标题
New Pharmacological Perspectives for the Leptin Receptor in the Treatment of Obesity
作者
关键词
-
出版物
Frontiers in Endocrinology
Volume 5, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2014-10-13
DOI
10.3389/fendo.2014.00167
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Leptin Induces Proliferation of Neuronal Progenitors and Neuroprotection in a Mouse Model of Alzheimer's Disease
- (2018) Rocío Pérez-González et al. JOURNAL OF ALZHEIMERS DISEASE
- Leptin Reduces Pathology and Improves Memory in a Transgenic Mouse Model of Alzheimer's Disease
- (2017) Steven J. Greco et al. JOURNAL OF ALZHEIMERS DISEASE
- Therapeutic potential of flurbiprofen against obesity in mice
- (2014) Toru Hosoi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain
- (2014) Eglantine Balland et al. Cell Metabolism
- Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress
- (2014) Toru Hosoi et al. EMBO Molecular Medicine
- Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis
- (2014) K. Byun et al. EMBO REPORTS
- Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity
- (2014) Xiang Yi et al. JOURNAL OF CONTROLLED RELEASE
- Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
- (2014) Jae Geun Kim et al. NATURE NEUROSCIENCE
- Comment on “The Use of BRET to Study Receptor-Protein Interactions”
- (2014) Ralf Jockers Frontiers in Endocrinology
- Design and validation of a homogeneous time-resolved fluorescence-based leptin receptor binding assay
- (2013) Virginie Vauthier et al. ANALYTICAL BIOCHEMISTRY
- GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet
- (2013) C. Clemmensen et al. DIABETES
- Unfolded Protein Response Signaling and Metabolic Diseases
- (2013) Jaemin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing
- (2013) L. De Ceuninck et al. JOURNAL OF CELL SCIENCE
- Dietary Components in the Development of Leptin Resistance
- (2013) Joseph R. Vasselli et al. Advances in Nutrition
- Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis
- (2013) Viola Nordström et al. PLOS BIOLOGY
- Phenotypic effects of an induced mutation of the ObRa isoform of the leptin receptor
- (2013) Zhiying Li et al. Molecular Metabolism
- Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner
- (2012) S Zhao et al. INTERNATIONAL JOURNAL OF OBESITY
- Food Intake Adaptation to Dietary Fat Involves PSA-Dependent Rewiring of the Arcuate Melanocortin System in Mice
- (2012) A. Benani et al. JOURNAL OF NEUROSCIENCE
- Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
- (2012) Timo D. Müller et al. JOURNAL OF PEPTIDE SCIENCE
- Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance
- (2012) Masahiro Usui et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis
- (2012) Y. Gao et al. MOLECULAR AND CELLULAR BIOLOGY
- Ligand-Induced Architecture of the Leptin Receptor Signaling Complex
- (2012) Liliya V. Mancour et al. MOLECULAR CELL
- The Role of Dietary Components in Leptin Resistance
- (2012) Joseph R. Vasselli Advances in Nutrition
- Fluvoxamine Attenuated Endoplasmic Reticulum Stress-Induced Leptin Resistance
- (2012) Toru Hosoi et al. Frontiers in Endocrinology
- Setting Up a Bioluminescence Resonance Energy Transfer High throughput Screening Assay to Search for Protein/Protein Interaction Inhibitors in Mammalian Cells
- (2012) Cyril Couturier et al. Frontiers in Endocrinology
- Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
- (2011) Bart C. De Jonghe et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Effects of chronic weight perturbation on energy homeostasis and brain structure in mice
- (2011) Y. Ravussin et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Selection of non-competitive leptin antagonists using a random nanobody-based approach
- (2011) Lennart Zabeau et al. BIOCHEMICAL JOURNAL
- First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors
- (2011) Caroline Corbel et al. Biotechnology Journal
- Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease
- (2011) Chuanyu Li et al. Current Alzheimer Research
- Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans
- (2011) Changting Xiao et al. DIABETES
- Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway
- (2011) Karin Séron et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Fall in Leptin Concentration Is a Major Determinant of the Metabolic Adaptation Induced by Caloric Restriction Independently of the Changes in Leptin Circadian Rhythms
- (2011) Virgile Lecoultre et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Genetic approaches to understanding human obesity
- (2011) Shwetha Ramachandrappa et al. JOURNAL OF CLINICAL INVESTIGATION
- Obesity/hyperleptinemic phenotype impairs structural and functional plasticity in the rat hippocampus
- (2011) Claudia A. Grillo et al. PHYSIOLOGY & BEHAVIOR
- Leptin is an effective treatment for hypothalamic amenorrhea
- (2011) S. H. Chou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System
- (2011) Qiang Liu et al. PLOS BIOLOGY
- Novel thiazolidinedione derivatives with anti-obesity effects: Dual action as PTP1B inhibitors and PPAR-γ activators
- (2010) Bharat Raj Bhattarai et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women
- (2010) Marleen Kars et al. DIABETES
- Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis
- (2010) A. S. Reed et al. DIABETES
- Intranasal delivery of mouse [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, improves energy balance, glycaemic control, insulin sensitivity and bone formation in leptin-resistant C57BLK/6-m db/db mice
- (2010) M. A. Waldrop et al. DIABETES OBESITY & METABOLISM
- Development and Characterization of High Affinity Leptins and Leptin Antagonists
- (2010) Michal Shpilman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels
- (2010) Laurence E. Ring et al. JOURNAL OF CLINICAL INVESTIGATION
- PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
- (2010) Ryoichi Banno et al. JOURNAL OF CLINICAL INVESTIGATION
- Transport across the Blood-Brain Barrier of Pluronic Leptin
- (2010) T. O. Price et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats
- (2010) M. Matheny et al. NEUROPHARMACOLOGY
- Inhibition of PTP1B by Trodusquemine (MSI-1436) Causes Fat-specific Weight Loss in Diet-induced Obese Mice
- (2010) Kristen A. Lantz et al. Obesity
- Multi-hormonal weight loss combinations in diet-induced obese rats: Therapeutic potential of cholecystokinin?
