Article
Chemistry, Multidisciplinary
Marine Z. C. Hatit, Curtis N. Dobrowolski, Melissa P. Lokugamage, David Loughrey, Huanzhen Ni, Chiara Zurla, Alejandro Da Silva J. Sanchez, Afsane Radmand, Sebastian G. Huayamares, Ryan Zenhausern, Kalina Paunovska, Hannah E. Peck, Jinwhan Kim, Manaka Sato, Jacob I. Feldman, Michael-Alexander Rivera, Ana Cristian, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Summary: Stereochemistry affects the pharmacokinetics, safety, and efficacy of small molecules. It is unclear whether the stereochemistry of a single compound within a multicomponent colloid can influence its activity in vivo.
Review
Cell Biology
Hua-Qian Yang, Fabio A. Echeverry, Assmaa ElSheikh, Ivan Gando, Sophia Anez Arredondo, Natalie Samper, Timothy Cardozo, Mario Delmar, Show-Ling Shyng, William A. Coetzee
Summary: Sarcolemmal/plasmalemmal ATP-sensitive K+ (K-ATP) channels play crucial roles in various cell types and tissues. Recent studies have highlighted that the surface expression of K-ATP channels is tightly regulated and has significant implications in both health and disease.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cell Biology
Kamilla M. E. Laidlaw, Daniel D. Bisinski, Sviatlana Shashkova, Katherine M. Paine, Malaury A. Veillon, Mark C. Leake, Chris MacDonald
Summary: Eukaryotic cells adjust their metabolism in response to extracellular environment, with downregulation of surface cargo proteins under nutrient stress to enhance nutrient uptake. Glucose starvation triggers various transcriptional responses, including increased internalization and nutrient transport, enabling cells to persist and maximize nutrient uptake during starvation.
JOURNAL OF CELL SCIENCE
(2021)
Article
Microbiology
Qiang-Qiang Wang, Ming Sun, Tao Tang, De-Hua Lai, Jing Liu, Sanjay Maity, Kai He, Xi-Ting Wu, Jiong Yang, Yue-Bao Li, Xiao-Yan Tang, Hui-Yong Ding, Geoff Hide, Mark Distefano, Zhao-Rong Lun, Xing-Quan Zhu, Shaojun Long
Summary: By studying the model apicomplexan Toxoplasma gondii, it was found that protein prenylation is associated with endocytic trafficking. Four non-classical endocytic proteins were identified to be involved in regulating endocytic transport in T. gondii, revealing their important role in the process.
Article
Cell Biology
Irene Tirado-Cabrera, Eduardo Martin-Guerrero, Sara Heredero-Jimenez, Juan A. Ardura, Arancha R. Gortazar
Summary: Mechanical stimulation and PTH1R activation regulate osteocyte function through primary cilium, affecting communication with osteoclasts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Robert C. C. Cail, Cyna R. R. Shirazinejad, David G. G. Drubin
Summary: Cail et al. demonstrate that induced nanoscale membrane curvature can recruit endocytic proteins and produce cargo-laden vesicles without the coat protein clathrin. However, the induced curvature does not bypass AP2 and FCHo1/2 functions. This work suggests that the essential function of clathrin is to physically stabilize the curvature of the evolving vesicle.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Immunology
Ertao Jia, Haiqiong Zhu, Hongling Geng, Li Zhong, Xia Qiu, Jingjing Xie, Yuya Xiao, Yubao Jiang, Min Xiao, Yanying Zhang, Jiaxin Wei, Dabin Tang, Jianyong Zhang
Summary: This study found that neutrophil-derived exosomes stimulated by monosodium urate (MSU) can inhibit the viability of osteoblasts and affect the expression levels of related genes, indicating that neutrophil-derived exosomes play a certain role in gouty bone erosion.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Cell Biology
Paula P. Coelho, Morag Park
Summary: This study uncovers a novel LC3C-dependent pathway (LEAP) that recruits selective cargo from the plasma membrane to the phagophores, and demonstrates the interaction between LC3C and endocytic cargo for targeted autophagic degradation. These findings provide new insights into the selective coupling of PM signaling and autophagic degradation with implications in various disease states.
Review
Biochemistry & Molecular Biology
Rajarshi Chakrabarti, Miriam Lee, Henry N. Higgs
Summary: Actin filaments play multiple roles in the secretory pathway and endosome dynamics in mammals, affecting Golgi structure maintenance, membrane cargo release, endocytosis, and endosomal sorting. The specific mechanisms and functions of actin in these processes require further investigation to fully understand membrane dynamics and related pathways like autophagy.
