydrogel allows for controlled release of siRNA-lipopolyplexes and improves the stability of fibrin. In vitro and in vivo experiments demonstrate that the combination of the lipid nonviral transfection vector and fibrin enhances siRNA transfection efficacy and muscle growth in mice.
REGENERATIVE BIOMATERIALS
(2023)
Article
Cell Biology
Martin Kiwanuka, Ghodeejah Higgins, Silindile Ngcobo, Juliet Nagawa, Dirk M. Lang, Muhammad H. Zaman, Neil H. Davies, Thomas Franz
Summary: This study investigated the effect of paclitaxel on the intracellular stiffness of human oesophageal cancer cells in vitro. It was found that paclitaxel-treated cells exhibited higher stiffness in the 2D environment and increased stiffness in the 3D environment at 24 hours. However, no significant differences in stiffness were observed at 48 hours. The treated cells also showed larger size and more circular shape in the 2D environment. There were no significant morphological differences between treated and untreated cells in the 3D environment.
INTEGRATIVE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hugo Krynauw, Rodaina Omar, Josepha Koehne, Georges Limbert, Neil H. Davies, Deon Bezuidenhout, Thomas Franz
SN APPLIED SCIENCES
(2020)