- (2010) James L. Trevaskis et al. PHYSIOLOGY & BEHAVIOR
- Hyperleptinemia Is Required for the Development of Leptin Resistance
- (2010) Zachary A. Knight et al. PLoS One
- Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity
- (2010) S. W. Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insights into amylin–leptin synergy
- (2010) James L. Trevaskis et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
- (2009) Lale Ozcan et al. Cell Metabolism
- Leptin-based glycopeptide induces weight loss and simultaneously restores fertility in animal models
- (2009) I. Kovalszky et al. DIABETES OBESITY & METABOLISM
- Oral delivery of mouse [d-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, in male C57BL/6J wild-type andob/obmice: effects on energy balance, glycaemic control and serum osteocalcin levels
- (2009) Z. M. Novakovic et al. DIABETES OBESITY & METABOLISM
- Pegylated Leptin Antagonist Is a Potent Orexigenic Agent: Preparation and Mechanism of Activity
- (2009) Eran Elinav et al. ENDOCRINOLOGY
- Mechanisms of Amylin/Leptin Synergy in Rodent Models
- (2009) Victoria F. Turek et al. ENDOCRINOLOGY
- Tat-modified Leptin is more Accessible to Hypothalamus through Brain-blood Barrier with a Significant Inhibition of Body-weight Gain in High-fat-diet Fed Mice
- (2009) C. Zhang et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling
- (2009) Seongjin Seo et al. HUMAN MOLECULAR GENETICS
- Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status
- (2009) Sharon E. Mitchell et al. JOURNAL OF PHYSIOLOGY-LONDON
- The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
- (2009) Yiguo Wang et al. NATURE
- Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy
- (2009) Eric Ravussin et al. Obesity
- Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin
- (2009) Jong Chul Won et al. Obesity
- Interaction of Leptin and Amylin in the Long-term Maintenance of Weight Loss in Diet-induced Obese Rats
- (2009) James L. Trevaskis et al. Obesity
- The Medical Risks of Obesity
- (2009) Xavier Pi-Sunyer POSTGRADUATE MEDICINE
- Fructose-induced leptin resistance: discovery of an unsuspected form of the phenomenon and its significance. Focus on “Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding,” by Shapiro et al.
- (2008) Joseph R. Vasselli AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin
- (2008) K. Rahmouni et al. DIABETES
- Functional Characterization of Naturally Occurring Pathogenic Mutations in the Human Leptin Receptor
- (2008) Wendy Kimber et al. ENDOCRINOLOGY
- Amylin-Mediated Restoration of Leptin Responsiveness in Diet-Induced Obesity: Magnitude and Mechanisms
- (2008) James L. Trevaskis et al. ENDOCRINOLOGY
- Initiation and execution of lipotoxic ER stress in pancreatic -cells
- (2008) D. A. Cunha et al. JOURNAL OF CELL SCIENCE
- Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli
- (2008) Michael Rosenbaum et al. JOURNAL OF CLINICAL INVESTIGATION
- Endoplasmic Reticulum Stress Induces Leptin Resistance
- (2008) T. Hosoi et al. MOLECULAR PHARMACOLOGY
- Neuroprotective actions of leptin on central and peripheral neurons in vitro
- (2008) G.H. Doherty et al. NEUROSCIENCE
- Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies
- (2008) J. D. Roth et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Megalin mediates the transport of leptin across the blood-CSF barrier
- (2007) Marcelo O. Dietrich et al. NEUROBIOLOGY OF AGING
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