Article
Neurosciences
Susan L. Cotman, Stephane Lefrancois
Summary: The CLN3 gene was discovered over two decades ago, but the exact function of its protein remains unknown. Loss of function mutations in CLN3 lead to juvenile neuronal ceroid lipofuscinosis, a fatal childhood onset neurodegenerative disease characterized by vision loss, seizures, progressive dementia, and premature death. Evidence suggests that CLN3 may play a role in regulating the cytoskeleton, membrane complexes, and small GTPases to mediate vesicular movement and membrane dynamics.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Vinicius de Paiva Goncalves, Marta Liliana Musskopf, Angeliz Rivera-Concepcion, Christina Yu, Sing Wai Wong, Stephen A. Tuin, Yizu Jiao, Cristiano Susin, Luis Carlos Spolidorio, Patricia Almeida Miguez
Summary: This study showed that hesperidin impaired osteoclastogenesis in vitro, but high-dose dietary hesperidin increased osteoclast numbers and promoted inflammation-induced alveolar bone loss in vivo. However, hesperidin at a dose of 500 mg/kg exhibited a bone-sparing effect on skeletal bones under physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ava Safaroghli-Azar, Mohammad-Javad Sanaei, Atieh Pourbagheri-Sigaroodi, Davood Bashash
Summary: Lipid signaling refers to the biological process in which a lipid messenger binds to a protein target, converting its effects to specific cellular responses. The family of phosphoinositide 3-kinase (PI3K) plays a crucial role in this pathway, affecting various aspects of cellular biology such as cell survival, proliferation, migration, endocytosis, intracellular trafficking, metabolism, and autophagy. Different classes of PI3Ks have been identified in yeast and mammals, with class I PI3Ks being extensively studied in cancer biology. Abnormal activation of class I PI3Ks has been implicated in human tumors, particularly through activating mutations in the PIK3CA gene. Class II and III PI3Ks are involved in regulating vesicle trafficking and autophagy processes. This review aims to discuss the latest research findings on PI3Ks-mediated cell biological processes and explore the mechanisms by which different types of phosphoinositides derived from PI3Ks act.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Elena Schwendich, Laura Salinas Tejedor, Gernot Schmitz, Markus Rickert, Juergen Steinmeyer, Stefan Rehart, Styliani Tsiami, Juergen Braun, Xenofon Baraliakos, Joerg Reinders, Elena Neumann, Ulf Mueller-Ladner, Silvia Capellino
Summary: Rheumatoid arthritis (RA) is associated with systemic osteoporosis, which leads to severe disability and low quality of life. Current therapies target osteoclasts to reduce bone degradation, but more treatment options would be required to promote bone protection by acting directly on osteoblasts (OB). Recently, the local production of dopamine in inflamed joints of RA has been observed. This study aimed to determine the implication of dopamine in the bone formation process in RA.
Article
Plant Sciences
Jingjing Xing, Dongchao Ji, Zhikun Duan, Tong Chen, Xiaomin Luo
Summary: The plant receptor-like kinase FERONIA (FER) plays multiple roles in regulating cellular processes such as cell growth, hormone signaling and response to pathogens. This study found that flg22 stimulus promotes the dissociation of FER from the plasma membrane and its localization to endosomes. FER undergoes constitutive endocytosis and recycling, and is essential for flg22 perception and immune activation.
Article
Biochemistry & Molecular Biology
Brendan T. Finicle, Kazumi H. Eckenstein, Alexey S. Revenko, Brooke A. Anderson, W. Brad Wan, Alison N. McCracken, Daniel Gil, David A. Fruman, Stephen Hanessian, Punit P. Seth, Aimee L. Edinger
Summary: In this study, it was found that SH-BC-893, a synthetic sphingolipid analog, significantly enhances the activity of ASOs and siRNAs without increasing the permeability of endosomes. Treatment with SH-BC-893 traps oligonucleotides within more permeable compartments and disrupts endolysosomal trafficking, leading to increased potency of oligonucleotides in extrahepatic tissues. Oral administration of SH-BC-893 in mice improved the efficacy of ASOs by 15-fold in the liver and enabled target RNA knockdown in the CNS and lungs.
NUCLEIC ACIDS RESEARCH
(2023)